EMPLOYMENT AGREEMENT
                             --------------------

THIS EMPLOYMENT AGREEMENT (the "Agreement") is made and entered into 
effective May 1, 1993 ("Effective Date") by and between ADVANCED POLYMER 
SYSTEMS, INC., a Delaware corporation, ("Corporation") and JOHN J. MEAKEM 
("Officer").

                                R E C I T A L
                                -------------

Corporation desires to employ officer as its President and Chief Executive 
Officer, and Officer is willing to accept such employment by Corporation, on 
the terms and subject to the conditions set forth in this Agreement.

                              A G R E E M E N T
                              -----------------

THE PARTIES AGREE AS FOLLOWS:

1.  DUTIES.
    ------
    1.1  POSITION.  Officer agrees to be employed by and to serve Corporation 
as its President and Chief Executive Officer during the term hereof, and 
Corporation agrees to employ and retain Officer in such capacities during the 
term hereof.  Officer shall devote his best efforts to the performance of his 
duties hereunder.  Officer shall have powers and duties commensurate with his 
positions as President and Chief Executive officer, and shall have 
appropriate office and secretarial assistance as necessary to perform such 
duties.  Officer shall not undertake other business activities during the 
term of his employment without the consent of the Board of Directors of 
Corporation.
    1.2  BOARD MEMBER.  So long as Officer is serving as its President and 
Chief Executive officer, Corporation shall cause Officer to be nominated for 
election as a Director at each annual meeting of Corporation's stockholders.
2.  EMPLOYMENT.
    ----------
    2.1  DEFINITION.  For purposes of this Agreement, "Termination for Cause" 
shall mean termination by Corporation of Officer's employment by Corporation 
by reason of Officer's dishonesty or fraud, or deliberate material injury or 
attempted material injury to Corporation, or by reason of Officer's material 
breach of this Agreement.
    2.2  TERM OF EMPLOYMENT.  Unless terminated earlier pursuant to this 
Section 2, the term of employment of Officer by Corporation shall be for a 
period of three years from the Effective Date.
    2.3  TERMINATION FOR CAUSE.  Termination for Cause may be effected by 
Corporation at any time by notice to Officer.  Upon a Termination for Cause, 
Corporation shall immediately pay to Officer any accrued salary, any other 
compensation to the extent earned, any benefits under any plans of 
Corporation in which Officer is a participant to the full extent of Officer's 
rights under such plans, any accrued vacation pay and any appropriate 
business expenses incurred by Officer in connection with his duties 
hereunder, all to the date of termination, but Officer shall not be paid any 
other compensation or reimbursement of any kind, including without 
limitation, severance compensation.
    2.4  DEATH; TERMINATION BY REASON OF DISABILITY.  In the event of 
Officer's death during the term of this Agreement, Officer's employment shall 
be deemed to have terminated as of the last day of the month during which his 
death occurs.  If officer, in the reasonable judgment of the Board of 
Directors of Corporation, has failed to perform his duties under this 
Agreement on account of illness or physical or mental incapacity and such 
illness or incapacity continues for a period of more than six consecutive 
months, Corporation shall have the right to terminate Officer's employment 
hereunder as of the last day of any month thereafter by notice to Officer.  
In either such event, Corporation shall pay to Officer or his estate, as the 
case may be, any accrued salary, any other compensation to the extent earned, 
any benefits under any plans of corporation in which Officer is a participant 
to the full extent of Officer's rights under such plans, any accrued vacation 
pay and any appropriate business expenses incurred by officer in connection 
with his duties hereunder, all to the date of termination, but no other 
compensation or reimbursement of any kind, except for any disability payments 
and benefits payable to Officer, under any disability plans then maintained 
by Corporation, up to the balance of the original three year term hereof.
3.  SALARY, OPTIONS AND BENEFITS.
    3.1  SALARY.  As payment for the services to be rendered by Officer as 
provided in Section 1 and subject to the terms and conditions of Section 2, 
Corporation agrees to pay to Officer a Salary at the rate of $285,000 per 
annum payable in equal semi-monthly installments, which salary shall be 
subject to annual review for consideration of any increase thereto. 
    3.2  ADDITIONAL BENEFITS.  During his term of employment, officer shall 
be entitled to the following benefits:
         3.2.1  BENEFIT PLANS.  Officer shall be eligible to participate in 
all benefit plans generally available to the senior management of 
Corporation, including such health and disability coverage and life insurance 
as is available from time to time, and any incentive plans adopted by 
Corporation.
         3.2.2  STOCK OPTION.  Corporation shall grant to officer incentive 
and nonstatutory options in the Company's usual form to acquire 150,000 
shares of Corporation's Common Stock, vesting in equal monthly installments 
over a period of three years, and to represent his total option awards for 
the period of the contract except as may be otherwise determined by the 
directors and except for a special 25,000 option grant attributable to the 
Premier, Inc. merger.
4.  CHANGE IN CONTROL OR EMPLOYMENT POSITION.
    4.1  TERMINATION BY EMPLOYEE ON CHANGE IN CONTROL.  In the event of a 
Change in Control (as defined herein) during the term of this Agreement, 
Officer shall be entitled to terminate his employment and receive Termination 
Benefits.  Said termination shall occur immediately upon officer providing 
notice to Corporation of such termination, which notice shall be given not 
later than ninety days after officer receives from Corporation notice of 
Change in Control.
    4.2  TERMINATION BY CORPORATION ON CHANGE IN CONTROL.  In the event of 
such Change in Control, Corporation shall be entitled to terminate Officer's 
employment.  Upon such termination, officer shall receive Extended 
Termination Benefits.  Said termination shall occur immediately upon 
Corporation providing notice to officer of such termination, which notice 
shall be given not later than sixty days after a Change in Control.
    4.3  CHANGE IN EMPLOYMENT POSITION.  If, at any time subsequent to a 
Change in Control and during the term of this Agreement, Officer is not re-
elected to or is removed from office as the chief executive officer of 
Corporation, or Officer's position as chief executive office of Corporation 
is reduced in terms of responsibility of indicia of status (collectively, a 
"Change of Employment Position") then Officer shall have the option to 
terminate this Agreement.  Such termination, if elected by Officer, shall be 
effective sixty days after officer has given written notice to Corporation of 
Officer's intention to terminate.  Upon such termination, Officer shall 
receive Extended Termination Benefits, determined as of the Termination Date 
rather than the date of Change of Control
    4.4  NOTICE OF CHANGE IN CONTROL.  Corporation shall give written notice 
of a Change in Control to Officer within five days of such event.
    4.5  DEFINITIONS.  For purposes of this Agreement, the following terms 
shall have the meanings assigned to them below:
         4.5.1  "CHANGE IN CONTROL" shall mean each of the following events:
                (i) The acquisition after the date hereof by any person as 
defined in Section 13(d) or 14(d)(2) of the Securities Exchange Act of the 
United States of America of more than fifty percent of the issued and 
outstanding shares of stock of Corporation.  A person shall not be deemed to 
have acquired stock merely because such person has been designated as a 
fiduciary or because such person has received upon distribution of any trust 
or estate or otherwise, as a result of the death of a prior stockholder, 
shares of stock; or
                (ii) The merger of Corporation with or into another 
corporation or consolidation into another corporation, and as a result 
thereof the stockholders of Corporation receive equity securities having less 
than fifty percent of the voting power of all securities issued by such 
corporation; or 
                (iii) The sale by Corporation of substantially all of the 
stock, business operations or assets of Corporation to an unrelated person 
not directly or indirectly controlled by Corporation's stockholders 
immediately prior to such transfer.
         4.5.2  "TERMINATION DATE" shall mean the last day officer is 
employed by Corporation or its successor.
         4.5.3  "TERMINATION BENEFITS" shall mean the amount of salary and 
bonuses paid to or for the benefit of Officer or otherwise earned by officer 
in accordance with the provisions of Section 3 hereof during the twelve-month 
period immediately preceding the Change in Control.  In the event that the 
Change in Control shall occur prior to one year from the date of this 
Agreement, Termination Benefits shall be the amount which Officer would have 
received during the initial twelve months of this Agreement.  Corporation, or 
its successor, shall pay the Termination Benefits to Officer for the twelve-
month period commencing on the Termination Date.  Said amounts, and benefits, 
shall be paid in the same manner as Officer received such amounts and 
benefits during employment.
         4.5.4  "EXTENDED TERMINATION BENEFITS" shall mean an amount equal to 
twice the Termination Benefits and shall be payable by Corporation, or its 
successor, one-half on the Termination Date and the remaining one-half on the 
first anniversary of the Termination Date.
    4.6  MITIGATION.  Officer shall not be required to mitigate the amount of 
any payment provided for in this Section by seeking other employment or 
otherwise, and the amount payable hereunder shall be payable even after he 
has taken other employment.
5.  NONCOMPETITION.
    During the time Officer is employed by corporation and for any additional 
period during which Corporation continues to pay to Officer the full 
compensation payable under the provisions of this Agreement (but not 
including Extended Termination Benefits as defined in Section 4.5.4), officer 
shall not, directly or indirectly, by way of ownership, management or 
otherwise, whether or not for compensation, either as a consultant, employer, 
employee, agent, principal, partner, stockholder (other than ownership of 
less than five percent of the outstanding capital stock of a publicly traded 
corporation), officer, director or in any other representative or individual 
capacity, engage in any activity competitive with Corporation or, directly or 
indirectly, solicit or hire to engage in any such business any person who is 
then or was within one year prior thereto an employee of Corporation.
6.  MISCELLANEOUS.
    6.1  CONFIDENTIALITY.   Officer recognizes that he now has knowledge of 
and will hereafter gain further knowledge of confidential information, trade 
secrets, confidential processes, and confidential "know-how" relating to, or 
concerned with the past, present or future business, finances, products, 
services and policies of Corporation (collectively, "Proprietary 
Information").  Officer agrees that all Proprietary Information shall be kept 
and treated by officer as confidential both during and after Officer's 
employment by Corporation, and that Officer will not, directly or indirectly, 
use, divulge, furnish or make accessible such information to any other person 
or entity (other than as required in the performance of his services 
hereunder), except as may be permitted in writing by Corporation's Board of 
Directors or as to such information: (i) as is within the public domain or 
comes within the public domain without any breach of this Agreement by 
Officer; (ii) which is subsequently disclosed to Officer by a third party not 
bound to keep such information confidential; or (iii) as is known to officer 
prior to his employment by Corporation and which was not disclosed to officer 
by Corporation or any affiliate or agent of Corporation.
    6.2  WAIVER.  The waiver of the breach of any provision of this Agreement 
shall not operate or be construed as a waiver of any subsequent breach of the 
same or other provision hereof.
    6.3  ENTIRE AGREEMENT; MODIFICATIONS.  Except as otherwise provided 
herein, this Agreement represents the entire understanding among the parties 
with respect to the subject matter hereof, and this Agreement supersedes any 
and all prior understandings, agreements, plans and negotiations, whether 
written or oral, with respect to the subject matter hereof, including without 
limitation, any understandings, agreements or obligations respecting any past 
or future compensation, bonuses, reimbursements or other payments to Officer 
from Corporation.  All modifications to the Agreement must be in writing and 
signed by the party against whom enforcement of such modification is sought.
    6.4  NOTICES.  All notices and other communications under this Agreement 
shall be in writing and shall be given by a nationally recognized overnight 
air courier service or first class mail, certified or registered with return 
receipt requested, and shall be deemed to have been duly given three days 
after mailing or one day after delivery to a nationally recognized overnight 
air courier service to the respective persons named below:
         If to Corporation:  Advanced Polymer Systems, Inc.
                             3696 Haven Avenue
                             Redwood City, California 94063
                             Attn: Vice President - Finance

          If to Officer:     John J. Meakem, Jr.
                             Armonk, N.Y.
Either party may change such party's address for notices by notice duly given 
pursuant to this Section 6.4.
    6.5  GOVERNING LAW; ARBITRATION.  This Agreement shall be governed by and 
construed in accordance with the laws of the State of California applicable 
to contracts entered into and wholly to be performed within the State of 
California by California residents.  All disputes, controversies or claims 
arising out of or related to: (i) the interpretation or enforcement of this 
Agreement; or (ii) any breach, termination or claim or invalidity of this 
Agreement shall be settled finally and without resort to any legal 
proceedings (except for the enforcement of the arbitration award) by 
arbitration conducted in accordance with the provisions of this Section 6.5.
Notwithstanding the foregoing, the remedy at law for any breach of the 
provisions of this Section 6.5 is acknowledged by the parties to be 
inadequate, and an aggrieved party seeking relief or remedies for such a 
breach shall have the right and is hereby granted the privilege, in addition 
to all other remedies at law or in equity, to temporary or permanent 
injunctive relief without the necessity or providing actual damage.  
Arbitrations under this Section 6.5 shall be conducted before a single 
arbitrator in accordance with the Commercial Arbitration Rules of the 
American Arbitration Association in San Francisco, California.  All decisions 
of the arbitrator resolving disputes, controversies, or claims shall he final 
and binding upon the parties both as to law and to fact and shall be 
enforceable at law or in equity by any court of competent jurisdiction.  Once 
an issue has been arbitrated pursuant hereto, the decision of the arbitrator 
shall be RES JUDICATA with respect to such issue.  The parties shall take 
whatever steps may be necessary to have the decision of the arbitrator 
carried out.  The parties shall cooperate with each other in causing the 
arbitration to be held in as efficient and expeditious a manner as 
practicable and in this connection to furnish such documents and make 
available themselves and such personnel as the arbitrator may request.  All 
fees and expenses attributable to the conduct of arbitration pursuant to this 
Section 6.5 shall be shared equally by the parties to the arbitration; 
PROVIDED, HOWEVER, that each party to the arbitration shall bear its own 
expenses (including but not limited to legal expenses).  Officer agrees that 
service upon Officer in any such action may be made by first class mail, 
certified or registered, in the manner provided for delivery of notices in 
Section 6.4.
    6.6  SEVERABILITY.  Should a court or other body of competent 
jurisdiction determine that any provision of this Agreement is excessive in 
scope or otherwise invalid or unenforceable, such provision shall be adjusted 
rather than voided, if possible, so that it is enforceable to the maximum 
extent possible, and all other provisions of this Agreement shall be deemed 
valid and enforceable to the extent possible.
    6.7  ASSIGNMENT.  This Agreement shall be binding upon and inure to the 
benefit of the executors, administrators, heirs, successors and assigns of 
the parties; provided, however, that except as herein expressly provided, 
this Agreement shall not be assignable either by Corporation (except to an 
affiliate of Corporation) or by Officer.  If this Agreement is assigned by 
Corporation, then Corporation shall remain primarily liable to Officer for 
the payment of all amounts due officer from Corporation under this Agreement.
    6.8  COUNTERPARTS.  This Agreement may be executed in one or more 
counterparts, all of which taken together shall constitute one and the same 
Agreement.
    6.9  WITHHOLDINGS.  All compensation and benefits to Officer hereunder 
shall be reduced by all federal, state, local and other withholdings and 
similar taxes and payments required by applicable law.
    IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of 
the day and year first above written.

                                            Corporation:

                                            ADVANCED POLYMER SYSTEMS, INC.

                                            By: /S/ Michael O'Connell
                                                ---------------------
                                            Title: Chief Financial Officer
                                                   -----------------------

                                            Officer:

                                            /S/ John J. Meakem, Jr.
                                            -----------------------

                                AMENDMENT
                                ---------

This Amendment to the Employment Agreement originally effective May 1, 1993, 
by and between Advanced Polymer Systems, Inc. ("Corporation") and John J. 
Meakem ("officer") is entered into effective May 1, 1995.

                           W I T N E S S E T H:
                           -------------------

The parties agree as follows:
  1.  Section 2.2 of the Employment Agreement entitled "Term of Employment" 
is 
      hereby amended to read in its entirety as follows:
      "2.2  TERM OF EMPLOYMENT.  Unless terminated earlier pursuant to this 
      Section 2, the term of employment of Officer by Corporation shall be 
for 
      a period of three years from May 1, 1995.  Thereafter, unless either 
      party shall give written notice to the other party not later than March 
      1st of each year of its intention not to automatically extend this 
      Agreement for an additional year, then the term of this Agreement shall 
      be automatically extended for an additional year.  For example, if 
      notice is not given by March 1, 1996, then the term of this Agreement 
      shall be extended through April 30, 1999.
  2.  The parties confirm that, as of the date of this Amendment, Officer's 
      salary has been increased to $315,000 per year.
  3.  In all other respects the provisions of the Employment Agreement are 
      hereby confirmed.
      In witness whereof, the parties have executed this Amendment.


                                          /S/ John J. Meakem, Jr.
                                          -----------------------
                                          John J. Meakem


                                          ADVANCED POLYMER SYSTEMS, INC.


                                          By: /S/ Michael O'Connell
                                              ---------------------

                                 AMENDMENT
                                 ---------

This Amendment to the Employment Agreement originally effective May 1, 1993, 
by and between Advanced Polymer Systems, Inc. ("Corporation") and John J. 
Meakem, Jr. ("officer") is entered into effective May 1, 1996.

                             W I T N E S E T H:
                             -----------------

The parties agree as follows:

  1.  Section 2.2. of the Employment Agreement entitled "Term of Employment"
      is hereby amended to read in its entirety as follows:

      "2.2 Term of Employment.  Unless terminated earlier pursuant to this 
      Section 2, the term of employment of Officer by Corporation shall be 
for 
      a period of three years from May 1, 1996.  Thereafter, unless either 
      party shall give written notice to the other party not later than March 
      1st of each year of its intention not to automatically extend this 
      Agreement for an additional year, then the term of the Agreement shall 
      be automatically extended for an additional year.  For example, if 
      notice is not given by March 1, 1997, then the term of this Agreement 
      shall be extended through April 30, 2000."

  2.  The parties confirm that, as of the date of this Amendment, Officer's 
      salary has been increased to $330,000 per year.

  3.  In all other respects the provisions of the Employment Agreement are
      hereby confirmed.

  In witness whereof, the parties have executed this Amendment.


                                               /S/ John J. Meakem, Jr.
                                               -----------------------
                                               John J. Meakem, Jr.


                                               ADVANCED POLYMER SYSTEMS, INC.


                                               By: /S/ Michael O'Connell
                                                   ---------------------

                        AMENDMENT TO EMPLOYMENT AGREEMENT
                        ---------------------------------

This Amendment to Employment Agreement (this "Amendment") is made and entered 
into effective April 26, 1999 by and between ADVANCED POLYMER SYSTEMS, INC., 
a Delaware corporation ("Corporation"), and JOHN J. MEAKEM ("Officer").

                               R E C I T A L S
                               ---------------

A.  Corporation and Meakem are parties to an Employment Agreement dated May 
1, 1993 providing for the Company's employment of Meakem as its President and 
Chief Executive Officer (as heretofore amended, the "Agreement"); and 

B.  The Board of Directors of Corporation has approved the following 
amendment to the Agreement and Meakem agrees to such amendment.

                                AGREEMENT
                                ---------

THE PARTIES AGREE that Section 4.5.1 of the Agreement ("Section 4.5.1") is 
hereby amended as follows and in all other respects the Agreement shall 
remain in full force and effect in accordance with its terms, as hereby 
amended.

(1)  The period at the end of clause (iii) of Section 4.5.1 shall be replaced 
with a semi-colon followed by the addition of the word "or"; and

(2)  a new clause (iv) shall be added to Section 4.5.1, which clause (iv) 
shall read in its entirely as follows:

"(iv) The individuals (the Initial Directors") who, as of the date of this 
Agreement, are members of the Board of Directors of the Corporation (the 
"Board") cease for any reason to constitute at least a majority of the 
members of the Board; PROVIDED, HOWEVER, that if the election, or nomination 
for election by the Corporation's stockholders, of any new director was 
approved by a vote of at least a majority of either (x) the Initial Directors 
or (y) the aggregate of the Initial Directors and any director referred to in 
this proviso, such new director shall be considered an Initial Director for 
purposes of this Agreement; PROVIDED, FURTHER, HOVEVER, that no individual 
shall be considered an Initial Director if such individual initially assumed 
office as a director as a result of either an actual or threatened election 
contest (an "Election Contest") regulated by Rule 14a-11 promulgated under 
the Securities Exchange Act of 1934 (or any successor rule or regulation) or 
any other actual or threatened solicitation of proxies or consents by or on 
behalf of any person other than a majority of the Initial Directors (a "Proxy 
Contest") including (without limitation) by reason of any agreement intended 
to avoid or settle any Election Contest or Proxy Contest.

IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the 
day and year first above written.

                                           CORPORATION

                                           ADVANCED POLYMER SYSTEMS, INC.


                                           By: /S/ John J. Meakem, Jr.
                                               -----------------------

                                           Title: Chairman, President, CEO
                                                  ------------------------


                                           OFFICER

                                           /S/ Michael O'Connell
                                           ---------------------