ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 Statement Regarding Computation of Per Share Earnings The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share Nine Months Ended September 30, 1997: 14,597,247 8 116,777,976 14,606,972 12 175,283,664 14,612,023 4 58,448,092 14,612,499 21 306,862,479 14,615,983 6 87,695,898 14,616,981 1 14,616,981 14,624,239 5 73,121,195 14,625,111 2 29,250,222 14,627,695 7 102,393,865 14,628,567 6 87,771,402 14,640,311 6 87,841,866 14,643,658 6 87,861,948 14,644,672 1 14,644,672 14,644,816 7 102,513,712 14,644,982 2 29,289,964 14,645,277 4 58,581,108 14,665,277 22 322,636,094 14,665,665 9 131,990,985 14,674,453 19 278,814,607 14,678,042 6 88,068,252 14,680,055 7 102,760,385 14,680,344 19 278,926,536 14,687,394 31 455,309,214 14,710,122 9 132,391,098 14,712,069 5 73,560,345 14,712,575 12 176,550,900 14,712,699 6 88,276,194 14,714,018 2 29,428,036 14,719,923 9 132,479,307 15,406,372 15 231,095,580 15,408,872 3 46,226,616 15,421,809 1 15,421,809 273 4,016,891,002 /273 14,713,886 (12,278,000) (0.83) Nine Months Ended September 30, 1998: 15,459,166 11 170,050,826 15,460,684 71 1,097,708,564 15,465,729 1 15,465,729 15,467,281 98 1,515,793,538 15,497,443 92 1,425,764,756 15,503,745 1 15,503,745 274 4,240,287,158 /274 15,475,501 (16,546,000) (1.07) Quarter Ended September 30, 1997: 14,687,394 30 440,621,820 14,710,122 9 132,391,098 14,712,069 5 73,560,345 14,712,575 12 176,550,900 14,712,699 6 88,276,194 14,714,018 2 29,428,036 14,719,923 9 132,479,307 15,406,372 15 231,095,580 15,408,872 3 46,226,616 15,421,809 1 15,421,809 92 1,366,051,705 /92 14,848,388 (5,984,000) (0.40) Quarter Ended September 30, 1998: 15,497,443 91 1,410,267,313 15,503,745 1 15,503,745 92 1,425,771,058 /92 15,497,512 (6,059,000) (0.39)