ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Days Shares Shares Loss Per Shares Outstanding X Days Outstanding Loss Share Six Months Ended June 30, 1996: 10,380,056 1 10,380,056 10,390,003 10 103,900,030 10,409,608 4 41,638,432 10,418,676 2 20,837,352 10,478,786 1 10,478,786 10,046,458 3 30,139,374 10,598,792 1 10,598,792 10,678,561 2 21,357,122 10,680,653 1 10,680,653 10,680,903 3 32,042,709 10,710,132 4 42,840,528 10,718,504 6 64,311,024 10,727,170 4 42,908,680 10,728,565 1 10,728,565 10,729,263 1 10,729,263 10,729,394 7 75,105,758 10,731,487 19 203,898,253 10,742,559 7 75,197,913 10,771,115 2 21,542,230 10,775,477 2 21,550,954 10,776,991 4 43,107,964 10,784,842 1 10,784,842 10,812,921 1 10,812,921 10,832,546 2 21,665,092 10,847,725 3 32,543,175 10,848,023 5 54,240,115 10,849,767 7 75,948,369 10,851,626 3 32,554,878 10,858,605 1 10,858,605 10,862,095 2 21,724,190 10,962,004 1 10,962,004 10,962,593 4 43,850,372 10,965,241 2 21,930,482 10,965,939 1 10,965,939 10,967,993 6 65,807,958 10,972,354 5 54,861,770 10,977,356 2 21,954,712 10,978,310 7 76,848,170 10,983,980 4 43,935,920 10,989,215 1 10,989,215 13,992,587 1 13,992,587 13,996,077 1 13,996,077 13,996,949 6 83,981,694 14,446,949 1 14,446,949 14,453,492 5 72,267,460 14,456,109 5 72,280,545 14,465,806 1 14,465,806 14,472,786 2 28,945,572 14,473,658 1 14,473,658 14,478,658 3 43,435,974 14,481,500 1 14,481,500 14,483,680 3 43,451,040 14,484,059 1 14,484,059 14,485,899 2 28,971,798 14,488,079 3 43,464,237 14,526,802 3 43,580,406 182 2,097,932,529/182 11,527,102 (4,400,000) (0.38) ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Days Shares Shares Loss Per Shares Outstanding X Days Outstanding Loss Share Six Months Ended June 30, 1997: 14,597,247 8 116,777,976 14,606,972 12 175,283,664 14,612,023 4 58,448,092 14,612,499 21 306,862,479 14,615,983 6 87,695,898 14,616,981 1 14,616,981 14,624,239 5 73,121,195 14,625,111 2 29,250,222 14,627,695 7 102,393,865 14,628,567 6 87,771,402 14,640,311 6 87,841,866 14,643,658 6 87,861,948 14,644,672 1 14,644,672 14,644,816 7 102,513,712 14,644,982 2 29,289,964 14,645,277 4 58,581,108 14,665,277 22 322,636,094 14,665,665 9 131,990,985 14,674,453 19 278,814,607 14,678,042 6 88,068,252 14,680,055 7 102,760,385 14,680,344 19 278,926,536 14,687,394 1 14,687,394 181 2,650,839,297/181 14,645,521 (6,294,000) (0.43) ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Days Shares Shares Loss Per Shares Outstanding X Days Outstanding Loss Share Quarter Ended June 30, 1996: 10,847,725 5 54,238,625 10,848,023 7 75,936,161 10,849,767 3 32,549,301 10,851,626 1 10,851,626 10,858,605 2 21,717,210 10,862,095 1 10,862,095 10,962,004 4 43,848,016 10,962,593 2 21,925,186 10,965,241 1 10,965,241 10,965,939 6 65,795,634 10,967,993 5 54,839,965 10,972,354 2 21,944,708 10,977,356 7 76,841,492 10,978,310 4 43,913,240 10,983,980 1 10,983,980 10,989,215 1 10,989,215 13,992,587 1 13,992,587 13,996,077 6 83,976,462 13,996,949 1 13,996,949 14,446,949 5 72,234,745 14,453,492 5 72,267,460 14,456,109 1 14,456,109 14,456,806 2 28,913,612 14,472,786 1 14,472,786 14,473,658 3 43,420,974 14,478,658 1 14,478,658 14,481,500 3 43,444,500 14,483,680 1 14,483,680 14,484,059 2 28,968,118 14,485,899 3 43,457,697 14,488,079 3 43,464,237 14,526,802 1 14,526,802 91 1,128,757,071 /91 12,404,122 (2,327,000) (0.19) Quarter Ended June 30, 1997: 0 14,644,816 2 29,289,632 14,644,982 2 29,289,964 14,645,277 4 58,581,108 14,665,277 22 322,636,094 14,665,665 9 131,990,985 14,674,453 19 278,814,607 14,678,042 6 88,068,252 14,680,055 7 102,760,385 14,680,344 19 278,926,536 14,687,394 1 14,687,394 91 1,335,044,957 /91 14,670,824 (3,201,000) (0.22)