UNITED STATES
                  SECURITIES AND EXCHANGE COMMISSION
                        Washington, DC.  20549
                                   
                               FORM 10-Q
                                   
(Mark One)

[ X ]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended     March 27, 1999
                                   --------------      
                                  or

[    ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934

For the transition period from ______ to ______

Commission File Number:             0-18281
                                   --------
 
                             Hologic, Inc.
         ---------------------------------------------------- 
        (Exact name of registrant as specified in its charter)
                                   
                  Delaware                04-2902449
      ------------------------    ---------------------------------- 
      (State of incorporation)   (I.R.S. Employer Identification No.)

           35 Crosby Drive, Bedford,  Massachusetts   01730
       ----------------------------------------    ----------
       (Address of principal executive offices)    (Zip Code)

                           (781) 999-7300
          --------------------------------------------------    
         (Registrant's telephone number, including area code)


Indicate  by  check  mark whether the registrant  (1)  has  filed  all
reports  required to be filed by Section 13 or 15(d) of the Securities
Exchange  Act  of  1934 during the preceding 12 months  (or  for  such
shorter period that the registrant was required to file such reports),
and  (2) has been subject to such filing requirements for the past  90
days.
                                                     Yes  X      No __


As  of May 5, 1999 13,415,940 shares of the registrant's Common Stock,
$.01 par value, were outstanding.

                            
                                   
                                   
                                   
                    HOLOGIC, INC. AND SUBSIDIARIES
                                   
                                 INDEX



                                                            Page
PART I - FINANCIAL INFORMATION                              ----

Item 1.  Financial Statements

          Consolidated Balance Sheets
          March 27, 1999 and September 26, 1998..............  3

          Consolidated Statements of Operations
          Three and Six Months Ended March 27, 1999
          and March 28, 1998.................................  4

          Consolidated Statements of Cash Flows
          Six Months Ended March 27, 1999
          and March 28, 1998.................................  5

          Notes to Consolidated Financial Statements.........  6


Item 2.  Management's Discussion and Analysis of
         Financial Condition and Results of Operations.......  9


PART II - OTHER INFORMATION.................................. 13


SIGNATURES................................................... 15

                                   
               
                                   
                                                                      
                                   
                    PART I - FINANCIAL INFORMATION
Item 1.   Financial Statements

                    HOLOGIC, INC. AND SUBSIDIARIES
                      CONSOLIDATED BALANCE SHEETS
                              (Unaudited)
                 (in thousands, except per share data)
                                   
                                ASSETS


                                                   March 27,    September 26,
                                                     1999            1998
                                                   ---------    -------------
                                                                
   CURRENT ASSETS:
    Cash and cash equivalents....................   $36,582        $48,423
    Short-term investments.......................    28,271         27,479
    Accounts receivable, less reserves
      of $2,600 and $2,100, respectively.........    31,703         29,287
    Inventories..................................    19,089         20,438
    Prepaid expenses and other current assets....     6,287          6,221
                                                    -------        --------
      Total current assets.......................   121,932        131,848
                                                    -------        -------
   
   PROPERTY AND EQUIPMENT, at cost:
    Equipment....................................    10,065          8,633
    Furniture and fixtures.......................     2,963          1,910
    Land.........................................     8,502              -
    Building and improvements....................    17,307              -
    Leasehold improvements.......................       609          1,729
    Construction in progress.....................         -         20,066
                                                     ------         ------
                                                     39,446         32,338
    Less- Accumulated depreciation
          and amortization.......................     6,387          6,440
                                                     ------         ------
                                                     33,059         25,898
                                                     ------         ------
   Other assets, net.............................    14,819         14,851
                                                    -------       --------
                                                   $169,810       $172,597
                                                   ========       ======== 

 
                 LIABILITIES AND STOCKHOLDERS' EQUITY
    
                                                   March 27,    September 26,
                                                     1999           1998
                                                   ---------     -----------
                                                              
   CURRENT LIABILITIES:
    Line of credit..............................   $ 1,523         $ 3,799
    Accounts payable............................     6,342           5,497
    Accrued expenses............................    10,602          12,453
    Deferred revenue............................    10,199          10,466
                                                   -------         -------     
       Total current liabilities................    28,666          32,215
                                                   -------         ------- 
   STOCKHOLDERS' EQUITY:
   Preferred stock, $.01 par value-
     Authorized - 1,623
     Issued and outstanding - none ............          -               -
    Common stock, $.01 par value-
     Authorized - 30,000 shares
     Issued - 13,415 and 13,378
      shares, respectively.....................        134             134
    Capital in excess of par value.............     95,452          95,100
    Retained earnings..........................     47,136          46,187
    Cumulative translation adjustment..........     (1,114)           (575)
    Treasury stock, at cost, 45 shares.........       (464)           (464)
                                                   --------         -------    
      Total stockholders' equity...............    141,144         140,382
                                                   --------        --------
                                                  $169,810        $172,597
                                                  ========        ========

   The accompanying notes are an integral part of these consolidated
                         financial statements.
        

                   HOLOGIC, INC. AND SUBSIDIARIES
                 CONSOLIDATED STATEMENTS OF OPERATIONS
                              (Unaudited)
                 (in thousands, except per share data)
                                   


       
                                 Three Months Ended     Six Months Ended
                                March 27,   March 28,   March 27,   March 28,
                                   1999       1998        1999        1998
                                --------   ---------   ---------   --------                                 
                                                         
REVENUES:
 Product sales................   $18,797     $29,455    $42,711     $54,594
 Other revenues...............       565         742      1,285       1,724
                                  ------     -------    -------     ------- 
                                  19,362      30,197     43,996      56,318
                                  ------     -------     ------     -------
COSTS AND EXPENSES:
 Cost of product sales........    11,533      14,662     24,324      27,402
 Research and development.....     2,643       2,506      5,101       4,845
 Selling and marketing........     4,711       7,840      9,970      14,589
 General and administrative...     2,877       2,282      5,047       4,577
                                 -------      ------     ------      ------
                                  21,764      27,290     44,442      51,413
                                 -------      ------     ------      ------  
    (Loss) income
      from operations.........    (2,402)      2,907       (446)      4,905

 Interest income..............       991       1,476      2,244       2,781

 Other expense................      (297)       (113)      (329)       (203)
                                  -------      ------     ------      ------
  
   (Loss) income before 
    (benefit) provision
    for income taxes..........    (1,708)      4,270      1,469      7,483

(BENEFIT) PROVISION
  FOR INCOME TAXES............    (  620)      1,550        520      2,700
                                  -------      -----       -----     -----

    Net (loss) income.........   $(1,088)     $2,720     $  949     $4,783
                                 ========     ======     ======     ======
NET (LOSS) INCOME PER COMMON AND
 COMMON EQUIVALENT SHARE:
    Basic earnings per share..   $   (.08)    $  .21     $  .07     $  .36
                                 =========    =======    ======     ======

    Diluted earnings per share.  $   (.08)    $  .20     $  .07     $  .35
                                 ========     ======     ======     =======

WEIGHTED AVERAGE NUMBER OF
 COMMON SHARES OUTSTANDING.....    13,365     13,197     13,353     13,165
                                   ======     ======     ======     ======
WEIGHTED AVERAGE NUMBER OF
 COMMON AND DILUTIVE POTENTIAL
 COMMON SHARES OUTSTANDING.....    13,365     13,759     13,628     13,774
                                   ======     ======     ======     ======
                                  
                                   
   The accompanying notes are an integral part of these consolidated
                         financial statements.
                                   
        
                           
                    HOLOGIC, INC. AND SUBSIDIARIES
                 CONSOLIDATED STATEMENTS OF CASH FLOWS
                              (Unaudited)
                            (in thousands)


                                                        Six Months Ended
                                                        ----------------
                                                     March 27,   March 28,
                                                       1999        1998
                                                     --------    ---------
                                                             
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net income.......................................     $949       $4,783
  Adjustments to reconcile net income to net cash
  (used in)  provided by operating activities-
     Depreciation and amortization.................    1,248          756
     Compensation expense related
     to issuance of stock options..................      126          138
     Changes in assets and liabilities-
       Accounts receivable.........................   (1,434)        (733)
       Inventories.................................    1,350       (5,237)
       Prepaid expenses and other current assets...      (30)         320
       Accounts payable............................      845        1,074
       Accrued expenses............................   (1,849)       1,365
       Deferred revenue............................     (267)       4,965
                                                      ------       ------ 
          Net cash provided by 
          operating activities.....................      936        7,431
                                                      -------       -----    
CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchase of held-to-maturity investments.........  (19,517)     (41,645)
  Sales of held-to-maturity investments............   17,183       50,095
  Purchases of property and equipment..............   (8,069)      (1,079)
  Decrease (increase) in other assets..............      256       (1,124)
                                                      ------       -------
       Net cash (used in) provided
       by investing activities.....................  (10,147)       6,247
                                                     --------      ------

CASH FLOWS FROM FINANCING ACTIVITIES:
  Net (decrease) increase in line of credit........   (2,276)         698
  Issuance of common stock pursuant to options
  and employee stock purchase plans................      159        1,058
  Tax benefit from stock option exercises..........       38          340
                                                       ------       -----
       Net cash (used in) provided
       by  financing activities....................   (2,079)       2,096
                                                      -------      ------
EFFECT OF EXCHANGE RATE CHANGES ON CASH............     (551)        (207)
                                                      -------      ------  
NET (DECREASE) INCREASE IN CASH AND
  CASH EQUIVALENTS.................................  (11,841)      15,565
CASH AND CASH EQUIVALENTS, beginning of period.....   48,423       28,092
                                                     --------      ------
CASH AND CASH EQUIVALENTS, end of period...........  $36,582      $43,657
                                                     =======      ======= 

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
  Cash paid during the period for income taxes.....     $356      $ 1,922
                                                        ====      =======  

  Cash paid during the period for interest.........      $80          $71
                                                         ==           ===


            The accompanying notes are an integral part of these
                    consolidated financial statements.
                                   
                                   
                    HOLOGIC, INC. AND SUBSIDIARIES
              NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                              (Unaudited)

(1)  Basis of Presentation

      The  consolidated  financial statements of  Hologic,  Inc.  (the
Company) presented herein have been prepared pursuant to the rules  of
the  Securities and Exchange Commission for quarterly reports on  Form
10-Q  and  do  not include all of the information and note disclosures
required   by   generally  accepted  accounting   principles.    These
statements  should  be  read  in  conjunction  with  the  consolidated
financial  statements and notes thereto for the year  ended  September
26,  1998,  included  in the Company's Form 10-K  as  filed  with  the
Securities and Exchange Commission on December 23, 1998.
     
      The  consolidated  balance  sheet as  of  March  27,  1999,  the
consolidated  statements of operations for the three  and  six  months
ended  March  27,  1999  and  March  28,  1998  and  the  consolidated
statements of cash flows for the six months ended March 27,  1999  and
March  28,  1998,  are  unaudited but, in the opinion  of  management,
include  all adjustments (consisting of normal, recurring adjustments)
necessary  for  a  fair  presentation of  results  for  these  interim
periods.

      The  results  of operations for the three and six  months  ended
March  28,  1999 are not necessarily indicative of the results  to  be
expected for the entire fiscal year ending September 25, 1999.
     
(2)  Summary of Significant Accounting Policies

      The  accompanying consolidated financial statements reflect  the
application of certain accounting policies described in this and other
notes to the consolidated financial statements.

      (a)   Inventories:  Inventories are stated at the lower of  cost
(first-in, first-out) or market and consist of the following:

                                            March 27,     September 26,
                                              1999             1998
                                            ---------      -----------
                                                (in thousands)

Raw materials and work-in-process........    $11,680         $13,859
Finished goods...........................      7,409           6,579
                                             -------         -------
                                             $19,089         $20,438
                                             =======         =======

       Work-in-process  and  finished  goods  inventories  consist  of
material, labor and manufacturing overhead.
                                   
    
      (b)  Earnings Per Share:  A reconciliation of basic and dilutive
share amounts are as follows:




                                    Three Months Ended       Six Months Ended
                                   March 27,   March 28,   March 27,    March 28,
                                    1999         1998        1999         1998
                                   ---------   ---------   ---------     --------    
                                                   (in thousands)
                                                               
                                             
Weighted average common
 shares outstanding.............    13,365        13,197      13,353       13,165 
Common stock equivalents
 outstanding pursuant to the 
 treasury stock method..........        --           562         275          609 
                                    -------       -------     ------       ------ 
Weighted average number of
 common and dilutive potential 
 common shares outstanding......    13,365        13,759      13,628       13,774
                                    ======        ======      ======       ====== 

 
     Anti-dilutive  shares  of 1,173 and 799 for  the  three  and  six
months  ended March 27, 1999, respectively, and 426 and  305  for  the
three  and  six months ended March 28, 1998, respectively,  have  been
excluded  from  the  weighted average number of  common  and  dilutive
potential common shares outstanding.

(3)  Line of Credit

      The Company has an international line of credit with a bank  for
the  equivalent of $3.0 million, which bears interest  at  PIBOR  plus
1.50%.   The borrowings under this line are denominated in  the  local
currency of its European subsidiaries and are primarily used by  these
subsidiaries to settle intercompany sales.

(4)  Concentration of Credit Risk

           The  Company  sells  certain of its systems  to  a  leasing
company,  which  in  turn leases the systems to  third  parties.   The
leasing  company accounted for 9% and 38% of product sales in the  six
months  ended  March 27, 1999 and March 28, 1998,  respectively.   The
Company  finances certain sales to Latin America over  a  two-to-three
year  time-frame.  At March 27, 1999, the Company had  total  accounts
receivable outstanding of approximately $7.7 million relating to these
sales,  of  which  $1.9 million were long-term and included  in  other
assets.   As  of  March 27, 1999, the Company has not experienced  any
significant  change in these receivables, however,  the  economic  and
currency  related  uncertainties in these countries may  increase  the
likelihood of non-payment.  As a result, the Company increased its bad
debt reserve in the second quarter of fiscal 1999.
                                   
(5)  Recent Accounting Pronouncements

      In  July 1997, the FASB issued Statement of Financial Accounting
Standards  ("SFAS  No.  131")  ,  Disclosures  About  Segments  of  an
Enterprise  and  Related Information.  SFAS No. 131  requires  certain
financial  and supplementary information to be disclosed on an  annual
and  interim  basis for each reportable segment of an  enterprise,  as
defined.   SFAS No. 131 is effective for fiscal years beginning  after
December  15, 1997.  Unless impracticable, companies would be required
to  disclose  similar  prior period information  upon  adoption.   The
Company  will  adopt  this  statement in their  fiscal  1999  year-end
financial statements.

     In  June  1998,  the  FASB issued SFAS No.  133,  Accounting  for
Derivative   Instruments  and  Hedging  Activities.   SFAS   No.   133
establishes   accounting  and  reporting  standards   for   derivative
instruments,  including  certain  derivative  instruments  investments
embedded  in other contracts (collectively referred to as derivatives)
and  for  hedging  activities.  SFAS No. 133 is effective  for  fiscal
years beginning after June 15, 1999.  The Company does not expect  the
adoption  of  this  statement  to  have  a  material  impact  on   its
consolidated financial position or results of operations.

(6)  Land, Building and Improvements

     In fiscal 1998, the Company purchased a 200,000 square foot
building for approximately $20 million in cash, and has incurred
approximately $5 million for renovations.  The Company moved its
headquarters and manufacturing into this facility on January 25, 1999.
The Company began to amortize the cost of the building straight-line
over 40 years in the second quarter of fiscal 1999.

(7)  Comprehensive (Loss) Income

     The  Company  adopted  SFAS 130, Reporting Comprehensive  Income,
effective  September  27,  1998.  SFAS 130 established  standards  for
reporting  and  display of comprehensive income and its components  in
the   financial  statements.   The  Company's  only  item   of   other
comprehensive   income   relates  to  foreign   currency   translation
adjustments,  and  is  presented separately on the  balance  sheet  as
required.   A  reconciliation of comprehensive  (loss)  income  is  as
follows:
     



                                     Three Months Ended           Six Months Ended
                                     ------------------         --------------------
                                     March 27,  March 28,       March 27,  March 28,
                                       1999       1998            1999       1998 
                                     --------   ---------       --------   ---------      
                                                                                                                  
                                                    (in thousands)
Net (loss) income as reported......  $(1,088)     $2,720           $949      $4,783    

Foreign currency translation 
    adjustment.....................     (530)       (165)          (539)       (208)
                                     --------     -------           ----     ------- 
Comprehensive (loss) income........  $(1,618)     $2,555           $410      $4,575
                                     ========     ======           =====     ======


(8)  Subsequent Event - Purchase and Sale Agreement


     On  April  28, 1999, Hologic signed a purchase and sale agreement
to  acquire  Delaware-based Direct Radiography Corporation ("DRC"),  a
wholly-owned  subsidiary of Sterling Diagnostic Imaging,  Inc.   Under
the   terms   of  the  agreement,  Hologic  will  purchase   DRC   for
approximately $30 million, comprised of $10 million in  cash  and  2.5
million shares of Hologic common stock.  In addition, Hologic  may  be
required to pay additional monies if the market value of the Company's
common  stock  issued  pursuant to the terms of this  agreement  falls
below  $20  million.  The closing of this acquisition  is  subject  to
satisfaction  of  certain  terms  and  conditions.   DRC  manufactures
digital  X-ray systems for medical imaging and non-destructive testing
applications.   Hologic  will use the purchase  accounting  method  to
account for the acquisition of DRC.
                                   
                                   
                                   
                                   
                                   
              PART I - FINANCIAL INFORMATION (Continued)

Item 2.        Management's Discussion and Analysis of Financial
          Condition and Results of Operations

                    HOLOGIC, INC. AND SUBSIDIARIES
Results of Operations

      The Company's results of operations have and may continue to  be
subject  to  significant  quarterly  variation.   The  results  for  a
particular quarter may vary due to a number of factors, including  the
Company's  proposed acquisition of Direct Radiography  Corp.  ("DRC"),
the  introduction  of  new  products or product  enhancements  by  the
Company  or its competitors, the timing of FDA approvals or clearances
for  such  introductions, the overall state of health  care  and  cost
containment  efforts,  the  development status  and  demand  for  drug
therapies   to   treat  osteoporosis,  the  status   and   amount   of
reimbursement  for  approved procedures, the use  of  mini  c-arms  in
minimally-invasive surgical procedures, the availability of  financing
alternatives,  including  fee-per-scan  programs,  for  the  Company's
products,  dependence on Physician Sales and Service, Inc. to  broaden
the  sales  of  the  Company's product to  the  primary  care  market,
economic  conditions in the Company's markets, the timing  of  orders,
the timing of expenditures in anticipation of future sales, the mix of
products  sold  by  the  Company, and pricing  and  other  competitive
conditions.

      Revenues.  Total revenues for the second quarter of fiscal  1999
decreased  36%  to  $19.4 million from $30.2  million  in  the  second
quarter  of  fiscal  1998.  Total revenues for the current  six  month
period decreased 22% to $44.0 million from $56.3 million for the first
six  months of fiscal 1998.  These decreases were primarily due  to  a
decrease in the total number of domestic DXA bone densitometer product
shipments,  especially to the primary care market including  strategic
alliance  sales to a leasing company.  The decrease in DXA  sales  was
partially offset by an increase in the number of mini c-arm and Sahara
(the  Company's ultrasound bone sonometer) product sales in  both  the
current quarter and current six month periods.  The increase in  sales
of  mini  c-arms were primarily from the Company's recently introduced
Premier  system.   Sahara sales increased in the current  quarter  due
primarily  to  sales in the United States, where the Company  received
marketing clearance from the FDA in March 1998.  The Company  did  not
have  marketing clearance for Sahara until late in the second  quarter
of  fiscal 1998.  Other revenues decreased for the current three month
period, as compared to the same period of the previous year, primarily
due  to  a  decrease in royalties from the license  of  the  Company's
technology  to Vivid Technologies, Inc.  Other revenues decreased  for
the  current six month period due to a decrease in royalties from  the
license of the Company's technology to Vivid Technologies, Inc. and  a
decrease  in  revenues received under a development  agreement  for  a
biochemical  marker strip test.  Partially offsetting these  decreases
was an increase in additional fee-per-scan revenues.

      Total  revenues for the second quarter of fiscal 1999  decreased
21%  from $24.6 million in the immediately preceding quarter primarily
due  to (i) a decrease in the number of DXA systems sold in the United
States  (ii) a decrease in the number of mini c-arms sold and (iii)  a
decrease in Sahara product sales.

     In  the  first  six months of fiscal 1999, approximately  62%  of
product sales were generated in the United States, 24% in Europe,   8%
in  Asia,  and  6% in other international markets.  In the  first  six
months  of  fiscal  1998,  approximately 71%  of  product  sales  were
generated  in  the  United  States,  18%  in  Europe,  7%   in   other
international markets, and 4% in Asia.

      Costs and Expenses.    The cost of product sales increased as  a
percentage of product sales to 61% in the current quarter from 50%  in
the  same quarter of fiscal 1998.  The cost of product sales increased
as  a  percentage  of product sales to 57% in the  current  six  month
period  of fiscal 1999 from 50% in the same six month period of fiscal
1998.   In  the  current  quarter and six month periods,  these  costs
increased as a percentage of product sales primarily due to a decrease
of approximately 50% in the number of DXA bone densitometers sold and,
to  a  lesser extent, lower average selling prices.  The reduction  in
DXA   sales  volume  resulted  in  the  under  absorption   of   fixed
manufacturing costs.

      Research  and development expenses increased 5% to $2.6  million
(14%  of total revenues) in the current quarter from $2.5 million  (8%
of  total  revenues) in the second quarter of fiscal  1998.   For  the
current  six month period, research and development expenses increased
5%  to  $5.1 million (12% of total revenues) from $4.8 million (9%  of
total  revenues)  for the first six months of 1998.  The  increase  in
research  and  development expenses in 1999 is primarily  due  to  the
addition  of engineering personnel and outside consultants working  on
the development of new products and product enhancements.

     Selling and marketing expenses decreased 40% to $4.7 million (25%
of  product  sales) in the current quarter from $7.8 million  (27%  of
product  sales) in the second quarter of fiscal 1998.  For the current
six  month period, selling and marketing expenses decreased 32% to $10
million  (23%  of  product sales) from $14.6 million (27%  of  product
sales) for the first six months of 1998.  The decrease in selling  and
marketing  expenses in 1999 is primarily due to a  decrease  in  sales
commissions paid to PSS based on the lower sales volume in the primary
care market in the United States.

     General and administrative expenses increased 26% to $2.9 million
(15% of total revenues) in the current quarter from  $2.3 million  (8%
of  total revenues) in the second quarter of fiscal 1998.  During  the
first  six months of fiscal 1999, general and administrative  expenses
increased 10% to $5 million (11% of total revenues) from $4.6  million
(8%  of  total  revenues)  in the first six  months  of  1998.   These
increases  in general and administrative expenses in fiscal 1999  were
primarily  due  to  an  increase in  the accounts  receivable  reserve
related to the Company's foreign receivables, especially in Brazil.

      In April 1999, Company implemented a cost-reduction strategy  in
an  effort to reduce operating expenses.  The Company reduced its U.S.
workforce  by  approximately 10% through  attrition  and  a  corporate
downsizing.   A   strategy  to  streamline   operations   and   reduce
discretionary spending for its existing business was also implemented.
The Company expects that the severance expenses incurred in connection
with  the  downsizing  will  be offset by the  cost  savings  achieved
through the reduction in decretionary spending in the third quarter of
fiscal  1999.  Additionally, the Company may incur additional expenses
in the third quarter relating to the proposed acquisition of DRC.

      Interest Income.  Interest income decreased to $991,000  in  the
current  quarter from $1.5 million in the same quarter of fiscal  1998
and  decreased  to $2.2 million in the current six month  period  from
$2.8  million in the comparable period in fiscal 1998 as  the  Company
held  a  lower  investment base than in the prior  year,  due  to  the
Company's use of funds to purchase a new facility.

     Other Expense. The Company incurred other expense of $297,000 and
$113,000 for the second quarter of fiscal 1999 and 1998, respectively.
For the first six months of fiscal 1999 and 1998, the Company incurred
other  expense of $329,000 and $203,000 respectively.  In the  current
quarter  and six month periods, these expenses include interest  costs
on  the  line of credit established for use by the Company's  European
subsidiaries  to  borrow funds in their local currencies  to  pay  for
intercompany sales, thereby reducing the foreign currency exposure  on
those  transactions and to foreign currency transaction  losses.   For
the second quarter and first six months of fiscal 1998, these expenses
were  primarily  attributable to the interest costs  on  the  line  of
credit  and,  to  a  lesser  extent, to foreign  currency  transaction
losses.   To the extent that foreign currency exchange rates fluctuate
in the future, the Company may be exposed to continued financial risk.
Although  the Company has established a borrowing line denominated  in
the two foreign currencies (the French Franc and the Belgian Franc) in
which  the  subsidiaries currently conduct business to  minimize  this
risk, there can be no assurance that the Company will be successful or
can fully hedge its outstanding exposure.
                                   
     Provision for Income Taxes.  The Company's effective tax rate was
approximately 35% and 36% in the first six months of fiscal  1999  and
1998,  respectively. The effective tax rate is less than the  combined
Federal  and  state  statutory rates due primarily  to  the  favorable
Federal  and state tax treatment afforded the Company's foreign  sales
corporation  and the favorable state tax treatment of certain  of  the
Company's interest income.

Liquidity and Capital Resources

     At March 27, 1999, working capital was approximately $93 million,
and  cash,  cash  equivalents and short-term investments  totaled  $65
million.   The  cash,  cash  equivalents  and  short-term  investments
balance  decreased approximately $11 million from September  26,  1998
primarily  due  to  payments  for facility  renovations  and  payments
against  the  European line of credit.  The Company  finances  certain
sales  to Latin America over a two-to-three year time-frame.  At March
27,  1999,  the  Company had total accounts receivable outstanding  of
approximately  $7.7  million relating to these sales,  of  which  $1.9
million were long-term and included in other assets.  As of March  27,
1999,  the Company has not experienced any significant change in these
receivables,  however, the economic and currency related uncertainties
in  these countries may increase the likelihood of non-payment.  As  a
result,  the  Company increased it's bad debt reserve  in  the  second
quarter.   In  the  first  six months of 1999, the  Company  purchased
approximately $8.1 million of property and equipment, which  consisted
primarily of building improvements, furniture and fixtures for the new
building  and,  to  a lesser extent, computers. The Company  purchased
this  200,000 square foot building for approximately $20  million  in
cash  in  fiscal  1998  and moved its headquarters  into  this
facility on January 25, 1999.

     On  April  28,  1999,  the Company signed  a  purchase  and  sale
agreement  to  acquire DRC.  DRC is a development stage  company  that
manufactures  digital  X-ray  systems for  medical  imaging  and  non-
destructive testing applications.  In connection with the acquisition,
the  Company  expects to incur monthly expenditures  of  approximately
$1-1.5  million to fund DRC's ongoing operations and commercialization
of  its products until meaningful revenue is achieved. Under the terms
of  the  agreement,  Hologic will purchase DRC for  approximately  $30
million,  comprised of $10 million in cash and 2.5 million  shares  of
Hologic  common  stock.  In addition, Hologic may be required  to  pay
additional  monies if the market value of the Company's  common  stock
issued  pursuant  to  the  terms of this  agreement  falls  below  $20
million.   The  closing of this acquisition is subject to satisfaction
of certain terms and conditions.
     
     Except  as  set  forth  above,  the  Company  does  not  have any
significant  capital commitments.  The Company believes that  existing
sources  of liquidity will provide adequate cash to fund the Company's
anticipated  working capital and other cash needs for the  foreseeable
future.

Year 2000 Readiness Disclosure

      The  year  2000  (Y2K)  issue is the potential  for  system  and
processing  failure of date-related data and the result  of  computer-
controlled  systems using two digits rather than four  to  define  the
applicable  year.  For  example, computer  programs  that  have  date-
sensitive  software may recognize a date using "00" as the  year  1900
rather than the year 2000. Systems that do not properly recognize date-
sensitive  information when the year changes to  2000  could  generate
system  failure or miscalculations causing disruptions of  operations,
including,  among  other  things,  a temporary  inability  to  process
transactions,  send  invoices or engage in similar  ordinary  business
activities.  The Company has defined Y2K compliance as the ability for
the  Company,  its products and suppliers to continue normal  business
activities in the year 2000 and beyond.

     The  Company  is  evaluating the Y2K issue with  respect  to  its
financial  and  management information systems, its products  and  its
suppliers.  At  this  point  in its assessment,  the  Company  is  not
currently aware of any Y2K problems that are reasonably likely to have
a  material effect on the Company's business, results of operations or
financial condition, without taking into account the Company's efforts
to avoid such problems.

     The  Company  is  completing its review  of  its  management  and
information  systems  for  Y2K compliance  and  has  identified  other
application software and hardware which must be upgraded to become Y2K
compliant.  The  Company believes that its accounting and  information
systems  are currently compliant as a result of installing an  upgrade
version  of the software made available through the annual maintenance
contract.   However, the Company uses other application  hardware  and
software  which  may  not be Y2K complaint.  Most upgrades  for  these
programs  are also available as part of an annual maintenance program.
The  Company  believes that it already has and installed most  of  the
necessary  upgrades for these programs or that the  upgrades  for  the
programs are otherwise available without material expenditure  by  the
Company.   The  Company anticipates that it will be able to  complete,
test  and implement all upgrades of this software that may be material
to   its  business  on  a  timely  basis.   There  is  a  risk   that,
notwithstanding its internal review, if the Company has  not  properly
identified  all  year  2000  compliance issues  with  respect  to  its
management  and information systems, the Company may not  be  able  to
implement all necessary changes to these systems on a timely basis and
within budget. Such a failure could result in a material disruption to
the  Company's  business, including the inability to  track  and  fill
orders  on a timely basis, which could have a material adverse  effect
on its business, results of operations and financial condition.

     The Company has evaluated its DXA products in production and they
are  currently  Y2K  compliant as of the end  of  January  1999.   The
Company  has also identified certain older models of its DXA  products
that will need computer hardware upgrades to become Y2K compliant. The
Company  plans  to  make  this software available,  at  the  Company's
expense,  to its customers by the end of May 1999 as this software  is
currently  in  beta  testing.  These costs  are  not  expected  to  be
material.   The  Company  believes that  its  Sahara  ultrasound  bone
sonometer is currently Y2K compliant.

      The Company is also exposed to the risk that it could experience
material  shipment  delays  from  its  major  component  suppliers  or
material sales delays from its major customers due to year 2000 issues
relating either to their management information or production systems.
The Company has inquired of these suppliers in an attempt to ascertain
their  year  2000 readiness. At this time, the Company  is  unable  to
estimate  the  nature  or  extent  of  any  potential  adverse  impact
resulting from the failure of third parties, such as its suppliers and
customers,  to  achieve  year 2000 compliance.  Moreover,  such  third
parties,  even  if year 2000 compliant, could experience  difficulties
resulting  from  year  2000 issues that may  affect  their  suppliers,
service  providers  and customers. As a result, although  the  Company
does  not  currently anticipate that it will experience  any  material
shipment  delays  from their major product suppliers or  any  material
sales  delays from its major customers due to year 2000 issues,  these
third  parties could experience year 2000 problems that could  have  a
material  adverse  effect  on  the  Company's  business,  results   of
operations and financial condition.

     Apart  from its activities described above, the Company does  not
have  and  does not plan to develop a contingency plan to address  Y2K
issues.   Should any unanticipated significant Y2K issues  arise,  the
Company's  failure to implement such a contingency plan could  have  a
material  adverse  affect  on its business,  financial  condition  and
results of operations.

     To the extent that the Company does not identify any material non-
compliant  year  2000 issues affecting the Company or  third  parties,
such as the Company's suppliers, service providers and customers,  the
most  reasonably likely worst case year 2000 scenario  is  a  systemic
failure  beyond  the  control  of the Company,  such  as  a  prolonged
telecommunications or electrical failure, or a general  disruption  in
United  States or global business activities that could  result  in  a
significant  economic downturn. The Company believes that the  primary
business  risks,  in  the event of such failure or  other  disruption,
would  include  but  not be limited to, loss of customers  or  orders,
increased operating costs, inability to obtain inventory on  a  timely
basis,   disruptions   in  product  shipments,   or   other   business
interruptions   of   a  material  nature,  as  well   as   claims   of
mismanagement, misrepresentation, or breach of contract, any of  which
could  have  a  material  adverse effect on  the  Company's  business,
results of operations and financial condition.

Item  3.   Quantitative and Qualitative Disclosure About Market Risk.
           Not applicable.



                      PART II - OTHER INFORMATION
                                   
                    HOLOGIC, INC. AND SUBSIDIARIES
                                   
Item 1.   Legal Proceedings.
     No material litigation.

Item 2.   Changes in Securities.
     None.

Item 3.   Defaults Upon Senior Securities.
     None.

Item 4.   Submission of Matters to a Vote of Security-Holders.

     The  Company held its Annual Meeting of Stockholders on  February
23, 1999 and adjourned the meeting until March 9, 1999 for the purpose
of  voting  on proposal 2.  At the February 23rd meeting, a  total  of
11,258,486 shares or 84% of the Common Stock issued and outstanding as
of  the record date, were represented at the meeting in person  or  by
proxy.   Set  forth below is a brief description of each matter  voted
upon  at  the  meetings and the voting results with  respect  to  each
matter.



     1.   A proposal to elect the following seven persons to serve  as
     members of the Company's Board of Directors for the ensuing  year
     and until their successors are duly elected:

  Name                     For               Withheld       Abstain
  -------------------      ----------        --------       -------
  S. David Ellenbogen      11,150,034        108,452           0
  Irwin Jacobs             11,148,572        109,914           0
  Steve L. Nakashige       11,148,012        110,474           0
  William A. Peck          11,150,034        108,452           0
  Gerald Segel             11,148,341        110,145           0
  Jay A. Stein             11,150,034        108,452           0
  Elaine Ullian            11,150,034        108,452           0

     2.   A proposal to approve the Company's 1999 Equity Incentive Plan.

          For: 5,291,707      Against: 4,373,001     Abstain: 43,229
     
     3.   A proposal to ratify the appointment of Arthur Andersen, LLP
          as independent public accountants of the Company.

          For: 11,182,460    Against: 54,337      Abstain: 21,198

Item 5.   Other Information.
     None.

Item 6.   Exhibits and Reports on Form 8-K.

     (a)  Exhibits furnished:
          (10) Hologic, Inc. Amended and Restated 1999 Equity
          Incentive Plan
          (27) Financial Data Schedule

     (b)  Reports on Form 8-K:
          None.

                    HOLOGIC, INC. AND SUBSIDIARIES
                                   
                              SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of
1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned thereunto duly authorized.




                                   Hologic, Inc.
                                   (Registrant)



May 11, 1999                 /s/ S. David Ellenbogen
- ------------                 ------------------------
Date                          S. David Ellenbogen
                              Chairman and Chief Executive Officer





May 11, 1999                  /s/ Glenn P. Muir
- ------------                  --------------------------
Date                          Glenn P. Muir
                              Vice President, Finance and Treasurer
                              (Principal Financial and Chief
                               Accounting Officer)