SECURITIES AND EXCHANGE COMMISSION
                   Washington, D.C. 20549

                         SCHEDULE TO

  Tender Offer Statement Under Section 14(d)(1) or 13(e)(1)
           of the Securities Exchange Act of 1934



                  IGENE BIOTECHNOLOGY, INC.
             (Name of Subject Company (Issuer))

                  IGENE BIOTECHNOLOGY, INC.
        (Names of Filing Persons (Issuer and Offeror)

 Warrants to Purchase Common Stock, $.01 Par Value Per Share
               (Title of Class of Securities)

                         451695100*
            (CUSIP Number of Class of Securities)


                      Edward Weisberger
                  IGENE Biotechnology, Inc.
                    9110 Red Branch Road
                  Columbia, Maryland 21045
                       (410) 997-2599
  (Name, Address and Telephone Number of Persons Authorized
                     to Receive Notices
       and Communications on Behalf of Filing Persons)

                          Copy to:
                    Cecil E. Martin, III
                      McGuireWoods LLP
                     7 Saint Paul Street
                         Suite 1000
               Baltimore, Maryland 21202-1671
                       (410) 659-4419

                  CALCULATION OF FILING FEE

 Transaction Valuation                 Amount of Filing Fee
 _____________________                 ____________________
    Not Applicable**                     Not Applicable**



     [ ] Check  the  box  if  any part of the filing fee is
offset  as  provided  by  Rule  0-11(a)(2) and identify the
filing  with  which the offsetting fee was previously paid.
Identify  the previous  filing  by  registration  statement
number, or the Form or Schedule and the date of its filing.

    Amount Previously Paid:        Filing Party:
  Form or Registration No.:        Date Filed:

     [x] Check  the  box  if  the  filing relates solely to
preliminary  communications made before the commencement of
a tender offer.

Check  the  appropriate  boxes  below   to  designate   any
transaction to which the statement relates:

     [ ] third party tender offer subject to Rule 14d-1.

     [x] issuer tender offer subject to Rule 13e-4.

     [ ] going private transaction subject to Rule 13e-3.

     [ ] amendment to Schedule 13D under Rule 13d-2.

Check the following box if the filing is a final
amendment reporting the results of the tender offer: [ ]

____________________

*Refers to common stock underlying the warrants and options.

**No filing fee is required because the filing contains only
preliminary communications made before the commencement of a
tender offer.
____________________



At  its  2008 Annual Meeting of Stockholders to be  held  on
November    3,   2008   (the   "Annual   Meeting"),    IGENE
Biotechnology,   Inc.   (the   "Company")   will   ask   its
stockholders  to  approve an amendment to  its  Articles  of
Incorporation,  as  amended,  to  increase  the  number   of
authorized shares of its common stock, par value  $0.01  per
share   (the   "Common   Stock"),   from   750,000,000    to
3,000,000,000  shares (the "Amendment").  In  the  Company's
proxy   statement  for  the  Annual  Meeting,  and  in   the
connection   with  the  proposed  Amendment,   the   Company
disclosed its intention to commence exchange offers pursuant
to which the Company will offer to exchange shares of Common
Stock for (i) outstanding warrants to purchase Common Stock,
and  (ii) outstanding options to purchase Common Stock.  The
Company  will not have sufficient shares of Common Stock  to
complete  the warrant and option exchange offers unless  the
Amendment  is  approved by the Company's  stockholders.  The
Company  plans  to  commence the exchange offers  after  the
mailing  date  of  the  proxy  statement,  but  before   the
scheduled date of the Annual Meeting.  The Company will  not
consummate  the  exchange  offers  until  after  the  Annual
Meeting,  and only if stockholder approval of the  Amendment
is  obtained.   Concurrently with  the  warrant  and  option
exchange offers, the Company contemplates an exchange  offer
of  shares  of Common Stock for all of its outstanding  debt
securities.

The  Company's  definitive proxy statement  filed  with  the
Securities and Exchange Commission (the "SEC") on October 2,
2008 is filed as Exhibit 99.1 hereto.

The  warrant  and  option exchange offers described  in  the
Proxy  Statement have not yet commenced.  Neither the  above
information nor the Proxy Statement constitutes an offer  to
warrant  holders  and  option  holders  to  exchange   their
warrants  and options.  At the time the warrant  and  option
exchange  offers  have commenced, the Company  will  provide
warrant  holders  and  option holders who  are  eligible  to
participate  in  the exchange offer with  written  materials
explaining  the precise terms and timing of the warrant  and
option  exchange  offers.   Persons  who  are  eligible   to
participate in the warrant and option exchange offers should
read  these  written materials carefully  when  they  become
available  because  they will contain important  information
about  the warrant and option exchange offers.  The  Company
will  also file these written materials with the SEC as part
of  a  tender offer statement upon the commencement  of  the
warrant  and option exchange offers.  The Company's  warrant
holders, option holders and other investors will be able  to
obtain these written materials and other documents filed  by
the  Company  with  the SEC free of charge  from  the  SEC's
website  at www.sec.gov.  In addition, the Company's warrant
holders, option holders and other investors may obtain  free
copies of the documents filed by the Company with the SEC by
directing  a written request to: IGENE Biotechnology,  Inc.,
9110  Red  Branch Road, Columbia, Maryland 21045, Attention:
Corporate Secretary.

Item 12.  Exhibits

Exhibit No.

99.1      Definitive Proxy Statement for the Company's  2008
          Annual  Meeting  of Stockholders  to  be  held  on
          November 3, 2008 (incorporated by reference to the
          Company's  Schedule  14A filed  with  the  SEC  on
          October 2, 2008).