Appendix B

                      ADVANCED POLYMER SYSTEMS, INC.

                    1997 EMPLOYEE STOCK PURCHASE PLAN


	 1.	PURPOSE.  This Advanced Polymer Systems, Inc. 1997 Employee Stock
Purchase Plan is designed to encourage and assist employees of Advanced
Polymer Systems, Inc. and participating subsidiaries to acquire an equity
interest in the Company through the purchase of shares of Company common
stock.

	 2.	DEFINITIONS.  As used herein, the following definitions shall
apply:

		(a)	"Administrator" shall mean the entity, either the Board or
the committee of the Board, responsible for administering this Plan, as
provided in Section 3.

		(b)	"Board" shall mean the Board of Directors of the Company, as
constituted from time to time.

		(c)	"Code" shall mean the Internal Revenue Code of 1986, as
amended from time to time, and any successor statute.

		(d)	"Company" shall mean Advanced Polymer Systems, Inc., a
Delaware corporation, and Participating Subsidiaries.

		(e)	"Common Stock" shall mean the Common Stock, $.01 par value,
of the Company.

		(f)	"Employee" shall mean any individual who is an employee of
the Company or a Participating Subsidiary within the meaning of Section
3401(c) of the Code and the Treasury Regulations thereunder.

		(g)	"Enrollment Date" shall have the meaning set forth in
Section 6.

		(h)	"Fair market value" means as of any given date:  (i) the
closing price of the Common Stock on the Nasdaq National Market as reported in
the Wall Street Journal; or (ii) if the Common Stock is no longer quoted on
the Nasdaq National Market, but is listed on an established stock exchange or
quoted on any other established interdealer quotation system, the closing
price for the Common Stock on such exchange or system, as reported in the Wall
Street Journal; or (iii) in the absence of an established market for the
Common Stock, the fair market value of the Common Stock as determined by the
Administrator in good faith.

		(i)	"Lower Price Enrollment Date" shall have the meaning set
forth in Section 6.

		(j)	"Option Period" shall have the meaning set forth in Section
7(b).

		(k)	"Participating Subsidiary" shall mean a Subsidiary which has
been designated by the Administrator as covered by the Plan.

		(l)	"Plan" shall mean this Advanced Polymer Systems, Inc. 1997
Employee Stock Purchase Plan, as it may be amended from time to time.

		(m)	"Purchase Date" shall have the meaning set forth in Section
9(a).

		(n)	"Section" unless the context clearly indicates otherwise,
shall refer to a Section of this Plan.

		(o)	"Subsidiary" shall mean a "subsidiary corporation" of the
Company, whether now or hereafter existing, within the meaning of Section
424(f) of the Code, but only for so long as it is a "subsidiary corporation."

		(p)	"Trading Day" means any day on which regular trading occurs
on any established stock exchange or market system on which the Common Stock
is traded.

	 3.	ADMINISTRATION.

		(a)	Administrator.  The Plan shall be administered by the Board
or, upon delegation by the Board, by a committee of the Board (in either case,
the "Administrator").  In connection with the administration of the Plan, the
Administrator shall have the powers possessed by the Board.  The Administrator
may act only by a majority of its members.  The Administrator may delegate
administrative duties to such employees of the Company as it deems proper, so
long as such delegation is not otherwise prohibited by Rule 16b-3 under the
Securities Exchange Act of 1934, as amended, or other applicable law.  The
Board at any time may terminate the authority delegated to any committee of
the Board pursuant to this Section 3(a) and revest in the Board the
administration of the Plan.

		(b)	Administrator Determinations Binding.  The Administrator may
adopt, alter and repeal administrative rules, guidelines and practices
governing the Plan and the options granted under it as it shall deem advisable
from time to time, may interpret the terms and provisions of the Plan and the
Options granted under it, may correct any defect, omission or inconsistency in
the Plan or in any Option; and may otherwise supervise the administration of
the Plan and the Options granted under it.  The Administrator may establish,
under guidelines from the Board, limits on the number of shares which may be
purchased by each participant on an annual or other periodic basis or on the
number of shares which may be purchased on any Purchase Date.  All decisions
made by the Administrator under the Plan shall be binding on all persons,
including the Company and all participants in the Plan.  No member of the
Administrator shall be liable for any action that he or she has in good faith
taken or failed to take with respect to this Plan.

	 4.	NUMBER OF SHARES.

		(a)	The Company has reserved for sale under the Plan 650,000
shares of Common Stock.  Shares sold under the Plan may be newly issued shares
or shares reacquired in private transactions or open market purchases, but all
shares sold under the Plan, regardless of source, shall be counted against the
650,000 share limitation.  If at any Purchase Date, the shares available under
the Plan are less than the number all participants would otherwise be entitled
to purchase on such date, purchases shall be reduced proportionately to
eliminate the deficit.  If, at any Purchase Date, the shares which may be
purchased by a participant are restricted on account of a limit on the
aggregate shares which may be purchased per employee, purchases under each
option shall be reduced proportionately.  Any funds that cannot be applied to
the purchase of shares due to such reductions shall be refunded to
participants as soon as administratively feasible.

		(b)	In the event of any reorganization, recapitalization, stock
split, reverse stock split, stock dividend, combination of shares, merger,
consolidation, offering of rights, or other similar change in the capital
structure of the Company, the Board may make such adjustment, if any, as it
deems appropriate in the number, kind, and purchase price of the shares
available for purchase under the Plan and in the maximum number of shares
subject to any option under the Plan.

	 5.	ELIGIBILITY REQUIREMENTS.

		(a)	Each Employee of the Company, except those described in the
next paragraph, shall become eligible to participate in the Plan in accordance
with Section 6 on the first Enrollment Date on or following commencement of
his or her employment by the Company or following such period of employment as
is designated by the Administrator from time to time.  Participation in the
Plan is entirely voluntary.

		(b)	The following Employees are not eligible to participate in
the Plan:

			   (i)	Employees who would, immediately upon enrollment
in the Plan, own directly or indirectly, or hold options or rights to acquire
stock possessing, five percent (5%) or more of the total combined voting power
or value of all classes of stock of the Company or any subsidiary of the
Company; and

			  (ii)	Employees who are customarily employed by the
Company fewer than twenty (20) hours per week or fewer than five (5) months in
any calendar year.

	 6.	ENROLLMENT.  Any eligible employee may enroll or re-enroll in the
Plan each year as of the close of the first trading day of:  (a) May and
November of each such year; or (b) such other days as may be established by
the Board from time to time (the "Enrollment Dates"); provided, that the first
Enrollment Date shall be April 30, 1997.  In order to enroll, an eligible
employee must complete, sign, and submit to the Company an enrollment form.
Any enrollment form received by the Company by the 20th day of the month
preceding an Enrollment Date (or by the Enrollment Date in the case of
employees hired after such 20th day or in the case of the first Enrollment
Date), or such other date established by the Administrator from time to time,
will be effective on that Enrollment Date.  In addition, the Administrator may
re-enroll existing participants in the Plan on any Enrollment Date (the "Lower
Price Enrollment Date") on which the fair market value of the Common Stock is
lower than the fair market value on such participant's existing Enrollment
Date.  A participant may elect not to re-enroll on a Lower Price Enrollment
Date by filing a written statement with the Company declaring such election
prior to the Lower Price Enrollment Date.

	 7.	GRANT OF OPTION ENROLLMENT.

		(a)	Enrollment or re-enrollment by a participant in the Plan on
an Enrollment Date will constitute the grant by the Company to the participant
of an option to purchase shares of Common Stock from the Company under the
Plan.  Any participant whose option expires and who has not withdrawn from the
Plan will automatically be re-enrolled in the Plan and granted a new option on
the Enrollment Date immediately following the date on which the option
expires.

		(b)	Except as provided in Section 10, each option granted under
the Plan shall have the following terms:

			   (i)	the option will have a term of not more than
twenty-four (24) months or such shorter option period as may be established by
the Board from time to time (the "Option Period"). Notwithstanding the
foregoing, however, whether or not all shares have been purchased thereunder,
the option will expire on the earlier to occur of:  (A) the completion of the
purchase of shares on the last Purchase Date occurring within twenty-four (24)
months after the Enrollment Date for such option, or such shorter option
period as may be established by the Board before an Enrollment Date for all
options to be granted on such date; or (B) the date on which the employee's
participation in the Plan terminates for any reason;

			  (ii)	payment for shares purchased under the option
will be made only through payroll withholding in accordance with Section 8;

			 (iii)	purchase of shares upon exercise of the option
will be effected only on the Purchase Dates established in accordance with
Section 9;

			  (iv)	the option, if not altered, amended or revoked
by the Company prior to the relevant Purchase Date, may be accepted only by
(x) there having been withheld from the compensation of the employee in
accordance with the terms of the Plan amounts sufficient to purchase the
Common Stock intended to be purchased under the option, and (y) the employee
being employed by the Company and not having withdrawn from the Plan on the
relevant Purchase Date.

			   (v)	the price per share under the option will be
determined as provided in Section 9;

			  (vi)	the maximum number of shares available for
purchase under an option for each one percent (1%) of compensation designated
by an employee in accordance with Section 8 will, unless otherwise established
by the Board before an Enrollment Date for all options to be granted on such
date, be determined by dividing $25,000 by the fair market value of a share of
Common Stock on the Enrollment Date, dividing the result by the maximum number
of percentage points that an employee may designate under Section 8 at the
time such option is granted, and multiplying the result by the number of
calendar years included in whole or in part in the period from grant to
expiration of the option;

			 (vii)	the option (taken together with all other
options then outstanding under this and all other similar stock purchase plans
of the Company and any subsidiary of the Company, collectively "Options") will
in no event give the participant the right to purchase shares at a rate per
calendar year which accrues in excess of $25,000 of fair market value of such
shares, less the fair market value of any shares accrued and already purchased
during such year under Options which have expired or terminated, determined at
the applicable Enrollment Dates; and

			(viii)	the option will in all respects be subject to
the terms and conditions of the Plan, as interpreted by the Administrator from
time to time.

	 8.	PAYROLL AND TAX WITHHOLDING; USE BY COMPANY.

		(a)	Each participant shall elect to have amounts withheld from
his or her compensation paid by the Company during the Option Period, at a
rate equal to any whole percentage up to a maximum of ten percent (10%), or
such lesser percentage as the Board may establish from time to time before an
Enrollment Date. Compensation includes regular salary payments, annual and
quarterly bonuses, hire-on bonuses, cash recognition awards, commissions,
overtime pay, shift premiums, and elective contributions by the participant to
qualified employee benefit plans, but excludes all other payments including,
without limitation, long-term disability or workers compensation payments, car
allowances, employee referral bonuses, relocation payments, expense
reimbursements (including but not limited to travel, entertainment, and moving
expenses), salary gross-up payments, and non-cash recognition awards.  The
participant shall designate a rate of withholding in his or her enrollment
form and may elect to increase or decrease the rate of contribution effective
as of any Enrollment Date, by delivery to the Company, not later than ten (10)
days before such Enrollment Date, of a written notice indicating the revised
withholding rate.

		(b)	Payroll withholdings shall be credited to an account
maintained for purposes of the Plan on behalf of each participant, as soon as
administratively feasible after the withholding occurs.  The Company shall be
entitled to use the withholdings for any corporate purpose, shall have no
obligation to pay interest on withholdings to any participant, and shall not
be obligated to segregate withholdings.

		(c)	Upon disposition of shares acquired by exercise of an
option, the participant shall pay, or make provision adequate to the Company
for payment of, all federal, state, and other tax (and similar) withholdings
that the Company determines, in its discretion, are required due to the
disposition, including any such withholding that the Company determines in its
discretion is necessary to allow the Company to claim tax deductions or other
benefits in connection with the disposition.  A participant shall make such
similar provisions for payment that the Company determines, in its discretion,
are required due to the exercise of an option, including such provisions as
are necessary to allow the Company to claim tax deductions or other benefits
in connection with the exercise of the option.

	 9.	PURCHASE OF SHARES.

		(a)	On the last Trading Day immediately preceding an Enrollment
Date (other than the first Enrollment Date), or on such other days as may be
established by the Board from time to time prior to an Enrollment Date for all
options to be granted on such Enrollment Date (each a "Purchase Date"), the
Company shall apply the funds then credited to each participant's payroll
withholdings account to the purchase of whole shares of Common Stock.  The
cost to the participant for the shares purchased under any option shall be not
less than eighty-five percent (85%) of the lower of:

			   (i)	the fair market value of the Common Stock on the
Enrollment Date for such option; or

			  (ii)	the fair market value of the Common Stock on the
date such option is exercised.

		(b)	Any funds in an amount less than the cost of one share of
Common Stock left in a participant's payroll withholdings account on a
Purchase Date shall be carried forward in such account for application on the
next Purchase Date.

		(c)	Notwithstanding the terms of Section 9(a), no funds credited
to any employee's payroll withholdings account shall be used to purchase
Common Stock on any date prior to the date that the Plan has been approved by
the stockholders of the Company, as noted in Section 21.  If such approval is
not forthcoming within one year from the date that the Plan was approved by
the Board of Directors, all amounts withheld shall be distributed to the
participants as soon as administratively feasible.

	10.	WITHDRAWAL FROM THE PLAN.  A participant may withdraw from the
Plan in full (but not in part) at any time, effective after written notice
thereof is received by the Company.  Unless the Administrator elects to permit
a withdrawing participant to invest funds credited to his or her withholding
account on the Purchase Date immediately following notice of withdrawal, all
funds credited to a participant's payroll withholdings account shall be
distributed to him or her without interest within sixty (60) days after notice
of withdrawal is received by the Company.  Any eligible employee who has
withdrawn from the Plan may enroll in the Plan again on any subsequent
Enrollment Date in accordance with the provisions of Section 6.

	11.	TERMINATION OF EMPLOYMENT.  Participation in the Plan terminates
immediately when a participant ceases to be employed by the Company for any
reason whatsoever (including death or disability) or otherwise becomes
ineligible to participate in the Plan.  As soon as administratively feasible
after termination, the Company shall pay to the participant or his or her
beneficiary or legal representative, all amounts credited to the participant's
payroll withholdings account; provided, however, that if a participant ceases
to be employed by the Company because of the commencement of employment with a
Subsidiary of the Company that is not a Participating Subsidiary, funds then
credited to such participant's payroll withholdings account shall be applied
to the purchase of whole shares of Common Stock at the next Purchase Date and
any funds remaining after such purchase shall be paid to the participant.

	12.	DESIGNATION OF BENEFICIARY.

		(a)	Each participant may designate one or more beneficiaries in
the event of death and may, in his or her sole discretion, change such
designation at any time.  Any such designation shall be effective upon receipt
in written form by the Company and shall control over any disposition by will
or otherwise.

		(b)	As soon as administratively feasible after the death of a
participant, amounts credited to his or her account shall be paid in cash to
the designated beneficiaries or, in the absence of a designation, to the
executor, administrator, or other legal representative of the participant's
estate.  Such payment shall relieve the Company of further liability with
respect to the Plan on account of the deceased participant.  If more than one
beneficiary is designated, each beneficiary shall receive an equal portion of
the account unless the participant has given express contrary written
instructions.

	13.	ASSIGNMENT.

		(a)	The rights of a participant under the Plan shall not be
assignable by such participant, by operation of law or otherwise.  No
participant may create a lien on any funds, securities, rights, or other
property held by the Company for the account of the participant under the
Plan, except to the extent that there has been a designation of beneficiaries
in accordance with the Plan, and except to the extent permitted by the laws of
descent and distribution if beneficiaries have not been designated.

		(b)	A participant's right to purchase shares under the Plan
shall be exercisable only during the participant's lifetime and only by him or
her, except that a participant may direct the Company in the enrollment form
to issue share certificates to the participant and his or her spouse in
community property, to the participant jointly with one or more other persons
with right of survivorship, or to certain forms of trusts approved by the
Administrator.

	14.	ADMINISTRATIVE ASSISTANCE.  If the Administrator in its discretion
so elects, it may retain a brokerage firm, bank, or other financial
institution to assist in the purchase of shares, delivery of reports, or other
administrative aspects of the Plan.  If the Administrator so elects, each
participant shall (unless prohibited by the laws of the nation of his or her
employment or residence) be deemed upon enrollment in the Plan to have
authorized the establishment of an account on his or her behalf at such
institution.  Shares purchased by a participant under the Plan shall be held
in the account in the name in which the share certificate would otherwise be
issued pursuant to Section 13(b).

	15.	COSTS.  All costs and expenses incurred in administering the Plan
shall be paid by the Company, except that any stamp duties or transfer taxes
applicable to participation in the Plan may be charged to the account of such
participant by the Company.  Any brokerage fees for the purchase of shares by
a participant shall be paid by the Company, but brokerage fees for the resale
of shares by a participant shall be borne by the participant.

	16.	EQUAL RIGHTS AND PRIVILEGES.  All eligible employees shall have
equal rights and privileges with respect to the Plan so that the Plan
qualifies as an "employee stock purchase plan" within the meaning of Section
423 of the Code and the related Treasury Regulations.  Any provision of the
Plan which is inconsistent with Section 423 of the Code shall without further
act or amendment by the Company or the Board be reformed to comply with the
requirements of Section 423.  This Section 16 shall take precedence over all
other provisions of the Plan.

	17.	APPLICABLE LAW.  The Plan shall be governed by the substantive
laws (excluding the conflict of laws rules) of the State of California.

	18.	MODIFICATION AND TERMINATION.

		(a)	The Board may amend, alter, or terminate the Plan at any
time, including amendments to outstanding options.  No amendment shall require
stockholder approval, except:

			   (i)	for an increase in the number of shares reserved
for purchase under the Plan;

			  (ii)	to the extent required for the Plan to comply
with Section 423 of the Code;

			 (iii)	to the extent required by other applicable laws,
regulations or rules; or

			  (iv)	to the extent the Board otherwise concludes that
stockholder approval is advisable.

		(b)	In the event the Plan is terminated, the Board may elect to
terminate all outstanding options either immediately or upon completion of the
purchase of shares on the next Purchase Date, or may elect to permit options
to expire in accordance with their terms (and participation to continue
through such expiration dates).  If the options are terminated prior to
expiration, all funds contributed to the Plan that have not been used to
purchase shares shall be returned to the participants as soon as
administratively feasible.

		(c)	In the event of the sale of all or substantially all of the
assets of the Company, or the merger of the Company with or into another
corporation, or the dissolution or liquidation of the Company, each option
outstanding under the Plan shall be assumed by any purchaser of all or
substantially all of the assets of the Company or by a successor by merger to
the Company (or the parent company of such purchaser or successor) in
compliance with Section 424 of the Code, unless otherwise provided by the
Board in its sole discretion, in which event, a Purchase Date shall occur
immediately before the effective date of such event.

	19.	RIGHTS AS AN EMPLOYEE.  Nothing in the Plan shall be construed to
give any person the right to remain in the employ of the Company or to affect
the Company's right to terminate the employment of any person at any time with
or without cause.

	20.	RIGHTS AS A SHAREHOLDER; DELIVERY OF CERTIFICATES.  Unless
otherwise determined by the Board, certificates evidencing shares purchased on
any Purchase Date shall be delivered to a participant only if he or she makes
a written request to the Administrator.  Participants shall be treated as the
owners of their shares effective as of the Purchase Date.

	21.	BOARD AND SHAREHOLDER APPROVAL.  The Plan was approved by the
Board of Directors on March 5, 1997, and by the holders of a majority of the
votes cast at a duly held shareholders' meeting on June 18, 1997, at which a
quorum of the voting power of the Company was represented in person or by
proxy.

Amended by the Board on:  March 25, 2004
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Approved by the stockholders on:  May 25, 2004
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Effective date of this Plan:  May 25, 2004
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Amended by the Board on:  January 11, 2005
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Approved by the stockholders on:
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Effective date of this Plan:
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