UNITED STATES
               SECURITIES AND EXCHANGE COMMISSION
                      Washington, DC  20549

                           FORM 10-K/A

[ X ]       ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF  THE
            SECURITIES EXCHANGE ACT OF 1934

For fiscal year ended:      September 27, 1997   or

[   ]       TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)  OF
            THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from __________ to ____________.

Commission File Number : 0-18281

                          Hologic, Inc.
     (Exact Name of Registrant as Specified in Its Charter)
                                
           Delaware                         04-2902449
   (State of Incorporation)      (I.R.S. Employer Identification No.)
                                
        590 Lincoln Street, Waltham, Massachusetts    02154
      (Address of principal executive offices)      (Zip Code)

                         (781) 890-2300
      (Registrant's telephone number, including area code)

Securities registered pursuant to Section 12(b) of  the  Act:  NONE

Securities registered pursuant to Section 12(g) of the Act:
                                        Common Stock, $.01 par value
                                        Rights  to Purchase Common Stock

    Indicate by check mark whether the registrant: (1) has  filed
all  reports required to be filed by Section 13 or 15(d)  of  the
Securities  Exchange Act of 1934 during the preceding  12  months
(or  for such shorter period that the registrant was required  to
file  such  reports),  and (2) has been subject  to  such  filing
requirements for the past 90 days.  Yes  X     No
                                        ---      ---
    Indicate  by  check mark if disclosure of  delinquent  filers
pursuant  to Rule 405 of Regulation S-K is not contained  herein,
and will not be contained, to the best of registrant's knowledge,
in  definitive  proxy or information statements  incorporated  by
reference in Part III of this Form 10-K or any amendment  to  the
Form 10-K.  [   ]

    The  aggregate market value of the registrant's Common  Stock
held  by non-affiliates of the registrant as of November 28, 1997
was $339,619,647 based on the price of the last reported sale  on
that date on the Nasdaq National Market.

    As  of November 28, 1997, there were 13,125,397 shares of the
registrant's Common Stock, $.01 par value, outstanding.

               DOCUMENTS INCORPORATED BY REFERENCE
(1) Proxy  Statement  for  the  Registrant's  Annual  Meeting   of
    Stockholders  held on February 24, 1998 (Part III:  Items  10,
    11, 12 and 13).



Item 14.    Exhibits, Financial Statement Schedules, and Reports
            on Form 8-K

(a)  The following documents are filed as part of this report

  (1)   Financial Statements
                                                                 
        Report of Independent Public Accountants                         
                                                                 
        Consolidated Balance Sheets as of September 27, 1997 and 
          September 28, 1996
                                                                 
        Consolidated Statements of Operations for the years ended        
          September 27, 1997, September 28, 1996 and September 30, 1995
                                                                 
        Consolidated Statements of Stockholders' Equity for the years    
          ended September 27, 1997, September 28, 1996 and September 30,
          1995
                                                                 
        Consolidated Statements of Cash Flows for the years ended        
          September 27, 1997, September 28, 1996 and September 30, 1995
                                                                 
        Notes to Consolidated Financial Statements                       

  (2)  Financial Statement Schedules

        The  following financial statement schedules are  filed  as
        part  of this report and should be read in conjunction with
        the consolidated financial statements:
     
         Schedule
         --------     
          Report of Independent Public Accountants on Schedule II
          Valuation and Qualifying Accounts

        All  other schedules have been omitted because they are not
        required  or because the required information is  given  in
        the Consolidated Financial Statements or Notes thereto.



  (3) Listing of Exhibits



Exhibit
Number                                                                Reference
                                                                    

2.01   Merger    Agreement   between   the   Company   and    its
       Massachusetts predecessor..................................         A
2.02   Agreement  and Plan of Merger between the Company,  Fenway
       Acquisition Corp.,and FluoroScan Imaging Systems, Inc......     I-2.01
3.01   Certificate  of Incorporation of the Company,  as  amended.     L-3.03
3.02   By-laws of the Company.....................................         A
4.01   Specimen  certificate for shares of the  Company's  Common
       Stock......................................................         A
4.02   Description   of   capital   stock   (contained   in   the
       Certificate of Incorporation of the Company,
       filed as Exhibit 3.01).....................................     L-3.03
4.03   Rights Agreement dated December 22, 1992...................         C
4.04   Amendment No. 1 to Rights Agreement........................         G
4.05   Amendment No. 2 to Rights Agreement........................        M-2
10.07  1986 Combination Stock Option Plan, as amended.............         F*
10.08  Second  Amended  and  Restated 1990 Non-Employee  Director
       Stock   Option   Plan......................................    L-10.26*
10.09  Employee Stock Purchase Plan of the Company................         F*
10.10  1995  Combination  Stock  Option  Plan.....................    L-10.25*
10.12  Form  of  Indemnification  Agreement  for  directors and
       certain officers of the Company............................         A*
10.17  Management  Agreement  between  the  Company   and   Vivid
       Technologies, Inc..........................................         A*
10.18  License   Agreement   between  the   Company   and   Vivid
       Technologies, Inc..........................................         A
10.20  Facility  lease  between the Company  and  Lincoln  Street
       Trust......................................................         B
10.21  Orion  Corporation  Soredex  Distribution  Agreement   for
       Scanora....................................................      D-10**
10.22  Employment  Agreement  with  an  officer  of  the  Company.         E*
10.25  Amendment  No.  1  to  the License Agreement  between  the
       Company and Vivid Technologies, Inc........................         K
10.26  Facility  Lease between the Company and Mangen  Management
       Company....................................................         K
10.32  First  Amendment to the facility lease between the Company
       and Lincoln Street Trust...................................     I-10.17
11.01  Statement re: Computation of Per Share Earnings............         N
21.01  Subsidiaries of the Company................................         N
23.01  Consent of Arthur Andersen LLP.............................         N
23.02  Consent of BDO Seidman, LLP................................         N
_______________________

*    Management compensation plan or arrangement
**   Confidentiality requested as to certain provisions



A.  The  above exhibits were previously filed as an exhibit of  the
    same number to the Company's Registration  Statement on Form S- 1
    (Registration No. 33-33128) filed on January  24,  1990  and
    are incorporated herein by reference.

B.  The  above exhibits were previously filed as an exhibit of  the
    same  number to the Company's 1990 Annual Report on  Form  10-K
    and are incorporated herein by reference.

C.  The  above  exhibit was previously filed as an exhibit  of  the
    same  number to the Company's 1992 Annual Report on  Form  10-K
    and is incorporated herein by reference.

D.  The  above  exhibit was previously filed as an exhibit  of  the
    referenced  number to the Company's Fiscal 1993  Third  Quarter
    Report on Form 10-Q and is incorporated herein by reference.

E.  The  above  exhibit was previously filed as an exhibit  of  the
    same  number to the Company's 1993 Annual Report on  Form  10-K
    and is incorporated herein by reference.

F.  The  above exhibits were previously filed as an exhibit of  the
    same  number to the Company's 1994 Annual Report on  Form  10-K
    and are incorporated herein by reference

G.  The  above  exhibit was previously filed as an exhibit  of  the
    same number to the Company's Registration Statement on Form  S-
    3  (Registration No. 33-65019) filed on December 14,  1995  and
    is incorporated herein by reference.

H.  The  above exhibits were previously filed as an exhibit of  the
    same  number to the Company's 1995 Annual Report on  Form  10-K
    and is incorporated herein by reference.

I.  The  above exhibits were previously filed as an exhibit of  the
    referenced  number of the Company's Registration  Statement  on
    Form  S-4  (Registration No. 333-08977) on August 6,  1996  and
    are incorporated herein by reference.

J.  The  above exhibit was previously filed as an exhibit  of  the
    same number to the Company's Registration Statement on Form  S-
    8  (Registration No. 333-11853) filed on September 12, 1996 and
    is incorporated herein by reference.

K.  The  above exhibits were previously filed as an exhibit of  the
    same  number to the Company's 1996 Annual Report on  Form  10-K
    and are incorporated herein by reference.

L.  The  above exhibits were previously filed as an exhibit of  the
    referenced  number to the Company's Fiscal 1996 Second  Quarter
    Report on Form 10-Q and are incorporated herein by reference.

M.  The  above  exhibit was previously filed as an exhibit  of  the
    referenced   number  to  Amendment  No.  1  to  the   Company's
    Registration  Statement  on Form 8-A/A (Registration  No.  000-
    18281) filed on January 17, 1997 and is incorporated herein  by
    reference.

N.  The  above exhibits were previously filed as an exhibit of  the
    same  number to the Company's 1997 Annual Report on  Form  10-K
    and are incorporated herein by reference.

(b)  Reports on Form 8-K:

     The Company did not file any current reports on 
     Form 8-K during the quarter ended September 27, 1997.

(d)  Financial Statement Schedules:

     The financial statement schedules
     required are included as part of Item (a)(2) above.






                           SIGNATURES


     Pursuant to the requirements of Section 13 or 15(d)  of  the
Securities  Exchange Act of 1934, the registrant has duly  caused
this  report  to  be  signed on its behalf  by  the  undersigned,
thereunto duly authorized.


                               Hologic, Inc.

Dated:  March 3, 1998          By: /s/ Glenn P.Muir
- --------------------           -------------------------------
                                   Glenn P. Muir, Treasurer and
                                   Chief Financial Officer