Exhibit 12 (b)


                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350
                       AS ADOPTED PURSUANT TO SECTION 906
                        OF THE SARBANES-OXLEY ACT OF 2002

I, Jimmy D. Gambill, Chief Executive Officer of the FRANKLIN MUTUAL SERIES FUND
INC. (the "Registrant"), certify, pursuant to 18 U.S.C. Section 1350 as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to my
knowledge:

      1.    The periodic report on Form N-CSR of the Registrant for the period
            ended 12/31/06 (the "Form N-CSR") fully complies with the
            requirements of Section 13(a) or 15(d) of the Securities Exchange
            Act of 1934; and

      2.    The information contained in the Form N-CSR fairly presents, in all
            material respects, the financial condition and results of operations
            of the Registrant.

Dated:  February 27, 2007

                       /S/JIMMY D. GAMBILL

                       Jimmy D. Gambill
                       Chief Executive Officer - Finance and Administration






                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350
                       AS ADOPTED PURSUANT TO SECTION 906
                        OF THE SARBANES-OXLEY ACT OF 2002

I, Galen G. Vetter, Chief Financial Officer of the FRANKLIN MUTUAL SERIES FUND
INC. (the "Registrant"), certify, pursuant to 18 U.S.C. Section 1350 as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to my
knowledge:

      1.    The periodic report on Form N-CSR of the Registrant for the period
            ended 12/31/06 (the "Form N-CSR") fully complies with the
            requirements of Section 13(a) or 15(d) of the Securities Exchange
            Act of 1934; and

      2.    The information contained in the Form N-CSR fairly presents, in all
            material respects, the financial condition and results of operations
            of the Registrant.

Dated:  February 27, 2007

                                    /S/GALEN G. VETTER

                                    Galen G. Vetter
                                    Chief Financial Officer