EXHIBIT 10.41
                                                                          
                     SECURITIES PURCHASE AGREEMENT

SECURITIES PURCHASE AGREEMENT dated as of October 15, 1997, between Bioject 
Medical Technologies Inc., an Oregon corporation (the "Company"), and Elan 
International Services, Ltd., a Bermuda corporation ("EIS).


R E C I T A L S:

A.  The Company desires to issue and sell to EIS and EIS desires to purchase 
from the Company, on the Closing Date (as defined below), as provided herein, 
a promissory  note in the original principal amount of $12,015,000, in the 
form attached hereto as Exhibit A (the "Promissory Note"), for aggregate 
consideration of $12,015,000 to be paid in cash by EIS to the Company on the 
Closing Date.

B.  The Company desires to issue and sell to EIS, and EIS desires to purchase 
from the Company, (i) 2,727,273 shares of the Company's common stock, without 
par value (the "Common Stock"), and (ii) a warrant to acquire 1,750,000 shares 
(subject to adjustment) of Common Stock, in the form attached hereto as 
Exhibit B (the "Warrant"), for aggregate consideration of $3,000,000  to be 
paid in cash by EIS to the Company on the Closing Date.

C.  In the event that Stockholder Approval (as defined herein) is obtained, 
the Promissory Note shall be exchanged by EIS for certain shares of Series A 
Convertible Preferred Stock (the "Series A Preferred Stock") and Series B 
Convertible Preferred Stock (the "Series B Preferred Stock"; together with the 
Series A Preferred Stock and the Series C Preferred Stock (as defined below), 
the "Preferred Stock"; together with the Common Stock and the Warrant, the 
"Securities"), as provided herein, which shall be issued to EIS pursuant to 
the Certificate of Designations in the form attached hereto as Exhibit C (the 
"Certificate of Designations").

D.  In the event that the Stockholder Approval is obtained, EIS has agreed 
that for a period of 30 months thereafter EIS may, at the Company's option 
(but subject to the conditions contained herein), be required to fund up to  
$4,000,000 to the Company to purchase  additional shares of preferred stock 
(the "Series C Preferred Stock").

E.  The Company has previously caused to be formed Bioject JV Subsidiary Inc., 
an Oregon corporation ("Newco"), for the purpose of developing and 
commercializing certain technologies relating to glucose monitoring.  The 
initial stockholders in Newco shall be the Company and EIS.  The parties 
intend, as provided herein, that the proceeds of the issuance of Promissory 
Note shall be applied by the Company solely to fund the Company's initial  
investment in Newco, as provided herein.

F.  The Company and EIS are executing and delivering on the date hereof a 
Registration Rights Agreement in the form attached hereto as Exhibit D (the 
"Registration Rights Agreement"; together with this Agreement, the Securities, 
and each other document or instrument executed and delivered in connection 
with the transactions contemplated hereby, the "Transaction Documents") in 
respect of the initial purchase of Common Stock and the Common Stock 
underlying the Securities and any other Common Stock that may at any time be 
acquired or owned by EIS or its affiliates.


A G R E E M E N T:

The parties agree as follows:

SECTION 1.  Closings.  (a)  Time and Place.  The closing of the transactions 
contemplated hereby (the "Closing") shall occur on the date hereof (the 
"Closing Date"), at the offices of counsel to EIS or such other place as the 
parties may agree.

(b)  Issuance of Securities.  At the Closing, (x) the Company shall issue and 
sell to EIS, and EIS shall purchase from the Company the Promissory Note, upon 
the terms and subject to the conditions set forth herein, for an aggregate 
purchase price of $12,015,000, and (y) the Company shall issue and sell to 
EIS, and EIS shall purchase from the Company (i) 2,727,273 shares of Common 
Stock (the "Initial Common Stock") and the Warrant, for an aggregate purchase 
price of $3,000,000  (the "Closing Consideration").  Of such Closing 
Consideration, $.001 per share of Common Stock issueable upon exercise of the 
Warrant shall be deemed allocated toward the purchase price of the Warrant.

(c)    Delivery.  At the Closing, EIS shall pay the purchase price for the  
Promissory Note, Initial Common Stock and the Warrant in cash by wire transfer 
to an account or accounts designated by the Company and the parties hereto 
shall execute and deliver to each other, as applicable:  (i) the Promissory 
Note; (ii) a certificate or certificates for the shares of the Initial Common 
Stock; (iii) the Warrant; and (iv) certificates as to the incumbency of the 
officers executing this Agreement and each of the other documents or 
instruments executed in connection herewith.   In addition, at the Closing, 
the Company shall cause to be delivered to EIS an opinion of counsel in form 
attached hereto as Exhibit E.

(d)   Additional Closings. (i) In the event that Stockholder Approval shall 
have been obtained on or prior to February 1, 1998, for a period of 30 months 
after the date thereof, upon at least 30 days notice, the Company shall be 
entitled from time to time, subject to the conditions herein, to require EIS 
to purchase all or part of the Series C Preferred Stock.  The Series C 
Preferred Stock shall be redeemable and convertible in the same manner and 
subject to the same other conditions as the Series B Preferred Stock; provided 
that the issuance and conversion prices of each share of  Series C Preferred 
Stock shall be equal to ten times the average of the last traded price for the 
shares of Common Stock as reported by the Nasdaq Stock Market for 10 
consecutive trading days ending on the day that is two business days prior to 
the date of such issuance .  In the event that Stockholder Approval has not 
been obtained on or prior to February 1, 1998, EIS, in its sole discretion, 
shall be entitled to deem such lack of approval as a rejection of the Proposal 
(as defined in Section 4(f)) by the Company's stockholders.

(ii)  It shall be a condition to EIS's obligation to purchase any Series C 
Preferred Stock that (A) each of the representations and warranties set forth 
in Section 2(a), (b)(iii), (c), (d) and (l) shall be true and correct in all 
material respects as if the date hereof were the proposed funding date 
thereof; provided, that any reference to the Quarterly Report shall refer to 
the most recent quarterly report on Form 10-Q and/or any report filed pursuant 
to Section 13 of the Securities Exchange Act of 1934 (the "Exchange Act"), 
required to be filed by the Company under applicable law immediately prior to 
such funding date and SEC Filings shall refer to all filings required to be 
made by the Company under applicable law on or prior to such date, (B) there 
shall be no default or breach in any material respect by the Company of a 
material obligation under any of the Transaction Documents  or any other 
agreement between the Company or any of its affiliates, on the one hand, and 
EIS or any of their affiliates, on the other hand, and (C) the Company shall 
have executed and delivered to EIS each document or instrument  that shall be 
customary and appropriate for such transaction, including duly executed and 
delivered counterparts of certificates for the Series C Preferred Stock.

(e)   Exemption from Registration.  The Securities will be issued under an 
exemption or exemptions from registration under the Securities Act of 1933, as 
amended; accordingly, the certificates evidencing the Securities shall, upon 
issuance, contain the following legend:

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE 
SECURITIES ACT OF 1933 AND MAY NOT UNDER ANY CIRCUMSTANCES BE  TRANSFERRED 
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE 
SECURITIES ACT OF 1933 AND ANY APPLICABLE STATE SECURITIES LAWS OR AN OPINION 
OF COUNSEL SATISFACTORY TO THE CORPORATION THAT REGISTRATION IS NOT REQUIRED 
UNDER SUCH ACT OR APPLICABLE STATE SECURITIES LAWS.

(f)   Registration Rights Agreement.  On the date hereof, the Company, and EIS 
are each executing and delivering the Registration Rights Agreement, covering 
the shares of Common Stock issuable hereunder or upon conversion, exercise or 
exchange of any of the Securities or any other shares of Common Stock 
hereafter acquired by EIS or its affiliates from the Company.

SECTION 2.  Representations and Warranties of the Company.  (a)  Organization.  
The Company is duly organized, validly existing and in good standing under the 
laws of the State of Oregon and has all requisite corporate power and 
authority to own and lease its properties, to carry on its business as 
presently conducted and as proposed to be conducted and to consummate the 
transactions contemplated hereby.  The Company is qualified and in good 
standing to do business in jurisdictions set forth on Schedule 2(a), which 
constitute all of the jurisdictions in which the nature of the business 
conducted or the property owned by it requires such qualification, except 
where the failure to so qualify would not have a material adverse effect on 
the business, prospects, properties or condition (financial or otherwise) of 
the Company (a "Material Adverse Effect").

(b)  Capitalization.  (i) The authorized and number of outstanding shares of 
capital stock of the Company as of September 30, 1997 is 22,475,688.

(ii)  Except as set forth in Schedule 2(b) and in the Company's quarterly 
report on Form 10-Q filed with the Securities and exchange Commission on 
August 14, 1997 (the "Quarterly Report"), as of the Closing there are no 
options, warrants or other rights outstanding to purchase or otherwise 
acquire, or any securities convertible into, any of the Company's authorized 
capital stock.  Other than as set forth in this Agreement and as described in 
Schedule 2(b), there are no agreements, arrangements or understandings 
concerning the voting, acquisition or disposition of any of the Company's 
outstanding securities to which the Company is a party or of which it is 
otherwise aware, and, other than as set forth in Schedule 2(b) or in the 
Registration Rights Agreement, there are no agreements to register any of the 
Company's outstanding securities under the U.S. federal securities acts.

(iii)  All of the outstanding shares of capital stock of the Company have been 
issued in accordance with applicable state and federal laws and regulations 
governing the sale and purchase of securities, all of such shares of have duly 
and validly issued and are fully paid and non-assessable, and none of such 
shares carries preemptive or similar rights.  

 (c)  Authorization of Transaction Documents.  The Company has full corporate 
power and authority to execute and deliver this Agreement and each of the 
other Transaction Documents, and to perform its obligations hereunder and 
thereunder.  Except for Stockholder Approval the execution, delivery and 
performance by the Company of the Transaction Documents (including the 
issuance and sale of the Securities) have been authorized by all requisite 
corporate actions by the Company; and the Transaction Documents (including the 
issuance and sale of the Securities) have been duly executed and delivered by 
the Company are the valid and binding obligations of the Company, enforceable 
against each in accordance with their respective terms.

(d)  No Violation.  The execution, delivery and performance by the Company of 
the Transaction Documents (including the issuance and sale of the Securities), 
and compliance with the provisions thereof by the Company, will not (i) 
violate any provision of applicable law, statute, rule or regulation 
applicable to the Company or any ruling, writ, injunction, order, judgment or 
decree of any court, arbitrator, administrative agency or other governmental 
body applicable to the Company or any of their respective properties or assets 
or (ii) conflict with or result in a breach of any of the terms, conditions or 
provisions of, or constitute (with notice or lapse of time or both) a default 
(or give rise to any right of termination, cancellation or acceleration) 
under, or result in the creation of, any Encumbrance (as defined below) upon 
any of the properties or assets of the Company under its Articles of 
Incorporation, as amended, its Certificate of Designations (in the form to be 
filed as provided herein) or By-laws, or any material contract to which the 
Company is a party, except where such violation, conflict or breach would not, 
individually or in the aggregate, have a Material Adverse Effect on the 
Company (as used in connection to either of them, a "Material Adverse 
Effect").  As used herein, "Encumbrance" shall mean any liens, charges, 
encumbrances, equities, claims, options, proxies, pledges, security interests, 
or other similar rights of any nature, except for such conflicts, breaches or 
defaults which would not, individually or in the aggregate, have a Material 
Adverse Effect.

(e)  Approvals.  Except as set forth on Schedule 2(e), no material permit, 
authorization, consent or approval of or by, or any notification of or filing 
with, any person or entity (governmental or otherwise) is required in 
connection with the execution, delivery or performance of the Transaction 
Documents (including the issuance and sale of the Securities) by the Company 
or Newco. Except for the Stockholder Approval, there is no approval of the 
Company's stockholders required under applicable laws in connection with the 
execution and delivery the Transaction Documents or the consummation of the 
transactions contemplated thereby, including the filing of the Certificate of 
Designations and the issuance of the Securities.

(f)  Filings, Taxes and Financial Statements.  (i)  The Company has filed its 
annual report on Form 10-K for the year ended March 31, 1997, its related 
proxy materials and its quarterly reports on Form 10-Q for the quarter ended 
June 30, 1997 and the Quarterly Report (collectively, including all exhibits 
and schedules required to be filed in connection therewith, the "SEC Filings") 
with the Securities and Exchange Commission, the Nasdaq Stock Market and any 
other required person or entity (governmental or otherwise) in a timely manner 
and as otherwise required by applicable laws and regulations, including the 
federal securities acts. The audited financial statements of the Company for 
the fiscal year ended March 31, 1997 included in the SEC Filings (the "Audited 
Financial Statements"), and the Company's unaudited balance sheet for the 
period ending June 30, 1997, together with the accompanying statements of 
operations and cash flows including the notes thereto (the "June Financial 
Statements"; collectively, with the Audited Financial Statements, the 
"Financial Statements") are accurate and complete in all material respects and 
fairly present the financial condition of the Company as at the dates thereof 
and have been prepared in accordance with generally accepted accounting 
principles applied on a consistent basis throughout the periods indicated 
(except as may be otherwise indicated in such financial statements or the 
notes thereto), subject, in the case of the June Financial Statements, to 
normal year-end audit adjustments (which shall not be material in the 
aggregate) and the absence of footnote disclosures.

(ii) The Company has filed in a timely manner all material federal, state, 
local and foreign tax returns, reports and filings (collectively, "Returns"), 
including income, franchise, property and other taxes, and has paid or accrued 
the appropriate amounts reflected on such Returns.  None of the Returns have 
been audited or challenged, nor has the Company received any notice of 
challenge nor have any of the amounts or other data included in the Returns 
been challenged or reviewed by any governmental authority.

(iii) Except as listed in Schedule 2(f), which sets forth a true and accurate 
list and description of any such plans maintained or sponsored by the Company 
or to which the Company is required to make contributions, the Company does 
not maintain, sponsor, is not required to make contributions to or otherwise 
have any liability with respect to any pension, profit sharing, thrift or 
other retirement plan, employee stock ownership plan, deferred compensation, 
stock ownership, stock purchase, performance share, bonus or other incentive 
plan, severance plan, health or group insurance plan, welfare plan, or other 
similar plan, agreement, policy or understanding (whether written or oral), 
whether or not such plan is intended to be qualified under Section 401(a) of 
the Code, within the meaning of Section 3(3) of the Employee Retirement Income 
Security Act of 1974, as amended, which plan covers any employee or former 
employee of the Company.

(g)  Absence of Changes.  Except as set forth on Schedule 2(g), since June 30, 
1997, there has not been (a) any material adverse change in the business, 
properties, condition (financial or otherwise), operations or prospects of the 
Company; (b) any damage, destruction or loss, whether or not covered by 
insurance, materially and adversely affecting the business, properties, 
condition (financial or otherwise), operations or prospects of the Company; 
(c) any declaration, setting aside or payment of any dividend or other 
distribution or payment (whether in cash, stock or property) in respect of the 
capital stock of the Company, or any redemption or other acquisition of such 
stock by the Company; (d) any disposal or lapse of any trade secret, 
invention, patent, trademark, trademark registration, service mark, service 
mark registration, copyright, copyright registration, or any application 
therefor or filing in respect thereof; (e) loss of the services of any of the 
key officers or key employees of the Company; (f) any incurrence of or entry 
into any liability, mortgage, lien, commitment or transaction, including 
without limitation, any borrowing (or assumption or guarantee thereof) or 
guarantee of a third party's obligations, or capital expenditure (or lease in 
the nature of a conditional purchase of capital equipment) in excess of 
$50,000; or (g) any material change by the Company in accounting methods or 
principles or (h) any change in the assets, liabilities, condition (financial 
or otherwise), results or operations or prospects of the Company from those 
reflected on the Quarterly Report, except changes in the ordinary course of 
business that have not, individually or in the aggregate, had a Material 
Adverse Effect.

(h)  No Liabilities.  Except as set forth in the Quarterly Report or Schedule 
2(h) attached hereto, neither the Company nor Newco nor any of their 
respective subsidiaries has incurred or suffered any liability or obligation, 
matured or unmatured, contingent or otherwise, except in the ordinary course 
of business that have not, individually or in the aggregate, had a Material 
Adverse Effect.

(i)  Properties and Assets; Etc.  (i)  The Company owns all of its properties 
and assets, including patents, patent applications, continuations, 
continuations-in-part, extensions, trademarks and trademark applications, 
know-how and other intellectual property, as reflected in the Financial 
Statements, subject in each case, to no Encumbrances required to be disclosed 
in the Financial Statements except as set forth therein. Except as set forth 
on Schedule 2(i), (i) all of the Company's patents, trademarks, service marks, 
trade names, and copyrights are owned by the Company free and clear of all 
liens, claims and encumbrances and are valid and duly issued or existing; none 
of the Company's rights in or use of such patents, trademarks, service marks, 
trade names or copyrights has been or is currently being threatened to be, 
challenged; to the best of the Company's knowledge, without making any inquiry 
other than those, if any, routinely conducted by the Company in the ordinary 
course of business, no  current or currently planned product based upon the 
Company's intellectual property would infringe any patent, trademark, service 
mark, trade name or copyright of any other person or entity issued or pending 
on the Closing Date if the Company were to distribute, sell or manufacture 
such products; and the Company is not aware, after due inquiry, of any actual 
or threatened claim by any person or entity alleging any infringement by the 
Company of a patent, trademark, service mark, trade name or copyright 
possessed by such Person; (ii) all of such patents, trademark registrations, 
service mark registrations, trade name registrations and copyrights and 
copyright registrations, whether foreign or domestic, have been duly issued 
and have not been canceled, abandoned, or otherwise terminated; and (iii) all 
of the Company's patent applications, trademark applications, service mark 
applications, trade name applications and copyright applications have been 
duly filed.

(ii) Each of the Contracts listed as an exhibit to the Company's Annual Report 
on Form 10-K for the year ended March 31, 1997 is a legal and valid agreement 
binding upon each of the parties thereto and is in full force and effect and, 
to the best knowledge of the Company, there is no breach or default by any 
party thereunder.  Such Contracts constitute all material agreements, 
arrangements or understandings required to be included in such annual Report 
under Securities and Exchange Commission regulations promulgated in connection 
therewith.

(iii)  The Company has and maintains adequate and sufficient insurance, 
including liability, casualty and products liability insurance, covering risks 
associated with its business, properties and assets, including insurance that 
is customary for companies similarly situated.

(iv)   To the best of its knowledge, the Company, its business and properties 
and assets are in compliance, in all material respects, with all applicable 
laws and regulations, including without limitation, those relating to (a) 
health, safety and employee relations, (ii) environmental matters, including 
the discharge of any hazardous or potentially hazardous materials into the 
environment, and (iii) the development, commercialization and sale of 
pharmaceutical and biotechnology products, including all applicable 
regulations of the U.S. Food and Drug Administration and comparable foreign 
regulatory authorities.

(j)   Legal Proceedings, etc. There is no legal, administrative, arbitration 
or other action or proceeding or governmental investigation pending or , to 
the best of the Company's knowledge threatened against the Company, or any 
director, officer or employee of the Company, which is required to be 
described in the Company's Quarterly Report on Form 10-Q and is not so 
described.  The Company is not in violation of or default under, any material 
laws,  judgments, injunctions, orders or decrees of any court, governmental 
department, commission, agency, instrumentality or arbitrator applicable to 
its business. 

(k)  Disclosure.  The Company's Annual Report on Form 10-K for the year ended 
March 31, 1997 and periodic reports subsequently filed under Section 13 of the 
Exchange Act, and the representations and warranties set forth herein and the  
Transaction Documents, when viewed collectively, do not contain any untrue 
statement of a material fact or omit to state any material fact necessary to 
make the statements contained herein and therein not misleading.	

(l) Brokers or Finders.  Other than as set forth on Schedule 2(l), the Company 
has not retained any investment banker, broker or finder in connection with 
the transactions contemplated by the Transaction Documents; and the Company 
agrees to indemnify and hold EIS harmless against any liability, settlement or 
expense arising out of, or in connection with, any claim related thereto.

SECTION 3.  Representation and Warranties of EIS.  EIS hereby represents and 
warrants to the Company as follows:

(a)  Organization.  EIS is a corporation duly organized, validly existing and 
in good standing under the laws of Bermuda and has all requisite corporate 
power and authority to own and lease its properties, to carry on its business 
as presently conducted and as proposed to be conducted and to consummate the 
transactions contemplated hereby.  EIS  is qualified and in good standing to 
do business in each jurisdiction in which the nature of the business conducted 
or the property owned by it requires such qualification, except where the 
failure to so qualify would not reasonably be expected to have a material 
adverse effect on the business or condition (financial or otherwise) of EIS.

(b)  Authorization of Agreement.  EIS has full legal right, power and 
authority to enter into this Agreement and purchase and accept the Note, and 
perform its obligations hereunder, which have been duly authorized by all 
requisite corporate action.  This Agreement and the  purchase of the Note are 
the valid and binding obligations of EIS, enforceable against them in 
accordance with their terms.

(c)  No Conflicts.  The execution, delivery and performance by EIS of this 
Agreement, the purchase and acceptance of the Note and compliance with 
provisions hereof by EIS, will not (i) violate any provisions of applicable 
law, statute, rule or regulation applicable to EIS or any ruling, written, 
injunction, order, judgment or decree of any court, arbitration, 
administrative agency of other governmental body applicable to EIS of any of 
its properties or assets or (ii) conflict with or result in any breach of any 
of the terms, conditions or provisions of, or constitute (with notice or lapse 
of time to both) a default (or give rise to any right of termination, 
cancellation or acceleration) under, or result in the creation of any 
Encumbrance upon any of the properties or assets of EIS under the Certificate 
of Incorporation or By-laws of EIS or any material contract to which EIS is 
party, except where such violation conflict or breach would not, individually 
or in the aggregate, have a material adverse effect on EIS.

(d)  Approvals.  No permit, authorization, consents or approval of or by, or 
any notification of or filing with, any person or entity (governmental or 
otherwise) is required in connection with the execution, delivery or 
performance of this Agreement or the Note (including the funding and 
acceptance thereof) by EIS.

(e)  Investment Representations.  (i)  EIS is sophisticated in transactions of 
this type and capable of evaluating the merits and risks of the transactions 
described herein and in the other Transaction Documents, and have the capacity 
to protect their own interests.  EIS has not been formed solely for the 
purpose of entering into the transactions described herein and therein and is 
acquiring the Securities for investment for its own account, not as a nominee 
or agent, and not with the view to, or for sale in connection with, any 
distribution of any part thereof; provided, that EIS shall be permitted to 
convert or exchange such Securities and/or transfer them as permitted herein 
and under applicable law.  EIS has been afforded the opportunity to ask 
questions of and information about the Company and its business and prospects, 
from management and representatives of the Company, and have relied on its own 
independent judgment in making a judgment about an investment in the 
Securities. 

(ii)  Nothing contained in this Section 3(e) shall limit any of the Company's 
representations or warranties or limit EIS's recourse in respect thereof.

(iii) Other than as set forth on Schedule 3(e)(iii), EIS have not retained any 
investment banker, broker or finder in connection with the transactions 
contemplated by the Transaction Documents; and EIS agree to indemnify and hold 
the Company harmless against any liability, settlement or expense arising out 
of, or in connection with, any claim related thereto.

SECTION 4.  Covenants of the Company.  (a) Non-disclosure.  From and after the 
date hereof, the Company shall not disclose to any person or entity (other 
than its directors, officers and agents who need to know such information in 
connection with the transactions described herein and the other Transaction 
Documents (each of whom shall be informed of this confidentiality provision 
and in respect of whose breaches the Company shall be responsible)) the 
content of this Agreement or any of the other Transaction Documents or the 
substance of the transactions described herein, without the prior written 
consent of EIS (which consent shall not be unreasonably withheld or delayed), 
except to the extent required by applicable laws or administrative or judicial 
processor in respect of press releases and periodic reports prepared in good 
faith by the Company; provided, that the Company shall provide EIS with a 
reasonable opportunity to review and approve such releases or reports.  This 
Section 4 shall not be construed to prohibit disclosure of any information 
which has not been previously determined to be confidential by EIS, or which 
shall have become publicly disclosed (other than by breach of the Company's 
obligations hereunder).

(b)   Board of Directors.  Coincident with Closing, the Company's board of 
directors shall be expanded by one member, from seven to eight members, and EIS 
shall be entitled to appoint a director to fill the vacancy so created (the 
"EIS Director"), who shall be a duly elected director.  From and after the 
date hereof and for so long as EIS and/or their respective affiliates own 
Securities that represent ownership of at least 5% (and 10% from and after 
October 15, 2004) of the Common Stock, on a  fully diluted basis the Company 
shall use its best efforts to cause the EIS Director to be elected to the 
Company's board of directors, by including the EIS Director in the management 
slate of directors at each meeting of stockholders at which an election of 
directors occurs.  Appointment of the EIS Director shall be subject to the 
consent of the Company, which shall not be unreasonably withheld or delayed, 
and which shall be based upon regulatory and fitness of character 
considerations.

(c)  Fully-diluted Stock Ownership.  Notwithstanding any other provision of 
this Agreement, in the event that EIS shall have determined that at any time 
it (together with its Affiliates, if applicable) holds or has the right to 
receive Common Stock (or securities or rights, options or warrants 
exercisable, exchangeable or convertible for or into Common Stock) 
representing in the aggregate in excess of 19.9% of the Company's outstanding 
Common Stock (assuming any such exercise, exchange or conversion, but not the 
exercise, exchange or conversion of any other similar securities), EIS shall 
have the right, in its sole discretion, rather than acquiring such securities 
from the Company, to exchange such number of securities, as are necessary to 
bring its holdings to below 19.9% of the voting securities of the Company, for 
non-voting, liquidation preference equity securities of the Company (which 
shall be reasonably satisfactory to the Company and EIS), which equity 
securities shall be entitled to all of the other rights and benefits of the 
Common Stock.  In the event that EIS shall undertake to exercise such right, 
EIS shall retain the additional right to exchange such new class of equity 
security for Common Stock, in its discretion.

(d)   Certain Prohibited Activities.  (i) For such time that the Promissory 
Note remains outstanding, the Company shall not, without EIS's written consent 
(which consent will not be unreasonably withheld or delayed): (a) acquire or 
dispose of  any material asset or business, other than in the ordinary course 
of business; (b) merge or consolidate with any other corporation or acquire 
control of any other corporation or business entity; or (c) incur any 
indebtedness or liens outside the ordinary course of business, which  ordinary 
course shall include equipment leases and working capital lines up to a 
maximum of the lesser of $5 million and 50% of  the Company's aggregate 
consolidated accounts receiveable and inventory;

(ii) In the event that Stockholder Approval is obtained, and after the 
redemption of the Promissory Note and issuance and sale of the Preferred Stock 
has occurred, the restrictions referred to in item (a) of Section 4(d) above 
shall continue, and the restrictions referred to in items (b) and  (c) above 
shall be of no further force or effect; provided that, they shall be replaced 
by the following restriction: without the written consent of EIS (which 
consent will not be unreasonably withheld or delayed) the Company shall not 
incur any indebtedness in excess of $10 million aggregate principal amount 
unless the Company can reasonably establish (based on prudent and customary 
commercial practices and standards in the capital markets) that the Company 
may incur such indebtedness from an institutional lender, venture capital firm 
or reputable so-called "hedge" fund, on a prudent and reasonable basis, based 
on the Company's then credit-worthiness, prospects, solvency and business 
(each of item (a) and (b) of Section 5(e)(i) and this Section 5(e)(ii), as 
applicable, a "Restricted Transaction").  Notwithstanding the foregoing, the 
Company may incur working capital lines and equipment leases from unaffiliated 
third parties in bona fide financing transactions in principal amounts up to 
the lesser of $5 million and 50% of the Company's aggregate consolidated 
accounts receivable and inventory.

(e) Stockholder Approval.  The Company shall prepare a Proxy Statement, call a 
Special Meeting of Stockholders to be held prior to February 1, 1998, and use 
its best efforts (including, without limitation, subject to their fiduciary 
duties as directors, the board of director affirmative recommendation that the 
stockholders of the Company vote to approve issuance and sale of the Series A 
and Series B Preferred Stock in exchange for the Promissory Note), all to the 
fullest extent permitted and as required under applicable law, to obtain 
thereat the approval (the "Stockholder Approval") of the proposal to issue and 
sell the Series A and Series B Preferred Stock and to authorize the issuance 
of the Series C Preferred Stock and amend the Company's Articles of 
Incorporation in connection therewith in  exchange for the Promissory Note 
(the "Proposal").  In the event that the Stockholders' Approval shall not have 
been obtained on or prior to February 1, 1998, EIS shall be entitled, in their 
sole discretion and upon at least 30-days notice to the Company, to consider 
such lack of approval as a rejection of the Proposal.  The Company shall 
provide a draft copy of such Proxy Statement to EIS at least five business 
days prior to the anticipated date of filing with the SEC, and the filing of 
the Proxy Statement shall be subject to EIS's approval thereof, which shall 
not be unreasonably withheld or delayed.

(f) Use of Proceeds.  The Company shall use the proceeds of the sale of  the 
Series C Preferred Stock, if any, solely for the purpose of meeting its 
capitalization and funding requirements to Newco, described as Additional 
Funding in the Bioject JV Subsidiary Inc. Subscription and Stockholder 
Agreement dated as of the date hereof.

SECTION 5.  Mutual Covenants of the Parties.  (a) Exchange.  In the event that 
Stockholder Approval is obtained, EIS shall tender the Promissory Note to the 
Company in exchange for the issuance to EIS of (i) that number of shares of 
the Series A Preferred Stock equal to (a) $10 million plus accrued and unpaid 
interest divided by (b) $15, and (ii) 134,333 shares of the Series B Preferred 
Stock such tender and exchange to be completed within 10 business days of the 
date of Stockholder Approval.

(b) Further Assurances.  From and after the date hereof, each of the parties 
hereto agree to do or cause to be done such further acts and things and 
deliver or cause to be delivered to each other such additional assignments, 
agreements, powers and instruments, as each may reasonably require or deem 
advisable to carry into effect the purposes of the Transaction Documents or to 
better to assure and confirm unto each other their respective rights, powers 
and remedies hereunder and thereunder.

(c) Preferred Stock Early Redemption.  In the event that the Company desires 
to engage in a Restricted Transaction to which EIS has reasonably withheld its 
consent (s provided herein), the Company shall have the right to redeem the 
remaining outstanding Preferred Stock, by paying to EIS the amount of unpaid 
dividends then accrued and unpaid, and issuing to EIS  a warrant (the 
"Contingent Warrant") in customary form and otherwise reasonably satisfactory 
to EIS which shall entitle EIS to purchase that number of shares of Common 
Stock (or securities or other property of its successor or acquirer, if any, 
in accordance with the Anti-Dilution Adjustments) into which the Preferred 
Stock would have been convertible had it not been redeemed under this 
provision, at an aggregate price equal to the sum of the entire amount of the 
Preferred Stock and an interest component on such sum of 9% per annum from 
redemption until the date of exercise.   The Contingent Warrant shall be 
transferable in accordance with Section 16 hereof.

(d) Technology Collaboration.  (i) Each of the parties hereto agree that 
commencing with the first quarter of 1998, upon written request from the 
Company, EIS shall cause to be invested up to $500,000 in the form of grants 
to the Company in support of the development of the Company's existing needle-
free injection technologies (the "Technology Collaboration") in four equal, 
quarterly (in arrears) payments of $125,000 each.

(ii) The first such technology referred to in Section 5(e)(i) shall be one or 
more pre-filled ampule projects mutually acceptable to EIS and the Company; 
and that other projects may be substituted on a mutually satisfactory basis if 
it is determined by the Company that the initial projects have no practical 
commercial potential.

(iii) All intellectual property and results of projects shall belong to the 
Company; provided, that EIS shall have a right of first refusal, on then-
current market terms, to conduct further development or commercialization of 
such intellectual property or results in conjunction with the Company, for the 
period of one year following completion of work directly funded by the grants 
contemplated herein.  During such one-year period, the Company shall not take 
any actions, including in concert with any third party, which would negatively 
effect EIS's right.

(e) Standstill.  EIS agrees that, for a period of three years from the date 
hereof, unless (i) a party shall have been specifically invited in writing by 
the Company or (ii) a party unaffiliated with EIS, without participation or 
encouragement of EIS or any of its affiliates (as such term is defined under 
the Securities Exchange Act of 1934 (the "1934 Act")), shall announce a tender 
offer or solicit proxies with respect to an acquisition proposal which has not 
been solicited by the Company's board of directors or attempts to control the 
management or business or affairs of the Company or otherwise acquire more 
than 10% of the Company's voting securities (outright or on an as converted 
basis; without approval from the Company's Board of Directors), neither EIS 
nor its affiliates shall in any manner, directly or indirectly, (a) effect or 
seek, offer or propose to effect or participate in (publicly or otherwise) (i) 
any acquisition of securities (or beneficial ownership thereof) or assets of 
the Company or its subsidiaries, (ii) any tender or exchange offer, merger or 
other business combination involving the Company or any of its subsidiaries, 
(iii) any recapitalization, restructuring, liquidation, dissolution or other 
extraordinary transaction with respect to the Company or its subsidiaries, or 
(iv) any solicitation of proxies (as such terms are defined under the 
regulations of the Securities and Exchange Commission) or consents to vote any 
voting securities of the Company; (b) form, join or participate in a group (as 
defined under the 1934 Act); (c) otherwise act to seek control or influence 
the management, board of directors or policies of the Company, or (d) take any 
action which may force the Company to make a public announcement regarding any 
matters enumerated in (a) above.

SECTION 6.  Entire Agreement.  This Agreement and the other Transaction 
Documents contain the entire understanding of the parties with respect to the 
subject matter hereof and supersede all prior agreements and understandings 
among the parties with respect thereto.

SECTION 7.  Survival and Indemnification.  (a) Survival Period.  The 
representations and warranties of the Company contained herein shall survive 
for a period of one year after the date hereof.  

(b)  Indemnification.  In addition to all rights and remedies available to the 
parties hereunder at law or in equity, the Company (in such capacity, an 
"Indemnifying Party") shall indemnify EIS, and its respective affiliates, and 
EIS' and its respective affiliates' stockholders, officers, directors, 
employees, agents, representatives, successors and assigns (collectively, the 
"Indemnified Person"), and save and hold EIS harmless from and against and pay 
on behalf of or reimburse each such Indemnified Person, as and when incurred, 
for any and all loss, liability, demand, claim, action, cause of action, cost, 
damage, deficiency, tax, penalty, fine or expense, whether or not arising out 
of any claims by or on behalf of such Indemnified Person or any third party, 
including interest, penalties, reasonable attorneys' fees and expenses and all 
amounts paid in investigation, defense or settlement of any of the foregoing 
(collectively, "Losses"), that any such Indemnified Person may suffer, sustain 
incur or become subject to, as a result of, in connection with, relating or 
incidental to or by virtue of:

(i) any misrepresentation or breach of warranty on the part of the 
Indemnifying Party under Section 2 of this Agreement; or

(ii) any nonfulfillment, default or breach of any covenant or agreement on the 
part of the Indemnifying Party under Section 4 of this Agreement. 


(c)   Maximum Recovery.  The maximum recovery of EIS under this Section 7 
shall not exceed $15 million.  No Indemnified Party shall assert any such 
claim unless Losses in respect thereof incurred by any Indemnified Party, when 
aggregated with all previous Losses hereunder, equal or exceed $250,000, and 
the obligation of the Indemnifying Party to indemnify shall not apply to the 
first $250,000 of losses to the Indemnified Person.

(d)   Exception.  Notwithstanding the foregoing, and subject to the following 
sentence, upon judicial determination that is final and no longer appealable, 
that the act or omission giving rise to the indemnification set forth above 
resulted primarily out of or was based primarily upon the Indemnified Person's 
negligence(unless such Indemnified Person's negligence was based upon the 
Indemnified Persons reliance in good faith upon any of the representations, 
warranties, covenants or promises made by the Indemnifying Party herein) the 
Indemnifying Party shall not be responsible for any Losses sought to be 
indemnified in connection therewith, and the Indemnifying Party shall be 
entitled to recover from the Indemnified Persons all amounts previously paid 
in full or partial satisfaction of such indemnity, together with all costs and 
expenses (including reasonable attorneys fees) of the Indemnifying Party 
reasonably incurred in connection with the Indemnified Party's claim for 
indemnity, together with interest at the rate per annum publicly announced by 
Morgan Guaranty Trust Company as its prime rate from the time of  payment of 
such amounts to the Indemnified Person until repayment to the Indemnifying 
Party.

(e)  Investigation.  All indemnification rights hereunder shall survive the 
execution and delivery of this Agreement and the consummation of the 
transactions contemplated hereby to the extent provided in Section 7(b) above, 
irrespective of any investigation, inquiry or examination made for or on 
behalf of, or any knowledge of the Indemnified Persons or the acceptance of 
any certificate or opinion. 

(f)   Contribution.  If the indemnity provided for the this Section 7 shall 
be, in whole or in part, unavailable to any Indemnified Person, due to Section 
7(b) being declared unenforceable by a court of competent jurisdiction based 
upon reasons of public policy, so that Section 7(b) shall be insufficient to 
hold each such Indemnified Person harmless from Losses which would otherwise 
be indemnified hereunder, then the Indemnifying Party and the Indemnified 
Person shall each contribute to the amount paid or payable for such Loss in 
such proportion as is appropriate to reflect not only the relative benefits 
received by the Indemnifying Party on the one hand and the Indemnified Person 
on the other, but also the relative fault of the Indemnifying Party and be in 
addition to any liability that the Indemnifying Party may otherwise have.  
Subject to Section 7(h) hereunder, the indemnity, contribution and expense 
reimbursement obligations that the Indemnifying Party has under this Section 7 
shall survive the expiration of the Transaction Documents.  The parties hereto 
further agree that the indemnification and reimbursement commitments set forth 
in this Agreement shall apply whether or not the Indemnified Person is a 
formal part to any such lawsuit, claims or other proceedings.

(g)  Limitation.  No claim shall be brought by an Indemnified Person in 
respect of any misrepresentation or breach of warranty under this Agreement 
after one year from and after the date hereof; and any claim for 
nonfulfillment, default or breach of any covenant shall be brought within one 
year of the date of that such Indemnified Person became aware or should have 
become aware of the nonfulfillment, default or breach.  Except as set forth in 
the previous sentence and in Section 7(c) above, this Section 7 is not 
intended to limit the rights or remedies otherwise available to any party 
hereto with respect to this Agreement or the Transaction Documents.

SECTION 8.  Notices.  All notices, demands and requests of any kind to be 
delivered to any party in connection with this Agreement shall be in writing 
and shall be deemed to have been duly given if personally delivered or if sent 
by nationally-recognized overnight courier or by registered or certified 
airmail, return receipt requested and postage prepaid, or by facsimile 
transmission, addressed as follows:

(i) if to the Company, to:

Bioject Medical Technologies, Inc.
7620 S.W. Bridgeport Road
Portland, Oregon
Facsimile: 503-620-6431
Attention: James C. O'Shea

with a copy to:

Bogle and Gates P.L.LC.
Two Union Square
601 Union St.
Seattle, WA 98101
Facsimile: (206) 621-2660
Attn: Christopher Barry

(ii) if to EIS, to:
Elan International Services, Ltd.

Flatts Smiths SL04
Bermuda
Facsimile: (441) 292-2224
Attention: President

with a copy to:
Brock Fensterstock Silverstein McAuliffe & Wade LLC
153 East 53rd Street 
New York, New York 10022
Facsimile: (212) 371-5500
Attention: David Robbins

or to such other address as the party to whom notice is to be given may have 
furnished to the other party hereto in writing in accordance with provisions 
of this Section 8.  Any such notice or communication shall be deemed to have 
been received (i) in the case of personal delivery or facsimile transmission, 
on the date of such delivery, (ii) in the case of nationally-recognized 
overnight courier, on the second business day after the date when sent and 
(iii) in the case of mailing, on the fifth business day following that day on 
which the piece of mail containing such communication is posted.  Notice 
hereunder may be given on behalf of the parties by their respective attorneys.

SECTION 9.  Withholding Taxes.  Amounts of income or other taxes 
which the Company is required by law to pay or withhold with respect to 
payments or distributions made by it to EIS pursuant to the terms of this 
Agreement and the Securities (the "Tax Amount") shall be deducted from such 
payment or distribution.  In the event that such a distribution made in 
property other than cash would require the Company by law to pay or withhold 
income taxes, prior to such distribution the Company shall advise EIS of the 
Tax Amount, and EIS shall promptly remit such Tax Amount to the Company in 
cash and the Company shall make such distribution of property to EIS, and in 
such event, the Company will (i) promptly pay the Tax Amount to the relevant 
taxing authority and (ii) provide to EIS such documentation necessary to 
permit EIS to reclaim the Tax Amount as a Foreign Tax Credit.  Notwithstanding 
the foregoing, the Company shall not withhold, and EIS shall not be required 
to pay, the Tax Amount if (i) EIS shall determine in good faith that on the 
basis of a written opinion of an independent tax advisor that there is 
substantial authority to determine that the Company is not required to 
withhold the Tax Amount and (ii) EIS shall agree in writing to indemnify the 
Company from and against all liability arising from a failure to pay or 
withhold the Tax Amount, including without limitation the Tax Amount, and any 
interest or penalty assessed thereon by such taxing authority.  It shall be a 
condition to any assignment of any Security that the assignee thereof be bound 
by this Section 9.

SECTION 10.  Amendments.  This Agreement may not be modified or 
amended, or any of the provisions hereof waived, except by written agreement 
of the Company and EIS.

SECTION 11.  Counterparts and Facsimile.      The Transaction 
Documents may be executed in any number of counterparts, and each such 
counterpart hereof shall be deemed to be an original instrument, but all such 
counterparts together shall constitute one agreement.  Each of the Transaction 
Documents may be signed and delivered to the other party by facsimile 
transmission; such transmission shall be deemed a valid signature.

SECTION 12.  Headings.  The section and paragraph headings 
contained in this Agreement are for reference purposes only and shall not 
affect in any way the meaning or interpretation of the Agreement.

SECTION 13.  Governing Law.  This Agreement shall be governed by 
and construed in accordance with the laws of the State of Oregon, without 
giving effect to principles of conflicts of laws.

SECTION 14.  Expenses.  Each of the parties shall be responsible 
for its own costs and expenses incurred in connection with the transactions 
contemplated hereby and by the other Transaction Documents.

SECTION 15.  Public Releases; Etc.  The parties shall reasonably 
agree upon the contents of any press release or releases and other public 
disclosure in respect of the transactions contemplated hereby, and except as 
may otherwise be required by applicable law or judicial or administrative 
process or which the Company concludes in good faith is required by applicable 
securities laws and regulations.

SECTION 16.  Schedules, etc.  All statements contained in any 
exhibit or schedule delivered by or on behalf of the parties hereto, or in 
connection with the transactions contemplated hereby, are an integral part of 
this Agreement and shall be deemed representations and warranties hereunder.


SECTION 17.  Assignments.  This Agreement and all of the 
provisions hereof shall be binding upon and inure to the benefit of the 
parties hereto and their respective successors and permitted assigns.  This 
Agreement, the other Transaction Documents, and the Securities may be 
transferred by EIS to affiliates and subsidiaries without restriction, and in 
addition,  to five non-affiliated institutions, who are accredited investors 
(as that term is defined under Regulation D of the Securities Act of 1933).


[Signature page follows]




IN WITNESS WHEREOF, each of the undersigned has duly executed this 
Securities Purchase Agreement as of the date first written above.


Bioject Medical Technologies Inc.


By:/s/ James C. O'Shea                        
Name:  James C. O'Shea
Title: President

Elan International Services, Ltd.


By:/s/ Kevin Insley                         
Name:  Kevin Insley
Title: President and Chief Financial Officer