EXHIBIT 10.45
 
                                    NEWCO
                   SUBSCRIPTION AND STOCKHOLDERS AGREEMENT

SUBSCRIPTION AND STOCKHOLDERS AGREEMENT, dated as of October 15, 1997, by and 
among Bioject JV Subsidiary Inc., an Oregon corporation ("Newco" or the 
"Company"), Bioject Medical Technologies Inc., an Oregon corporation 
("Bioject"), and Elan International Services, Ltd., a Bermuda corporation 
("EIS"; together with Bioject, the "Stockholders"; each sometimes referred to 
herein as a "Stockholder").


R E C I T A L S:

A. The Company desires to issue and sell to EIS and Bioject (the 
"Purchasers"), and the Purchasers desire to purchase from the Company, for 
aggregate consideration of $15,000,000, shares of the Company's common stock 
(the "Shares"), without par value (the "Common Stock"), as set forth herein.  
The Shares issuable hereunder are entitled to the benefits of a Registration 
Rights Agreement between the Company and the Purchasers dated as of the date 
hereof and attached hereto as Exhibit A (the "Registration Rights Agreement").

B. After consummation of the transactions contemplated hereby, EIS initially 
shall own Shares representing 19.9% of the Common Stock, and Bioject initially 
shall own Shares representing 80.1% of the Common Stock.

C. The Stockholders and the Company desire to set forth herein certain 
provisions relating to the governance of the Company and transfer of shares of 
Common Stock and/or certain securities convertible, exchangeable or 
exercisable for or into shares of Common Stock.


A G R E E M E N T:

The parties agree as follows:

ARTICLE I
DEFINITIONS; AUTHORIZATIONS; CLOSINGS

1.1 Defined Terms. As used herein, the terms below shall have the following 
meanings:

"Affiliate" shall have the meaning set forth in Section 12b-2 of the 
Securities Exchange Act of 1934, as amended.

"Company Securities" shall mean the Common Stock and any additional share of 
Common Stock issued or issuable to any Stockholder upon the conversion, 
exchange or exercise of any other security or right.

"Fully Diluted Common Stock" shall mean all of the Common Stock of the 
Company, assuming conversion, exercise or exchange of all outstanding 
convertible, exchangeable or exercisable securities, options, warrants and 
similar instruments for or into Common Stock.

"License Agreement" shall mean that agreement dated as of the date hereof by 
and between Elan Corporation, plc, an Irish public limited company ("Elan") 
and the Company in connection with the licensing of Glucose Monitor Technology 
(as defined therein) by Elan to the Company.

"Permitted Transferee" shall mean (i) any Affiliate of EIS or Bioject, as 
applicable, or (ii) any other Person who acquires Company Securities from EIS 
or Bioject in a transaction that is exempt from registration under the 
Securities Act of 1933, as amended, other than under Rule 144 thereunder or a 
similar rule or regulation providing for the sale of securities to the public.

"Person" shall mean an individual, partnership, joint venture, corporation, 
trust or unincorporated organization, a government or any department, agency 
or political subdivision thereof, or any other entity.

"Restricted Securities" shall mean Company Securities issued pursuant to this 
Agreement, including Common Stock and any securities convertible, exercisable 
or exchangeable for or into Common Stock or any other shares of Common Stock 
hereafter acquired by EIS or Bioject.

"Stockholder" means any of EIS, Bioject, any Permitted Transferee or any other 
Person who subsequently becomes bound by this Agreement as a holder of Company 
Securities.

1.2 Authorizations; Etc.  The Company has authorized the issuance (i) to EIS 
of 199,000 shares of Common Stock, and (ii) to Bioject of 801,000 shares of 
Common Stock issuable as provided in Section 1.3 hereof.

1.3  Closings. (a) The closing of the transactions contemplated hereby (the 
"Closing") shall occur on the date hereof, at the offices of counsel to EIS in 
New York, New York, or such other place as the parties may agree.

(b) As a condition of the Closing of the transactions contemplated hereby, the 
Company shall produce its certificate of incorporation and by-laws for review 
and approval (which approval shall not be unreasonably withheld) by EIS.

(c)  At the Closing, (x) the Company shall issue and sell to EIS, and EIS 
shall purchase from the Company, upon the terms and subject to the conditions 
set forth herein, for an aggregate purchase price of $2,985,000, 199,000 
shares of Common Stock and (y) the Company shall issue and sell to Bioject, 
and Bioject shall purchase from the Company, upon the terms and conditions set 
forth herein, for an aggregate purchase price of $12,015,000, 801,000 shares 
of Common Stock.

(d) At the Closing, the parties hereto shall execute and deliver to each 
other, as applicable:

(1) (i) certificates in respect of the Common Stock described above; (ii) the 
Registration Rights Agreement (together with this Agreement, the "Newco 
Transaction Documents"); and

(2) certificates as to the incumbency of the officers executing the Newco 
Transaction Documents and such other matters as shall be customary for 
transactions of this type and as may be reasonably requested by each of the 
parties hereto of the other.

In addition, at the Closing, the Company shall cause to be delivered to the 
Purchasers an opinion of counsel, in a form reasonably satisfactory to the 
Purchasers, covering the due authority of the Company and the due 
authorization of the Newco Transaction Documents, the due issuance of the 
Securities, no violations of law or charter documents and other customary 
matters, which opinion may contain customary exceptions.

(e) The Shares will be issued under an exemption or exemptions from 
registration under the Securities Act; accordingly, the certificates 
evidencing the Shares shall, upon issuance, contain the following legend:

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE 
SECURITIES ACT OF 1933 AND MAY NOT UNDER ANY CIRCUMSTANCES BE  TRANSFERRED 
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE 
SECURITIES ACT OF 1933 OR AN OPINION OF COUNSEL SATISFACTORY TO THE 
CORPORATION THAT REGISTRATION IS NOT REQUIRED UNDER SUCH ACT.

The Common Stock is afforded the rights and benefits as described in the 
Registration Rights Agreement.

1.4 Additional Funding.

(a) Each of the Stockholders agrees to provide additional funding to the 
Company (the "Additional Funding") following the earlier of the date Bioject's 
shareholders approve the issuance of Preferred Stock to EIS and February 1, 
1998; provided, that (i) the Company's board of directors shall determine, in 
good faith, that such funds are required at such time for development of the 
first product or products based upon Glucose Monitor Technology (as defined in 
the License Agreement, the "Products") and the Glucose Monitor Technology, and 
(ii) such development of the Products is consistent with the Company's then-
current business plan, which business plan shall have been approved by the 
Company's board of directors and approved by Bioject and EIS (which approval 
shall not be unreasonably withheld or delayed).

(b) The Stockholders shall be obligated to provide the additional funds in 
combined increments of $1 million, which shall be provided 80.1% by Bioject, 
to an aggregate maximum of $4,005,000, and 19.9% by EIS, to an aggregate 
maximum of $995,000.  In no event shall EIS be obligated to fund an amount in 
excess of 25% of the amount of Additional Funding provided by Bioject to the 
Company, and in any event, EIS's obligation to provide it's portion of the 
Additional Funding shall terminate at the conclusion of the 30-month period 
following the earlier of the date Bioject's shareholders approve the issuance 
of Preferred Stock to EIS and February 1, 1998.

(c) It shall be a condition to the Stockholders' respective obligations to 
make any Additional Funding, or payments in connection with Further 
Development (as defined below), that (A) there shall be no material default or 
breach by the Company of any material obligations under any of the Newco 
Transaction Documents (as hereinafter defined) or any other agreement between 
the Company or any of its affiliates, on the one hand, and the Stockholders or 
any of their affiliates, on the other hand, (B) the Company shall have 
executed and delivered to each Stockholder each document or instrument that 
shall be customary and appropriate for such transaction as reasonably 
determined by such Stockholder and the Company, and (C) each Stockholder shall 
consent to make its own portion of such Additional Funding or Further 
Development payments, which consent shall not be unreasonably withheld or 
delayed.

(d) At the option of the Company's Board of Directors, the Additional Funding 
shall be evidenced by Common Stock or Preferred Stock of the Company, with 
such price and terms as the Board of Directors shall in good faith determine.

1.5. Further Development.

After such time, if any, as Newco has expended [confidential portion omitted]
million on research and development in connection with the research,
development and commercialization of the Products resulting from Glucose
Monitor Technology (including the Additional Funding), in the event that the
Company's board of directors shall reasonably determine in good faith that the
Company shall require further funding in order to complete such research,
development and commercialization (the "Further Development"), EIS shall
undertake to provide such funding in accordance with the following limits and
conditions:

(a) the maximum contribution which must be made by EIS under this Section 
shall be [confidential portion omitted] million;

(b) EIS shall have reasonably and in good faith determined that the Further 
Development funding is likely to result in the [confidential portion omitted],
as contemplated by the Company's then-current business plan;

(c) such funding shall be in minimum increments of $500,000;

(d) the Company shall have a market capitalization (if publicly held), or a 
valuation as determined by a financial advisory or investment firm 
satisfactory to each of Bioject and EIS (if privately held) of less than
[confidential portion omitted] million at the time of the Company's request
for such funding;

(e) such Further Development funding shall constitute senior debt of the 
Company, and be evidenced by a secured promissory note issued upon terms and 
conditions satisfactory to each of EIS and the Company acting reasonably, 
which shall be consistent with similar "arms-length" transactions then-being 
consummated in the capital markets; such promissory note to bear interest at a 
rate per annum equal to [confidential portion omitted] for a term of three
years.

1.6 Representations and Warranties of the Company.  The Company  hereby 
represents and warrants to each of the Stockholders as follows, as of the date 
hereof:

(a)  Organization.  The Company is a corporation duly organized, validly 
existing and is in good standing under the laws of Oregon, and has all the 
requisite corporate power and authority to own and lease its properties, to 
carry on its business as presently conducted and as proposed to be conducted 
and to carry out the transaction contemplated hereby.  The Company is 
qualified and in good standing to do business in each jurisdiction in which 
the nature of the business conducted or the property owned by it requires such 
qualification, except where the failure to so qualify would not reasonably be 
expected to have a material adverse effect on the business of the Company.

(b) Capitalization. (i) The authorized and outstanding shares of capital stock 
of the Company as of the date hereof, are set forth on Schedule 1.6(b)(i) 
hereto.

(ii) All of the outstanding shares of capital stock of the Company have been 
issued in accordance with applicable laws and regulations governing the sale 
and purchase of securities and none of such shares carries preemptive or 
similar rights.

(c) Authorization. The execution, delivery and performance by the Company of 
this Agreement and each of the Transaction Documents, have been duly 
authorized by all requisite corporate actions; and this Agreement and each 
other of the Transaction Documents have been duly executed and delivered by 
the Company and are the valid and binding obligation of the Company, 
enforceable against it in accordance with their respective terms.

(d)  No Conflicts.  The execution, delivery and performance by the Company of 
this Agreement and the other Newco Transaction Documents, the issuance, sale 
and delivery of the Common Stock (and the issuance of any Common Stock 
issuable upon the conversion of any convertible security, and compliance with 
the provisions hereof by the Company, will not (a) violate any provision of 
applicable law, statute, rule or regulation applicable to the Company or any 
ruling, writ, injunction, order, judgment or decree of any court, arbitrator, 
administrative agency or other governmental body applicable to the Company or 
any of their respective properties or assets or (b) conflict with or result in 
any breach of any of the terms, conditions or provisions of, or constitute 
(with notice or lapse of time or both) a default (or give rise to any right of 
termination, cancellation or acceleration) under, or result in the creation 
of, any Encumbrance (as defined below) upon any of the properties or assets of 
the Company under, the charter or organizational documents of either or any 
material contract to which the Company is a party, except where such 
violation, conflict or breach would not, individually or in the aggregate, 
have a material adverse effect on the Company.  As used herein, "Encumbrance" 
shall mean any liens, charges, encumbrances, equities, claims, options, 
proxies, pledges, security interests, or other similar rights of any nature.

(e)  Approvals.  No permit, authorization, consent or approval of or by, or 
any notification of or filing with, any person or entity (governmental or 
private) is required in connection with the execution, delivery or performance 
of this Agreement by the Company.

(f)  Authorization of the Shares; Etc.  The issuance, sale and delivery by the 
Company of the Shares, as contemplated by the Newco Transactions Documents, 
have been duly authorized by all requisite corporate action of the Company, 
and such securities, when issued as contemplated hereby, will be validly 
issued and outstanding, fully paid and nonassessable and not subject to 
preemptive or any other similar rights of the stockholders of the Company  or 
others.

(g) Disclosure.  To the best of its knowledge, this Agreement and the other 
Newco Transaction Documents do not contain any untrue statement of a material 
fact or omit to state any material fact necessary to make the statements 
contained herein and therein not misleading.

1.7  Representations and Warranties of the Stockholders.  Each of EIS and 
Bioject hereby represent and warrant to the Company as follows:

(a) Organization.  Each of the Stockholders is a corporation duly organized, 
validly existing and, if applicable, in good standing under the laws of its 
jurisdiction of organization and has all the requisite corporate power and 
authority to own and lease its properties, to carry on its business as 
presently conducted and as proposed to be conducted and to carry out the 
transactions contemplated hereby.

(b) Authority.  Each of the Stockholders has full legal right, power and 
authority to enter into this Agreement and the Newco Transaction Documents and 
to perform their respective obligations hereunder and thereunder, which have 
been duly authorized and by all requisite corporate action.  This Agreement is 
the valid and binding obligation of the Stockholders, enforceable against them 
in accordance with its terms.

(c) No Conflicts.  The execution, delivery and performance by each of the 
Stockholders of this Agreement and the other Newco Transaction Documents, 
purchase of the Common Stock (and the purchase of any Common Stock issuable 
upon the conversion or exercise of any convertible or exchangeable security), 
and compliance with the provisions hereof by the Stockholders will not (a) 
violate any provision of applicable law, statute, rule or regulation 
applicable to the Stockholders or any ruling, writ, injunction, order, 
judgment or decree of any court, arbitrator, administrative agency or other 
governmental body applicable to the Stockholders or any of their respective 
properties or assets or (b) conflict with or result in any breach of any of 
the terms, conditions or provisions of, or constitute (with notice or lapse of 
time or both) a default (or give rise to any right of termination, 
cancellation or acceleration) under, or result in the creation of, any 
Encumbrance (as defined below) upon any of the properties or assets of the 
Stockholders under, the charter or organizational documents of either or any 
material contract to which the Stockholders are a party, except where such 
violation, conflict or breach would not, individually or in the aggregate, 
have a material adverse effect on the Stockholders.  As used herein, 
"Encumbrance" shall mean any liens, charges, encumbrances, equities, claims, 
options, proxies, pledges, security interests, or other similar rights of any 
nature

(d) Approvals.  No permit, authorization, consent or approval of or by, or any 
notification of or filing with, any person or entity (governmental or private) 
(collectively, "Approval") is required in connection with the execution, 
delivery or performance of this Agreement by the Stockholders; nor is any 
Approval required by the Stockholders in order to fulfill their respective 
obligations hereunder or under any of the Newco Transaction Documents.

(e) Investment Representations. Each of the Stockholders is capable of 
evaluating the merits and risks of their respective investment in the Company.  
None of the Stockholders have been formed solely for the purpose of making 
this investment and are acquiring the Securities and, as applicable, the 
underlying Common Stock for investment for their own account, not as a nominee 
or agent, and not with the view to, or for resale in connection with, any 
distribution of any part thereof.  The Stockholders understand that the Shares 
have not been registered under the Securities Act of 1933, as amended (the 
"Securities Act"), or applicable state and other securities laws by reason of 
a specific exemption from the registration provisions of the Securities Act 
and applicable state and other securities laws, the availability of which 
depends upon, among other things, the bona fide nature of the investment 
intent and the accuracy of such Stockholders' representations as expressed 
herein.  The Stockholders understand that no public market now exists for any 
of the Shares and that there is no assurance that a public market will ever 
exist for the Shares.

ARTICLE II
BOARD OF DIRECTORS

2.1  Board of Directors.  From and after the date hereof, and until such time 
as the Company's securities are registered under the Securities Exchange Act 
of 1934, as amended (the "Exchange Act"), or listed on a stock exchange or 
quoted on an electronic quotation system, each of EIS and Bioject and their 
respective Permitted Transferees shall use its best efforts (including voting 
all of their shares of Common Stock) to cause the board of directors of the 
Company to consist of five directors, designated as set forth below; provided 
that the parties shall make such adjustments in the arrangements required by 
this Section 2.1 as the board of directors shall deem necessary and proper in 
connection with obtaining material investments from unaffiliated third 
parties:

(a) Designation of Directors. EIS shall be entitled to designate one 
director (the "EIS Director") and Bioject shall be entitled to designate four 
directors (the "Bioject Directors").  The Company's by-laws shall not provide 
for a board of directors that contains staggered terms.  As of the date 
hereof, the Company shall have a five-member board.

(b) Committees of the Board of Directors and Subsidiaries.  The rights to 
designate directors provided in Section 2.1(a) shall also apply, 
proportionally, to any committees of the board of directors and to any board 
of directors of any Subsidiary of the Company.

2.2  Removal.  In the event that (a) EIS shall request, by written notice 
thereof to Bioject, that an EIS Director be removed, or (b) Bioject shall 
request, by written notice thereof to EIS, that a Bioject Director be removed, 
then each Stockholder shall take all actions required by Section 2.4 to effect 
such result.  If the majority of the Company's board of directors shall object 
to the appointment of any director on a commercially reasonable basis, such 
director shall be removed (or not elected) and the party that designates such 
director shall designate another director.

2.3  Vacancies.  In the event that a vacancy is created on the board of 
directors at any time by the death, disability, retirement, resignation or 
removal of any director, or otherwise there shall exist or occur any vacancy 
on the board, each of EIS and Bioject and each of their respective Permitted 
Transferees hereby agrees to cause the director(s) designated by it and then 
serving (subject to each such person's fiduciary duties as a director) to vote 
for that individual designated to fill such vacancy and serve as a director by 
whichever of the Stockholders that had designated (pursuant to Section 2.1 
hereof) the director whose death, disability, retirement, resignation or 
removal resulted in such vacancy on the board; provided, however, that such 
other individual so designated may not previously have been a director of the 
Company who was removed for cause from the board.

2.4  Covenant to Vote.  (a) Each of EIS and Bioject and each of their 
respective Permitted Transferees hereby agrees to take or assist such other 
Persons to take all actions necessary to call, or cause the Company or the 
appropriate officers or directors of the Company to call, a special or annual 
meeting of stockholders of the Company and to vote all shares of Common Stock 
owned or held of record by such Person at any such annual or special meeting 
in favor of, or to consent by written consent in lieu of any such meeting to, 
the election of a board of directors consistent with, and the taking of any 
other action to effect the intent of, this Article II.  In addition, each of 
EIS and Bioject and each of their respective Permitted Transferees agrees to 
vote, or consent with respect to, the shares of Common Stock owned or held of 
record by such Person, or over which such Person has voting control, upon any 
other matter arising under this Agreement submitted to a vote or consent of 
the Company's stockholders in a manner so as to implement the terms of this 
Agreement.

(b) Approval of a majority of the board shall be required for any and all 
material determinations regarding the Company, including (i) acquisition of 
material assets (including without limitation, intellectual property), (ii) 
incurrence of debt or liens, (iii) payment of dividends or distributions in 
respect of or redemption of equity, (iv) disposition of material assets and 
changes in business lines or material Company budgets, or (v) any other 
transaction not in the ordinary course of business.

2.5  Termination of Voting Agreements.  The covenants and agreements 
contained in this Article II shall terminate upon the earlier of (i) the tenth 
anniversary of the date of this Agreement and (ii) the date that either (1) 
EIS and its Permitted Transferees and (2) Bioject and its Permitted 
Transferees each own in the aggregate Securities representing less than 5% of 
the Fully Diluted Common Stock of the Company.


ARTICLE III
TRANSFERS OF RESTRICTED SECURITIES

3.1  General. From and after the date hereof, and until such time as the 
Company's securities are registered under the Exchange Act, or listed on a 
stock exchange or quoted on an electronic quotation system, no Stockholder 
shall, directly or indirectly, sell, assign, pledge, encumber, hypothecate or 
otherwise transfer (in each case, a "Transfer") any Company Securities except 
in accordance with this Agreement.  The Company shall not, and shall not 
permit any transfer agent or registrar for the Company Securities to, transfer 
upon the books of the Company any Company Securities from any Stockholder to 
any Transferee (as hereinafter defined), in any manner, except in accordance 
with this Agreement, and any purported transfer not in compliance with this 
Agreement shall be void.

3.2  Legends; Securities Subject to this Agreement.  In the event a 
Stockholder shall Transfer any Restricted Securities (including any such 
Restricted Securities acquired after the date hereof) to any Person (all 
Persons acquiring Restricted Securities from a Stockholder, as described in 
this Article III, regardless of the method of transfer, shall be referred to 
collectively as "Transferees" and individually as a "Transferee") in 
accordance with this Agreement, such securities shall nonetheless bear legends 
as provided in this Agreement and in Section 6.1 hereof, as the case may be; 
provided, however, that the provisions of this Section 3.2 shall not apply in 
respect of a sale of Restricted Securities in a registered public offering 
under the Securities Act or pursuant to Rule 144, or any successor rule under 
the Securities Act.

3.3  No Violations or Breach.  Notwithstanding any other provision of this 
Agreement, no Stockholder shall, directly or indirectly, Transfer any 
Restricted Securities at any time if such action would constitute a violation 
of any federal or state securities or blue sky laws or a breach of the 
conditions to any exemption from registration of Restricted Securities under 
any such laws or a breach of any undertaking or agreement of such Stockholder 
entered into pursuant to such laws or in connection with obtaining an 
exemption thereunder.

3.4  Transferee Bound.  No Stockholder shall effect a Transfer of Restricted 
Securities unless such Transferee shall agree to be bound by this Agreement, 
and shall further agree to permit EIS or Bioject, as applicable, to act on 
their behalf in accordance with the provisions of this Agreement.

ARTICLE IV
RIGHT OF FIRST OFFER

4.1  Transfers by the Stockholders.  (a)     Notice of Intention.  If at any
time a Stockholder shall desire to Transfer any Restricted Securities owned by
it (such Stockholder desiring to Transfer such securities being referred to 
herein as a "Selling Stockholder"), in any transaction or series of related 
transactions, then such Selling Stockholder shall deliver prior written notice 
of its desire to Transfer (a "Notice of Intention") to (i) the Company and 
(ii) the party who is not the Selling Stockholder (for purposes of this 
Article IV, the party who is "not the Selling Stockholder" shall mean Bioject 
if the Selling Stockholder is the EIS or an EIS Transferee, and EIS if the 
Selling Stockholder is Bioject or a Bioject Transferee), and (iii) any 
Permitted Transferees, as applicable, setting forth such Selling Stockholder's 
desire to make such Transfer, the number and class of Company Securities 
proposed to be transferred (the "Offered Shares") and the proposed form of 
transaction (the "Transaction Proposal"), together with any documentation 
relating thereto and the price at which such Selling Stockholder proposes to 
Transfer the Offered Shares (the "Offer Price").  The "Right of First Offer" 
provided for in this Article IV shall be subject to any "Tag-Along Right" 
benefitting a Stockholder which may be provided for by Article V, subject to 
the exceptions set forth therein. The parties shall make such adjustments in 
the arrangements required by this Article IV as the board of directors shall 
deem necessary and proper in connection with obtaining material investments 
from unaffiliated third parties.

(b)   Notice of Exercise.  Upon receipt of the Notice of Intention, the party 
who is not the Selling Stockholder shall have the right to purchase at the 
Offer Price the Offered Shares, exercisable by the delivery of notice to the 
Selling Stockholder (the "Notice of Exercise"), with a copy to the Company 
within 10 business days from the date of receipt of the Notice of Intention.  
If no such Notice of Exercise has been delivered by the party who is not the 
Selling Stockholder within such 10 business-day period, or such Notice of 
Exercise does not relate to all the Offered Shares covered by the Notice of 
Intention, then the Selling Stockholder shall be entitled to Transfer the 
Offered Shares to the intended Transferee.

(c)  Obligation to Sell.  In the event that the party who is not the Selling 
Stockholder exercises its right to purchase Offered Shares in accordance with 
Section 4.1(b), then the Selling Stockholder must sell the Offered Shares to 
such party, in the amounts set forth in the Notice of Intention, after not 
less than five business and not more than 15 business days from the date of 
the delivery of the Notice of Exercise.

(d)  Termination.  The rights and obligations of each of the Stockholders 
pursuant to the Right of First Offer provided herein shall terminate with 
respect to each such party on the earlier of (i) the tenth anniversary of the 
date hereof and (ii) with respect to such party's rights, the first date that 
EIS on the one hand, and Bioject on the other, plus, in each case, their 
respective Permitted Transferees, beneficially own, in the aggregate, Company 
Securities representing less than 2 1/2% of the Fully Diluted Common Stock 
and, with respect to each such group's obligations, the first date that the 
other group (including Permitted Transferees) beneficially own, in the 
aggregate, Company Securities representing less than 2 1/2% of the Fully 
Diluted Common Stock and (iii) the date the Company's common stock is 
registered under the Exchange Act or listed on a stock exchange or quoted 
on an electronic quotation system.

4.2  Closing.  At the closing of the purchase of Offered Shares (scheduled in 
accordance with Section 4.1(c)), the Selling Stockholder shall deliver 
certificates evidencing the Offered Shares being sold, duly endorsed, or 
accompanied by written instruments of transfer in form reasonably satisfactory 
to the party who is not the Selling Stockholder, duly executed by the Selling 
Stockholder, free and clear of any adverse claims, against payment of the 
purchase price therefor in cash, and such other customary documents as shall 
be necessary in connection therewith.

ARTICLE V
TAG-ALONG RIGHTS

5.1   Tag-Along Procedures.  For purposes of this Section "Common Stock" shall 
include Common Stock underlying securities convertible thereto; provided that 
the parties shall make such adjustments in the arrangements required by this 
Section 5.1 as the board of directors shall deem necessary and proper in 
connection with obtaining material investments from unaffiliated third 
parties.

(a)  Tag-Along Right. Subject to Section 5.3, any one Stockholder (the 
"Transferring Stockholder") shall not Transfer (either directly or 
indirectly), in any one transaction or series of related transactions, to any 
Person or group of Persons, Company Securities representing, in the aggregate, 
more than 5% of the Common Stock unless the terms and conditions of such 
Transfer shall include an offer to the other Stockholders (the "Remaining 
Stockholders"), at the same price and on the same terms and conditions as the 
Transferring Stockholder has agreed to sell its Company Securities.

(b)   Notice.  In the event a Transferring Stockholder proposes to Transfer 
any Common Stock in a transaction subject to this Section 5.1, it shall 
notify, or cause to be notified, the Remaining Stockholders in writing of each 
such proposed Transfer.  Such notice shall set forth: (i) the name of the 
transferee and the number of shares of Common Stock proposed to be 
transferred, (ii) the proposed amount and form of consideration and terms and 
conditions of payment offered by the transferee (the "Transferee Terms") and 
(iii) that the transferee has been informed of the "Tag-Along Right" provided 
for in this Section 5.1, if such right is applicable, and has agreed to 
purchase shares of Common Stock from the Transferring Stockholder in 
accordance with the terms hereof.

(c)   Exercise.  The Tag-Along Right may be exercised by the Remaining 
Stockholders by delivery of a written notice to the Transferring Stockholder 
(the "Tag-Along Notice") within five business days following receipt of the 
notice specified in the preceding subsection.  The Tag-Along Notice shall 
state the number of shares of Common Stock owned by the Remaining Stockholder 
which the Remaining Stockholder wishes to include in such Transfer; provided, 
however, that without the written consent of the Transferring Stockholder, the 
number of shares belonging to the Remaining Stockholder included in such 
Transfer may not be greater than such Remaining Stockholder's percentage 
beneficial ownership of Common Stock (on a fully diluted basis) multiplied by 
the total number of shares of common stock to be sold by both the transferring 
stockholder and all remaining stockholders.  Upon receipt of a Tag-Along 
Notice, the Transferring Stockholder shall be obligated to transfer at least 
the entire number of shares of Common Stock set forth in the Tag-Along Notice 
to the Transferee on the Transferee Terms; provided, however, that the 
Transferring Stockholder shall not consummate the purchase and sale of any 
shares hereunder if the Transferee does not purchase all shares.  If no Tag-
Along Notice has been delivered to the Transferring Stockholder prior to the 
expiration of the five-day period referred to above and if the provisions of 
this Section have been complied with in all respects, the Transferring 
Stockholder shall have the right for a 60 day calendar day period to Transfer 
Common Stock to the Transferee on the Transferee Terms without further notice 
to any other party, but after such 60-day period, no such Transfer may be made 
without again giving notice to the Remaining Stockholders of the proposed 
Transfer and complying with the requirements of this Article V.

5.2   Closing.  At the closing of any Transfer of Common Stock subject to this 
Article V, the Transferring Stockholder, and the Remaining Stockholder, in the 
event such Tag-Along Right is exercised, shall deliver certificates evidencing 
such shares of Common Stock as have been Transferred by each, duly endorsed, 
or accompanied by written instruments of transfer in form reasonably 
satisfactory to the Transferee, free and clear of any adverse claim, against 
payment of the purchase price therefor.

5.3    Exceptions.  Notwithstanding the foregoing, this Article V shall not 
apply to any sale of Common Stock pursuant to an effective registration 
statement under the Securities Act in a bona fide public offering, sales made 
in compliance with Rule 144, or any successor rule under the Securities Act.

5.4   Termination.  This Article V shall terminate on earlier of (i) the 
seventh anniversary of the date hereof or (ii) the first date that either EIS 
or Bioject beneficially own shares of Common Stock representing less than 2 
1/2% of the Fully Diluted Common Stock or (iii) the date the Company's common 
stock is registered under the Exchange Act or listed on a stock exchange or 
quoted on an electronic quotation system.

ARTICLE VI
MISCELLANEOUS

6.1   Administrative Services Agreement.  In consideration of EIS's agreement 
to invest in the Company, as soon as practicable after the date hereof, the 
Company and Bioject shall enter into an administrative services and support 
agreement (which shall be reasonably satisfactory to EIS) which shall contain 
provisions to the effect that Bioject shall provide commercially reasonable 
and customary support and administrative services to the Company in connection 
with the performance of the Company's obligations hereunder and under the 
License Agreement.

6.2   Endorsement of Stock Certificates.  Each of the Stockholders hereby 
agrees that, in addition to any legends required by any other agreement, each 
outstanding certificate representing shares of Company Securities subject to 
this Agreement shall bear an endorsement reading substantially as follows 
until the restrictions (including without limitation, the transfer 
restrictions) with respect to such Company Securities are no longer effective:

THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN TRANSFER 
RESTRICTIONS SET FORTH IN A STOCKHOLDERS AGREEMENT DATED AS OF OCTOBER 15, 
1997, A COPY OF WHICH MAY BE OBTAINED FROM THE COMPANY AT ITS PRINCIPAL 
EXECUTIVE OFFICE, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, 
HYPOTHECATED OR OTHERWISE DISPOSED OF WITHOUT COMPLYING WITH THE TERMS AND 
CONDITIONS OF SUCH AGREEMENTS.

6.3   Term.  Except as otherwise provided herein, this Agreement shall 
terminate upon the sale of all Company Securities now owned by EIS and Bioject 
(or their respective Permitted Transferees) in compliance with the provisions 
hereof to parties not bound hereby, as provided herein.

6.4   Injunctive Relief. The parties hereto hereby agree and acknowledge that 
it will be impossible to measure in money the damages that would be suffered 
if any party should breach any obligation, covenant or representation herein 
imposed or made, and that, in the event of such breach, a non-breaching party 
will be irreparably damaged and will not have an adequate remedy at law.  Any 
such non-breaching party shall, therefore, be entitled to injunctive relief, 
including specific performance, to enforce such obligations, and if any action 
should be brought in equity to enforce any of the provisions of this 
Agreement, none of the other parties hereto shall raise the defense that there 
is an adequate remedy at law.

6.5   Notices.  All notices, other communications or documents provided for or 
permitted to be given hereunder, shall be made in writing and shall be given 
either personally by hand-delivery, by telex or facsimile transmission, by 
mailing the same in a sealed envelope, certified first-class mail, postage 
prepaid, return receipt requested, or by air courier guaranteeing overnight 
delivery:
(i) if to the Company or Bioject, to:

Bioject JV Subsidiary Inc.
        or
Bioject Medical Technologies Inc.
7620 S.W. Bridgeport Road
Portland, Oregon 97224
Telecopier: 503-620-6431
Attention: President

with a copy to:

Bogle & Gates P.L.L.C.
Two Union Square
601 Union Street
Seattle, Washington 98101-2346
Telecopier:206-620-2660
Attention: Christopher Barry

(ii) if to EIS, to:

Elan International Services, Ltd.
Flatts Smiths SL04
Bermuda
Telecopier: (441) 292-2224
Attention: President

with a copy to:

Brock Fensterstock Silverstein McAuliffe & Wade LLC
153 East 53rd Street
New York, New York 10022
Telecopier: (212) 371-5500
Attention: David Robbins

Each Stockholder, by written notice given to the Company in accordance with 
this Section 6.5 may change the address to which notices, other communication 
or documents are to be sent to such Stockholder.  All notices, other 
communications or documents shall be deemed to have been duly given when 
received.  Whenever pursuant to this Agreement any notice is required to be 
given by any Stockholder to any other Stockholder or Stockholders, such 
Stockholder may request from the Company a list of addresses of all 
Stockholders of the Company, which list shall be promptly furnished to such 
Stockholder.

6.6   Assignment.  Except as expressly permitted hereunder, neither this 
Agreement nor any of the rights or obligations hereunder may be assigned by 
any party hereto without the prior written consent of the other parties 
hereto.  Subject to the foregoing, this Agreement shall inure to the benefit 
of and be binding upon the parties and successors and assigns of each of the 
parties.  If any Stockholder shall acquire any Restricted Securities in any 
manner, whether by operation of law or otherwise, such Restricted Securities 
shall be held subject to all of the terms of this Agreement.

6.7   Governing Law.  This Agreement shall be governed by and construed in 
accordance with the laws of the State of Oregon without regard to the 
principles of conflicts of laws.

6.8   Headings.  The headings in this Agreement are inserted for convenience 
of reference only and shall not constitute a part of this Agreement.

6.9   Severability.  In the event that any one or more of the provisions 
contained herein, or the application thereof in any circumstance, is held 
invalid, illegal or unenforceable, the validity, legality and enforceability 
of any such provision in every other respect and of the remaining provisions 
contained herein shall not be affected or impaired thereby.

6.10   Amendments and Waiver.  No provision of this Agreement may be amended, 
nor performance of any covenant or agreement waived, except by a written 
instrument executed by each of the Company, EIS and Bioject.  Neither a 
failure nor a delay in exercising any right, power or privilege of a party 
hereunder shall operate as a waiver of, or a consent to the modification of, 
the terms hereof unless given by that party in writing.  The waiver by any 
party hereto of a breach of any provision of this Agreement shall not operate 
or be construed as a waiver of any preceding or succeeding breach.

6.11  Inspection.  So long as this Agreement shall be in effect, this 
Agreement shall be made available for inspection by any stockholder of the 
Company at the principal offices of the Company.

6.12  Counterparts.  This Agreement may be executed in two or more  
counterparts, each of which shall be deemed an original and all of which when 
taken together shall constitute one and the same Agreement.

[Signature page follows]


IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the 
date first set forth above.

Bioject JV Subsidiary Inc.



By:/s/ James C. O'Shea
Name:  James C. O'Shea
Title: President

Bioject Medical Technologies Inc.



By:/s/ James C. O'Shea
Name:  James C. O'Shea
Title: President

Elan International Services, Ltd.



By:/s/ Kevin Insley
Name:  Kevin Insley
Title: President and Chief Financial Officer