SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C.  20549

                                 FORM 8-K

                              CURRENT REPORT

  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


  Date of Report (Date of earliest event reported) January 13, 1998.


                           SEPRAGEN CORPORATION
          (Exact name of registrant as specified in its charter)



      California               0-25726           68-0073366
  (State or other            (Commission         (IRS Employer
  jurisdiction of            File Number)        Identification
  incorporation)                                 No.)



                           30689 Huntwood Avenue
                         Hayward, California 94544
             (Address of principal executive office, zip code)


  Registrant's telephone number, including area code:  (510) 476-0760


  (Former name or former address, if changed since last report):  N/A






                         THIS IS PAGE 1 OF 5 PAGES

  Item 4

  Changes in Registrant's Certifying Accountant

            (i)  Effective January 13, 1998,  Coopers & Lybrand LLP, was
  dismissed as independent accountants for Sepragen Corporation.

            (ii) Commencing  with the  audit  report  and the  financial
  statements  for the  Company's fiscal  year ended  December 31,  1996,
  Coopers  & Lybrand  LLP's opinion  on the  financial condition  of the
  Company was modified due to recurring losses and cash flow deficiencies
  from operations that raised substantial uncertainty as to the Company's
  ability to continue as a going concern, as more fully described in Note
  1 to the Company's financial statements for such period.

            (iii)     The decision  to change the  Company's independent
  accountants was approved by the Board of Directors of the Company.

            (iv) There have  been and are no  current disagreements with
  Coopers  & Lybrand  LLP  on  any matter  of  accounting principles  or
  practices,  financial  statements  disclosure, or  auditing  scope  or
  procedure.


  Item 7

  Financial Statements and Exhibits

            The following Exhibits are filed as part of this report.

  16.1      Letter on Change in Certifying Accountant.

                                SIGNATURES

            Pursuant to the requirements of the Securities Exchange Act
  of 1934, the Registrant has caused this report to be signed on its behalf
  by the undersigned duly authorized.

                                     SEPRAGEN CORPORATION


  Date: January 20, 1998             By:  /s/ Vinit Saxena              
                                     Vinit  Saxena, Chief  Executive 
                                     Officer, President, 
                                     Principal Financial Officer and 
                                     Chief Accounting Officer




                             INDEX TO EXHIBITS

                                                         Sequential
  No.                 Description                        Page No.

  16.1                Letter on Change in 
                      Certifying Accountant                   5