January 5, 2004 EDGAR United States Securities and Exchange Commission Judiciary Plaza 450 Fifth Street, N.W. Washington, D.C. 20549 Re: Form N-CSR John Hancock World Fund (the "Registrant") on behalf of: John Hancock Biotechnology Fund John Hancock Health Sciences Fund File Nos. 33-10722; 811-4932 Ladies and Gentlemen: Enclosed herewith for filing pursuant to the Investment Company Act of 1940 and the Securities Exchange Act of 1934 is the Registrant's Form N-CSR filing for the period ending October 31, 2003. If you have any questions or comments regarding this filing, please contact the undersigned at (617) 375-1722. Sincerely, /s/Brian E. Langenfeld Brian E. Langenfeld Attorney and Assistant Secretary ITEM 1. REPORT TO STOCKHOLDERS. John Hancock Health Sciences Fund ANNUAL REPORT 10.31.03 Sign up for electronic delivery at www.jhancock.com/funds/edelivery [A 2" x 1" John Hancock (Signature)/John Hancock Funds logo in lower, center middle of page. A tag line below reads "JOHN HANCOCK FUNDS."] [A photo of Maureen Ford goldfarb, Chairman and Chief Executive Officer, flush left next to first paragraph.] WELCOME Table of contents Your fund at a glance page 1 Manager's report page 2 A look at performance page 6 Growth of $10,000 page 7 Fund's investments page 8 Financial statements page 11 Trustees & officers page 25 For your information page 29 Dear Fellow Shareholders, The stock market has made a strong recovery in 2003. Historically low interest rates, improving corporate earnings and government stimulus in the form of tax cuts gave investors hope that the economy would begin to strengthen, which it did. The market's move up began in April and the breadth of the rally was enormous. As a result, the major indexes were able to wipe out their first-quarter losses and post solid gains year-to-date through October 31. With technology leading the way, the tech-heavy Nasdaq Composite Index rose 45.22% through October, while the Dow Jones Industrial Average was up 19.82% and the Standard & Poor's 500 Index returned 21.19%. With falling interest rates, bonds also did well, although they began to reverse course in July. High yield bonds led the pack, returning 24.23% through October, as measured by the Lehman Brothers High Yield Index. In other news, we are pleased to inform you that on September 28, 2003, the Boards of Directors of Canada-based Manulife Financial Corporation and Boston-based John Hancock Financial Services, Inc., the parent company of John Hancock Funds, unanimously voted to merge the two companies. Please be assured that the completion of the merger -- anticipated to occur in the first half of 2004 -- will have no effect on your investment in our John Hancock mutual funds. Your fund's adviser and board of trustees will remain the same, as will your relationship with your financial adviser. The merger is subject to customary closing conditions, including receipt of required regulatory approvals and approval by John Hancock stockholders. If you only own shares in a John Hancock mutual fund you are not affected and will not receive a proxy. Additional information on this transaction is available on our Web site: www.jhfunds.com. If you have questions about the merger, you may also call 800-732-5543. Separately, for information about your investments in John Hancock funds, please contact your financial adviser or our Customer Service representatives at 800-225-5291. Sincerely, /S/ MAUREEN FORD GOLDFARB Maureen Ford Goldfarb, Chairman and Chief Executive Officer This commentary reflects the chairman's views as of October 31, 2003. They are subject to change at any time. YOUR FUND AT A GLANCE The Fund seeks long-term growth of capital by nor- mally investing at least 80% of its assets in stocks of U.S. and foreign health-care companies. Over the last twelve months * Health-care stocks posted decent returns, but lagged the overall stock market as investors moved toward higher-growth sectors. * The Fund benefited from its holdings in biotech companies with success in cancer-related treatments. * Some health-care service companies disappointed. [Bar chart with heading "John Hancock Health Sciences Fund." Under the heading is a note that reads "Fund performance for the year ended October 31, 2003." The chart is scaled in increments of 5% with 0% at the bottom and 15% at the top. The first bar represents the 14.77% total return for Class A. The second bar represents the 13.95% total return for Class B. The third bar represents the 13.95% total return for Class C. A note below the chart reads "Total returns for the Fund are at net asset value with all distributions reinvested."] Top 10 holdings 5.7% Amgen, Inc. 5.5% Pfizer, Inc. 5.2% Medtronic, Inc. 3.7% UnitedHealth Group, Inc. 3.2% Genentech, Inc. 2.9% Stryker Corp. 2.8% Wyeth 2.7% Zimmer Holdings, Inc. 2.6% St. Jude Medical, Inc. 2.5% Teva Pharmaceutical Industries Ltd. As a percentage of net assets on October 31, 2003. MANAGER'S REPORT BY LINDA I. MILLER, CFA, PORTFOLIO MANAGER John Hancock Health Sciences Fund "Health-care stocks posted decent gains during the 12 months ended October, 31, 2003..." Health-care stocks posted decent gains during the 12 months ended October, 31, 2003, although they lagged the overall stock market. The biotechnology sector led the pack with much-better-than-market returns. Biotech stocks were boosted initially by greater investor receptivity to companies with longer-term growth prospects, then later by positive clinical trial results from a number of products in development and a jumpstart in product approvals by the FDA. Medical device makers continued their strong overall performance, though some large-cap names lagged. Health-care service companies posted mixed results, with drug distribution, managed care and hospital companies weak for much of the period. Many stocks of big multinational pharmaceutical companies performed poorly during the year, accounting for some of the year's biggest disappointments. They suffered from a variety of ills, including having too few new blockbusters to fuel profits, as well as increased competition from generic drug makers, despite the weakening of the U.S. dollar against major foreign currencies and the potential for a benign Medicare drug benefit passing through Congress. In contrast, investors became more enthusiastic about generic drug companies and specialty companies, based on the number of drugs that faced patent expiration and the development of attractive niche market opportunities. PERFORMANCE AND STRATEGY REVIEW For the 12 months ended October 31, 2003, John Hancock Health Sciences Fund's Class A, Class B and Class C shares posted total returns of 14.77%, 13.95% and 13.95%, respectively, at net asset value. During the same period, the Russell 3000 Healthcare Index returned 15.03% and the more broadly diversified average health/biotechnology fund had a total return of 21.19%, according to Lipper, Inc.,1 while the Standard & Poor's 500 Index returned 20.79%. Keep in mind that your net asset value return will be different from the Fund's performance if you were not invested in the Fund for the entire period and did not reinvest all distributions. See pages six and seven for historical performance results. [A photo of Linda Miller flush right next to first paragraph.] The Fund's underperformance of its peer group can be attributed mainly to its focus on the broader health-care stock universe. Other funds with narrower investment parameters generally were more concentrated in biotech stocks, which were the best-performing health-care group. Our decision to underweight pharmaceutical companies, and good stock selection within that group, benefited the Fund's performance. Our holdings in U.K.-based AstraZeneca posted strong returns during the year, buoyed in part by the company's new products, such as heartburn medication Nexium, which helped offset competition from generic drug makers. Our emphasis on specialty and generic drug manufacturers -- such as Biovail and Teva Pharmaceutical Industries -- was rewarded. Even though we maintained an underweighting relative to our benchmark in large multinational pharmaceutical companies, we didn't completely sidestep their problems, as holdings Johnson & Johnson, Eli Lilly, Wyeth and Pfizer came under pressure. "Among our best performers during the year were companies involved in cancer treatment and research." CANCER-RELATED TREATMENTS HELP BOOST BIOTECHS Among our best performers during the year were companies involved in cancer treatment and research. Genentech posted significant profits and earnings during the period, driven by strong sales of its flagship non-Hodgkin's lymphoma drug Rituxan and its breast cancer therapy Herceptin. Part of the stock's most recent rise can be traced to hopes about the company's experimental therapy Avastin, which fights cancer by stopping the blood supply to tumors. It may be the first of the so-called anti-angiogenesis drugs to reach the market. Amgen, the world's largest biotech company and one of the Fund's largest holdings during the period, also enjoyed better earnings due to stronger sales of many of its cancer-related medicines. These included its anemia treatments and infection-fighting drugs often used by patients undergoing chemotherapy treatments. The company also posted strong sales increases of rheumatoid arthritis drug Enbrel, which is also used to treat other immune related disorders like the skin disease psoriasis. Millennium Pharmaceuticals also performed well, largely based on the May FDA approval of its breakthrough cancer drug Velcade, used to treat a rare bone marrow cancer. Celgene enjoyed growing sales of Thalomid, a drug used to treat a cancer of plasma cells contained in bone marrow. But not all biotech stocks were winners. Trimeris, which was troubled by questions about sales of the biotech firm's new HIV therapy, declined during the year and we sold it. Another disappointment was IDEC Pharmaceuticals, which slumped due to concerns over its proposed merger with rival Biogen, although it posted profit increases toward the end of the period on higher sales of Rituxan. [Table at top left-hand side of page entitled "Top five industry groups." The first listing is Medical devices & products 21%, the second is Drugs--specialty & generic 20%, the third Drugs--biotechnology 19%, the fourth Drugs--major 13% and the fifth Insurance 7%.] [Pie chart at middle of page with heading "Portfolio diversification As a percentage of net assets on 10-31-03." The chart is divided into two sections (from top to left): Common stocks 94%, and Short-term investments & other 6%. ] HEALTH-CARE DEVICE AND SERVICE COMPANIES MIXED Health-care device and service companies turned in mixed results for the year. Some of our best performers in this area were Zimmer Holdings and Stryker Corp., which were driven higher by continued strong demand for artificial hip and knee devices from aging Baby Boomers. Cardiovascular device maker St. Jude Medical also performed well, powered by strong sales of implants to regulate racing heartbeats, and solid sales in its pacemakers and artificial heart valves. Broad service providers like drug distributors Cardinal Health and AmerisourceBergen, on the other hand, proved to be disappointing during the period and we sold our stakes. [Table at top of page entitled "SCORECARD." The header for the left column is "INVESTMENT" and the header for the right column is "PERIOD'S PERFORMANCE...AND WHAT'S BEHIND THE NUMBERS." The first listing is Genentech followed by an up arrow with the phrase "Strong demand for company's cancer treatments." The second listing is AstraZeneca followed by an up arrow with the phrase "Sales of heartburn drug boost profits." The third listing is Charles River Laboratories followed by a down arrow with the phrase "Drug and biotech companies chop spending on supplies."] OUTLOOK We remain optimistic about the outlook for health-care companies over the long term, but note that there are some considerations that may affect their near-term returns. Major consolidations may cause repercussions that are difficult to anticipate at this point. A protracted rebound in economic activity may further prompt investors to rotate away from this defensive sector in favor of faster-growing, economically sensitive companies. In addition, continuing government scrutiny of product marketing and manufacturing and Medicare billing practices may continue to grab headlines. And there are always existing risks that accompany this industry including: new product development; the rising costs of research, development, manufacturing and sales; execution success of business consolidations; and the weaker economic condition of payers for health care around the world. In addition, many stocks have sharply appreciated over the past year and could be subject to profit taking or weakness based on dilution from stock and/or other financings. That said, over the longer term, we believe that strong demographic trends, value-added new technology, moderating political risk and low interest rates also could work in the industry's favor. "A protracted rebound in economic activity may further prompt investors to rotate away from this defensive sector..." This commentary reflects the views of the portfolio manager through the end of the Fund's period discussed in this report. The manager's statements reflect her own opinions. As such, they are in no way guarantees of future events, and are not intended to be used as investment advice or a recommendation regarding any specific security. They are also subject to change at any time as market and other conditions warrant. Sector investing is subject to greater risks than the market as a whole. 1 Figures from Lipper, Inc. include reinvested dividends and do not take into account sales charges. Actual load-adjusted performance is lower. A LOOK AT PERFORMANCE For the period ended October 31, 2003 Class A Class B Class C Inception date 10-1-91 3-7-94 3-1-99 Average annual returns with maximum sales charge (POP) One year 9.04% 8.95% 11.82% Five years 3.77% 3.76% -- Ten years 11.36% -- -- Since inception -- 10.05% 3.35% Cumulative total returns with maximum sales charge (POP) One year 9.04% 8.95% 11.82% Five years 20.32% 20.29% -- Ten years 193.37% -- -- Since inception -- 151.93% 16.62% Performance figures assume all distributions are reinvested. Returns with maximum sales charge reflect a sales charge on Class A shares of 5% and Class C shares of 1%, and the applicable contingent deferred sales charge (CDSC) on Class B and Class C shares. The Class B shares' CDSC declines annually between years 1-6 according to the following schedule: 5, 4, 3, 3, 2, 1%. No sales charge will be assessed after the sixth year. Class C shares held for less than one year are subject to a 1% CDSC. The return and principal value of an investment in the Fund will fluctuate, so that shares, when redeemed, may be worth more or less than the original cost. The returns reflect past results and should not be considered indicative of future performance. The performance table above and the chart on the next page do not reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. GROWTH OF $10,000 This chart shows what happened to a hypothetical $10,000 investment in Class A shares for the period indicated. For comparison, we've shown the same investment in two separate indexes. Line chart with the heading "GROWTH OF $10,000." Within the chart are four lines. The first line represents Russell 3000 Healthcare Index and is equal to $38,709 as of October 31, 2003. The second line represents the value of the hypothetical $10,000 investment made in the John Hancock Health Sciences Fund, before sales charge, and is equal to $30,888 as of October 31, 2003. The third line represents the value of the same hypothetical investment made in the John Hancock Health Sciences Fund, after sales charge, and is equal to $29,337 as of October 31, 2003. The fourth line represents Standard & Poor's 500 Index and is equal to $26,968 as of October 31, 2003. Cum Value of $10K Cum Value of $10K S&P 500 Russell 3000 Plot Date (No Load) (w/Load) Index Healthcare Index 10/31/1993 $10,000 $9,500 $10,000 $10,000 4/30/1994 10,636 10,102 9,768 9,818 10/31/1994 11,399 10,826 10,387 11,538 4/30/1995 12,664 12,028 11,474 13,105 10/31/1995 14,933 14,183 13,133 16,063 4/30/1996 18,619 17,684 14,941 18,624 10/31/1996 16,909 16,060 16,297 19,881 4/30/1997 17,370 16,498 18,696 22,585 10/31/1997 21,412 20,336 21,531 26,484 4/30/1998 25,052 23,794 26,373 33,569 10/31/1998 24,390 23,165 26,266 35,327 4/30/1999 24,109 22,898 32,129 37,617 10/31/1999 24,670 23,431 33,008 38,362 4/30/2000 29,024 27,567 35,383 39,546 10/31/2000 35,977 34,170 35,018 47,290 4/30/2001 31,983 30,376 30,793 43,644 10/31/2001 31,098 29,536 26,297 43,027 4/30/2002 30,795 29,248 26,905 40,678 10/31/2002 26,914 25,562 22,325 35,107 4/30/2003 27,372 25,997 23,324 36,409 10/31/2003 $30,888 $29,337 $26,968 $38,709 Class B 1 Class C 1 Period beginning 3-7-94 3-1-99 Without sales charge $25,193 $11,778 With maximum sales charge $25,193 $11,662 Index 1 $26,737 $9,083 Index 2 $37,907 2 $9,865 Assuming all distributions were reinvested for the period indicated, the table above shows the value of a $10,000 investment in the Fund's Class B and Class C shares, respectively, as of October 31, 2003. Performance of the classes will vary based on the difference in sales charges paid by shareholders investing in the different classes and the fee structure of those classes. Standard & Poor's 500 Index -- Index 1 -- is an unmanaged index that includes 500 widely traded common stocks. Russell 3000 Healthcare Index -- Index 2 -- is a capitalization-weighted index composed of companies involved in medical services or health care. It is not possible to invest directly in an index. Index figures do not reflect sales charges and would be lower if they did. 1 No contingent deferred sales charge applicable. 2 Period beginning 2-28-94. FINANCIAL STATEMENTS FUND'S INVESTMENTS Securities owned by the Fund on October 31, 2003 This schedule is divided into two main categories: common stocks and short-term investments. Common stocks are further broken down by industry group. Short-term investments, which represent the Fund's cash position, are listed last. SHARES ISSUER VALUE COMMON STOCKS 93.76% $266,247,040 (Cost $193,544,474) Drugs -- Biotechnology 19.17% 54,425,700 260,000 Amgen, Inc.* + 16,057,600 125,000 Amylin Pharmaceuticals, Inc.* + 3,416,250 35,000 Biogen, Inc.* 1,416,450 67,600 BioMarin Pharmaceutical, Inc.* + 473,200 105,000 Chiron Corp.* + 5,736,150 110,000 Genentech, Inc.* + 9,016,700 125,000 Genzyme Corp.* + 5,737,500 125,000 Human Genome Sciences, Inc.* + 1,738,750 40,000 IDEC Pharmaceuticals Corp.* 1,405,200 140,000 Kosan Biosciences, Inc. 1,283,800 35,000 MedImmune, Inc.* 933,100 175,000 Millennium Pharmaceuticals, Inc.* + 2,786,000 65,000 OSI Pharmaceuticals, Inc.* 1,820,000 100,000 Protein Design Labs, Inc.* 1,348,000 100,000 Tularik, Inc.* + 1,257,000 Drugs -- Diversified 3.16% 8,986,600 140,000 Abbott Laboratories 5,966,800 60,000 Johnson & Johnson 3,019,800 Drugs -- Major 13.32% 37,822,100 65,000 AstraZeneca Plc American Depositary Receipts (ADR) (United Kingdom) 3,099,200 75,000 Lilly (Eli) & Co. 4,996,500 160,000 Novartis AG (ADR) (Switzerland)+ 6,139,200 495,000 Pfizer, Inc. 15,642,000 180,000 Wyeth 7,945,200 Drugs -- Specialty and Generic 19.90% 56,496,335 110,000 Alcon, Inc. (Switzerland)* 6,062,100 80,000 Allergan, Inc. 6,049,600 75,000 Atrix Laboratories, Inc.* + 1,506,750 75,000 Biovail Corp. (Canada)* 1,803,750 75,000 Celgene Corp.* + 3,126,750 25,000 Eon Labs, Inc.* 1,052,750 120,000 Forest Laboratories, Inc.* + 6,001,200 115,000 Gilead Sciences, Inc.* + 6,276,700 100,000 Medicines Co. (The)* + 2,665,000 170,000 Mylan Laboratories, Inc. 4,105,500 65,000 Neurocrine Biosciences, Inc.* + 3,043,950 85,000 NPS Pharmaceuticals, Inc.* + 2,238,050 126,471 Teva Pharmaceutical Industries Ltd. (ADR) (Israel) 7,194,935 100,000 Vicuron Pharmaceuticals, Inc. * + 1,835,000 90,000 Watson Pharmaceutical, Inc.* 3,534,300 Health Care -- Hospitals 0.58% 1,646,750 35,000 Universal Health Services, Inc. (Class B)* 1,646,750 Health Care -- Services 4.99% 14,173,150 85,000 Advisory Board Co. (The)* + 3,093,150 175,000 Caremark Rx, Inc.* + 4,383,750 125,000 Covance, Inc.* 3,253,750 25,000 DaVita, Inc.* 877,500 60,000 ICON Plc (ADR) (Ireland) * + 2,565,000 Instruments -- Scientific 4.66% 13,240,300 135,000 Affymetrix, Inc.* + 3,460,050 85,000 Fisher Scientific International, Inc. * 3,421,250 100,000 Invitrogen Corp.* 6,359,000 Insurance 7.45% 21,152,600 50,000 Anthem, Inc.* 3,421,500 90,000 Mid Atlantic Medical Services, Inc.* 5,256,000 205,000 UnitedHealth Group, Inc. + 10,430,400 23,000 Wellpoint Health Networks, Inc.* 2,044,700 Medical Devices and Products 20.53% 58,303,505 45,000 Biomet, Inc. 1,613,700 95,000 Boston Scientific Corp.* 6,433,400 77,892 DENTSPLY International, Inc. + 3,442,048 34,100 Diagnostic Products Corp. 1,391,962 85,000 Edwards Lifesciences Corp.* 2,465,000 65,000 Guidant Corp. 3,315,650 325,000 Medtronic, Inc. 14,810,250 43,015 Respironics, Inc.* 1,793,295 125,000 St. Jude Medical, Inc. * 7,270,000 100,000 Stryker Corp. + 8,111,000 120,000 Zimmer Holdings, Inc.* + 7,657,200 INTEREST PAR VALUE ISSUER, DESCRIPTION, MATURITY DATE RATE (000s OMITTED) VALUE SHORT-TERM INVESTMENTS 34.68% $98,487,049 (Cost $98,487,049) Joint Repurchase Agreement 6.29% Investment in a joint repurchase agreement transaction with Barclays Capital, Inc. -- Dated 10-31-03, due 11-03-03 (Secured by U.S. Treasury Inflation Indexed Bond 3.625% due 04-15-28, U.S. Treasury Inflation Indexed Note 1.875% due 07-15-13) 1.020% $17,860 17,860,000 SHARES Cash Equivalents 28.39% AIM Cash Investment Trust** 80,627,049 80,627,049 TOTAL INVESTMENTS 128.44% $364,734,089 OTHER ASSETS AND LIABILITIES, NET (28.44%) ($80,773,302) TOTAL NET ASSETS 100.00% $283,960,787 + All or a portion of this security is on loan as of October 31, 2003. * Non-income producing security. ** Represents investment of security lending collateral. Parenthetical disclosure of a foreign country in the security description represents country of a foreign issuer. The percentage shown for each investment category is the total value of that category as a percentage of the net assets of the Fund. See notes to financial statements. ASSETS AND LIABILITIES October 31, 2003 This Statement of Assets and Liabilities is the Fund's balance sheet. It shows the value of what the Fund owns, is due and owes. You'll also find the net asset value and the maximum offering price per share. ASSETS Investments at value (cost $292,031,523), including $79,523,464 of securities loaned $364,734,089 Cash 517 Receivable for investments sold 5,110,790 Receivable for shares sold 71,218 Dividends and interest receivable 42,422 Other assets 12,345 Total assets 369,971,381 LIABILITIES Payable for investments purchased 4,364,469 Payable for shares repurchased 212,780 Payable for securities on loan 80,627,049 Payable to affiliates Management fee 583,494 Distribution and service fee 21,022 Other 112,024 Other payables and accrued expenses 89,756 Total liabilities 86,010,594 NET ASSETS Capital paid-in 227,586,064 Accumulated net realized loss on investments (16,322,155) Net unrealized appreciation of investments and translation of assets and liabilities in foreign currencies 72,702,655 Accumulated net investment loss (5,777) Net assets $283,960,787 NET ASSET VALUE PER SHARE Based on net asset values and shares outstanding Class A ($116,932,277 [DIV] 2,938,717 shares) $39.79 Class B ($154,325,548 [DIV] 4,181,151 shares) $36.91 Class C ($12,702,962 [DIV] 344,173 shares) $36.91 MAXIMUM OFFERING PRICE PER SHARE Class A 1 ($39.79 [DIV] 95%) $41.88 Class C ($36.91 [DIV] 99%) $37.28 1 On single retail sales of less than $50,000. On sales of $50,000 or more and on group sales the offering price is reduced. See notes to financial statements. OPERATIONS For the year ended October 31, 2003 This Statement of Operations summarizes the Fund's investment income earned and expenses incurred in operat- ing the Fund. It also shows net gains (losses) for the period stated. INVESTMENT INCOME Dividends (net of foreign withholding taxes of $18,094) $1,307,602 Securities lending 279,472 Interest 165,864 Total investment income 1,752,938 EXPENSES Investment management fee 2,133,426 Class A distribution and service fee 328,600 Class B distribution and service fee 1,546,915 Class C distribution and service fee 119,789 Transfer agent fee 1,340,342 Accounting and legal services fee 98,619 Custodian fee 68,652 Registration and filing fee 48,897 Auditing fee 31,200 Printing 29,542 Miscellaneous 21,613 Trustees' fee 17,160 Legal fee 4,666 Interest 344 Total expenses 5,789,765 Less expense reductions (10,915) Net expenses 5,778,850 Net investment loss (4,025,912) REALIZED AND UNREALIZED GAIN Net realized gain on investments 19,286,206 Change in net unrealized appreciation (depreciation) of Investments 21,020,091 Translation of assets and liabilities in foreign currencies 29 Net realized and unrealized gain 40,306,326 Increase in net assets from operations $36,280,414 See notes to financial statements. CHANGES IN NET ASSETS These Statements of Changes in Net Assets show how the value of the Fund's net assets has changed during the last two periods. The dif- ference reflects earnings less expenses, any investment gains and losses, distributions, if any, paid to shareholders and any increase or decrease in money share- holders invested in the Fund. YEAR YEAR ENDED ENDED 10-31-02 10-31-03 INCREASE (DECREASE) IN NET ASSETS From operations Net investment loss ($5,230,634) ($4,025,912) Net realized gain (loss) (15,488,263) 19,286,206 Change in net unrealized appreciation (depreciation) (31,410,259) 21,020,120 Increase (decrease) in net assets resulting from operations (52,129,156) 36,280,414 From Fund share transactions (54,454,608) (36,109,836) NET ASSETS Beginning of period 390,373,973 283,790,209 End of period 1 $283,790,209 $283,960,787 1 Includes accumulated net investment loss of $5,482 and $5,777, respectively. See notes to financial statements. FINANCIAL HIGHLIGHTS CLASS A SHARES The Financial Highlights show how the Fund's net asset value for a share has changed since the end of the previous period. PERIOD ENDED 10-31-99 10-31-00 10-31-01 10-31-02 10-31-03 PER SHARE OPERATING PERFORMANCE Net asset value, beginning of period $33.89 $34.28 $49.99 $40.06 $34.67 Net investment loss 1 (0.18) (0.33) (0.37) (0.41) (0.38) Net realized and unrealized gain (loss) on investments 0.57 16.04 (5.99) (4.98) 5.50 Total from investment operations 0.39 15.71 (6.36) (5.39) 5.12 Less distributions From net realized gain -- -- (3.57) -- -- Net asset value, end of period $34.28 $49.99 $40.06 $34.67 $39.79 Total return 2 (%) 1.15 45.83 (13.56) (13.45) 14.77 RATIOS AND SUPPLEMENTAL DATA Net assets, end of period (in millions) $93 $178 $145 $110 $117 Ratio of expenses to average net assets (%) 1.60 1.50 1.50 1.59 1.67 Ratio of net investment loss to average net assets (%) (0.52) (0.75) (0.87) (1.06) (1.04) Portfolio turnover (%) 61 147 91 85 95 See notes to financial statements. FINANCIAL HIGHLIGHTS CLASS B SHARES PERIOD ENDED 10-31-99 10-31-00 10-31-01 10-31-02 10-31-03 PER SHARE OPERATING PERFORMANCE Net asset value, beginning of period $32.69 $32.83 $47.55 $37.68 $32.39 Net investment loss 1 (0.41) (0.60) (0.63) (0.63) (0.59) Net realized and unrealized gain (loss) on investments 0.55 15.32 (5.67) (4.66) 5.11 Total from investment operations 0.14 14.72 (6.30) (5.29) 4.52 Less distributions From net realized gain -- -- (3.57) -- -- Net asset value, end of period $32.83 $47.55 $37.68 $32.39 $36.91 Total return 2 (%) 0.43 44.84 (14.18) (14.04) 13.95 RATIOS AND SUPPLEMENTAL DATA Net assets, end of period (in millions) $152 $294 $231 $162 $154 Ratio of expenses to average net assets (%) 2.30 2.20 2.20 2.29 2.37 Ratio of net investment loss to average net assets (%) (1.22) (1.46) (1.57) (1.76) (1.74) Portfolio turnover (%) 61 147 91 85 95 See notes to financial statements. FINANCIAL HIGHLIGHTS CLASS C SHARES PERIOD ENDED 10-31-99 3 10-31-00 10-31-01 10-31-02 10-31-03 PER SHARE OPERATING PERFORMANCE Net asset value, beginning of period $33.94 $32.83 $47.55 $37.68 $32.39 Net investment loss 1 (0.28) (0.64) (0.63) (0.63) (0.59) Net realized and unrealized gain (loss) on investments (0.83) 15.36 (5.67) (4.66) 5.11 Total from investment operations (1.11) 14.72 (6.30) (5.29) 4.52 Less distributions From net realized gain -- -- (3.57) -- -- Net asset value, end of period $32.83 $47.55 $37.68 $32.39 $36.91 Total return 2 (%) (3.27)4 44.84 (14.18) (14.04) 13.95 RATIOS AND SUPPLEMENTAL DATA Net assets, end of period (in millions) $2 $14 $15 $12 $13 Ratio of expenses to average net assets (%) 2.40 5 2.20 2.20 2.29 2.37 Ratio of net investment loss to average net assets (%) (1.30) 5 (1.50) (1.58) (1.76) (1.73) Portfolio turnover (%) 61 147 91 85 95 1 Based on the average of the shares outstanding. 2 Assumes dividend reinvestment and does not reflect the effect of sales charges. 3 Class C shares began operations on 3-1-99. 4 Not annualized. 5 Annualized. See notes to financial statements. NOTES TO STATEMENTS NOTE A Accounting policies John Hancock Health Sciences Fund (the "Fund") is a nondiversified series of John Hancock World Fund, an open-end management investment company registered under the Investment Company Act of 1940. The investment objective of the Fund is to achieve long-term growth of capital. The Trustees have authorized the issuance of multiple classes of shares of the Fund, designated as Class A, Class B and Class C shares. The shares of each class represent an interest in the same portfolio of investments of the Fund and have equal rights as to voting, redemptions, dividends and liquidation, except that certain expenses, subject to the approval of the Trustees, may be applied differently to each class of shares in accordance with current regulations of the Securities and Exchange Commission and the Internal Revenue Service. Shareholders of a class that bears distribution and service expenses under the terms of a distribution plan have exclusive voting rights to that distribution plan. Significant accounting policies of the Fund are as follows: Valuation of investments Securities in the Fund's portfolio are valued on the basis of market quotations, valuations provided by independent pricing services or, if quotations are not readily available, or if the value has been materially affected by events occurring after the closing of a foreign market, at fair value as determined in good faith in accordance with procedures approved by the Trustees. Short-term debt investments maturing within 60 days are valued at amortized cost, which approximates market value. Investments in AIM Cash Investment Trust are valued at their net asset value each business day. All portfolio transactions initially expressed in terms of foreign currencies have been translated into U.S. dollars as described in "Foreign currency translation" below. Joint repurchase agreement Pursuant to an exemptive order issued by the Securities and Exchange Commission, the Fund, along with other registered investment companies having a management contract with John Hancock Advisers, LLC (the "Adviser"), a wholly owned subsidiary of The Berkeley Financial Group, LLC, may participate in a joint repurchase agreement transaction. Aggregate cash balances are invested in one or more large repurchase agreements, whose underlying securities are obligations of the U.S. government and/or its agencies. The Fund's custodian bank receives delivery of the underlying securities for the joint account on the Fund's behalf. The Adviser is responsible for ensuring that the agreement is fully collateralized at all times. Foreign currency translation All assets or liabilities initially expressed in terms of foreign currencies are translated into U.S. dollars based on London currency exchange quotations as of 5:00 P.M., London time, on the date of any determination of the net asset value of the Fund. Transactions affecting statement of operations accounts and net realized gain (loss) on investments are translated at the rates prevailing at the dates of the transactions. The Fund does not isolate that portion of the results of operations resulting from changes in foreign exchange rates on investments from the fluctuations arising from changes in market prices of securities held. Such fluctuations are included with the net realized and unrealized gain or loss from investments. Reported net realized foreign currency exchange gains or losses arise from sales of foreign currency, currency gains or losses realized between the trade and settlement dates on securities transactions and the difference between the amounts of dividends, interest and foreign withholding taxes recorded on the Fund's books and the U.S. dollar equivalent of the amounts actually received or paid. Net unrealized foreign currency exchange gains and losses arise from changes in the value of assets and liabilities, other than investments in securities, resulting from changes in the exchange rates. Investment transactions Investment transactions are recorded as of the date of purchase, sale or maturity. Net realized gains and losses on sales of investments are determined on the identified cost basis. Capital gains realized on some foreign securities are subject to foreign taxes, which are accrued as applicable. Class allocations Income, common expenses and realized and unrealized gains (losses) are determined at the fund level and allocated daily to each class of shares based on the appropriate net asset value of the respective classes. Distribution and service fees, if any, are calculated daily at the class level based on the appropriate net asset value of each class and the specific expense rate(s) applicable to each class. Expenses The majority of expenses are directly identifiable to an individual fund. Expenses that are not readily identifiable to a specific fund are allocated in such a manner as deemed equitable, taking into consideration, among other things, the nature and type of expense and the relative sizes of the funds. Bank borrowings The Fund is permitted to have bank borrowings for temporary or emergency purposes, including the meeting of redemption requests that otherwise might require the untimely disposition of securities. The Fund has entered into a syndicated line of credit agreement with various banks. This agreement enables the Fund to participate with other funds managed by the Adviser in an unsecured line of credit with banks, which permits borrowings of up to $250 million, collectively. Interest is charged to each fund, based on its borrowing. In addition, a commitment fee is charged to each fund based on the average daily unused portion of the line of credit and is allocated among the participating funds. The Fund had no borrowing activity under the line of credit during the year ended October 31, 2003. Securities lending The Fund may lend securities to certain qualified brokers who pay the Fund negotiated lender fees. The loans are collateralized at all times with cash or securities with a market value at least equal to the market value of the securities on loan. As with other extensions of credit, the Fund may bear the risk of delay of the loaned securities in recovery or even loss of rights in the collateral, should the borrower of the securities fail financially. At October 31, 2003, the Fund loaned securities having a market value of $79,523,464 collateralized by cash in the amount of $80,627,049. The cash collateral was invested in a short-term instrument. Federal income taxes The Fund qualifies as a "regulated investment company" by complying with the applicable provisions of the Internal Revenue Code and will not be subject to federal income tax on taxable income that is distributed to shareholders. Therefore, no federal income tax provision is required. For federal income tax purposes, the Fund has $11,828,742 of a capital loss carryforward available, to the extent provided by regulations, to offset future net realized capital gains. To the extent that such carryforward is used by the Fund, no capital gain distributions will be made. The entire amount of the loss carryforward expires October 31, 2010. Dividends, interest and distributions Dividend income on investment securities is recorded on the ex-dividend date or, in the case of some foreign securities, on the date thereafter when the Fund identifies the dividend. Interest income on investment securities is recorded on the accrual basis. Foreign income may be subject to foreign withholding taxes, which are accrued as applicable. The Fund records distributions to shareholders from net investment income and net realized gains on the ex-dividend date. Distributions paid by the Fund with respect to each class of shares are calculated in the same manner, at the same time and are in the same amount, except for the effect of expenses that may be applied differently to each class. As of October 31, 2003, there were no distributable earnings on a tax basis. Such distributions and distributable earnings, on a tax basis, are determined in conformity with income tax regulations, which may differ from accounting principles generally accepted in the United States of America. Distributions in excess of tax basis earnings and profits, if any, are reported in the Fund's financial statements as a return of capital. Use of estimates The preparation of these financial statements, in accordance with accounting principles generally accepted in the United States of America, incorporates estimates made by management in determining the reported amount of assets, liabilities, revenues and expenses of the Fund. Actual results could differ from these estimates. NOTE B Management fee and transactions with affiliates and others The Fund has an investment management contract with the Adviser. Under the investment management contract, the Fund pays a quarterly management fee to the Adviser equivalent, on an annual basis, to the sum of: (a) 0.80% of the first $200,000,000 of the Fund's average daily net asset value and (b) 0.70% of the Fund's daily average net asset value in excess of $200,000,000. The Fund has an agreement with its custodian bank under which custody fees are reduced by brokerage commission offsets applied during the period. Accordingly, the expense reductions related to custody fee offsets amounted to $10,915, and had no impact on the Fund's ratio of expenses to average net assets, for the year ended October 31, 2003. The Fund has Distribution Plans with John Hancock Funds, LLC ("JH Funds"), a wholly owned subsidiary of the Adviser. The Fund has adopted Distribution Plans with respect to Class A, Class B and Class C pursuant to Rule 12b-1 under the Investment Company Act of 1940 to reimburse JH Funds for the services it provides as distributor of shares of the Fund. Accordingly, the Fund makes monthly payments to JH Funds at an annual rate not to exceed 0.30% of Class A average daily net asset value and 1.00% of Class B and Class C average daily net asset value. A maximum of 0.25% of such payments may be service fees as defined by the Conduct Rules of the National Association of Securities Dealers. Under the Conduct Rules, curtailment of a portion of the Fund's 12b-1 payments could occur under certain circumstances. Class A and Class C shares are assessed up-front sales charges. During the year ended October 31, 2003, JH Funds received net up-front sales charges of $183,894 with regard to sales of Class A shares. Of this amount, $24,958 was retained and used for printing prospectuses, advertising, sales literature and other purposes, $126,566 was paid as sales commissions to unrelated broker-dealers and $32,370 was paid as sales commissions to sales personnel of Signator Investors, Inc. ("Signator Investors"), a related broker-dealer. The Adviser's indirect parent, John Hancock Life Insurance Company ("JHLICo"), is the indirect sole shareholder of Signator Investors. During the year ended October 31, 2003, JH Funds received net up-front sales charges of $12,993 with regard to sales of Class C shares. Of this amount, $12,184 was paid as sales commissions to unrelated broker-dealers and $809 was paid as sales commissions to sales personnel of Signator Investors. Class B shares that are redeemed within six years of purchase are subject to a contingent deferred sales charge ("CDSC") at declining rates, beginning at 5.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Class C shares that are redeemed within one year of purchase are subject to a CDSC at a rate of 1.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Proceeds from the CDSCs are paid to JH Funds and are used in whole or in part to defray its expenses for providing distribution related services to the Fund in connection with the sale of Class B and Class C shares. During the year ended October 31, 2003, CDSCs received by JH Funds amounted to $333,187 for Class B shares and $1,669 for Class C shares. The Fund has a transfer agent agreement with John Hancock Signature Services, Inc., an indirect subsidiary of JHLICo. Effective January 1, 2003, the Fund pays a monthly transfer agent fee at an annual rate of 0.05% of the average daily net asset value, plus a fee based on the number of shareholder accounts and reimbursement for certain out-of-pocket expenses. Until January 1, 2003, the Fund paid a monthly transfer agent fee based on the number of shareholder accounts plus certain out-of-pocket expenses. The Fund had an agreement with the Adviser to perform necessary tax, accounting and legal services for the Fund. The compensation for the year was at an annual rate of approximately 0.04% of the average net asset value of the Fund. The Fund had an independent advisory board composed of scientific and medical experts who provided the investment officers of the Fund with advice and consultation on health-care developments, for which the Fund paid the advisory board a fee. The Board of Trustees voted to discontinue the advisory board effective July 15, 2003. Ms. Maureen Ford Goldfarb and Mr. John M. DeCiccio are directors and/or officers of the Adviser and/or its affiliates, as well as Trustees of the Fund. The compensation of unaffiliated Trustees is borne by the Fund. The unaffiliated Trustees may elect to defer for tax purposes their receipt of this compensation under the John Hancock Group of Funds Deferred Compensation Plan. The Fund makes investments into other John Hancock funds, as applicable, to cover its liability for the deferred compensation. Investments to cover the Fund's deferred compensation liability are recorded on the Fund's books as an other asset. The deferred compensation liability and the related other asset are always equal and are marked to market on a periodic basis to reflect any income earned by the investments as well as any unrealized gains or losses. The Deferred Compensation Plan investments had no impact on the operations of the Fund. NOTE C Fund share transactions This listing illustrates the number of Fund shares sold and repurchased during the last two periods, along with the corresponding dollar value. The Fund has an unlimited number of shares authorized with no par value. YEAR ENDED 10-31-02 YEAR ENDED 10-31-03 SHARES AMOUNT SHARES AMOUNT CLASS A SHARES Sold 811,501 $30,907,585 611,552 $22,343,109 Repurchased (1,238,558) (46,192,043) (856,289) (30,738,589) Net decrease (427,057) ($15,284,458) (244,737) ($8,395,480) CLASS B SHARES Sold 629,775 $23,090,576 333,518 $11,357,801 Repurchased (1,767,118) (61,384,888) (1,141,112) (38,411,221) Net decrease (1,137,343) ($38,294,312) (807,594) ($27,053,420) CLASS C SHARES Sold 97,382 $3,575,235 65,171 $2,217,346 Repurchased (128,009) (4,451,073) (86,440) (2,878,282) Net decrease (30,627) ($875,838) (21,269) ($660,936) NET DECREASE (1,595,027) ($54,454,608) (1,073,600) ($36,109,836) NOTE D Investment transactions Purchases and proceeds from sales or maturities of securities, other than short-term securities and obligations of the U.S. government, during the year ended October 31, 2003, aggregated $250,581,133 and $304,809,906, respectively. The cost of investments owned on October 31, 2003, including short-term investments, for federal income tax purposes was $296,524,935. Gross unrealized appreciation and depreciation of investments aggregated $69,608,061 and $1,398,907, respectively, resulting in net unrealized appreciation of $68,209,154. The difference between book basis and tax basis net unrealized appreciation of investments is attributable primarily to the tax deferral of losses on certain sales of securities. NOTE E Reclassification of accounts During the year ended October 31, 2003, the Fund reclassified amounts to reflect a decrease in accumulated net realized loss on investments of $285, a decrease in accumulated net investment loss of $4,025,617 and a decrease in capital paid-in of $4,025,902. This represents the amount necessary to report these balances on a tax basis, excluding certain temporary differences, as of October 31, 2003. Additional adjustments may be needed in subsequent reporting periods. These reclassifications, which have no impact on the net asset value of the Fund, are primarily attributable to certain differences in the computation of distributable income and capital gains under federal tax rules versus accounting principles generally accepted in the United States of America, and book and tax differences in accounting for net operating loss and deferred compensation. The calculation of net investment loss per share in the Fund's Financial Highlights excludes these adjustments. AUDITORS' REPORT Report of Pricewaterhouse- Coopers LLP, Independent Auditors To the Board of Trustees and Shareholders of John Hancock Health Sciences Fund, In our opinion, the accompanying statement of assets and liabilities, including the schedule of investments, and the related statements of operations and of changes in net assets and the financial highlights present fairly, in all material respects, the financial position of the John Hancock Health Sciences Fund (the "Fund") at October 31, 2003, the results of its operations, the changes in its net assets and the financial highlights for the periods indicated, in conformity with accounting principles generally accepted in the United States of America. These financial statements and financial highlights (hereafter referred to as "financial statements") are the responsibility of the Fund's management; our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits of these financial statements in accordance with auditing standards generally accepted in the United States of America, which require that we plan and perform the audits to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that our audits, which included confirmation of securities owned at October 31, 2003, by correspondence with the custodian and brokers, provide a reasonable basis for our opinion. PricewaterhouseCoopers LLP Boston, Massachusetts December 15, 2003 TAX INFORMATION Unaudited For federal income tax purposes, the following information is furnished with respect to the distributions of the Fund, if any, paid during its taxable year ended October 31, 2003. The fund hereby designates the maximum amount allowable of its net taxable income as qualified dividend income as provided in the Jobs and Growth Tax Relief Reconciliation Act of 2003. This amount will be reflected on Form 1099-DIV for the calendar year 2003. Shareholders will be mailed a 2003 U.S. Treasury Department Form 1099-DIV in January 2004. This will reflect the total of all distributions that are taxable for the calendar year 2003. TRUSTEES & OFFICERS This chart provides information about the Trustees and Officers who oversee your John Hancock fund. Officers elected by the Trustees manage the day-to-day operations of the Fund and execute policies formulated by the Trustees. INDEPENDENT TRUSTEES NUMBER OF NAME, AGE TRUSTEE JOHN HANCOCK PRINCIPAL OCCUPATION(S) AND OTHER OF FUND FUNDS OVERSEEN DIRECTORSHIPS DURING PAST 5 YEARS SINCE 1 BY TRUSTEE Dennis S. Aronowitz, Born: 1931 1991 21 Professor of Law, Emeritus, Boston University School of Law (as of 1996); Director, Brookline Bancorp (since 1998). Richard P. Chapman, Jr., Born: 1935 1991 21 President and Chief Executive Officer, Brookline Bancorp Inc. (lending) (since 1972); Director, Lumber Insurance Co. (insurance) (until 2000); Chairman and Director, Northeast Retirement Services, Inc. (retirement administration) (since 1998). William J. Cosgrove, Born: 1933 1991 21 Vice President, Senior Banker and Senior Credit Officer, Citibank, N.A. (retired 1991); Executive Vice President, Citadel Group Representatives, Inc. (financial reinsurance); Trustee, Hudson City Savings Bank (since 1995); Director, Hudson City Bancorp (since 1999); Trustee, Scholarship Fund for Inner City Children (since 1986). Richard A. Farrell, Born: 1932 1996 21 President, Farrell, Healer & Co., Inc. (venture capital management firm) (since 1980) and President, the Venture Capital Fund of NE (since 1980); prior to 1980, headed the venture capital group at Bank of Boston Corporation; Trustee, Marblehead Savings Bank (since 1994). William F. Glavin,2 Born: 1932 1996 21 President Emeritus, Babson College (as of 1998); Vice Chairman, Xerox Corporation (until 1989); Director, Reebok, Inc. (until 2002) and Inco Ltd. (until 2002). John A. Moore,2 Born: 1939 1996 29 President and Chief Executive Officer, Institute for Evaluating Health Risks, (nonprofit institution) (until 2001); Chief Scientist, Sciences International (health research) (since 1998); Principal, Hollyhouse (consulting) (since 2000); Director, CIIT (nonprofit research) (since 2002). Patti McGill Peterson,2 Born: 1943 1996 29 Executive Director, Council for International Exchange of Scholars (since 1998); Vice President, Institute of International Education (since 1998); Senior Fellow, Cornell Institute of Public Affairs, Cornell University (until 1997); President Emerita of Wells College and St. Lawrence University; Director, Niagara Mohawk Power Corporation (electric utility). John W. Pratt, Born: 1931 1996 21 Professor of Business Administration Emeritus, Harvard University Graduate School of Business Administration (as of 1998). INTERESTED TRUSTEES 3 NAME, AGE NUMBER OF POSITION(S) HELD WITH FUND TRUSTEE JOHN HANCOCK PRINCIPAL OCCUPATION(S) AND OTHER OF FUND FUNDS OVERSEEN DIRECTORSHIPS DURING PAST 5 YEARS SINCE 1 BY TRUSTEE John M. DeCiccio, Born: 1948 2001 51 Trustee Executive Vice President and Chief Investment Officer, John Hancock Financial Services, Inc.; Director, Executive Vice President and Chief Investment Officer, John Hancock Life Insurance Company; Chairman of the Committee of Finance of John Hancock Life Insurance Company; Director, John Hancock Subsidiaries, LLC (Subsidiaries, LLC), Hancock Natural Resource Group, Independence Investment LLC, Declaration Management Research LLC, John Hancock Advisers, LLC (the "Adviser"), The Berkeley Financial Group, LLC ("The Berkeley Group"), John Hancock Funds, LLC ("John Hancock Funds") and Massachusetts Business Development Corporation; Director, John Hancock Insurance Agency, Inc. ("Insurance Agency, Inc.") (until 1999). Maureen Ford Goldfarb, Born: 1955 2000 51 Trustee, Chairman, President and Chief Executive Officer Executive Vice President, John Hancock Financial Services, Inc., John Hancock Life Insurance Company; Chairman, Director, President and Chief Executive Officer, the Adviser and The Berkeley Group; Chairman, Director, President and Chief Executive Officer, John Hancock Funds; Chairman, Director, President and Chief Executive Officer, Sovereign Asset Management Corporation ("SAMCorp."); Director, Independence Investment LLC, Subsidiaries, LLC and Signature Services; Senior Vice President, MassMutual Insurance Co. (until 1999). PRINCIPAL OFFICERS WHO ARE NOT TRUSTEES NAME, AGE POSITION(S) HELD WITH FUND OFFICER PRINCIPAL OCCUPATION(S) AND OF FUND DIRECTORSHIPS DURING PAST 5 YEARS SINCE Richard A. Brown, Born: 1949 2000 Senior Vice President and Chief Financial Officer Senior Vice President, Chief Financial Officer and Treasurer, the Adviser, John Hancock Funds and The Berkeley Group; Second Vice President and Senior Associate Controller, Corporate Tax Department, John Hancock Financial Services, Inc. (until 2001). Thomas H. Connors, Born: 1959 1992 Vice President and Compliance Officer Vice President and Compliance Officer, the Adviser and each of the John Hancock funds; Vice President, John Hancock Funds. William H. King, Born: 1952 1991 Vice President and Treasurer Vice President and Assistant Treasurer, the Adviser; Vice President and Treasurer of each of the John Hancock funds; Assistant Treasurer of each of the John Hancock funds (until 2001). Susan S. Newton, Born: 1950 1991 Senior Vice President, Secretary and Chief Legal Officer Senior Vice President, Secretary and Chief Legal Officer, SAMCorp., the Adviser and each of the John Hancock funds, John Hancock Funds and The Berkeley Group; Vice President, Signature Services (until 2000); Director, Senior Vice President and Secretary, NM Capital. The business address for all Trustees and Officers is 101 Huntington Avenue, Boston, Massachusetts 02199. The Statement of Additional Information of the Fund includes additional information about members of the Board of Trustees of the Fund and is available, without charge, upon request, by calling 1-800-225-5291. 1 Each Trustee serves until resignation, retirement age or until his or her successor is elected. 2 Member of Audit Committee. 3 Interested Trustees hold positions with the Fund's investment adviser, underwriter and certain other affiliates. OUR FAMILY OF FUNDS - ------------------------------------------------------- Equity Balanced Fund Classic Value Fund Core Equity Fund Focused Equity Fund Growth Trends Fund International Fund Large Cap Equity Fund Large Cap Growth Fund Large Cap Select Fund Mid Cap Growth Fund Multi Cap Growth Fund Small Cap Equity Fund Small Cap Growth Fund Sovereign Investors Fund U.S. Global Leaders Growth Fund - ------------------------------------------------------- Sector Biotechnology Fund Financial Industries Fund Health Sciences Fund Real Estate Fund Regional Bank Fund Technology Fund - ------------------------------------------------------- Income Bond Fund Government Income Fund High Income Fund High Yield Bond Fund Investment Grade Bond Fund Strategic Income Fund - ------------------------------------------------------- Tax-Free Income California Tax-Free Income Fund High Yield Municipal Bond Fund Massachusetts Tax-Free Income Fund New York Tax-Free Income Fund Tax-Free Bond Fund - ------------------------------------------------------- Money Market Money Market Fund U.S. Government Cash Reserve For more complete information on any John Hancock Fund and a prospectus, which includes charges and expenses, call your financial professional, or John Hancock Funds at 1-800-225-5291. Please read the prospectus carefully before investing or sending money. FOR YOUR INFORMATION INVESTMENT ADVISER John Hancock Advisers, LLC 101 Huntington Avenue Boston, Massachusetts 02199-7603 PRINCIPAL DISTRIBUTOR John Hancock Funds, LLC 101 Huntington Avenue Boston, Massachusetts 02199-7603 CUSTODIAN The Bank of New York One Wall Street New York, New York 10286 TRANSFER AGENT John Hancock Signature Services, Inc. 1 John Hancock Way, Suite 1000 Boston, Massachusetts 02217-1000 LEGAL COUNSEL Hale and Dorr LLP 60 State Street Boston, Massachusetts 02109-1803 INDEPENDENT AUDITORS PricewaterhouseCoopers LLP 125 High Street Boston, Massachusetts 02110 HOW TO CONTACT US On the Internet www.jhfunds.com By regular mail John Hancock Signature Services, Inc. 1 John Hancock Way, Suite 1000 Boston, MA 02217-1000 By express mail John Hancock Signature Services, Inc. Attn: Mutual Fund Image Operations 529 Main Street Charlestown, MA 02129 Customer service representatives 1-800-225-5291 24-hour automated information 1-800-338-8080 TDD line 1-800-554-6713 The Fund's voting policies and procedures are available without charge, upon request: By phone 1-800-225-5291 On the Fund's Web site www.jhfunds.com/proxy On the SEC's Web site www.sec.gov [A 1 1/2" x 1/2" John Hancock (Signature) logo in upper left hand corner. A tag line below reads "JOHN HANCOCK FUNDS."] 1-800-225-5291 1-800-554-6713 (TDD) 1-800-338-8080 EASI-Line www.jhfunds.com Now available: electronic delivery www.jhancock.com/funds/edelivery This report is for the information of the shareholders of the John Hancock Health Sciences Fund. 2800A 10/03 12/03 John Hancock Biotechnology Fund ANNUAL REPORT 10.31.03 Sign up for electronic delivery at www.jhancock.com/funds/edelivery [A 2" x 1" John Hancock (Signature)/John Hancock Funds logo in lower, center middle of page. A tag line below reads "JOHN HANCOCK FUNDS."] [A photo of Maureen Ford Goldfarb, Chairman and Chief Executive Officer, flush left next to first paragraph.] WELCOME Table of contents Your fund at a glance page 1 Manager's report page 2 A look at performance page 6 Growth of $10,000 page 7 Fund's investments page 8 Financial statements page 10 Trustees & officers page 23 For your information page 29 Dear Fellow Shareholders, The stock market has made a strong recovery in 2003. Historically low interest rates, improving corporate earnings and government stimulus in the form of tax cuts gave investors hope that the economy would begin to strengthen, which it did. The market's move up began in April and the breadth of the rally was enormous. As a result, the major indexes were able to wipe out their first-quarter losses and post solid gains year-to-date through October 31. With technology leading the way, the tech-heavy Nasdaq Composite Index rose 45.22% through October, while the Dow Jones Industrial Average was up 19.82% and the Standard & Poor's 500 Index returned 21.19%. With falling interest rates, bonds also did well, although they began to reverse course in July. High yield bonds led the pack, returning 24.23% through October, as measured by the Lehman Brothers High Yield Index. In other news, we are pleased to inform you that on September 28, 2003, the Boards of Directors of Canada-based Manulife Financial Corporation and Boston-based John Hancock Financial Services, Inc., the parent company of John Hancock Funds, unanimously voted to merge the two companies. Please be assured that the completion of the merger -- anticipated to occur in the first half of 2004 -- will have no effect on your investment in our John Hancock mutual funds. Your fund's adviser and board of trustees will remain the same, as will your relationship with your financial adviser. The merger is subject to customary closing conditions, including receipt of required regulatory approvals and approval by John Hancock stockholders. If you only own shares in a John Hancock mutual fund you are not affected and will not receive a proxy. Additional information on this transaction is available on our Web site: www.jhfunds.com. If you have questions about the merger, you may also call 800-732-5543. Separately, for information about your investments in John Hancock funds, please contact your financial adviser or our Customer Service representatives at 800-225-5291. Sincerely, /S/ MAUREEN FORD GOLDFARB Maureen Ford Goldfarb, Chairman and Chief Executive Officer This commentary reflects the chairman's views as of October 31, 2003. They are subject to change at any time. YOUR FUND AT A GLANCE The Fund seeks long-term capital appreciation by normally invest ing at least 80% of its assets in stocks of U.S. and foreign biotechnology companies princi- pally engaged in the research, development and manufacture of various biotech- nology products, services and processes. Over the last twelve months * Biotechnology stocks posted very strong returns, outpacing the overall stock market. * The Fund benefited from its holdings in companies with success in cancer-related treatments. * Disappointing sales from new drugs hurt some companies. [Bar chart with heading "John Hancock Biotechnology Fund." Under the heading is a note that reads "Fund performance for the year ended October 31, 2003." The chart is scaled in increments of 10% with 0% at the bottom and 40% at the top. The first bar represents the 33.15% total return for Class A. The second bar represents the 32.24% total return for Class B. The third bar represents the 32.24% total return for Class C. A note below the chart reads "Total returns for the Fund are at net asset value with all distributions reinvested."] Top 10 holdings 10.6% Amgen, Inc. 5.9% Genentech, Inc. 5.8% Gilead Sciences, Inc. 4.2% Affymetrix, Inc. 4.1% ILEX Oncology, Inc. 4.0% Chiron Corp. 4.0% Invitrogen Corp. 4.0% Genzyme Corp. 4.0% Millennium Pharmaceuticals, Inc. 3.8% MGI Pharma, Inc. As a percentage of net assets on October 31, 2003. MANAGER'S REPORT BY LINDA I. MILLER, CFA, PORTFOLIO MANAGER John Hancock Biotechnology Fund The biotechnology sector posted strong returns during the 12 months ended October 31, 2003, outperforming the broader stock market by a wide margin. Much of the sector's first-half success can be tied to investors' more receptive mood for companies with longer-term growth prospects. With that, a number of stocks that had been shunned and beaten down the most during the previous year suddenly became market favorites. Later in the period, the biotech sector was powered by positive clinical trial results and a jumpstart in product approvals, as the FDA accelerated the drug approval process and announced new initiatives aimed at cutting the cost of drug development by further reducing agency review times. One indication of the biotech sector's vigor was positive restructuring within the industry, with many companies able to finance future growth through various forms of financing and partnering transactions. And, after a year-long drought of initial public offerings in the sector, a couple of biotech companies went public late in the period and more are indicating that they plan to do the same in the coming months. Furthermore, there was some consolidation within the industry, which also served as a positive for biotech stocks. "The biotechnology sector posted strong returns...outperforming the broader stock market by a wide margin." PERFORMANCE AND STRATEGY REVIEW For the 12 months ended October 31, 2003, John Hancock Biotechnology Fund's Class A, Class B and Class C shares posted total returns of 33.15%, 32.24% and 32.24%, respectively, at net asset value. During the same period, the more broadly diversified average health/biotechnology fund had a total return of 21.19%, according to Lipper, Inc.,1 while the Standard & Poor's 500 Index returned 20.79% and the Nasdaq Biotech Index returned 39.85%. Keep in mind that your net asset value return will be different from the Fund's performance if you were not invested in the Fund for the entire period and did not reinvest all distributions. See pages six and seven for historical performance results. [A photo of Linda Miller flush right next to first paragraph.] The Fund's outperformance of its peer group can be attributed in part to its investment focus on the narrow biotech sector. Other funds with broader investment parameters generally weren't as concentrated in biotech stocks, which were among the best-performing subgroups in health care. The Fund also benefited from good stock selection and a relatively high concentration of assets across biotechnology stocks during the year. "Among our best perform- ers during the year were companies involved in developing and marketing cancer treatments and cancer research." CANCER-RELATED TREATMENTS BOOST BOTTOM LINE Among our best performers during the year were companies involved in developing and marketing cancer treatments and cancer research. Genentech posted significant profits and earnings gains during the period, driven by strong sales of its flagship non-Hodgkin's lymphoma drug Rituxan -- marketed in a co-promotion agreement with drug maker IDEC -- and its breast cancer therapy Herceptin. Part of the stock's most recent rise can be traced to hopes for the company's experimental therapy Avastin, which fights cancer by stopping the blood supply to tumors. It may be the first of the so-called anti-angiogenesis drugs to reach the market. Amgen, the world's largest biotech company and the Fund's largest holding during the period, also enjoyed better earnings due to stronger sales of many of its cancer-related medicines including Aranesp, a new, long-lasting version of the company's flagship anemia treatment Epogen; Neupogen; and its longer-lasting formulation, Neulasta, used to fight infections in patients undergoing chemotherapy. The company also posted strong sales increases of rheumatoid arthritis drug Enbrel, which is also used to treat other autoimmune disorders like the skin disease psoriasis. Cancer drug maker ILEX Oncology also turned in good returns for the year, boosted in part by increased revenues from cancer treatment Campath, as well as enthusiasm about the company's receiving FDA fast-track status for its experimental drug Clofarabine, used to treat a form of leukemia in children. The accelerated review status, which the company received in the last weeks of the period, means that the FDA could make a decision on Ilex's application to market the drug within six months, rather than the normal 12 months. Millennium Pharmaceuticals also performed well, largely on the May approval of its breakthrough cancer drug Velcade, used to treat a rare bone marrow cancer. Celgene Corp. enjoyed growing sales of Thalomid, a drug used to treat multiple myeloma, a cancer of plasma cells contained in bone marrow. LAGGARDS The stocks of companies that supply the biotech industry generally lagged the sector overall during the period due in part to reduced spending on drug research. Charles River Laboratories, for example, slumped in response to a slowdown in business for its laboratory animal research models. Another disappointment was Trimeris, which was troubled by concerns about sales of the biotech firm's new HIV therapy. We sold both stocks. IDEC Pharmaceuticals declined in part due to concerns over its proposed merger with rival Biogen, although it posted profit increases toward the end of the period on higher sales of Rituxan. [Pie chart at middle of page with heading "Portfolio diversification As a percentage of net assets on 10-31-03." The chart is divided into two sections (from top to left): Common stocks 98%, and Short-term investments & other 2%.] [Table at top of page entitled "SCORECARD." The header for the left column is "INVESTMENT" and the header for the right column is "PERIOD'S PERFORMANCE...AND WHAT'S BEHIND THE NUMBERS." The first listing is Genentech followed by an up arrow with the phrase "Strong demand for company's cancer treatments." The second listing is ILEX Oncology followed by an up arrow with the phrase "Investors cheer FDA approval of pediatric leukemia drug." The third listing is Charles River Laboratories followed by a down arrow with the phrase "Drug and biotech companies chop spending on supplies."] OUTLOOK We remain optimistic about the long-term prospects for biotechnology stocks, although investors should temper their short-term expectations after such a strong runup. Many maturing biotechnology companies have graduated to the ranks of mid-size pharmaceutical companies. The valuations these stocks carry have risen and lie in sharp contrast to underperforming multinational pharmaceutical stock valuations. However, we believe the growth prospects for this sector still remain robust. In our view, there may be the risk that value-oriented investors in the health-care segment may rotate from the more expensively priced biotech companies to cheaper drug companies at some point. Additionally, fundamental challenges remain for the industry, including the risks of new product development; high research, development, manufacturing and sales costs; and the weak economic conditions of payers for health care around the world -- especially as systems stretch to afford these relatively expensive biotechnology medications. That said, we expect that event-driven performance, reflecting new information presented at major medical meetings and FDA deadlines for product reviews, will continue to favorably affect the industry. Longer term, strong demographic trends, value-added new technology, moderating political risk and low interest rates also could work in the industry's favor. "...we believe the growth prospects for this sector still remain robust..." This commentary reflects the views of the portfolio manager through the end of the Fund's period discussed in this report. The manager's statements reflect her own opinions. As such, they are in no way guarantees of future events, and are not intended to be used as investment advice or a recommendation regarding any specific security. They are also subject to change at any time as market and other conditions warrant. Sector investing is subject to greater risks than the market as a whole. 1 Figures from Lipper, Inc. include reinvested dividends and do not take into account sales charges. Actual load-adjusted performance is lower. A LOOK AT PERFORMANCE For the period ended October 31, 2003 Class A Class B Class C Inception date 3-1-01 3-1-01 3-1-01 Average annual returns with maximum sales charge (POP) One year 26.54% 27.24% 29.82% Since inception -12.39% -12.31% -11.64% Cumulative total returns with maximum sales charge (POP) One year 26.54% 27.24% 29.82% Since inception -29.75% -29.58% -28.12% Performance figures assume all distributions are reinvested. Returns with maximum sales charge reflect a sales charge on Class A shares of 5% and Class C shares of 1%, and the applicable contingent deferred sales charge (CDSC) on Class B and Class C shares. The Class B shares' CDSC declines annually between years 1-6 according to the following schedule: 5, 4, 3, 3, 2, 1%. No sales charge will be assessed after the sixth year. Class C shares held for less than one year are subject to a 1% CDSC. The return and principal value of an investment in the Fund will fluctuate, so that shares, when redeemed, may be worth more or less than the original cost. The returns reflect past results and should not be considered indicative of future performance. The performance table above and the chart on the next page do not reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. The Fund's performance results reflect any applicable expense reductions, without which the expenses would increase and results would have been less favorable. These reductions can be terminated in the future. See the prospectus for details. GROWTH OF $10,000 This chart shows what happened to a hypothetical $10,000 investment in Class A shares for the period indicated. For comparison, we've shown the same investment in two separate indexes. Line chart with the heading "GROWTH OF $10,000." Within the chart are four lines. The first line represents Standard & Poor's 500 Index and is equal to $8,831 as of October 31, 2003. The second line represents the Nasdaq Biotechnology Index and is equal to $7,550 as of October 31, 2003. The third line represents Index 1 and is equal to $5,399 as of October 31, 2002. The third line represents the value of the hypothetical $10,000 investment made in the John Hancock Biotechnology Fund, before sales charge, and is equal to $7,398 as of October 31, 2003. The fourth line represents the value of the same hypothetical $10,000 investment made in the John Hancock Biotechnology Fund, after sales charge, and is equal to $7,025 as of October 31, 2003. Cum Value Cum Value Nasdaq of $10K of $10K S&P 500 Biotechnology Plot Date (No Load) (w/Load) Index Index 3/1/01 $10,000 $9,500 $10,000 $10,000 4/30/2001 9,870 9,373 10,094 9,476 10/31/2001 9,490 9,012 8,621 8,975 4/30/2002 6,927 6,578 8,820 6,769 10/31/2002 5,556 5,276 7,318 5,315 4/30/2003 5,586 5,305 7,646 5,966 10/31/2003 7,398 7,025 8,831 7,550 Class B Class C 1 Period beginning 3-1-01 3-1-01 Without sales charge $7,260 $7,260 With maximum sales charge $7,042 $7,188 Index 1 $8,831 $8,831 Index 2 $7,550 $7,550 Assuming all distributions were reinvested for the period indicated, the table above shows the value of a $10,000 investment in the Fund's Class B and Class C shares, respectively, as of October 31, 2003. Performance of the classes will vary based on the difference in sales charges paid by shareholders investing in the different classes and the fee structure of those classes. Standard & Poor's 500 Index -- Index 1 -- is an unmanaged index that includes 500 widely traded common stocks. Nasdaq Biotechnology Index -- Index 2 -- is an unmanaged index that represents the largest and most actively traded Nasdaq biotechnology stocks. It is not possible to invest directly in an index. Index figures do not reflect sales charges and would be lower if they did. 1 No contingent deferred sales charge applicable. FINANCIAL STATEMENTS FUND'S INVESTMENTS Securities owned by the Fund on October 31, 2003 This schedule is divided into two main categories: common stocks and short-term investments. Common stocks are further broken down by industry group. Short-term investments, which represent the Fund's cash position, are listed last. SHARES ISSUER VALUE COMMON STOCKS 98.27% $18,576,175 (Cost $15,112,367) Biotechnology 98.27% 18,576,175 40,000 Abgenix, Inc.* + 490,000 31,000 Affymetrix, Inc.* + 794,530 35,000 Alkermes, Inc.* 453,950 32,500 Amgen, Inc.* 2,007,200 26,000 Amylin Pharmaceuticals, Inc.* + 710,580 4,000 Atrix Laboratories, Inc.* + 80,360 14,000 Celgene Corp.* + 583,660 14,000 Chiron Corp. * 764,820 25,000 Esperion Therapeutics, Inc.* + 596,750 11,500 Fisher Scientific International, Inc. 462,875 13,500 Genentech, Inc.* 1,106,595 16,500 Genzyme Corp.* 757,350 20,000 Gilead Sciences, Inc.* + 1,091,600 35,000 Human Genome Sciences, Inc.* 486,850 16,000 IDEC Pharmaceuticals Corp.* 562,080 37,000 ILEX Oncology, Inc.* 771,820 12,000 Invitrogen Corp.* 763,080 30,000 Kosan Biosciences, Inc.* 275,100 50,000 Medarex, Inc.* 357,500 18,000 Medicines Co. (The)* 479,700 19,000 MGI Pharma, Inc.* 713,640 47,000 Millennium Pharmaceuticals, Inc.* 748,240 11,500 Neurocrine Biosciences, Inc.* + 538,545 13,000 NPS Pharmaceuticals, Inc.* + 342,290 18,000 OSI Pharmaceuticals, Inc.* 504,000 30,000 Protein Design Labs, Inc.* 404,400 12,000 Sepracor, Inc. * 319,560 15,000 Serona SA, American Depositary Receipt (ADR) (Switzerland) + 258,600 20,000 Telik, Inc.* + 406,400 30,000 Tularik, Inc.* + 377,100 20,000 Vicuron Pharmaceuticals, Inc. * 367,000 INTEREST PAR VALUE ISSUER, DESCRIPTION, MATURITY DATE RATE (000s omitted) VALUE SHORT-TERM INVESTMENTS 35.54% $6,718,801 (Cost $6,718,801) Joint Repurchase Agreement 5.87% Investment in a joint repurchase agreement transaction with Barclays Capital, Inc. -- Dated 10-31-03, due 11-03-03 (Secured by U.S. Treasury Inflation Indexed Bond, 3.625% due 04-15-28 and U.S. Treasury Inflation Indexed Note, 1.875% due 07-15-13) 1.02% $1,109 1,109,000 SHARES Cash Equivalents 29.67% AIM Cash Investment Trust** 5,609,801 5,609,801 TOTAL INVESTMENTS 133.81% $25,294,976 OTHER ASSETS AND LIABILITIES, NET (33.81%) ($6,391,589) TOTAL NET ASSETS 100.00% $18,903,387 * Non-income producing security. ** Represents investment of security lending collateral. + All or a portion of this security is on loan on October 31, 2003. Parenthetical disclosure of a foreign country in the security description represents country of a foreign issuer. The percentage shown for each investment category is the total value of that category as a percentage of the net assets of the Fund. See notes to financial statements. FINANCIAL STATEMENTS ASSETS AND LIABILITIES October 31, 2003 This Statement of Assets and Liabilities is the Fund's balance sheet. It shows the value of what the Fund owns, is due and owes. You'll also find the net asset value and the maximum offering price per share. ASSETS Investments at value (cost $21,831,168), including $5,512,776 of securities loaned $25,294,976 Cash 921 Receivable for shares sold 22,628 Interest receivable 31 Receivable from affiliates 11,496 Other assets 269 Total assets 25,330,321 LIABILITIES Payable for investments purchased 744,362 Payable for shares repurchased 7,798 Payable for securities on loan 5,609,801 Payable to affiliates Management fee 13,876 Distribution and service fee 1,179 Other 9,277 Other payables and accrued expenses 40,641 Total liabilities 6,426,934 NET ASSETS Capital paid-in 22,723,242 Accumulated net realized loss on investments (7,283,646) Net unrealized appreciation of investments 3,463,808 Accumulated net investment loss (17) Net assets $18,903,387 NET ASSET VALUE PER SHARE Based on net asset values and shares outstanding Class A ($8,121,387 [DIV] 1,098,977 shares) $7.39 Class B ($8,310,777 [DIV] 1,144,564 shares) $7.26 Class C ($2,471,223 [DIV] 340,400 shares) $7.26 MAXIMUM OFFERING PRICE PER SHARE Class A 1 ($7.39 [DIV] 95%) $7.78 Class C ($7.26 [DIV] 99%) $7.33 1 On single retail sales of less than $50,000. On sales of $50,000 or more and on group sales the offering price is reduced. See notes to financial statements. OPERATIONS For the year ended October 31, 2003 This Statement of Operations summarizes the Fund's investment income earned and expenses incurred in operat- ing the Fund. It also shows net gains (losses) for the period stated. INVESTMENT INCOME Securities lending $21,395 Interest 6,784 Dividend income (net of foreign withholding taxes of $528) 2,526 Total investment income 30,705 EXPENSES Investment management fee 110,374 Class A distribution and service fee 15,799 Class B distribution and service fee 51,741 Class C distribution and service fee 18,232 Transfer agent fee 78,217 Registration and filing fee 50,346 Auditing fee 18,500 Custodian fee 13,096 Printing 11,058 Accounting and legal services fee 3,524 Miscellaneous 1,712 Trustees' fee 648 Legal fee 305 Interest 112 Total expenses 373,664 Less expense reductions (128,462) Net expenses 245,202 Net investment loss (214,497) REALIZED AND UNREALIZED GAIN (LOSS) Net realized loss on investments (1,112,209) Change in unrealized appreciation (depreciation) of investments 4,607,427 Net realized and unrealized gain 3,495,218 Increase in net assets from operations $3,280,721 See notes to financial statements. CHANGES IN NET ASSETS These Statements of Changes in Net Assets show how the value of the Fund's net assets has changed during the last two periods. The dif- ference reflects earnings less expenses, any investment gains and losses, distributions, if any, paid to shareholders and any increase or decrease in money share- holders invested in the Fund. YEAR YEAR ENDED ENDED 10-31-02 10-31-03 INCREASE (DECREASE) IN NET ASSETS From operations Net investment loss ($209,026) ($214,497) Net realized loss (5,977,530) (1,112,209) Change in net unrealized appreciation (depreciation) (1,212,776) 4,607,427 Increase (decrease) in net assets resulting from operations (7,399,332) 3,280,721 Distributions to shareholders From net investment income Class A (7,371) -- From Fund share transactions 5,858,644 5,261,545 NET ASSETS Beginning of period 11,909,180 10,361,121 End of period 1 $10,361,121 $18,903,387 1 Includes accumulated net investment loss of $6 and $17, respectively. See notes to financial statements. FINANCIAL HIGHLIGHTS CLASS A SHARES The Financial Highlights show how the Fund's net asset value for a share has changed since the end of the previous period. FINANCIAL HIGHLIGHTS PERIOD ENDED 10-31-01 1 10-31-02 10-31-03 PER SHARE OPERATING PERFORMANCE Net asset value, beginning of period $10.00 $9.49 $5.55 Net investment loss 2 (0.07) (0.09) (0.08) Net realized and unrealized gain (loss) on investments (0.44) (3.84) 1.92 Total from investment operations (0.51) (3.93) 1.84 Less distributions From net investment income -- (0.01) -- Net asset value, end of period $9.49 $5.55 $7.39 Total return 3,4 (%) (5.10) 5 (41.46) 33.15 RATIOS AND SUPPLEMENTAL DATA Net assets, end of period (in millions) $6 $5 $8 Ratio of expenses to average net assets (%) 1.60 6 1.60 1.60 Ratio of adjusted expenses to average net assets 7 (%) 4.34 6 2.59 2.65 Ratio of net investment loss to average net assets (%) (1.15) 6 (1.29) (1.35) Portfolio turnover (%) 63 97 130 See notes to financial statements. FINANCIAL HIGHLIGHTS CLASS B SHARES PERIOD ENDED 10-31-01 1 10-31-02 10-31-03 PER SHARE OPERATING PERFORMANCE Net asset value, beginning of period $10.00 $9.44 $5.49 Net investment loss 2 (0.13) (0.14) (0.13) Net realized and unrealized gain (loss) on investments (0.43) (3.81) 1.90 Total from investment operations (0.56) (3.95) 1.77 Net asset value, end of period $9.44 $5.49 $7.26 Total return 3,4 (%) (5.60) 5 (41.84) 32.24 RATIOS AND SUPPLEMENTAL DATA Net assets, end of period (in millions) $4 $4 $8 Ratio of expenses to average net assets (%) 2.30 6 2.30 2.30 Ratio of adjusted expenses to average net assets 7 (%) 5.05 6 3.29 3.35 Ratio of net investment loss to average net assets (%) (2.01) 6 (1.99) (2.05) Portfolio turnover (%) 63 97 130 See notes to financial statements. FINANCIAL HIGHLIGHTS CLASS C SHARES PERIOD ENDED 10-31-01 1 10-31-02 10-31-03 PER SHARE OPERATING PERFORMANCE Net asset value, beginning of period $10.00 $9.44 $5.49 Net investment loss 2 (0.13) (0.14) (0.13) Net realized and unrealized gain (loss) on investments (0.43) (3.81) 1.90 Total from investment operations (0.56) (3.95) 1.77 Net asset value, end of period $9.44 $5.49 $7.26 Total return 3,4 (%) (5.60) 5 (41.84) 32.24 RATIOS AND SUPPLEMENTAL DATA Net assets, end of period (in millions) $2 $2 $2 Ratio of expenses to average net assets (%) 2.30 6 2.30 2.30 Ratio of adjusted expenses to average net assets 7 (%) 5.05 6 3.29 3.35 Ratio of net investment loss to average net assets (%) (2.07) 6 (1.99) (2.05) Portfolio turnover (%) 63 97 130 1 Class A, Class B and Class C shares began operations on 3-1-01. 2 Based on the average of the shares outstanding. 3 Assumes dividend reinvestment and does not reflect the effect of sales charges. 4 Total returns would have been lower had certain expenses not been reduced during the periods shown. 5 Not annualized. 6 Annualized. 7 Does not take into consideration expense reductions during the periods shown. See notes to financial statements. NOTES TO STATEMENTS NOTE A Accounting policies John Hancock Biotechnology Fund (the "Fund") is a non-diversified series of John Hancock World Fund, an open-end management investment company registered under the Investment Company Act of 1940. The investment objective of the Fund is to achieve long-term capital appreciation. The Trustees have authorized the issuance of multiple classes of shares of the Fund, designated as Class A, Class B and Class C shares. The shares of each class represent an interest in the same portfolio of investments of the Fund and have equal rights as to voting, redemptions, dividends and liquidation, except that certain expenses, subject to the approval of the Trustees, may be applied differently to each class of shares in accordance with current regulations of the Securities and Exchange Commission and the Internal Revenue Service. Shareholders of a class that bears distribution and service expenses under the terms of a distribution plan have exclusive voting rights to that distribution plan. Significant accounting policies of the Fund are as follows: Valuation of investments Securities in the Fund's portfolio are valued on the basis of market quotations, valuations provided by independent pricing services or at fair value as determined in good faith in accordance with procedures approved by the Trustees. Short-term debt investments maturing within 60 days are valued at amortized cost, which approximates market value. Investments in AIM Cash Investment Trust are valued at their net asset value each business day. Joint repurchase agreement Pursuant to an exemptive order issued by the Securities and Exchange Commission, the Fund, along with other registered investment companies having a management contract with John Hancock Advisers, LLC (the "Adviser"), a wholly owned subsidiary of The Berkeley Financial Group, LLC, may participate in a joint repurchase agreement transaction. Aggregate cash balances are invested in one or more large repurchase agreements, whose underlying securities are obligations of the U.S. government and/or its agencies. The Fund's custodian bank receives delivery of the underlying securities for the joint account on the Fund's behalf. The Adviser is responsible for ensuring that the agreement is fully collateralized at all times. Investment transactions Investment transactions are recorded as of the date of purchase, sale or maturity. Net realized gains and losses on sales of investments are determined on the identified cost basis. Class allocations Income, common expenses and realized and unrealized gains (losses) are determined at the fund level and allocated daily to each class of shares based on the appropriate net asset value of the respective classes. Distribution and service fees, if any, are calculated daily at the class level based on the appropriate net asset value of each class and the specific expense rate(s) applicable to each class. Expenses The majority of expenses are directly identifiable to an individual fund. Expenses that are not readily identifiable to a specific fund are allocated in such a manner as deemed equitable, taking into consideration, among other things, the nature and type of expense and the relative sizes of the funds. Bank borrowings The Fund is permitted to have bank borrowings for temporary or emergency purposes, including the meeting of redemption requests that otherwise might require the untimely disposition of securities. The Fund has entered into a syndicated line of credit agreement with various banks. This agreement enables the Fund to participate with other funds managed by the Adviser in an unsecured line of credit with banks, which permits borrowings of up to $250 million, collectively. Interest is charged to each fund, based on its borrowing. In addition, a commitment fee is charged to each fund based on the average daily unused portion of the line of credit and is allocated among the participating funds. The Fund had no borrowing activity under the line of credit during the year ended October 31, 2003. Securities lending The Fund may lend securities to certain qualified brokers who pay the Fund negotiated lender fees. The loans are collateralized at all times with cash or securities with a market value at least equal to the market value of the securities on loan. As with other extensions of credit, the Fund may bear the risk of delay of the loaned securities in recovery or even loss of rights in the collateral, should the borrower of the securities fail financially. On October 31, 2003, the Fund loaned securities having a market value of $5,512,776 collateralized by cash in the amount of $5,609,801. The cash collateral was invested in a short-term instrument. Federal income taxes The Fund qualifies as a "regulated investment company" by complying with the applicable provisions of the Internal Revenue Code and will not be subject to federal income tax on taxable income that is distributed to shareholders. Therefore, no federal income tax provision is required. For federal income tax purposes, the Fund has $6,698,221 of a capital loss carryforward available, to the extent provided by regulations, to offset future net realized capital gains. To the extent that such carryforward is used by the Fund, no capital gain distributions will be made. The loss carryforward expires as follows: October 31, 2009 -- $139,642, October 31, 2010 -- $5,173,442, and October 31, 2011 -- $1,385,137. Dividends, interest and distributions Dividend income on investment securities is recorded on the ex-dividend date or, in the case of some foreign securities, on the date thereafter when the Fund identifies the dividend. Interest income on investment securities is recorded on the accrual basis. Foreign income may be subject to foreign withholding taxes, which are accrued as applicable. The Fund records distributions to shareholders from net investment income and net realized gains on the ex-dividend date. Distributions paid by the Fund with respect to each class of shares are calculated in the same manner, at the same time and are in the same amount, except for the effect of expenses that may be applied differently to each class. As of October 31, 2003, there were no distributable earnings on a tax basis. Such distributions and distributable earnings, on a tax basis, are determined in conformity with income tax regulations, which may differ from accounting principles generally accepted in the United States of America. Distributions in excess of tax basis earnings and profits, if any, are reported in the Fund's financial statements as a return of capital. Use of estimates The preparation of these financial statements, in accordance with accounting principles generally accepted in the United States of America, incorporates estimates made by management in determining the reported amount of assets, liabilities, revenues and expenses of the Fund. Actual results could differ from these estimates. NOTE B Management fee and transactions with affiliates and others The Fund has an investment management contract with the Adviser. Under the investment management contract, the Fund pays a monthly management fee to the Adviser equivalent, on an annual basis, to the sum of: (a) 0.90% of the first $500,000,000 of the Fund's average daily net asset value, (b) 0.85% of the next $500,000,000 and (c) 0.80% of the Fund's average daily net asset value in excess of $1,000,000,000. The Adviser has agreed to limit the Fund's total expenses, excluding the distribution and service fees, to 1.30% of the Fund's average daily net asset value, at least until February 28, 2004. Accordingly, the expense reductions related to the total expense limitation amounted to $128,462 for the year ended October 31, 2003. The Adviser reserves the right to terminate this limitation in the future. The Fund has Distribution Plans with John Hancock Funds, LLC ("JH Funds"), a wholly owned subsidiary of the Adviser. The Fund has adopted Distribution Plans with respect to Class A, Class B and Class C pursuant to Rule 12b-1 under the Investment Company Act of 1940 to reimburse JH Funds for the services it provides as distributor of shares of the Fund. Accordingly, the Fund makes monthly payments to JH Funds at an annual rate not to exceed 0.30% of Class A average daily net asset value and 1.00% of Class B and Class C average daily net asset value. A maximum of 0.25% of such payments may be service fees as defined by the Conduct Rules of the National Association of Securities Dealers. Under the Conduct Rules, curtailment of a portion of the Fund's 12b-1 payments could occur under certain circumstances. Class A and Class C shares are assessed up-front sales charges. During the year ended October 31, 2003, JH Funds received net up-front sales charges of $68,423 with regard to sales of Class A shares. Of this amount, $10,775 was retained and used for printing prospectuses, advertising, sales literature and other purposes, $55,074 was paid as sales commissions to unrelated broker-dealers and $2,574 was paid as sales commissions to sales personnel of Signator Investors, Inc. ("Signator Investors"), a related broker-dealer. The Adviser's indirect parent, John Hancock Life Insur ance Company ("JHLICo"), is the indirect sole shareholder of Signator Investors. During the year ended October 31, 2003, JH Funds received net up-front sales charges of $5,474 with regard to sales of Class C shares. Of this amount, $5,050 was paid as sales commissions to unrelated broker-dealers and $424 was paid as sales commissions to sales personnel of Signator Investors. Class B shares that are redeemed within six years of purchase are subject to a contingent deferred sales charge ("CDSC") at declining rates, beginning at 5.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Class C shares that are redeemed within one year of purchase are subject to a CDSC at a rate of 1.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Proceeds from the CDSCs are paid to JH Funds and are used in whole or in part to defray its expenses for providing distribution related services to the Fund in connection with the sale of Class B and Class C shares. During the year ended October 31, 2003, CDSCs received by JH Funds amounted to $22,271 for Class B shares and $186 for Class C shares. The Fund had a transfer agent agreement with John Hancock Signature Services, Inc., an indirect subsidiary of JHLICo. Effective January 1, 2003, the Fund pays a monthly transfer agent fee at an annual rate of 0.05% of the average daily net asset value, plus a fee based on the number of shareholder accounts and reimbursement for certain out-of-pocket expenses. Until January 1, 2003, the Fund paid a monthly transfer agent fee based on the number of shareholder accounts, plus certain out-of-pocket expenses. The Fund has an agreement with the Adviser to perform necessary tax, accounting and legal services for the Fund. The compensation for the year was at an annual rate of approximately 0.03% of the average net asset value of the Fund. The Fund had an independent advisory board composed of scientific and medical experts who provided the investment officers of the Fund with advice and consultation on health-care developments, for which the Fund paid the advisory board a fee. The Board of Trustees voted to discontinue the advisory board effective July 15, 2003. The Adviser and other subsidiaries of JHLICo owned 300,000 shares of beneficial interest of the Fund on October 31, 2003. Ms. Maureen Ford Goldfarb and Mr. John M. DeCiccio are directors and/or officers of the Adviser and/or its affiliates, as well as Trustees of the Fund. The compensation of unaffiliated Trustees is borne by the Fund. The unaffiliated Trustees may elect to defer for tax purposes their receipt of this compensation under the John Hancock Group of Funds Deferred Compensation Plan. The Fund makes investments into other John Hancock funds, as applicable, to cover its liability for the deferred compensation. Investments to cover the Fund's deferred compensation liability are recorded on the Fund's books as an other asset. The deferred compensation liability and the related other asset are always equal and are marked to market on a periodic basis to reflect any income earned by the investments as well as any unrealized gains or losses. The Deferred Compensation Plan investments had no impact on the operations of the Fund. NOTE C Fund share transactions This listing illustrates the number of Fund shares sold, reinvested and repurchased during the last two periods, along with the corresponding dollar value. The Fund has an unlimited number of shares authorized with no par value. YEAR ENDED 10-31-02 YEAR ENDED 10-31-03 SHARES AMOUNT SHARES AMOUNT CLASS A SHARES Sold 409,749 $3,245,104 559,783 $3,876,141 Distribution reinvested 389 3,952 -- -- Repurchased (209,765) (1,422,329) (274,305) (1,674,677) Net increase 200,373 $1,826,727 285,478 $2,201,464 CLASS B SHARES Sold 656,696 $5,487,821 715,050 $4,927,300 Repurchased (275,485) (1,934,504) (354,315) (2,274,524) Net increase 381,211 $3,553,317 360,735 $2,652,776 CLASS C SHARES Sold 97,638 $826,162 111,436 $716,782 Repurchased (58,498) (347,562) (52,642) (309,477) Net increase 39,140 $478,600 58,794 $407,305 NET INCREASE 620,724 $5,858,644 705,007 $5,261,545 NOTE D Investment transactions Purchases and proceeds from sales or maturities of securities other than short-term securities and obligations of the U.S. government, during the year ended October 31, 2003, aggregated $20,464,013 and $15,621,966, respectively. The cost of investments owned on October 31, 2003, including short-term investments, for federal income tax purposes was $22,416,592. Gross unrealized appreciation and depreciation of investments aggregated $3,019,422 and $141,038, respectively, resulting in net unrealized appreciation of $2,878,384. The difference between book basis and tax basis net unrealized appreciation of investments is attributable primarily to the tax deferral of losses on certain sales of securities. NOTE E Reclassification of accounts During the year ended October 31, 2003, the Fund reclassified amounts to reflect a decrease in accumulated net realized loss on investments of $11, a decrease in accumulated net investment loss of $214,486 and a decrease in capital paid-in of $214,497. This represents the amount necessary to report these balances on a tax basis, excluding certain temporary differences, as of October 31, 2003. Additional adjustments may be needed in subsequent reporting periods. These reclassifications, which have no impact on the net asset value of the Fund, are primarily attributable to certain differences in the computation of distributable income and capital gains under federal tax rules versus accounting principles generally accepted in the United States of America and book and tax differences in accounting for net operating loss and deferred compensation. The calculation of net investment loss per share in the Fund's Financial Highlights excludes these adjustments. AUDITORS' REPORT Report of Pricewaterhouse- Coopers LLP, Independent Auditors To the Board of Trustees and Shareholders of John Hancock Biotechnology Fund, In our opinion, the accompanying statement of assets and liabilities, including the schedule of investments and the related statements of operations and of changes in net assets and the financial highlights present fairly, in all material respects, the financial position of the John Hancock Biotechnology Fund (the "Fund") at October 31, 2003, the results of its operations, the changes in its net assets and the financial highlights for the periods indicated, in conformity with accounting principles generally accepted in the United States of America. These financial statements and financial highlights (hereafter referred to as "financial statements") are the responsibility of the Fund's management; our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits of these financial statements in accordance with auditing standards generally accepted in the United States of America, which require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that our audits, which included confirmation of securities owned at October 31, 2003, by correspondence with the custodian and brokers, provide a reasonable basis for our opinion. PricewaterhouseCoopers LLP Boston, Massachusetts December 15, 2003 TAX INFORMATION Unaudited For federal income tax purposes, the following information is furnished with respect to the distributions of the Fund, if any, paid during its taxable year ended October 31, 2003. The fund hereby designates the maximum amount allowable of its net taxable income as qualified dividend income as provided in the Jobs and Growth Tax Relief Reconciliation Act of 2003. This amount will be reflected on Form 1099-DIV for the calendar year 2003. Shareholders will be mailed a 2003 U.S. Treasury Department Form 1099-DIV in January 2004. This will reflect the total of all distributions that are taxable for the calendar year 2003. TRUSTEES & OFFICERS This chart provides information about the Trustees and Officers who oversee your John Hancock fund. Officers elected by the Trustees manage the day-to-day operations of the Fund and execute policies formulated by the Trustees. INDEPENDENT TRUSTEES NUMBER OF NAME, AGE TRUSTEE JOHN HANCOCK PRINCIPAL OCCUPATION(S) AND OTHER OF FUND FUNDS OVERSEEN DIRECTORSHIPS DURING PAST 5 YEARS SINCE 1 BY TRUSTEE Dennis S. Aronowitz, Born: 1931 2001 21 Professor of Law, Emeritus, Boston University School of Law (as of 1996); Director, Brookline Bancorp (since 1998). Richard P. Chapman, Jr., Born: 1935 2001 21 President and Chief Executive Officer, Brookline Bancorp Inc. (lending) (since 1972); Director, Lumber Insurance Co. (insurance) (until 2000); Chairman and Director, Northeast Retirement Services, Inc. (retirement administration) (since 1998). William J. Cosgrove, Born: 1933 2001 21 Vice President, Senior Banker and Senior Credit Officer, Citibank, N.A. (retired 1991); Executive Vice President, Citadel Group Representatives, Inc. (financial reinsurance); Trustee, Hudson City Savings Bank (since 1995); Director, Hudson City Bancorp (since 1999); Trustee, Scholarship Fund for Inner City Children (since 1986). Richard A. Farrell, Born: 1932 2001 21 President, Farrell, Healer & Co., Inc. (venture capital management firm) (since 1980) and President, the Venture Capital Fund of NE (since 1980); prior to 1980, headed the venture capital group at Bank of Boston Corporation; Trustee, Marblehead Savings Bank (since 1994). William F. Glavin, 2 Born: 1932 2001 21 President Emeritus, Babson College (as of 1998); Vice Chairman, Xerox Corporation (until 1989); Director, Reebok, Inc. (until 2002) and Inco Ltd. (until 2002). John A. Moore, 2 Born: 1939 2001 29 President and Chief Executive Officer, Institute for Evaluating Health Risks, (nonprofit institution) (until 2001); Chief Scientist, Sciences International (health research) (since 1998); Principal, Hollyhouse (consulting) (since 2000); Director, CIIT (nonprofit research) (since 2002). Patti McGill Peterson, 2 Born: 1943 2001 29 Executive Director, Council for International Exchange of Scholars (since 1998); Vice President, Institute of International Education (since 1998); Senior Fellow, Cornell Institute of Public Affairs, Cornell University (until 1997); President Emerita of Wells College and St. Lawrence University; Director, Niagara Mohawk Power Corporation (electric utility). John W. Pratt, Born: 1931 2001 21 Professor of Business Administration Emeritus, Harvard University Graduate School of Business Administration (as of 1998). INTERESTED TRUSTEES 3 NAME, AGE NUMBER OF POSITION(S) HELD WITH FUND TRUSTEE JOHN HANCOCK PRINCIPAL OCCUPATION(S) AND OTHER OF FUND FUNDS OVERSEEN DIRECTORSHIPS DURING PAST 5 YEARS SINCE 1 BY TRUSTEE John M. DeCiccio, Born: 1948 2001 51 Trustee Executive Vice President and Chief Investment Officer, John Hancock Financial Services, Inc.; Director, Executive Vice President and Chief Investment Officer, John Hancock Life Insurance Company; Chairman of the Committee of Finance of John Hancock Life Insurance Company; Director, John Hancock Subsidiaries, LLC (Subsidiaries, LLC), Hancock Natural Resource Group, Independence Investment LLC, Declaration Management Research LLC, John Hancock Advisers, LLC (the "Adviser"), The Berkeley Financial Group, LLC ("The Berkeley Group"), John Hancock Funds, LLC ("John Hancock Funds") and Massachusetts Business Development Corporation; Director, John Hancock Insurance Agency, Inc. ("Insurance Agency, Inc.") (until 1999). Maureen Ford Goldfarb, Born: 1955 2001 51 Trustee, Chairman, President and Chief Executive Officer Executive Vice President, John Hancock Financial Services, Inc., John Hancock Life Insurance Company; Chairman, Director, President and Chief Executive Officer, the Adviser and The Berkeley Group; Chairman, Director, President and Chief Executive Officer, John Hancock Funds; Chairman, Director, President and Chief Executive Officer, Sovereign Asset Management Corporation ("SAMCorp."); Director, Independence Investment LLC, Subsidiaries, LLC and Signature Services; Senior Vice President, MassMutual Insurance Co. (until 1999). PRINCIPAL OFFICERS WHO ARE NOT TRUSTEES NAME, AGE POSITION(S) HELD WITH FUND OFFICER PRINCIPAL OCCUPATION(S) AND OF FUND DIRECTORSHIPS DURING PAST 5 YEARS SINCE Richard A. Brown, Born: 1949 2001 Senior Vice President and Chief Financial Officer Senior Vice President, Chief Financial Officer and Treasurer, the Adviser, John Hancock Funds and The Berkeley Group; Second Vice President and Senior Associate Controller, Corporate Tax Department, John Hancock Financial Services, Inc. (until 2001). Thomas H. Connors, Born: 1959 2001 Vice President and Compliance Officer Vice President and Compliance Officer, the Adviser and each of the John Hancock funds; Vice President, John Hancock Funds. William H. King, Born: 1952 2001 Vice President and Treasurer Vice President and Assistant Treasurer, the Adviser; Vice President and Treasurer of each of the John Hancock funds; Assistant Treasurer of each of the John Hancock funds (until 2001). Susan S. Newton, Born: 1950 2001 Senior Vice President, Secretary and Chief Legal Officer Senior Vice President, Secretary and Chief Legal Officer, SAMCorp., the Adviser and each of the John Hancock funds, John Hancock Funds and The Berkeley Group; Vice President, Signature Services (until 2000); Director, Senior Vice President and Secretary, NM Capital. The business address for all Trustees and Officers is 101 Huntington Avenue, Boston, Massachusetts 02199. The Statement of Additional Information of the Fund includes additional information about members of the Board of Trustees of the Fund and is available, without charge, upon request, by calling 1-800-225-5291. 1 Each Trustee serves until resignation, retirement age or until his or her successor is elected. 2 Member of Audit Committee. 3 Interested Trustees hold positions with the Fund's investment adviser, underwriter and certain other affiliates. OUR FAMILY OF FUNDS - --------------------------------------------------------------- Equity Balanced Fund Classic Value Fund Core Equity Fund Focused Equity Fund Growth Trends Fund International Fund Large Cap Equity Fund Large Cap Growth Fund Large Cap Select Fund Mid Cap Growth Fund Multi Cap Growth Fund Small Cap Equity Fund Small Cap Growth Fund Sovereign Investors Fund U.S. Global Leaders Growth Fund - --------------------------------------------------------------- Sector Biotechnology Fund Financial Industries Fund Health Sciences Fund Real Estate Fund Regional Bank Fund Technology Fund - --------------------------------------------------------------- Income Bond Fund Government Income Fund High Income Fund High Yield Bond Fund Investment Grade Bond Fund Strategic Income Fund - --------------------------------------------------------------- Tax-Free Income California Tax-Free Income Fund High Yield Municipal Bond Fund Massachusetts Tax-Free Income Fund New York Tax-Free Income Fund Tax-Free Bond Fund - --------------------------------------------------------------- Money Market Money Market Fund U.S. Government Cash Reserve For more complete information on any John Hancock Fund and a prospectus, which includes charges and expenses, call your financial professional, or John Hancock Funds at 1-800-225-5291. Please read the prospectus carefully before investing or sending money. ELECTRONIC DELIVERY Now available from John Hancock Funds Instead of sending annual and semiannual reports and prospectuses through the U.S. mail, we'll notify you by e-mail when these documents are available for online viewing. How does electronic delivery benefit you? * No more waiting for the mail to arrive; you'll receive an e-mail notification as soon as the document is ready for online viewing. * Reduces the amount of paper mail you receive from John Hancock Funds. * Reduces costs associated with printing and mailing. Sign up for electronic delivery today at www.jhancock.com/funds/edelivery OUR WEB SITE A wealth of information-- www.jhfunds.com View the latest information for your account. - ------------------------------------------------ Transfer money from one account to another. - ------------------------------------------------ Get current quotes for major market indexes. - ------------------------------------------------ Use our online calculators to help you with your financial goals. - ------------------------------------------------ Get up-to-date commentary from John Hancock Funds investment experts. - ------------------------------------------------ Access forms, applications and tax information. - ------------------------------------------------ FOR YOUR INFORMATION INVESTMENT ADVISER John Hancock Advisers, LLC 101 Huntington Avenue Boston, Massachusetts 02199-7603 PRINCIPAL DISTRIBUTOR John Hancock Funds, LLC 101 Huntington Avenue Boston, Massachusetts 02199-7603 CUSTODIAN The Bank of New York One Wall Street New York, New York 10286 TRANSFER AGENT John Hancock Signature Services, Inc. 1 John Hancock Way, Suite 1000 Boston, Massachusetts 02217-1000 LEGAL COUNSEL Hale and Dorr LLP 60 State Street Boston, Massachusetts 02109-1803 INDEPENDENT AUDITORS PricewaterhouseCoopers LLP 125 High Street Boston, Massachusetts 02110 HOW TO CONTACT US On the Internet www.jhfunds.com By regular mail John Hancock Signature Services, Inc. 1 John Hancock Way, Suite 1000 Boston, MA 02217-1000 By express mail John Hancock Signature Services, Inc. Attn: Mutual Fund Image Operations 529 Main Street Charlestown, MA 02129 Customer service representatives 1-800-225-5291 24-hour automated information 1-800-338-8080 TDD line 1-800-554-6713 The Fund's voting policies and procedures are available without charge, upon request: By phone 1-800-225-5291 On the Fund's Web site www.jhfunds.com/proxy On the SEC's Web site www.sec.gov [A 1 1/2" x 1/2" John Hancock (Signature) logo in upper left hand corner. A tag line below reads "JOHN HANCOCK FUNDS."] 1-800-225-5291 1-800-554-6713 (TDD) 1-800-338-8080 EASI-Line www.jhfunds.com Now available: electronic delivery www.jhancock.com/funds/edelivery This report is for the information of the shareholders of the John Hancock Biotechnology Fund. 7300A 10/03 12/03 ITEM 2. CODE OF ETHICS. As of the end of the period, October 31, 2003, the registrant has adopted a code of ethics, as defined in Item 2 of Form N-CSR, that applies to its Chief Executive Officer, Chief Financial Officer and Treasurer (respectively, the principal executive officer, the principal financial officer and the principal accounting officer, the "Senior Financial Officers"). A copy of the code of ethics is filed as an exhibit to this Form N-CSR. ITEM 3. AUDIT COMMITTEE FINANCIAL EXPERT. William F. Glavin is the audit committee financial expert and is "independent", pursuant to general instructions on Form N-CSR Item 3. ITEM 4. PRINCIPAL ACCOUNTANT FEES AND SERVICES. Not applicable at this time. ITEM 5. AUDIT COMMITTEE OF LISTED REGISTRANTS. Not applicable at this time. ITEM 6. [RESERVED] ITEM 7. DISCLOSURE OF PROXY VOTING POLICIES AND PROCEDURES FOR CLOSED-END MANAGEMENT INVESTMENT COMPANIES. Not applicable. ITEM 8. [RESERVED] ITEM 9. CONTROLS AND PROCEDURES. (a) Based upon their evaluation of the registrant's disclosure controls and procedures as conducted within 90 days of the filing date of this Form N-CSR, the registrant's principal executive officer and principal financial officer have concluded that those disclosure controls and procedures provide reasonable assurance that the material information required to be disclosed by the registrant on this report is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission's rules and forms. (b) There were no changes in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal half-year (the registrant's second fiscal half-year in the case of an annual report) that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. ITEM 10. EXHIBITS. (a)(1) Code of Ethics for Senior Financial Officers is attached. (a)(2) Separate certifications for the registrant's principal executive officer and principal financial officer, as required by Section 302 of the Sarbanes-Oxley Act of 2002 and Rule 30a-2(a) under the Investment Company Act of 1940, are attached. (b)(1) Separate certifications for the registrant's principal executive officer and principal financial officer, as required by 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, and Rule 30a-2(b) under the Investment Company Act of 1940, are attached. The certifications furnished pursuant to this paragraph are not deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, or otherwise subject to the liability of that section. Such certifications are not deemed to be incorporated by reference into any filing under the Securities Act of 1933 or the Securities Exchange Act of 1934, except to the extent that the Registrant specifically incorporates them by reference. (c)(1) Contact person at the registrant SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. By: - ------------------------------ Maureen Ford Goldfarb Chairman, President and Chief Executive Officer Date: December 18, 2003 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By: - ------------------------------- Maureen Ford Goldfarb Chairman, President and Chief Executive Officer Date: December 18, 2003 By: - ----------------------- Richard A. Brown Senior Vice President and Chief Financial Officer Date: December 18, 2003