UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                             SCHEDULE 14A INFORMATION
 Proxy Statement Pursuant to Section 14(a) of Securities Exchange Act of 1934

Filed by the Registrant:   /x/
Filed by a Party other than the Registrant:   / /
Check the appropriate box:

/ /   Preliminary Proxy Statement
/ /   Confidential, for Use of the Commission Only (as permitted by Rule 
      14a-6(e)(2))
/x/   Definitive Proxy Statement
/ /   Definitive Additional Materials
/ /   Soliciting Material Pursuant to Section 240.14a-11(c) or 
      Section 240.14a-12

                           Agouron Pharmaceuticals, Inc.
                          10350 North Torrey Pines Road
                           La Jolla, California  92037
               (Name of Registrant as Specified in its Charter)

                        _________________________________
        (Name of Person(s) Filing Proxy Statement if other than Registrant)

Payment of Filing Fee: (Check the Appropriate Box)

/x/   $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), 14a-6(i)(2),
      or Item 22a(2) of Schedule 14a).
/ /   $500 per each party to the controversy pursuant to Exchange Act Rule
      14a-6(i)(3).
/ /   Fee computed on the table below per Exchange Act Rules 14a-6(i)(4) and 
      0-11.

    1.  Title of each class of securities to which transaction applies:  ____

    2.  Aggregate number of securities to which transaction applies:  ____

    3.  Per unit price or other underlying value of transaction computed  
        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the  
        filing fee is calculated and state how it was determined):  ____

    4.  Proposed maximum aggregate value of transaction:  _______

    5.  Total fee paid:  _______

/ /   Fee paid previously with preliminary materials.

/ /   Check box if any part of the fee is offset as provided by Exchange Act  
      Rule 0-11(a)(2) and identify the filing for which the offsetting fee  
      was paid previously.  Identify the previous filing by registration  
      statement number, or the Form or Schedule and the date of its filing.

    1.  Amount Previously Paid:   _______________

    2.  Form, Schedule or Registration Statement No.:   ______________

    3.  Filing Party:   ________________

    4.  Date Filed:   ________________



                          AGOURON PHARMACEUTICALS, INC.
                          10350 North Torrey Pines Road
                         La Jolla, California 92037-1020

                   NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                        TO BE HELD ON NOVEMBER 7, 1996

     The Annual Meeting of Shareholders ("Meeting") of Agouron 
Pharmaceuticals, Inc., a California corporation (the "Company") will be held 
at the Sheraton Grande Torrey Pines, 10950 North Torrey Pines Road, La Jolla, 
California 92037, on Thursday, November 7, 1996, at 9:00 a.m. for the 
following purposes:

1.     To elect nine directors of the Company, all of whom shall serve until 
       the 1997 Annual Meeting of Shareholders (and until the election and 
       qualification of their successors);

2.     To consider and vote upon approval of the Company's 1996 Stock Option 
       Plan;

3.     To ratify the selection of independent accountants; and

4.     To consider and act upon such other business as may properly be 
       presented to the Meeting or any adjournments or postponements thereof.

     Only shareholders of record as of the close of business on September 24, 
1996 will be entitled to notice of and to vote at the Meeting or any 
adjournments or postponements thereof.  A list of shareholders entitled to 
vote at the Meeting will be available for inspection at the offices of the 
Company for 10 days before the Meeting.

     All shareholders are cordially invited to attend the Meeting in person. 
Regardless of whether you plan to attend the Meeting, please sign and date 
the enclosed Proxy and return it promptly in the accompanying envelope, 
postage for which has been provided if mailed in the United States.  The 
prompt return of Proxies will ensure a quorum and save the Company the 
expense of further solicitation.  Any shareholder returning the enclosed 
Proxy may revoke it prior to its exercise by voting in person at the Meeting 
or by filing with the Secretary of the Company a written revocation or a duly 
executed Proxy bearing a later date.


                                     By Order of the Board of Directors




                                     Gary E. Friedman
                                     Secretary


La Jolla, California
September 24, 1996



                         AGOURON PHARMACEUTICALS, INC.
                          10350 North Torrey Pines Road
                         La Jolla, California 92037-1020

                                PROXY STATEMENT

                       ANNUAL MEETING OF SHAREHOLDERS
                       TO BE HELD ON NOVEMBER 7, 1996


                             GENERAL INFORMATION

     This Proxy Statement is furnished in connection with the solicitation of 
Proxies by and on behalf of the Board of Directors ("Board") of Agouron 
Pharmaceuticals, Inc., a California corporation (the "Company"), for use at 
the Company's Annual Meeting of Shareholders for the fiscal year ended June 
30, 1996 (the "Meeting") to be held at the Sheraton Grande Torrey Pines, 
10950 North Torrey Pines Road, La Jolla, California 92037, on Thursday, 
November 7, 1996 at 9:00 a.m., and at any adjournments or postponements 
thereof, for the purposes set forth in the preceding notice.  It is 
anticipated that this Proxy Statement and the accompanying Proxy will be 
mailed to the Company's shareholders on or about September 25, 1996.

     Any shareholder returning the enclosed Proxy may revoke it prior to its 
exercise by voting in person at the Meeting or by filing with the Secretary 
of the Company a written revocation or a duly executed Proxy bearing a later 
date.

     All shares represented by valid Proxies will be voted in accordance with 
the directions specified thereon and otherwise in accordance with the 
judgment of the proxyholders.  Any duly executed Proxy on which no direction 
is specified will be voted for the election of the nominees named herein to 
the Board and in favor of Proposals 2 and 3 described in the Notice of 
Meeting and this Proxy Statement.

     The expense of printing and mailing Proxy material will be borne by the 
Company.  In addition to the solicitation of Proxies by mail, solicitation 
may be made by certain directors, officers or other employees of the Company 
by telephone, telegraph, facsimile or in person.  No additional compensation 
will be paid to such persons for such solicitation.  No other individuals or 
entities will receive compensation for the solicitation of Proxies.  However, 
the Company will request brokers, nominees, fiduciaries and custodians to 
forward Proxy materials to the beneficial owners of the Company's shares and 
the Company will reimburse such brokers or other persons for their reasonable 
out-of-pocket expenses incurred in connection with forwarding such materials.


                    SHARES OUTSTANDING AND VOTING RIGHTS

     Only shareholders of record as of the close of business on September 24, 
1996 (the "Record Date") will be entitled to vote at the Meeting.  As of 
September 16, 1996, there were outstanding 13,500,134 shares of common stock.

     Holders of common stock are entitled to one vote per share on all 
matters brought before the Meeting and to cumulate votes for the election of 
the nine directors.  Therefore, in voting for directors, each outstanding 
share of common stock is entitled to nine votes which may be cast for one 
candidate or distributed in any manner among the nominees for director. 
However, the right to cumulate votes in favor of one or more candidates may 
not be exercised until the candidate or candidates have been nominated and 
the shareholder has given notice at the Meeting of the intention to cumulate 
votes.

     The persons authorized to vote shares represented by executed Proxies 
for common stock in the enclosed form (if authority to vote for the election 
of directors is not withheld) will have full discretion and authority to vote 
cumulatively and to allocate votes among any or all of the nominees as they 
may determine or, if authority to vote for a specified candidate or 
candidates had been withheld, among those candidates for whom authority to 
vote has not been withheld.

     The required quorum for the Meeting shall consist of a majority of the 
outstanding shares of common stock which are entitled to vote in person or by 
proxy at the Meeting.  Assuming that a quorum is present at the Meeting, the 
nine persons receiving the highest number of votes will be elected to the 
Board.  The required vote for the approval of other business matters is set 
forth in the discussion of such matters.


                               1

                           BOARD OF DIRECTORS

     Under the bylaws of the Company, the number of directors is to be not 
less than six nor more than eleven, with the actual number to be fixed from 
time to time by resolution of the Board.  The Board has fixed at nine the 
number of directors to be elected at the 1996 Annual Meeting of Shareholders. 
Under the terms of the Series A Preferred Stock Purchase Agreement, the 
Company has agreed to nominate for election to the Board a designee (Ms. 
Cloherty) of a holder of shares issued on conversion of the Series A 
preferred stock.  See "CERTAIN TRANSACTIONS."

     Nine directors are to be elected at the Meeting, each to serve until the 
next Annual Meeting of Shareholders and until their respective successors are 
elected or appointed.  Unless authority to vote for all directors is 
withheld, it is intended that the shares represented by the enclosed Proxy 
will be voted for the election of the nominees named.  In the event any of 
them shall become unable or unwilling to accept nomination or election, the 
shares represented by the enclosed Proxy will be voted for the election of 
such other person as the Board may recommend in his or her place.  The Board 
has no reason to believe that any such nominee will be unable or unwilling to 
serve.

                              ELECTION OF DIRECTORS
                            (Item 1 on the Proxy Card)

     The nine nominees for election as directors, all of whom are members of 
the present Board, are Peter Johnson, Gary E. Friedman, John N. Abelson, 
Patricia M. Cloherty, A.E. Cohen, Michael E. Herman, Irving S. Johnson, 
Antonie T. Knoppers and Melvin I. Simon.  Their terms will last until the 
1997 Annual Meeting of Shareholders.  Certain information concerning the 
nominees for directors is set forth below.

     The Board recommends that you vote FOR the nominees for directors, as 
set forth in Item 1 on the Proxy Card.

Nominees for Election as Directors

   Name                       Age         Position
   Peter Johnson              51          President, Chief Executive Officer
                                            and Director
   Gary E. Friedman           49          Vice President, General Counsel, 
                                            Secretary and Director
   John N. Abelson, Ph.D.(1)  57          Director
   Patricia M. Cloherty(2)    54          Director
   A.E. Cohen(1)              60          Director
   Michael E. Herman(1)       55          Director
   Irving S. Johnson, Ph.D.   71          Director
   Antonie T. Knoppers, M.D., 
     Ph.D.(2)                 81          Director
   Melvin I. Simon, Ph.D.(2)  59          Director
     
- -----------------------------
(1)  Member of Directors Compensation Committee
(2)  Member of Audit Committee

                               2

     Peter Johnson, a founder of the Company, has served as a director and as 
president and chief executive officer of the Company since its inception in 
1984.  Through 1989, Mr. Johnson held various positions with The Agouron 
Institute, including executive director.  Mr. Johnson received a M.A. from 
the University of California, San Diego.

     Gary E. Friedman, a founder of the Company, has served as a director 
since its inception, as the Secretary of the Company since May 1986 and as 
vice president and general counsel since December 1991.  Previously, from 
1982 until December 1991, Mr. Friedman was a principal of the law firm of 
Friedman, Jay & Cramer, a Professional Corporation.  Mr. Friedman is a 
California Certified Specialist in Taxation.  Mr. Friedman received a J.D. 
and a M.B.A. from the University of California, Berkeley and a L.L.M. in 
taxation from the University of San Diego.

     John N. Abelson, a founder of the Company, has served as a director 
since its inception.  Dr. Abelson, a molecular biologist, is a member of the 
National Academy of Sciences.  Since 1982, Dr. Abelson has been a member of 
the faculty of the Division of Biology at the California Institute of 
Technology where, from October 1989 until June 1995, he served as chairman. 
Previously, Dr. Abelson was a member of the faculty in the Department of 
Chemistry at the University of California, San Diego.  Dr. Abelson received a 
Ph.D. in biophysics from The Johns Hopkins University and was a postdoctoral 
fellow at the Laboratory of Molecular Biology in Cambridge, England.  Dr. 
Abelson also serves as a director of The Agouron Institute.

     Patricia M. Cloherty joined the Board in December 1988.  Since 1970, Ms. 
Cloherty has been associated with Patricof & Co. Ventures, Inc. (formerly 
Alan Patricof Associates, Inc.), a New York venture capital firm 
 ("Patricof"), and has been a general partner of its funds since 1973.  In 
1993, she was elected president of Patricof.  Ms. Cloherty also served as 
deputy administrator for the U.S. Small Business Administration in 1977 and 
1978.  Ms. Cloherty also serves on the board of directors of several private 
companies.

     A.E. Cohen joined the Board in March 1992.  Mr. Cohen is an independent 
management consultant.  From 1957 until his retirement in January 1992, Mr. 
Cohen held various positions at Merck & Co., Inc., including senior vice 
president and president of the Merck Sharp & Dohme International Division. 
Currently, Mr. Cohen is the chairman of the board of Neurobiological 
Technologies, Inc. and is a member of the board of directors of Akzo N.V., 
Immunomedics, Inc., Teva Pharmaceutical Industries Ltd. and Vasomedical, 
Inc., all of which are public companies.  Mr. Cohen also serves on the board 
of directors of several private companies.

     Michael E. Herman joined the Board in October 1992.  Mr. Herman is a 
private investor, as well as president and chief operating officer of the 
Kansas City Royals Baseball Team.  From October 1974 until his retirement in 
1990, Mr. Herman held various positions at Marion Laboratories, Inc. (now 
Hoechst Marion Roussel), including executive vice president and chief 
financial officer.  Currently, Mr. Herman serves as chairman of the finance 
committee of the Ewing Marion Kauffman Foundation, a private foundation 
located in Kansas City where, from 1985 through 1990, he was the president 
and chief operating officer.   Mr. Herman is also a member of the board of 
directors of Cerner Corporation and Seafield Capital, both of which are 
public companies, and serves on the board of directors of several private 
companies.  

     Irving S. Johnson joined the Board in May 1989.  Dr. Johnson is an 
independent consultant in biomedical research working with numerous private 
companies.  From 1953 until his retirement in November 1988, Dr. Johnson held 
various positions at Eli Lilly and Company, including vice president of 
research from 1973 until 1988.  Dr. Johnson also served on several committees 
of the National Academy of Sciences, the Office of Technology Assessment and 
the National Institutes of Health.  Currently, he is a member of the board of 
directors of Allelix Biopharmaceuticals Inc. and Ligand Pharmaceuticals 
Incorporated, both of which are public companies.  Dr. Johnson received a 
Ph.D. in developmental biology from the University of Kansas.

     Antonie T. Knoppers joined the Board in July 1991.  Dr. Knoppers is an 
independent management consultant.  From 1952 until his retirement in 1975, 
Dr. Knoppers held various positions at Merck & Co., Inc., including vice 
chairman of the board and president and chief operating officer.  Dr. 
Knoppers is a member of the board of directors of Centocor, Inc., a public 
biotechnology company.  In addition, he is a former chairman of the U.S. 
Council of the International Chamber of Commerce and a member of the advisory 
board of PaineWebber Development Corporation, an affiliate of PaineWebber 
Incorporated.  Dr. Knoppers received a M.D. from the University of Amsterdam 
and a Ph.D. from the University of Leiden, The Netherlands.

     Melvin I. Simon, a founder of the Company, has served as a director 
since its inception.  Dr. Simon, a molecular geneticist, is a member of the 
National Academy of Sciences.  Currently, Dr. Simon is chairman of the 
Division of Biology at the California Institute of Technology where he has 
been a member of the faculty since 1982.  Previously, Dr. Simon was a member 
of the faculty in the Department of Biology at the University of California, 
San Diego.  Dr. Simon received a Ph.D. in biochemistry from Brandeis 
University.  Dr. Simon also serves as a director of The Agouron Institute.

                               3

Committees and Meetings of the Board

     The Company has a Directors Compensation Committee and an Audit 
Committee.  The Company does not have a Nominating Committee.  During the 
fiscal year ended June 30, 1996, the Board held six meetings.  

     During the fiscal year ended June 30, 1996, members of the Audit 
Committee consisted of Ms. Cloherty, Chairperson, Dr. Knoppers and Dr. Simon. 
The Audit Committee oversees the Company's accounting and financial reporting 
policies, makes recommendations to the Board regarding the appointment of 
independent accountants, reviews with the independent accountants the 
accounting principles and practices followed by the Company and the adequacy 
thereof, approves the Company's annual audit and financial results and any 
material change in accounting principles, policies and procedures and makes 
recommendations to the Board with regard to any of the preceding.  The Audit 
Committee held two meetings in the fiscal year ended June 30, 1996.

     During the fiscal year ended June 30 1996, members of the Directors 
Compensation Committee consisted of Mr. Herman, Chairman, Dr. Abelson, and 
Mr. Cohen.  The Directors Compensation Committee recommends to the Board the 
Company's overall compensation and the individual compensation elements for 
the Company's executive officers and directors.  The Directors Compensation 
Committee does not approve grants of stock options to executive officers and 
directors under the Company's stock option plans.  The Directors Compensation 
Committee held two meetings in the fiscal year ended June 30, 1996.  During 
fiscal 1996, the full Board was responsible for approving grants of options 
to executive officers who are not also directors; the Disinterested Stock 
Option Committee was responsible for approving grants of options to 
directors, including directors who were also executive officers of the 
Company.  During the 1996 fiscal year, the members of the Disinterested Stock 
Option Committee consisted of Dr. Abelson, Ms. Cloherty, Mr. Cohen, Mr. 
Herman, Dr. Johnson, Dr. Knoppers and Dr. Simon.  The Disinterested Stock 
Option Committee took action by unanimous written consent without a meeting 
on one occasion during fiscal 1996.  On August 15, 1996, the effective date 
of changes made to Section 16(b) of the Securities Exchange Act of 1934, the 
Disinterested Stock Option Committee was disbanded as the committee's actions 
could thereafter be performed by the full Board of Directors.

     No incumbent director attended fewer than 75% of the aggregate of the 
Board and Committee meetings in which such director was entitled to 
participate.

                               4

      SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The following table sets forth information as of September 24, 1996 
relating to the beneficial ownership of the Company's common stock by (i) 
each person known by the Company to beneficially own more than 5% of the 
outstanding shares of the Company's common stock, (ii) each director, (iii) 
each of the executive officers named in the Summary Compensation Table below, 
and (iv) all executive officers and directors as a group.

                                                   Beneficial Ownership(1)     
                                                Number of      Percentage of
         Beneficial Owner                        Shares            Total     
     Peter Johnson(2)                            273,500           2.0%
     Gary E. Friedman(2) Family Trust            112,181             *
     John N. Abelson(2)(3)(7)                     63,055             *
     Patricia M. Cloherty(2)(4)                  332,502           2.5
     A. E. Cohen(2)                               28,750             *
     Michael E. Herman(2)(5)                      40,250             *
     Irving S. Johnson(2)                         23,750             *
     Antonie T. Knoppers(2)                       23,850             *
     Melvin I. Simon(2) and 
         Linda F. Simon Living Trust(3)(6)        75,000             *
     Neil J. Clendeninn                           47,150             *
     Robert C. Jackson                           101,250             *
     Barry D. Quart                               37,582             *
     R. Kent Snyder(8)                            45,366             *
     The Agouron Institute                       716,000           5.3
     505 Coast Boulevard
     La Jolla, CA  92037

All executive officers and directors
          as a group (15 persons)              1,292,560           9.1
     
- ------------------------------
*       less than 1%.
(1)     Unless otherwise indicated, the persons named in the above table 
        exercise sole voting and investment powers with respect to all shares 
        beneficially owned by them, subject to applicable community property
        laws.  The number of shares beneficially owned includes the following
        number of shares issuable upon exercise of stock options exercisable
        within 60 days of September 24, 1996:  Mr. Johnson, 237,650 shares; 
        Mr. Friedman, 76,400 shares; Dr. Abelson, 5,000 shares; Mr. Cohen, 
        23,750 shares; Mr. Herman, 23,750 shares; Dr. Johnson, 23,600 shares; 
        Dr. Knoppers, 22,750 shares; Dr. Simon, 5,000 shares; Dr. Clendeninn, 
        47,150 shares; Dr. Jackson, 100,750 shares; Dr. Quart 37,150 shares; 
        Mr. Snyder, 42,900 shares; and all executive officers and directors 
         as a group, 732,981 shares.
(2)     Director. 
(3)     Does not include 716,000 shares held by The Agouron Institute, of 
        which Drs. Abelson and Simon are directors.  As directors, they share 
        voting and investment powers as to the shares held by The Agouron 
        Institute.
(4)     Includes 332,502 shares which are held by APA Excelsior II, L.P. 
        ("APA") and Excelsior Venture Capital Holdings (Jersey) Ltd., of 
        which Ms. Cloherty may be deemed to share beneficial ownership.  Ms. 
        Cloherty is a general partner of a partnership which is the general 
        partner of APA and, as such, shares voting and investment powers with 
        the other general partners.  Ms. Cloherty is also president of 
        Patricof & Co. Ventures, Inc. ("Patricof"), investment advisor to 
        Jersey and, as such, shares investment power with the other officers 
        of Patricof.  However, Patricof does not have power to vote the 
        shares owned by Jersey but does make recommendations to those 
        entities.  See "CERTAIN TRANSACTIONS."
(5)     Includes 10,000 shares held by the Herman Family Trading Company, a 
        family partnership of which Mr. Herman is the general partner, 5,000 
        shares held by Vail Fishing Partners in which Mr. Herman has a 50% 
        general partner interest and 1,500 shares held by Mrs. Herman, of 
        which Mr. Herman disclaims any beneficial ownership.
(6)     Shared voting and investment power.
(7)     Includes 500 shares held by Dr. Abelson as custodian for his minor 
        children, of which Dr. Abelson disclaims any beneficial ownership.
(8)     Includes 400 shares held by immediate family members, of which Mr. 
        Snyder disclaims any beneficial ownership.


                               5

                           EXECUTIVE COMPENSATION

Compensation of Directors

     Non-employee members of the Board receive cash compensation in the 
amount of $250 per Board meeting for their services as Board members, and are 
eligible for reimbursement of their expenses incurred to attend such meeting 
in accordance with Company policy.  In addition to meeting fees, certain non-
employee directors received consulting fees during fiscal 1996.  For 
scientific consultation,  Dr. Abelson received $30,040; Dr. Knoppers, $4,500; 
Dr. Johnson, $18,750 and Dr. Simon, $27,400.  For special consultation 
concerning corporate development issues, Mr. Cohen received $18,750 and Mr. 
Herman received $19,000.

Compensation of Executive Officers

     The following table sets forth the aggregate compensation paid or 
accrued by the Company to the Chief Executive Officer and to the four other 
most highly compensated executive officers whose annual compensation exceeded 
$100,000 for the fiscal year ended June 30, 1996 (collectively the "named 
executive officers") for service during the fiscal years ended June 30, 1996, 
1995 and 1994:

                         Summary Compensation Table

                                                   Long-Term
                                                  Compensation
   Name                   Annual Compensation       Awards(2)
 Principal                                            Stock       All Other
 Position              Year  Salary(1)     Bonus     Options  Compensation(3)
Peter Johnson          1996   $285,000   $100,000     90,000     $  1,647
President and Chief    1995    253,500     70,000(4)  78,200          948
Executive Officer      1994    205,000     50,000     91,200          899

Neil J. Clendeninn     1996    192,900     40,000     22,000        1,685
Vice President,        1995    187,900     88,309(5)  10,000      131,619
Clinical Affairs       1994    177,200     35,000     18,300      107,056

Robert C. Jackson      1996    184,000     45,000     22,000        1,647
Vice President,        1995    179,000     30,000(4)  12,000          948
Research & Development 1994    156,600     35,000     33,000          899

Barry D. Quart(5)      1996    165,000     70,500(6)  36,000       16,587
Vice President,        1995    150,600     57,000(4)  30,000        9,005
Regulatory Affairs     1994    142,000     32,500     26,800       68,453

R. Kent Snyder         1996    178,500     62,200(6)  32,000        1,777
Vice President,        1995    158,000     55,000(4)  20,000        1,014
Commercial Affairs     1994    149,000     53,000     40,800          720
     

(1)     Includes amounts deferred out of compensation under the Company's 
        401(k) Plan otherwise payable in cash during each fiscal year.
(2)     The Company has made no restricted stock awards, has not granted any 
        stock appreciation rights and has no other long-term incentive plans.
(3)
     (a)      During 1996, the Company made matching contributions to the 
              Company's 401(k) Plan in the following amounts: Mr. Johnson, 
              $1,647; Dr. Clendeninn, $1,685; Dr. Jackson, $1,647; Dr. Quart, 
              $1,959 and Mr. Snyder, $1,777. 
     (b)      During 1995, the Company made matching contributions to the 
              Company's 401(k) Plan in the following amounts:  Mr. Johnson, 
              $948; Dr. Clendeninn, $900; Dr. Jackson, $948; Dr. Quart, $557; 
              and Mr. Snyder, $1,014.
     (c)      During 1994, the Company made matching contributions to the 
              Company's 401(k) Plan in the following amounts:  Mr. Johnson, 
              $899; Dr. Clendeninn, $1,047; Dr. Jackson, $899; Dr. Quart, 
              $1,047; and Mr. Snyder, $720.
     (d)      During 1996, the Company reimbursed Dr. Quart for relocation 
              costs in the amount of $14,628.
     (e)      During 1995, the Company reimbursed certain officers for 
              relocation costs as follows:  Dr. Clendeninn, $130,719 and Dr. 
              Quart, $8,448.
     (f)      During 1994, the Company reimbursed certain officers for 
              relocation costs as follows:  Dr. Clendeninn, $106,009 and Dr. 
              Quart, $67,406.
(4)    Cash bonus shown in year earned; actually paid in fiscal 1996.  For 
       Dr. Quart and Mr. Snyder, a portion of the bonus amount was 
       subsequently used to partially repay their outstanding relocation 
       loans.
(5)     A portion of the bonus was used to partially repay an outstanding 
        relocation loan and $43,982 of the bonus was directly applied to the 
        reduction of such loan.
(6)     For Dr. Quart and Mr. Snyder, a portion of the bonus amount was 
        subsequently used to partially repay their outstanding relocation 
        loans.

                               6


The following table sets forth certain information with respect to individual 
grants of stock options made during the fiscal year ended June 30, 1996, to 
each of the named executive officers:

                           Option Grants in Fiscal 1996

                                                Potential Realizable Value at
                                                    Assumed Annual Rates of 
                                                    Stock Price Appreciation
                    Individual Grants                   for Option Term(2)
                       % of Total
                         Options
                       Granted to
                        Employees
              Options   in Fiscal  Exercise  Expiration
Name         Granted(1)    Year      Price      Date        5%          10%

P. Johnson    82,836#    7.1%      $41.875    6/10/06  $2,180,700  $5,526,000
               7,164*    0.6        41.875    6/10/06     188,600     477,900

N. Clendeninn 14,836#    1.3        41.875    6/10/06     390,600     989,700
               7,164*    0.6        41.875    6/10/06     188,600     477,900

R. Jackson    14,836#    1.3        41.875    6/10/06     390,600     989,700
               7,164*    0.6        41.875    6/10/06     188,600     477,900

B. Quart      28,836#    2.5        41.875    6/10/06     759,100   1,923,700
               7,164*    0.6        41.875    6/10/06     188,600     477,900

K. Snyder     24,836#    2.1        41.875    6/10/06     653,800   1,656,800
               7,164*    0.6        41.875    6/10/06     188,600     477,900
- ------------------------------
(1)     During fiscal 1996, the Agouron Stock Option Plan ("Plan") for 
        executive officers was administered by the Board or by the
        Disinterested Stock Option Committee of the Board if the grant was to 
        an executive officer who was also a director.  The Board, based upon 
        the recommendation of the Directors Compensation Committee, 
        determines the number of shares to be granted and the term of such 
        grants to each executive officer.  The options granted in fiscal 1996 
        were either incentive stock options(*) or non-statutory stock 
        options(#), have exercise prices equal to the fair market values on 
        the date of grant, vest over a period of three years and have a term 
        of ten years.  Upon certain corporate events as defined in the Plan 
        which result in a change of control, the exercise date of all 
        outstanding options for all employees including executive officers 
        may be accelerated.  The Plan also permits the Company to assist an 
        employee in using a so-called "cashless" exercise procedure to pay 
        the option exercise price. 

(2)     Potential realizable value is based on an assumption that the stock 
        price of the common stock appreciates at the annual rate shown 
        (compounded annually) from the date of grant until the end of the ten 
        year option term. These numbers are calculated based on the 
        requirements promulgated by the Securities and Exchange Commission 
        and do not reflect the Company's estimate of future stock price 
        growth.  Any such growth would benefit all shareholders.

The following table sets forth certain information with respect to each 
exercise of stock options during the fiscal year ended June 30, 1996, by each 
of the named executive officers and the number and value of unexercised 
options held by such named executive officers as of June 30, 1996:

                          Option Exercises in Fiscal 1996
                       And Value of Options at June 30, 1996
          
                                Number of Unexercised   Value of Unexercised
                                      Options at      In-the-Money Options at
          Shares                     June 30, 1996         June 30, 1996(1)
        Acquired on  Value   Exercisable             Exercisable
Name     Exercise   Realized            Unexercisable           Unexercisable

Johnson    20,000   $588,240    225,150     204,250   $5,757,300  $2,473,300
Clendeninn  5,000    128,375     44,150      51,150    1,289,700     757,800
Jackson      0         0         95,750      51,250    2,773,700     703,900
Quart      13,000    349,250     34,150      80,650      890,200     994,800
Snyder     28,750    726,037     37,900      71,150      953,900     902,500
- --------------------------
(1)     Value calculated as market value of Company stock on June 30, 1996 
        ($39.00), minus exercise price multiplied by the number of shares.

                               7

Compensation Committee Report on Executive Compensation(1)

Overview and Philosophy

     The Directors Compensation Committee (the "Committee") is composed 
entirely of outside directors and is responsible for developing and making 
recommendations to the Board with respect to the Company's executive 
compensation policies and practices, including the establishment of the 
annual total compensation for the chief executive officer (the "CEO") and all 
executive officers.  The Committee has available to it an outside 
compensation consultant and access to independent compensation data.  The 
Board is responsible for approving and implementing the compensation 
recommendations of the Committee.  The recommendations made by the Committee 
to the Board during 1996 were approved without any significant modification.

     The objectives of the Company's executive compensation program are to 
attract, retain and motivate highly qualified executive personnel.  These 
objectives are satisfied through the use of three principal compensation 
elements:  base salary, cash bonus payments and stock options.

Base Salary

     Base salary levels for the Company's executive officers are based on the 
concept of pay for performance and are competitively set relative to the 
compensation of other executives in the biotechnology industry.  Extensive 
salary survey data is available on the industry (notably, the annual 
"Biotechnology Compensation and Benefits Survey" conducted by Radford 
Associates and Alexander & Alexander Consulting Group) and is utilized by the 
Committee in establishing annual base salaries.  In determining base 
salaries, the Committee also considers corporate performance and progress in 
the immediately-preceding fiscal year, individual experience and performance, 
specific issues which are relevant to the Company and general economic 
conditions.  The base salary of the CEO and all other executive officers is 
reviewed annually.  During fiscal year 1996, the base salaries paid to the 
executive officers other than the CEO approximated the 75th percentile of the 
above-noted industry survey data.

Bonus Payments

     Annual cash bonus payments are discretionary unless otherwise required 
pursuant to an employment agreement.  Only one executive officer has such an 
agreement:  Dr. Jackson is to receive a minimum annual bonus payment of 
$30,000.  Bonus payments, if any, to other executive officers, including the 
CEO, or payments above the required annual minimum, are based on two 
principal factors:  corporate performance as compared to the Company's annual 
goals and objectives and individual performance relative to corporate 
performance and individual goals and objectives.  The bonus payments to Dr. 
Quart and Dr. Clendeninn in 1994 were pursuant to their employment agreements 
and mandatory for only their first year of employment.

     Bonus payments in 1996 were generally in recognition of the satisfaction 
of several significant corporate objectives during the year, including the 
establishment of a major corporate collaboration, a successful public 
offering of common stock, and the continued preclinical and clinical 
development of the Company's leading cancer and anti-viral agents.

     Bonus payment recommendations for executive officers other than the CEO 
are initiated by the CEO and submitted to the Committee for review and 
subsequent submission to the Board.  Bonus payment recommendations for the 
CEO are initiated by the Committee and submitted to the Board.

     Total base salary and any bonus payments are compared to "total 
compensation" as reported by the previously noted industry survey.  Such 
total compensation for the executive officers of the Company is at or above 
the averages of such data, which reflects the Committee's belief that the 
relative levels of corporate performance and increase in shareholder value 
during the period were also above average.

- --------------------------
(1)     The material in this report is not soliciting material, is not deemed 
        filed with the SEC, and is not incorporated by reference in any 
        filing of the Company under the Securities Act of 1933 (the 
        "SecuritiesAct"), as amended, or the Securities Exchange Act of 1934 
        (the "Exchange Act"), as amended, whether made before or after the 
        date of this Proxy Statement and irrespective of any general 
        incorporation language in such filing.

                               8

Stock Options

     To conserve its cash resources, the Company places special emphasis on 
equity-based incentives to attract, retain and motivate executive officers as 
well as other employees.  Under the Company's stock option plans, grants are 
generally priced at the fair market value on the date of grant, vest over a 
period of three or four years and have a term of ten years.  Grants are made 
to all employees on their date of hire based on salary level and position. 
All employees, including executive officers, are eligible for subsequent, 
discretionary grants which are generally based on either individual or 
corporate performance.  It is the Committee's intent that the interests of 
the Company shareholders and the executive officers be closely aligned 
through the use of stock options.  Option grants recommended by the Committee 
are submitted to the Board for approval.  Based on recent peer-company proxy 
data compiled by the Company, the level of option grants to each executive 
officer in 1996 remains competitive, and the resultant total option position 
as a percent of total shares outstanding represents approximately the 60th to 
80th percentile of such positions.

Chief Executive Officer Compensation

     During 1996, Mr. Johnson's base salary of $285,000 was based on 
individual and corporate performance, and was between the 50th and 75th 
percentile of the updated industry data for base salaries of CEOs.

     During 1996, Mr. Johnson was awarded a bonus of $100,000 in recognition 
of the satisfaction of several significant corporate objectives, including 
the continued preclinical and clinical development of two product candidates, 
the creation of a significant corporate alliance, and a secondary offering of 
the Company's common stock.  The Committee believes that Mr. Johnson has made 
a significant contribution during 1996 in establishing a sound base for 
enhancing shareholder value through his managerial and entrepreneurial 
efforts.

     The stock options awarded to Mr. Johnson during fiscal 1996 are 
competitive and consistent with the purpose of the stock option plans.  The 
resultant total option position as a percent of total shares outstanding 
represents approximately the 75th percentile for peer CEO positions.

Executive Compensation Deduction Limitations

     In 1993, Section 162(m) of the Internal Revenue Code ("Section 162(m)") 
was enacted which disallows the deductibility by the Company of any 
compensation over $1 million per year paid to each of the chief executive 
officer and the four other most highly compensated executive officers, unless 
certain performance-based compensation criteria are satisfied.  While it is 
the Committee's firm belief and intent that compensation from base salary and 
cash bonus payments will not approach the annual Section 162(m) limitation in 
the foreseeable future, additional "compensation" from the exercise of option 
grants pursuant to the Company's stock option plans could result in the 
annual limitation being exceeded.  Accordingly, the 1990 Stock Option Plan 
contains provisions which are necessary before "compensation" resulting from 
an option grant under such Plan can qualify for an exemption from the $1 
million limitation.  The Committee will continue to monitor all forms of 
compensation to its executive officers to ensure that the Company may 
maximize the tax benefits of such compensation.

Directors Compensation Committee

      Michael E. Herman, Chairman
      John N. Abelson, Ph.D.
      A. E. Cohen


Directors Compensation Committee Interlocks and Insider Participation

     The Directors Compensation Committee is composed exclusively of three 
outside directors:  Mr. Herman, Mr. Cohen and Dr. Abelson.  The Company is 
not aware of any Committee interlocks. 

                               9

Performance Measurement Comparison(1)

     The chart set forth below shows the value of an investment of $100 on 
June 30, 1991 in the Company's common stock, The Nasdaq Stock Market Index 
(U.S. Companies) ("Nasdaq Market (US)") and the Nasdaq Pharmaceutical Index 
("Nasdaq Pharmaceuticals").  The total returns assume the reinvestment of 
dividends, although dividends have not been declared on the Company's common 
stock.  The Company's common stock is traded on The Nasdaq Stock Market and 
is a component of both the Nasdaq Market (US) and the Nasdaq Pharmaceutical 
Index.  The comparisons in the chart are required by the Securities and 
Exchange Commission and are not intended to forecast or be an indicator of 
possible future performance of the Company's common stock.

                                     [GRAPH]

                      6/30/91  6/30/92  6/30/93  6/30/94  6/30/95  6/30/96
Agouron Common Stock  $100.00  $ 83.93  $ 71.43  $ 80.36   168.75   278.57
Nasdaq Market (US)     100.00   120.13   151.08   152.52   203.59   261.40
Nasdaq Pharmaceuticals 100.00   124.51   108.23    90.53   120.17   177.03
     
- ---------------------------
 (1)     This section is not "soliciting material," is not deemed filed with 
         the Securities and Exchange Commission and is not to be incorporated 
         by reference in any filing of the Company under the Securities Act 
         or the Exchange Act.

                               10

                              CERTAIN TRANSACTIONS

     The Agouron Institute ("Institute") is a holder of 716,000 shares of 
common stock.  Material business transactions between the Company and the 
Institute require approval by a majority of the disinterested directors of 
the Company.  The Company and the Institute have two common directors (Drs. 
Abelson and Simon) and no common officers.

     As part of its employment agreement with Mr. Snyder, the Company 
provided him with a six-year, non-interest bearing $85,000 employee 
relocation loan.  The loan is secured by real property.  At September 24, 
1996 the principal balance of the loan outstanding was $14,208.

     As part of its employment agreement with Dr. Quart, the Company provided 
him with a four year, non-interest bearing $60,000 employee relocation loan. 
The loan is secured by real property.  At September 24, 1996, the principal 
balance of the loan outstanding was $22,884.

     All transactions with affiliates have been and will continue to be on 
terms no less favorable to the Company than could be obtained from 
unaffiliated parties.  Furthermore, all transactions with affiliates and any 
loans to Company officers, affiliates or shareholders must be approved by a 
majority of the disinterested directors.

     In connection with its Series A preferred stock purchase (converted in 
October 1990 to common stock), APA Excelsior II, L.P. was contractually 
granted the right to designate a nominee (Ms. Cloherty) for election to the 
Board.  The Company will use its best efforts to encourage its shareholders 
to elect Ms. Cloherty to the Board. 

     As permitted by California law, the articles of incorporation and bylaws 
of the Company currently provide for the limitation of director liability for 
monetary damages for breach of duty to the Company and for indemnification of 
agents (including officers and directors) to the full extent permitted under 
the California General Corporations Law.  The Company has entered into 
Indemnification Agreements with all of its directors and officers. 
Additionally, the Company has in effect a directors and officers liability 
insurance policy which insures directors and officers of the Company against 
loss arising from claims made against them due to wrongful acts while acting 
in their individual and collective capacities as directors and officers.


                    SUBMISSION OF SHAREHOLDER PROPOSALS

     Shareholders are advised that any shareholder proposal intended for 
consideration at the 1997 Annual Meeting of Shareholders must be received by 
the Company on or before May 31, 1997 to be included in the Proxy materials 
for the 1997 Annual Meeting.  It is recommended that shareholders submitting 
proposals direct them to the Secretary of the Company and utilize Certified 
Mail-Return Receipt Requested.


                       FINANCIAL STATEMENTS AVAILABLE

     Financial statements for the Company are included in the Company's 
Annual Report to Shareholders for the fiscal year ended June 30, 1996. 
Additional copies of these statements and the Annual Report to the Securities 
and Exchange Commission on Form 10-K (excluding exhibits, unless such 
exhibits have been specifically incorporated by reference therein) may be 
obtained without charge upon written request to:  Investor Relations, Agouron 
Pharmaceuticals, Inc., 10350 North Torrey Pines Road, La Jolla, California 
92037-1020 or by calling (619) 622-3000.  Web Site address: 
http://www.agouron.com.

                               11

                APPROVAL OF THE COMPANY'S 1996 STOCK OPTION PLAN
                         (Item 2 on the Proxy Card)

     On August 7, 1996, the Board of Directors approved the Agouron 
Pharmaceuticals, Inc. 1996 Stock Option Plan (the "1996 Plan").  Under the 
1996 Plan, 2,000,000 shares of Common Stock have been reserved for issuance 
to employees, officers, directors and consultants.  The Company has two 
additional stock option plans:  (1) the 1985 Stock Option Plan (the 1985 
Plan") and (2) the 1990 Stock Option Plan (the "1990 Plan").  The 1985 Plan 
and the 1990 Plan are hereafter referred to as the 1985 and 1990 Plans.  As 
of June 30, 1996, there were 3,414,357 outstanding stock options under the 
1985 and 1990 Plans (of which 1,330,965 were exercisable) with an aggregate 
total exercise price of approximately $75,156,000; the average per share 
exercise price of these outstanding stock options was $22.01.  During fiscal 
1996, options for 1,162,475 shares were granted at an average exercise price 
of $38.96 per share.  At June 30, 1996, only 218,801 stock options remained 
available for grant under the 1985 and 1990 Plans.

     The Board believes that the Company's stock option programs have created 
significant incentives for its employees, officers, directors and 
consultants.  The Board considers it important for the future success of the 
Company to continue to grant stock options on a basis comparable with those 
granted by other companies with which it competes in attracting, retaining 
and motivating qualified personnel.  The Board is requesting shareholder 
approval of the 1996 Plan in order to satisfy the requirements of the 
Internal Revenue Code ("Code") for issuance of incentive stock options and to 
comply with certain prerequisites for the application of Code Section 162(m). 
If shareholders elect not to approve the amendment, the Board, using its 
general authority to issue stock options, can grant non-statutory stock 
options to purchase the Company's common stock.

Required Vote

     Approval by the holders of a majority of the shares of the Company's 
common stock represented and voting at the Meeting on this matter (which 
shares constitute at least a majority of the required quorum for the Meeting) 
is required for the adoption of this proposal.  For purposes of calculating 
the vote necessary for approval, abstentions and non-votes are not counted.

     The Board recommends that you vote FOR the approval of this proposal, 
which is set forth as Item 2 on the Proxy Card.


Description of the 1996 Stock Option Plan

     The essential features of the 1996 Plan are outlined below.  For a 
complete understanding of the terms of the 1996 Plan, see Exhibit A.

     The purpose of the 1996 Plan is to encourage officers, directors, 
employees and consultants of the Company to acquire or increase their 
proprietary interest in the success of the Company and to continue their 
affiliation with the Company.  Eligible employees may be granted either 
"incentive stock options" or "non-statutory stock options" under the 1996 
Plan.  Subject to certain conditions, officers, directors and consultants who 
are not employees may be granted "non-statutory stock options" under the 1996 
Plan.  An incentive stock option is an option which qualifies for certain 
favorable income tax treatment under the Internal Revenue Code.  A non-
statutory stock option is an option which is not an incentive stock option 
for federal income tax purposes.

     In August 1996, the Board approved the 1996 Plan, under which 2,000,000 
shares of Common Stock were reserved for issuance to employees, officers, 
directors and consultants.  The total number of shares available under the 
1996 Plan, the number of shares subject to outstanding options and the 
exercise price per share of outstanding options will be subject to adjustment 
upon the occurrence of stock dividends, recapitalizations, consolidations, 
stock splits, combinations or exchanges of shares of stock or other increases 
or decreases in the number of shares of the Company's common stock effected 
without receipt of consideration by the Company, in order to preclude the 
dilution or enlargement of benefits under the 1996 Plan.  The Board may also 
make such equitable adjustments to the 1996 Plan and outstanding options as 
it deems appropriate in order to preclude the dilution or enlargement of 
benefits under the 1996 Plan upon exchange of all of the outstanding common 
stock of the Company for a different class or series of capital stock or the 
separation of assets of the Company, including a spin-off or other 
distribution of stock or property by the Company.  If any option under the 
1996 Plan terminates or expires, the shares allocable to the unexercised 
portion of the option will again be available for purposes of the 1996 Plan. 
In certain circumstances, where an optionee uses stock to exercise an option, 
only the net shares issued to the optionee are counted against the number of 
shares issued under the 1996 Plan.  Certain stock issuances which are later 
forfeited by the optionee do not count as grants under the 1996 Plan.

                               12

     A dissolution or liquidation of the Company, a merger or consolidation 
in which the Company is not the surviving corporation, a reverse merger in 
which the Company is the surviving corporation but the Company's Common Stock 
outstanding immediately preceding the merger is converted by virtue of the 
merger into other property, or other capital reorganization in which more 
than fifty percent (50%) of the Company's Common Stock is exchanged (unless 
the dissolution or liquidation plan, agreement of merger or consolidation or 
capital reorganization corporate documents expressly provide to the 
contrary), shall cause each outstanding option to terminate, provided that 
each optionee shall have the right immediately prior to the occurrence of 
such event to exercise his or her option in whole or in part; however, the 
exercise date of outstanding options shall not be accelerated by such event 
if and to the extent:  (i) the option in connection with such event is either 
to be assumed by the successor corporation or parent thereof or to be 
replaced with a comparable option to purchase shares of the capital stock of 
the successor corporation or parent thereof; or (ii) the option is to be 
replaced by a comparable cash incentive program of the successor corporation 
based on the value of the option on the date of such event.  Notwithstanding 
the preceding, if within one year from the date of such event, an employee's 
employment is involuntarily terminated, then the employee's outstanding stock 
options, if any, shall become immediately exercisable.


Administration of the 1996 Plan

     The 1996 Plan is administered by the Board, except that the Board may 
delegate all or any part of its authority to administer the 1996 Plan with 
respect to any group or groups of persons eligible to receive options to such 
persons or committee as the Board may determine.  The Board has currently 
delegated to a committee, composed of certain of the Company's executive 
officers, the authority to administer the 1996 Plan with respect to persons 
who are neither officers nor directors of the Company.  Further references 
herein to the administration of the 1996 Plan by the Board refer to the Board 
or its delegates, unless the context otherwise indicates.  Whether or not the 
Board has delegated administrative authority, the Board has final power to 
determine all questions of policy or expediency that may arise in the 
administration of the 1996 Plan.

     The Board has the power to make all determinations necessary or 
advisable for the administration of the 1996 Plan.  The Board also has the 
final power to construe and interpret the 1996 Plan and the options granted 
under it.  The Board determines, within the limits of the Plan, the persons 
to whom and the time or times at which options shall be granted, the type of 
options to be granted (whether incentive stock options or non-statutory stock 
options), the number of shares to be subject to each option, the duration of 
each option, the option price and the time or times within which, during the 
term of option, all or any portion of an option becomes exercisable 
 ("vests").  The Company's current form of stock option agreement provides 
that an option vests over a three or four year period.  In the event that an 
employee terminates his or her employment with the Company, unless the Board 
otherwise elects, the then nonvested portion of his or her option is 
forfeited.  Subject to the terms and conditions of the 1996 Plan, the Board 
may modify an outstanding option (including lowering the option price or 
changing incentive stock options into non-statutory stock options), change 
the vesting schedule, extend or renew outstanding options granted under the 
1996 Plan or accept the surrender of outstanding options (to the extent not 
previously exercised) and authorize the granting of new options in 
substitution therefor.  The Board may permit an option to be exercised before 
it is vested, subject to repurchase rights which terminate on a vesting 
schedule identical to the vesting schedule of the option.  The Board may also 
establish other limitations or restrictions upon exercise of options.

Grant and Exercise of Incentive Stock Options and Non-statutory Stock Options

     All employees of the Company are eligible to receive incentive stock 
options and non-statutory stock options under the 1996 Plan.  Subject to 
certain conditions, officers, directors and consultants of the Company who 
are not employees are eligible to receive non-statutory stock options but not 
incentive stock options.  To the extent required by Section 162(m) to qualify 
future compensation as "performance based," options to purchase more than 
750,000 shares may not be granted in a fiscal year to any individual 
participant in the 1996 Plan.

     Incentive stock options may be granted by the Board at any time prior to 
August 7, 2006.  Options shall be evidenced by agreements in such form as the 
Board shall from time to time determine, consistent with the terms of the 
1996 Plan.  The price per share under each incentive stock option must be at 
least 100% of the fair market value of the common stock on the date the 
option is granted.  The Board can set any price it wishes for shares granted 
under non-statutory stock options.  The price for shares may be paid in any 
combination of cash, by cashier's or certified check, personal check 
acceptable to the Company, shares of the Company's Common Stock (including 
previously owned Common Stock or Common Stock issuable in connection with the 
exercise) or "built-in gain" in any options which are terminated as part of 
such exercise.  The Board may take such steps it deems necessary to 
facilitate the payment of the option price.  However, payment of the option 
price must be in such form as the Board determines and the Board may require 
satisfaction of any rules or conditions it deems necessary in connection with 
the payment of the option price or on  account of any assistance given an 
optionee to facilitate such payment.  The aggregate fair market value 
(determined 

                               13

as of the time the option is granted) of stock with respect to which 
incentive stock options are exercisable for the first time by an employee 
during a calendar year can not exceed $100,000.

     Except as otherwise provided in the option agreement between the Company 
and the optionee, each option expires on the date set forth in such 
agreement.  The term of each incentive stock option cannot be more than ten 
years from the date on which the option is granted.

     To the extent required by Internal Revenue Code Section 422, options 
granted under the 1996 Plan may not be transferred other than by will or the 
laws of descent and distribution and may be exercised during the holder's 
lifetime only by the holder.  However, non-statutory stock options can be 
transferred to a trust for the benefit of the optionee, or members of his 
family.

Amendment and Termination

     The Board may at any time revise, amend, suspend or terminate the 1996 
Plan.  No amendment shall, without the approval of the shareholders, change 
the number of shares for which incentive stock options may be granted under 
the 1996 Plan, reduce the price per share at which incentive stock options 
may be offered under the 1996 Plan below 100% of the fair market value on the 
date of grant, or modify the eligibility requirements for the class of 
employees eligible to receive incentive stock options.

Tax Withholding

     Optionees are required to pay the Company cash for the amount of the tax 
liability incurred by the optionee in connection with the exercise of his or 
her option.  However, the Board may in its sole discretion permit an optionee 
to reimburse the Company for such tax liability by the actual or imputed 
delivery to the Company of shares of its Common Stock.

Federal Income Tax Consequences

     The principal tax consequences of the grant and exercise of incentive 
stock options and non-statutory stock options under current provisions of the 
federal income tax laws may be summarized as follows:

     1.     Incentive Stock Options.  The grant of an incentive stock option 
does not produce taxable income for the employee or a tax deduction for the 
Company.  Upon exercise of an incentive stock option, the excess of the fair 
market value of the shares acquired over the amount paid by the employee for 
the shares will be an item of tax preference to the employee, which may be 
subject to the alternative minimum tax for the taxable year of exercise.  If 
no disposition of the stock is made within two years from the date of grant 
of the incentive stock option nor within one year after the transfer of the 
shares to the employee, the employee will not realize ordinary income as a 
result of the exercise and subsequent sale of the incentive stock option. 
Any gain or loss realized on the ultimate sale of the shares must be reported 
by the employee as long-term capital gain or loss.  The Company is not 
entitled to any deduction as a result of the exercise of the incentive stock 
option.

     If the employee disposes of the shares within the two-year or one-year 
periods referred to above, the excess of the fair market value of the shares 
at the time of exercise (or the proceeds of disposition, if less) over the 
amount paid by the employee for the shares will at that time be taxable to 
the employee as ordinary income.  The same amount will be deductible by the 
Company, subject to the general rules relating to the reasonableness of 
compensation.  The excess (if any) of the proceeds of disposition over the 
fair market value of the shares on the date of exercise must be reported by 
the employee as a long-term capital gain if the shares have been held for 
more than one year, or as a short-term capital gain if the shares have been 
held for one year or less.  If no gain is realized, there will be no ordinary 
income and any loss will be long-term or short-term capital loss.

     2.     Non-Statutory Stock Options.  The grant of a non-statutory stock 
option under the 1996 Plan does not produce taxable income for the optionee 
or a tax deduction for the Company.  Except as described below, upon exercise 
of a non-statutory stock option, the excess of the fair market value of the 
shares acquired over the amount paid by the optionee will be taxable to the 
optionee as ordinary income.

     The Company will be entitled to a deduction for income tax purposes in 
an amount equal to the ordinary income taxable to the optionee in the year in 
which such ordinary income is recognized.  Any additional profit or loss 
realized by an optionee on disposition of the shares will not result in any 
additional tax deduction to the Company.

     Similar rules apply if the Company permits the exercise of an "unvested" 
option with the issued stock being subject to certain repurchase rights or 
other substantial risks of forfeiture.

                               14

3.     Using Stock to Exercise Options.  Special rules apply if an optionee 
uses already owned stock of the Company to pay all or part of the exercise 
price of an incentive or non-statutory stock option.  The use of already 
owned stock to pay all or part of the exercise price of a non-statutory stock 
option permits an optionee to defer the date when the gain on the surrendered 
shares which are used to pay the exercise price of the option is recognized 
for tax purposes.  That is, using already owned shares to exercise a non-
statutory stock option permits an optionee to finance the exercise of the 
option without paying current tax on the unrealized appreciation in value of 
the surrendered shares.  An option exercise using already owned stock is 
treated as a "tax-free exchange" with respect to that number of shares 
received on the option exercise which equals the number of shares 
surrendered.  The optionee's basis in these shares is the same as his or her 
basis in the shares surrendered , and the capital gain holding period on such 
shares runs without interruption from the date when the surrendered shares 
were acquired.  Any additional shares received by the optionee on the 
exercise will trigger ordinary income taxation equal to the fair market value 
of the additional shares over the consideration paid by the optionee in 
connection with the exercise.  The optionee's basis in the additional shares 
is equal to their fair market value on the date the shares were received, and 
the capital gain holding period on such shares commences on that date. 
Similarly, the use of previously owned stock to pay the exercise price of an 
incentive stock option permits an employee to defer tax recognition of gain 
on the surrendered shares.  However, if an employee pays all or part of the 
exercise price of an incentive stock option by surrendering stock previously 
acquired in the exercise of any other incentive stock option and such 
previously acquired stock has not been held for the statutory holding period, 
then the surrender of such stock to exercise the incentive stock option will 
be treated as a disqualifying disposition of the prior incentive stock option 
with the tax consequences described in Paragraph 1 above.  Furthermore, 
complex tax rules apply concerning the use of shares to exercise an incentive 
stock option, especially with regard to an employee's basis in the shares 
received on the exercise.

Accounting Treatment

     Under the present financial accounting rules, neither the grant nor the 
exercise of options issued to employees at fair market value will result in 
any charge to the Company's earnings.  However, the Company will be required 
to calculate the "fair value" of all option grants at the time of grant and 
disclose such value on a pro-forma basis.  The grant of options with exercise 
prices less than the fair market value of the shares at the time of grant 
will result in a compensation expense equal to the discount from market at 
the time of grant.  The Company will have to report such expense pro rata as 
the shares underlying the option become exercisable.  Accordingly, the grant 
of discounted options under the 1996 Plan would result in a charge to 
reported earnings.  In all events, the number of dilutive options outstanding 
under the 1996 Plan will be a factor in determining the Company's reported 
earnings per share.


                               15

             RATIFICATION OF SELECTION OF INDEPENDENT ACCOUNTANTS
                         (Item 3 on the Proxy Card)

     The Board has selected the firm of Price Waterhouse LLP as independent 
accountants for the Company for the fiscal year ending June 30, 1997, it 
being intended that such selection would be proposed for ratification by the 
affirmative vote of a majority of the shares of the Company's common stock 
represented and voting at the Meeting on this matter (which shares constitute 
at least a majority of the required quorum for the Meeting).  For purposes of 
calculating the vote necessary for ratification of the selection of 
independent accountants, abstentions and non-votes are not counted.  One or 
more members of Price Waterhouse LLP are expected to be present at the 
Meeting and will be available to respond to questions and make a statement if 
they desire to do so.

     The Board recommends that you vote FOR the ratification of the selection 
of Price Waterhouse LLP, which is set forth as Item 3 on the Proxy Card.


                                OTHER MATTERS

     The Company's Annual Report for the fiscal year ended June 30, 1996 
accompanies this Proxy Statement.

     Section 16(a) of the Securities Exchange Act of 1934 requires the 
Company's executive officers and directors, and persons who own more than 10% 
of a registered class of the Company's equity securities, to file reports of 
ownership and changes in ownership with the Securities and Exchange 
Commission and The Nasdaq Stock Market.  Executive officers, directors and 
greater than 10% shareholders are required by Securities and Exchange 
Commission regulation to furnish the Company with copies of all Section 16(a) 
forms they file.  Based solely on review of the copies of such forms 
furnished to the Company, or written representations that no Forms 5 were 
required, the Company believes that, during the applicable reporting period 
ending June 30, 1996, all Section 16(a) filing requirements applicable to its 
executive officers, directors and greater than 10% beneficial owners were 
satisfied.

     The Company's Board does not know of any other matters to be presented 
at the Meeting.  However, if any other business is properly presented at the 
Meeting for action, the persons named in the enclosed form of Proxy will vote 
such Proxy according to their best judgment on such matters.

BY ORDER OF THE BOARD OF DIRECTORS




Gary E. Friedman, Secretary
September 24, 1996



                               16


                                EXHIBIT A

                       AGOURON PHARMACEUTICALS, INC.
                          1996 STOCK OPTION PLAN
            (Adopted by the Board of Directors August 7, 1996)
             (Approved by the Shareholders ___________, 1996)


1.     Purpose.

     This 1996 Stock Option Plan is intended to encourage stock ownership in 
Agouron Pharmaceuticals, Inc. by the officers, directors, employees and 
consultants of the Company and its affiliates in order to promote their 
interest in the success of the Company and to encourage their continued 
affiliation.  All options granted under this 1996 Stock Option Plan are 
intended to be either (a) Incentive Stock Options or (b) Non-Statutory Stock 
Options.

2.     Definitions.

     As used herein the following definitions shall apply:

     "Act" shall mean the Securities Exchange Act of 1934, as amended from 
time to time.

     "Affiliate" shall mean any corporation defined as a "parent corporation" 
or a "subsidiary corporation" by Code Section 424(e) and (f), respectively.

     "Agreement" shall mean either a 1996 Incentive Stock Option Agreement or 
a 1996 Non-Statutory Stock Option Agreement, embodying the terms of the 
agreement between the Company and the Optionee with respect to Optionee's 
Option.

     "Board" shall mean the Board of Directors of the Company.

     "Code" shall mean the Internal Revenue Code of 1986, as amended from 
time to time.

     "Company" shall mean Agouron Pharmaceuticals, Inc., a California 
corporation.

     "Consultant" shall mean any person who is placed on the Company's 
Consultants List by the Board and who agrees in writing to be included 
thereon.

     "Disability" or "Disabled" shall mean the condition of being "disabled" 
within the meaning of Section 422(c)(6) of the Code or any successor 
provision.

     "Director" shall mean an individual member of the Board.

     "Employee" shall mean any salaried employee of the Company or its 
Affiliates, including those employees who are officers of the Company or its 
Affiliates.

     "ERISA" shall mean the Employee Retirement Income Security Act or the 
rules thereunder, as amended from time to time.

     "Fair Market Value" of Stock on a given date shall mean an amount per 
share as determined by the Board or its delegates by applying any reasonable 
valuation method determined without regard to any restriction other than a 
restriction which, by its terms, will never lapse.  Notwithstanding the 
preceding, if the Stock is traded upon an established stock exchange, then 
the "Fair Market Value" of Stock on a given date per share shall be deemed to 
be the average of the highest and lowest selling price per share of the Stock 
on the principal stock exchange on which the Stock is then trading or, if 
there was no trading of the Stock on that day, on the next preceding day on 
which there was such trading; if the Stock is not traded upon an established 
stock exchange but is quoted on a quotation system, the "Fair Market Value" 
of Stock on a given date shall be deemed to be the mean between the closing 

                               A-1

representative "bid" and "ask" prices per share of the Stock on such date as 
reported by such quotation system or, if there was no trading of the Stock on 
that day, on the next preceding day on which there was such trading.

     "Incentive Stock Option" shall mean an option granted pursuant to the 
Plan which is designated by the Board or its delegates as an "Incentive Stock 
Option" and which qualifies as an incentive stock option under Section 422 of 
the Code or any successor provision.  

     "Non-Statutory Stock Option" shall mean a stock option granted pursuant 
to the Plan which is not an Incentive Stock Option.

     "Option" shall refer to either or both an Incentive Stock Option or Non-
Statutory Stock Option, as the context shall indicate.

     "Optionee" shall mean the recipient of an Incentive Stock Option or a 
Non-Statutory Stock Option. 

     "Option Price" shall mean the price per share of Stock to be paid by the 
Optionee upon exercise of the Option.

     "Option Stock" shall mean the total number of shares of Stock the 
Optionee shall be entitled to purchase pursuant to the Agreement.

     "Plan" shall mean this Agouron Pharmaceuticals, Inc. 1996 Stock Option 
Plan, as amended from time to time.

     "Reporting Person" shall mean an Optionee who is required to file 
statements relating to his or her beneficial ownership of Stock with the SEC 
pursuant to Section 16(a) of the Act.

     "Rule 16b-3" shall mean Rule 16b-3 (as amended from time to time), 
promulgated by the SEC under the Act, and any successor thereto.

     "SEC" shall mean the Securities and Exchange Commission.

     "Stock" shall mean the no par Common Stock of the Company.

3.     Administration.

     The Plan shall be administered by the Board; provided, however, that the 
Board may delegate all or any part of its authority to administer the Plan in 
its entirety or, with respect to any group or groups of persons eligible to 
receive Options hereunder, to such persons or committee as the Board shall in 
its sole discretion determine.  The Board and its delegates may adopt, amend 
and rescind such rules and regulations for carrying out the Plan and 
implementing agreements and take such act as it deems proper.  The 
interpretation, construction and application by the Board or any individuals 
who are delegated authority by the Board to administer the Plan or any of the 
provisions of the Plan or any Option granted thereunder shall be final and 
binding on the Company, all Optionees, their legal representatives, and any 
person who may acquire an Option directly from an Optionee by permitted 
transfer, bequest or inheritance.  Reference to administrative acts by the 
Board in the Plan shall also refer to acts by its delegates, unless the 
context otherwise indicates.  Whether or not the Board has delegated 
administrative authority, the Board has the final power to determine all 
questions of policy or expediency that may arise in administration of the 
Plan.

4.     Eligibility.

     Only Employees are eligible to receive Incentive Stock Options under the 
Plan.  Employees, officers, Directors and Consultants of the Company or its 
Affiliates are eligible to receive Non-Statutory Stock Options under the 
Plan.

     No person shall be eligible to receive an Option for a larger number of 
shares than is recommended for him by the Board.  Any Optionee may hold more 
than one Option (whether Incentive Stock Options, Non-Statutory Stock 
Options, or both), but only on the terms and conditions and subject to the 
restrictions set forth herein.

                               A-2

     Incentive Stock Options granted to an Employee who owns stock at the 
time the Incentive Stock Option is granted, representing more than ten  
percent (10%) of the total combined voting power of all classes of stock of 
the Company and its Affiliates, shall be granted at an Option Price at least 
one hundred ten percent (110%) of the Fair Market Value of the Stock at the 
time the Incentive Stock Option is granted.  In determining ownership of 
Stock by an Employee, the attribution standards set forth in Code Section 
424(d) shall be applicable.

5.     Stock Subject to the Plan.

     Options granted under the Plan shall be for shares of the Company's 
authorized but unissued or re-acquired Stock.  The aggregate number of shares 
of Stock which may be subject to Options pursuant to the Plan shall not 
exceed two million (2,000,000) shares.  The number of shares available shall 
be adjusted as provided in Paragraph 6(j) below.  Stock issued under other 
stock option plans of the Company shall not be counted against the maximum 
number of shares that can be issued under the Plan.

     In the event that any outstanding Option expires or is terminated for 
any reason, the shares of Stock allocable to the unexercised portion of such 
Option may again be subject to an Option under the Plan.

     If an Optionee pays all or part of any Option Price with shares of 
Stock, the number of shares deemed to be issued to the Optionee (and counted 
against the maximum number of shares that can be issued under the Plan) shall 
be the number of shares transferred to the Optionee by the Company, less the 
number of shares transferred by the Optionee to the Company as payment. 
Stock issued on the exercise of an Option which is forfeited in accordance 
with the conditions contained in the grant by the Optionee after issuance 
shall be deemed to have never been issued under the Plan and, accordingly, 
shall not be counted against the maximum number of shares that can be issued 
under the Plan.  Notwithstanding the terms of the previous two sentences, the 
maximum number of shares for which Incentive Stock Options may be issued 
under the Plan shall be two million (2,000,000) shares, subject to adjustment 
as provided under Paragraph 6(j), regardless of the fact that under the terms 
of the preceding sentences, a lesser number of shares is deemed to be issued 
pursuant to the exercise of Incentive Stock Options.

6.     Terms and Conditions of Options.

     The Board or its delegates shall authorize the granting of all Options 
under the Plan with such Options to be evidenced by Incentive Stock Option 
Agreements or Non-Statutory Stock Option Agreements, as the case may be. 
Each Agreement shall be in such form as the Board may approve from time to 
time.  Each Agreement shall comply with and be subject to the following terms 
and conditions:

(a)     Type of Option; Number of Shares.  Each particular Option Agreement 
shall state the type of Options to be granted (whether Incentive Stock 
Options or Non-Statutory Stock Options) and the number of shares to which the 
Option pertains.  Under no circumstances shall the aggregate Fair Market 
Value of the Stock (determined as of the time the Option is granted) with 
respect to which incentive stock options are exercisable for the first time 
by any Employee during any calendar year (under all incentive stock option 
plans of the Company and its Affiliates) exceed $100,000.

(b)     Option Price.  Each particular Option Agreement shall state the 
Option Price.  The Option Price for an Incentive Stock Option shall not be 
less than one hundred percent (100%) of the Fair Market Value per share of 
Stock on the date the Incentive Stock Option is granted. The Option Price for 
a Non-Statutory Stock Option shall be the price per share of Stock set by the 
Board or its delegates.

(c)     Certificate Legends.  Certificates for shares of Stock issued and 
delivered to Reporting Persons may be legended, as the Board deems 
appropriate, if required by the provisions of any applicable rule or 
regulation.

(d)     Medium and Time of Payment.  The aggregate Option Price shall be 
payable upon the exercise of the Option and shall be paid in any combination 
of: 

        (i)      United States cash currency; 

        (ii)     a cashier's or certified check to the order of the Company; 

                               A-3

        (iii)    a personal check acceptable to the Company; 

        (iv)     to the extent permitted by the Board, shares of Stock of the 
        Company (including previously owned Stock or Stock issuable in 
        connection with the Option exercise), properly endorsed to the 
        Company, whose Fair Market Value on the date of exercise equals the 
        aggregate Option Price of the Option being exercised; or

        (v)      to the extent permitted by the Board, the Optionee's 
        entering into an agreement with the Company, whereby a portion of the
        Optionee's Options are terminated and where the "built-in gain" on 
        any Options which are terminated as part of such agreement equals the 
        aggregate Option Price of the Option being exercised.  "Built-in 
        gain" means the excess of the aggregate Fair Market Value of any 
        Stock otherwise issuable on exercise of a terminated Option, over the 
        aggregate Option Price otherwise due the Company on such exercise.  

The Board may permit deemed or constructive transfer of shares in lieu of 
actual transfer and physical delivery of certificates.  Except to the extent 
prohibited by applicable law, the Board may take any necessary or appropriate 
steps in order to facilitate the payment of any such Option Price.  Without 
limiting the foregoing, the Board may cause the Company to loan the Option 
Price to the Optionee or to guarantee that any Stock to be issued will be 
delivered to a broker or lender in order to allow the Optionee to borrow the 
Option Price.  The Board, in its sole and exclusive discretion, may require 
satisfaction of any rules or conditions in connection with payment of the 
Option Price at any particular time, in any particular form, or with the 
Company's assistance.  If Stock used to pay any Option Price is subject to 
any prior restrictions imposed in connection with any plan of the Company 
(including this Plan), an equal number of the shares of Stock acquired on 
exercise shall be made subject to such prior restrictions in addition to any 
further restrictions imposed on such Stock by the terms of the Optionee's 
Agreement or by the Plan.

(e)     Duration of Options.  Each particular Option Agreement shall state 
the term of the Option; provided, however, that all Incentive Stock Options 
granted under this Plan shall expire and not be exercisable after the 
expiration of ten (10) years from the date granted; provided, further, that 
any Incentive Stock Option granted to an Employee who owns stock at the time 
the Incentive Stock Option is granted representing more than ten percent 
(10%) of the total combined voting power of all classes of stock of the 
Company and its Affiliates shall expire and not be exercisable after the 
expiration of five (5) years from the date granted.  Non-Statutory Stock 
Options shall expire and not be exercisable after the date set by the Board 
or its delegates in the particular Option Agreement, or on any later date 
subsequently approved by the Board or its delegates.

(f)     Exercise of Options.

        (i)     Each particular Option Agreement shall state when the 
        Optionee's right to purchase Stock pursuant to the terms of an Option 
        are exercisable in whole or in part.  Subject to the earlier 
        termination of the right to exercise the Options as provided under 
        this Plan, Options shall be exercisable in whole or in part as the 
        Board, in its sole and exclusive discretion, may provide in the 
        particular Option Agreement, as amended.  The Board may at any time 
        increase the percentage an Option is otherwise exercisable under the 
        terms of a particular Option Agreement.  The Board, in its sole and 
        exclusive discretion, may permit the issuance of Stock underlying an 
        Option prior to the date the Option is otherwise exercisable, 
        provided such Stock is subject to repurchase rights which expire pro 
        rata as the Option would otherwise have become exercisable.

       (ii)     If the Optionee does not exercise in any one (1) year period 
       the full number of shares to which he or she is then entitled to 
       exercise, the Optionee may exercise those shares in any subsequent 
       year during the term of the Option.

(g)     Transfer of Options.  An attempted non-permitted transfer of an 
Option shall be void.

(h)     Death of Optionee.  If the Optionee who is an Employee, officer or 
Director of the Company or its Affiliates dies while in the employ or service 
of the Company or its Affiliates or within a period of three (3) months after 
termination of such employment or term of corporate office and before he or 
she has fully

                               A-4
exercised an Option, the Option may be exercised, regardless of 
the expiration date stated in the particular Option Agreement (to the extent 
that the Option was exercisable on the date of death and had not previously 
been exercised), for one (1) year after the date of the Optionee's death. 
Such exercise may be made by a personal representative of the Optionee or by 
any person or persons who shall have acquired the Option directly from the 
Optionee by bequest or inheritance.  Notwithstanding the foregoing, an 
Incentive Stock Option may not be exercised after ten (10) years following 
the date of grant.

(i)     Termination of Employment or Service Other than Death.  Subject to 
the provisions of Paragraph 6(h) above, in the event that an Optionee who is 
an Employee, officer or Director of the Company or its Affiliates shall cease 
to be employed by or perform services for the Company or its Affiliates prior 
to the Option's expiration date, the exercise of Options held by such 
Optionee shall be subject to such limitations on the periods of time during 
which such Options may be exercised as may be specified in the particular 
Option Agreement, as amended, between the Optionee and the Company. 
Notwithstanding the foregoing (and subject to the provisions of Paragraph 
6(h) above), an Optionee who is Disabled on the date of termination of 
employment or term of corporate office may exercise his or her Option, to the 
extent that the Option was exercisable on the date of such termination and 
had not previously been exercised, for one (1) year from the date of such 
termination; provided, however, that an Option may not be exercised after the 
expiration date set forth in the particular Option Agreement, as amended. 
Whether authorized leave of absence or absence for military or governmental 
service shall constitute termination of employment for purposes of the Plan 
shall be determined by the Board in their sole and exclusive discretion.  No 
provision of the Plan shall be construed so as to grant any individual the 
right to remain in the employ or service of the Company for any period of 
specific duration.

(j)     Recapitalization. 

        (i)     The number of shares issuable under the Plan and the number 
        and amount of the Option Stock and the Option Price of outstanding 
        Options shall be proportionately adjusted for any increase or 
        decrease in the number of issued shares of Stock resulting from a 
        subdivision or consolidation of shares, or for the payment of a stock 
        dividend, or any other increase or decrease in the number of such 
        shares effected without receipt of consideration by the Company in 
        order to preclude the dilution or enlargement of benefits under the 
        Plan.  

        (ii)     The Board, in its sole and exclusive discretion, may make 
        such equitable adjustments to the Plan and outstanding Options, as it 
        deems appropriate in order to preclude the dilution or enlargement of 
        benefits under the Plan, upon exchange of all of the outstanding 
        stock of the Company for a different class or series of capital stock 
        or the separation of assets of the Company, including a spin-off or 
        other distribution of stock or property by the Company.  

        (iii)     If the Company shall be the surviving corporation in any 
        merger or consolidation, each outstanding Option shall pertain to and 
        apply to the securities to which a holder of the number of shares of 
        Option Stock would have been entitled.  A dissolution or liquidation 
        of the Company, a merger (other than a merger the principal purpose 
        of which is to change the state of the Company's incorporation) or 
        consolidation in which the Company is not the surviving corporation, 
        a reverse merger in which the Company is the surviving corporation 
        but the Company's Common Stock outstanding immediately preceding the 
        merger is converted by virtue of the merger into other property, or 
        other capital reorganization in which more than fifty percent (50%) 
        of the Company's Common Stock is exchanged (unless the dissolution or 
        liquidation plan, merger or consolidation agreement or capital 
        reorganization corporate documents expressly provide to the contrary) 
        shall cause each outstanding Option to terminate, provided, that each 
        Optionee shall, immediately prior to such event, have the right to 
        exercise his or her Option in whole or in part, unless the Option in 
        connection with such event is either to be assumed by the successor 
        corporation or parent thereof, or to be replaced with a comparable 
        option to purchase shares of the capital stock of the successor 
        corporation or parent thereof, or the Option is to be replaced by a 
        comparable cash incentive program of the successor corporation based 
        on the value of the Option on the date of such event. 
        Notwithstanding the preceding, if, within one (1) year from the date 
        of such event, an Employee's employment is involuntarily terminated, 
        then the Employee's outstanding Options, if any, shall become 
        immediately exercisable.  

                               A-5

        (iv)     All adjustments required by the preceding paragraphs shall 
        be made by the Board, whose determination in that respect shall be 
        final, binding and conclusive, provided, that adjustments shall not 
        be made in a manner that causes an Incentive Stock Option to fail to 
        continue to qualify as an "incentive stock option" within the meaning 
        of Code Section 422.

        (v)     Except as expressly provided in this Paragraph 6(j), an 
        Optionee shall have no rights by reason of any subdivision or 
        consolidation of shares of stock of any class, or the payment of any 
        stock dividend, or any other increase in the number of shares of 
        stock of any class by reason of any dissolution, liquidation, merger, 
        consolidation, reorganization, or separation of assets, and any issue 
        by the Company of shares of stock of any class, or securities 
        convertible into shares of stock of any class, shall not affect, and 
        no adjustment by reason thereof shall be made with respect to, the 
        number or amount of the Option Stock or the Option Price of 
        outstanding Options.

        (vi)     The grant or existence of an Option shall not affect in any 
        way the right or power of the Company to make adjustments, 
        reclassifications, reorganizations or changes in its capital or 
        business structure, or to merge, consolidate, dissolve, liquidate, or 
        sell or transfer all or any part of its business or assets.

(k)     Rights as a Shareholder.  An Optionee shall not have rights as a 
shareholder with respect to any shares until the date of the issuance of a 
stock certificate to him or her for such shares.  No adjustment shall be made 
for dividends (ordinary or extraordinary, whether in cash, securities or 
other property) or distributions or other rights for which the record date is 
prior to the date of issuance of such stock certificate, except as provided 
in Paragraph 6(j) above.

(l)     Modification, Extension and Renewal of Options.  Subject to the terms 
and conditions of the Plan, the Board may modify (including lowering the 
Option Price or changing Incentive Stock Options into Non-Statutory Stock 
Options), extend or renew outstanding Options granted under the Plan, or 
accept the surrender of outstanding Options under this Plan and/or other 
stock option plans of the Company (to the extent not previously exercised) 
and authorize the granting of new Options in substitution therefor. 
Notwithstanding the foregoing, no modification of an Option shall, without 
the consent of the Optionee, alter or impair any rights or obligations under 
any Option previously granted under the Plan.

(m)     Investment Purpose.  Each Option under the Plan shall be granted on 
the condition that the purchase of Stock thereunder shall be for investment 
purposes for the Optionee's own account and not with a view to resale or 
distribution.  In the event the Stock subject to such Option is registered 
under the Securities Act of 1933, as amended, or in the event a resale of 
such Stock without such registration would otherwise be permissible, such 
condition shall be inoperative if, in the opinion of counsel for the Company, 
such condition is not required under the Securities Act of 1933, or any other 
applicable law, regulation or rule of any governmental agency.

(n)     Transfer and Exercise of Options.  To the extent required by Code 
Section 422, each Incentive Stock Option shall state that it is not 
transferable or assignable by Optionee otherwise than by will or the laws of 
descent and distribution, and that during an Optionee's lifetime, such 
Incentive Stock Option shall be exercisable only by the Optionee.

(o)     Other Provisions.  Each Option Agreement may contain such other 
provisions, including without limitation, restrictions upon the exercise or 
transferability of the Option, as the Board may deem advisable.  Any 
Incentive Stock Option Agreement shall contain such limitations and 
restrictions upon the exercise of the Incentive Stock Option as shall be 
necessary in order that such Incentive Stock Option shall be an "incentive 
stock option" as defined in Code Section 422, or to conform to any change in 
the law.

(p)     Withholding Taxes.  When the Company becomes required to collect 
federal and state income and employment taxes in connection with the exercise 
of an Option ("withholding taxes"), the Optionee shall promptly pay to the 
Company the amount of such taxes in cash, unless the Board permits or 
requires payment in another form.  Subject to such conditions as it may 
require, the Board, in its sole discretion, may allow an Optionee to 
reimburse the Company for payment of withholding taxes with shares of Stock. 
If an Optionee is a Reporting Person at the time of exercise and is given an 
election to pay any withholding taxes with Stock, the Board shall have sole 
discretion to approve or disapprove such election.

                               A-6

(q)     Limitation on Grants.  The following limitation will apply to grants 
of Options under the Plan: no Employee will be granted Options under the Plan 
to receive more than seven hundred fifty thousand (750,000) shares of Stock 
in any one fiscal year.  The limitation set forth in this Paragraph 6(q) is 
intended to satisfy the requirements applicable to Options intended to 
qualify as "performance-based compensation" within the meaning of Section 
162(m) of the Code.  In the event that such limitation is not required to 
qualify Options as performance-based compensation, this limitation shall not 
apply under the Plan.

7.     Term of Plan.

     Incentive Stock Options may be granted pursuant to the Plan from time to 
time within a period of ten (10) years from the date the Plan is adopted by 
the Board, or the date the Plan is approved by the shareholders of the 
Company, whichever is earlier.

8.     Amendment of Plan.

     With respect to any shares at the time not subject to Options, the Board 
may from time to time, insofar as permitted by law, suspend or discontinue 
the Plan or revise or amend the Plan in any respect whatsoever, except that, 
without approval of the shareholders, no such revision or amendment shall 
change the number of shares for which Options may be granted under the Plan, 
change the designation of the class of persons eligible to receive Options 
under the Plan, materially increase the benefits accruing to Optionees under 
the Plan, or decrease the price at which Incentive Stock Options may be 
granted.  Furthermore, without the approval of the shareholders, the Plan may 
not, be amended in any manner that will cause Incentive Stock Options issued 
under it to fail to meet the requirements of "incentive stock options" as 
defined in Code Section 422.  The Board may amend the Plan from time to time 
to the extent necessary to comply with any applicable law,  rule or other 
regulatory requirement.

9.     Application of Funds.

     The proceeds received by the Company from the sale of Stock pursuant to 
the exercise of an Option will be used for general corporate purposes.

10.     No Obligation to Exercise Option.

     The granting of an Option shall impose no obligation upon the Optionee 
to exercise such Option.

11.     Indemnification.

     In addition to such other rights of indemnification as they may have as 
Directors, Employees or agents of the Company, the Directors, or any 
individuals who are delegated authority by the Board to administer the Plan, 
shall be indemnified by the Company against:  (i) their reasonable expenses, 
including attorneys' fees actually and necessarily incurred in connection 
with the defense of any action, suit or proceeding, or in connection with any 
appeal therein, to which they or any of them may be a party by reason of any 
action taken or failure to act under or in connection with the Plan or any 
Option granted thereunder; and (ii) against all amounts paid by them in 
settlement thereof (provided such settlement is approved by independent legal 
counsel selected by the Company), or paid by them in satisfaction of a 
judgment in any such action, suit or proceeding, except in actions to matters 
as to which it shall be adjudged in such action, suit or proceeding that such 
Director or individual is liable for negligence or misconduct in the 
performance of his duties; this indemnification is expressly conditioned upon 
the indemnified party, within ninety (90) days after institution of any such 
action, suit or proceeding, offering the Company in writing the opportunity, 
at its own expense, to handle and defend the same.

12.     Approval of Shareholders.

     The portions of the Plan dealing with Incentive Stock Options shall not 
take effect unless approved by the shareholders of the Company's preferred 
 (if any) and Common Stock, which approval must occur within a period 
commencing twelve (12) months before and ending twelve (12) months after the 
date the Plan is adopted by the 

                               A-7

Board.  Nothing in the Plan shall be construed to limit the authority of the 
Company to exercise its corporate rights and powers, including the right of 
the Company to grant non-statutory options for proper corporate purposes.


     Adopted by the Board of Directors on August 7, 1996.

                                       AGOURON PHARMACEUTICALS, INC.



                                       By:______________________________
                                          Peter Johnson, President & CEO


                               A-8



                      AGOURON PHARMACEUTICALS, INC.
                     10350 North Torrey Pines Road
                    La Jolla, California  92037-1020
        THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The undersigned hereby appoints Peter Johnson and Gary E. Friedman, and 
each of them, with full power of substitution, as proxies to represent and to 
vote, as designated below, all the shares of common stock of Agouron 
Pharmaceuticals, Inc., held of record by the undersigned on September 24, 
1996, at the Annual Meeting of Shareholders to be held on November 7, 1996 
and at any adjournments or postponements thereof.
     THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED 
HEREIN BY THE UNDERSIGNED SHAREHOLDER.  IF NO OTHER DIRECTION IS MADE, THIS 
PROXY WILL BE VOTED FOR THE ELECTION OF THE DIRECTOR NOMINEES LISTED ON THE 
OTHER SIDE AND FOR PROPOSALS 2 AND 3.  IF CUMULATIVE VOTING PROCEDURES ARE 
INVOKED AT THE MEETING AND THIS PROXY CARD INDICATES "FOR" OR GIVES NO 
DIRECTION ON PROPOSAL 1, THE DESIGNATED PROXIES ARE AUTHORIZED TO DISTRIBUTE 
THE VOTES REPRESENTED BY THIS PROXY IN THEIR DISCRETION SO AS TO ELECT THE 
MAXIMUM NUMBER OF MANAGEMENT NOMINEES WHICH MAY BE ELECTED BY CUMULATIVE 
VOTING.
                           (continued on  reverse side)
                              FOLD AND DETACH HERE   



The Board recommends a vote FOR Proposals 1, 2, and 3.
                                                 FOR ALL          WITHHELD
1.   Proposal 1-                                 NOMINEES         FOR ALL
     ELECTION OF DIRECTORS                        /   /            /   /
     Peter Johnson       Gary E. Friedman
     John N. Abelson     Patricia M. Cloherty
     A. E. Cohen         Michael E. Herman
     Irving S. Johnson   Antonie T. Knoppers
     Melvin I. Simon

     WITHHELD FOR:  (To withhold authority to, write  that nominee's name in 
the space provided below.)

_______________________________________________________________

                                                 FOR      AGAINST    ABSTAIN
2.     Proposal 2-
          APPROVAL OF THE                       /   /      /   /      /   /
          COMPANY'S 1996
          STOCK OPTION PLAN

3.     Proposal 3-
          RATIFICATION OF                      /   /      /   /      /   /
          THE SELECTION OF 
          INDEPENDENT
          ACCOUNTANTS

4.     IN THEIR DISCRETION, THE PROXIES ARE AUTHORIZED TO VOTE UPON SUCH 
OTHER BUSINESS AS MAY PROPERLY COME BEFORE  THE MEETING.

Signature(s)___________________________________  Date ______________________
NOTE:  Please sign as name appears hereon.  Joint owners should each sign. 
When signing as attorney, executor, administrator, trustee or guardian, 
please give full title as such.

                             FOLD AND DETACH HERE