ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share Nine Months Ended September 30, 1996: 10,380,056 1 10,380,056 10,390,003 10 103,900,030 10,409,608 4 41,638,432 10,418,676 2 20,837,352 10,478,786 1 10,478,786 10,046,458 3 30,139,374 10,598,792 1 10,598,792 10,678,561 2 21,357,122 10,680,653 1 10,680,653 10,680,903 3 32,042,709 10,710,132 4 42,840,528 10,718,504 6 64,311,024 10,727,170 4 42,908,680 10,728,565 1 10,728,565 10,729,263 1 10,729,263 10,729,394 7 75,105,758 10,731,487 19 203,898,253 10,742,559 7 75,197,913 10,771,115 2 21,542,230 10,775,477 2 21,550,954 10,776,991 4 43,107,964 10,784,842 1 10,784,842 10,812,921 1 10,812,921 10,832,546 2 21,665,092 10,847,725 3 32,543,175 10,848,023 5 54,240,115 10,849,767 7 75,948,369 10,851,626 3 32,554,878 10,858,605 1 10,858,605 10,862,095 2 21,724,190 10,962,004 1 10,962,004 10,962,593 4 43,850,372 10,965,241 2 21,930,482 10,965,939 1 10,965,939 10,967,993 6 65,807,958 10,972,354 5 54,861,770 10,977,354 2 21,954,708 10,978,310 7 76,848,170 10,983,980 4 43,935,920 10,989,215 1 10,989,215 13,992,587 1 13,992,587 13,996,077 1 13,996,077 13,996,949 6 83,981,694 14,446,949 1 14,446,949 14,453,492 5 72,267,460 14,456,109 5 72,280,545 14,465,806 1 14,465,806 14,472,786 2 28,945,572 14,473,658 1 14,473,658 14,478,658 3 43,435,974 14,481,500 1 14,481,500 14,483,680 3 43,451,040 14,484,059 1 14,484,059 14,485,899 2 28,971,798 14,488,079 3 43,464,237 14,526,802 3 43,580,406 14,526,802 23 334,116,446 14,531,016 1 14,531,016 14,543,516 20 290,870,320 14,543,736 1 14,543,736 14,544,318 18 261,797,724 14,545,238 2 29,090,476 14,545,321 7 101,817,247 14,555,018 14 203,770,252 14,556,217 5 72,781,085 14,557,089 1 14,557,089 274 3,435,807,916/274 12,539,445 (6,422,000) (0.51) Average Loss Days Share Shares Per Shares Outstanding X Day Outstanding Loss Share Nine Months Ended September 30, 1997: 14,597,247 8 116,777,976 14,606,972 12 175,283,664 14,612,023 4 58,448,092 14,612,499 21 306,862,479 14,615,983 6 87,695,898 14,616,981 1 14,616,981 14,624,239 5 73,121,195 14,625,111 2 29,250,222 14,627,695 7 102,393,865 14,628,567 6 87,771,402 14,640,311 6 87,841,866 14,643,658 6 87,861,948 14,644,672 1 14,644,672 14,644,816 7 102,513,712 14,644,982 2 29,289,964 14,645,277 4 58,581,108 14,665,277 22 322,636,094 14,665,665 9 131,990,985 14,674,453 19 278,814,607 14,678,042 6 88,068,252 14,680,055 7 102,760,385 14,680,344 19 278,926,536 14,687,394 31 455,309,214 14,710,122 9 132,391,098 14,712,069 5 73,560,345 14,712,575 12 176,550,900 14,712,699 6 88,276,194 14,714,018 2 29,428,036 14,719,923 9 132,479,307 15,406,372 15 231,095,580 15,408,872 3 46,226,616 15,421,809 1 15,421,809 273 4,016,891,002/273 14,713,886 (12,278,000) (0.83) Quarter Ended September 30, 1996 14,526,802 23 334,116,446 14,531,016 1 14,531,016 14,543,516 20 290,870,320 14,543,736 1 14,543,736 14,544,318 18 261,797,724 14,545,238 2 29,090,476 14,545,321 7 101,817,247 14,555,018 14 203,770,252 14,556,217 5 72,781,085 14,557,089 1 14,557,089 92 1,337,875,391/92 14,542,124 (2,022,000) (0.14) Quarter Ended September 30, 1997: 14,687,394 30 440,621,820 14,710,122 9 132,391,098 14,712,069 5 73,560,345 14,712,575 12 176,550,900 14,712,699 6 88,276,194 14,714,018 2 29,428,036 14,719,923 9 132,479,307 15,406,372 15 231,095,580 15,408,872 3 46,226,616 15,421,809 1 15,421,809 92 1,366,051,705/92 14,848,388 (5,984,000) (0.40)