July 28, 1997 Ms. Janet M. Walter 225 W. 20th Street, Apt. 4W New York, NY 10011 Dear Janet: I am pleased to present for your consideration the following proposal to join Aronex as Vice President, Marketing and Business Development. In this position you will report directly to me. Your responsibilities will include defining strategy and implementing commercialization plans for the Company's products. Additional responsibilities include directing new business development activities, corporate partnering, and in-licensing and out-licensing activities. Directly reporting to you will be Larry Hope. Joe Wyse, who oversees contracts and patents will report to you once his current Pharmaceutical Development responsibilities are completed. A starting date of August 15, 1997 is anticipated, although I would prefer an earlier start date, if possible. Compensation for the position would include the following: Base salary: $13,333.34 monthly Stock Option: 100,000 options at fair market value, 30,000 to vest upon joining Aronex. The balance will vest over four years at a rate of 1/48 per month. Bonus: A target annual bonus of 20% of base salary in cash and/or stock options, dependent upon you meeting Company goals and Board approval. Benefits: Benefits would include medical, dental, and disability, 401K plan, stock purchase plan, medical benefits, cafeteria plan, three weeks annual vacation, and all other Company benefits defined in the Company's Benefits Summary which is enclosed. Relocation: Up to two trips to Houston to select new housing. Moving costs of personal property. In order for you not to have to pay for two residences during transition, Aronex will pay up to two months rent for temporary housing in the Houston area if there is overlap in your rent costs between New York and Texas. The Company will also cover gross-up costs related to your relocation expenses that are not tax deductible. Ms. Janet M. Walter July 28, 1997 Page 2 Goals and Incentive Milestones: o In-license product which has in-vitro and in-vivo activity and is within one year of clinical testing. The incentive is 25,000 options at fair market value at the time of issuance when the milestone is met for each compound in-licensed. o Successfully launch AtragenTM within three months of NDA approval, or consummate a licensing agreement which provides the Company with a minimum of $5M in cash or equity investment. The incentive is 25,000 options at fair market value at the time of issuance when the milestone is met. If AtragenTM is launched by Aronex, generate a minimum of $2M sales within 12 months of launch. The incentive is 25,000 options at fair market value at the time of issuance when the milestone is met. o Out license NyotranTM to corporate partners in Europe and Asia and arrange co-promotion deal in North America which guarantees a minimum of $20M with $15M in cash or equity investment. The Incentive is 50,000 options at fair market value at the time of issuance when the milestone is met. In the event deals are done with regional companies rather than a multinational, incentive payouts are as follows: >=$1M=5,000 options at fair market value at the time of issuance when the milestone is met; >=$3M=10,000 at fair market value at the time of issuance when the milestone is met; >=$5M=25,000 options at fair market value at the time of issuance when the milestone is met. Excluded are Rhone-Poulenc Rorer, Pharmacia-Upjohn, Fresenius and Sanofi. In addition to the above milestones, following are several objectives that are high priority: - Define market potential, positioning, and competitive challenges for each of the Company's products. - Assist in increasing product awareness for the Company's product ongoing opinion leading clinicians. - Assure that development programs for each product isadequate for competitive marketing positioning. Ms. Janet M. Walter July 28, 1997 Page 3 Employment Agreement: A one year severance package of base salary and benefits if terminated by the Company for reasons other than cause. I believe this package is very reasonable and reflects the importance of the position and the value we perceive you will bring to Aronex. I hope you find this proposal acceptable. I look forward to you joining Aronex as early as possible Best regards, By:/S/JAMES M. CHUBB, PH.D. James M. Chubb, Ph.D. President JMC/cc Enclosure Accepted and Agreed upon this 28TH day of July, 1997 by By:/S/JANET M. WALTER Janet M. Walter