Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM


We consent to the incorporation by reference in the following
Registration Statements:

1) Registration Statement (Form S-3 No. 33-88972), of A.P. Pharma,
Inc.,
2) Registration Statement (Form S-3 No. 333-00759), of A.P. Pharma,
Inc.,
3) Registration Statement (Form S-3 No. 333-042527), of A.P. Pharma,
Inc.,
4) Registration Statement (Form S-3 No. 333-69815), of A.P. Pharma,
Inc.,
5) Registration Statement (Form S-3 No. 333-115163), of A.P. Pharma,
Inc.,
6) Registration Statement (Form S-8 No. 333-06841), pertaining to the
1992 Stock Plan of A.P. Pharma, Inc.,
7) Registration Statement (Form S-8 No. 333-60585), pertaining to the
1992 Stock Plan of A.P. Pharma, Inc.,
8) Registration Statement (Form S-8 No. 333-35151), pertaining to the
1997 Employee Stock Purchase Plan of A.P. Pharma, Inc.,
9) Registration Statement (Form S-8 No. 333-90428), pertaining to the
2002 Equity Incentive Plan and Non-Qualified Stock Option Plan of A.P.
Pharma, Inc., and
10) Registration Statement (Form S-8 No. 333-118546), pertaining to the
2002 Equity Incentive Plan and 1997 Employee Stock Purchase Plan of
A.P. Pharma, Inc.;

of our reports dated March 11, 2005 with respect to the consolidated
financial statements and schedule of A.P. Pharma, Inc., A.P. Pharma,
Inc. management's assessment of the effectiveness of internal control
over financial reporting, and the effectiveness of internal control
over financial reporting of A.P. Pharma, Inc., included in this Annual
Report (Form 10-K) for the year ended December 31, 2004.





                                   /s/ERNST & YOUNG LLP

Palo Alto, California
March 11, 2005