May 9, 1996

Meris Laboratories, Inc.
2890 Zanker Road
San Jose, CA  95134
Attn:  William Neeley

         RE:  Silicon Valley Bank Loan

Dear Dr. Neeley:

         This  letter is written in  connection  with that  certain  Amended and
Restated Loan and Security  Agreement  between  Silicon Valley Bank ("Bank") and
Meris  Laboratories,  Inc.  ("Borrower")  dated April 21, 1995, and related loan
documents (as amended from time to time, collectively, the "Loan Agreement").

         Section  6.8 of the Loan  Agreement  as amended  requires  Borrower  to
maintain on a monthly basis a minimum Quick Ratio of 0.75:1.00.  Section 6.10 of
the Loan Agreement as amended requires Borrower to maintain on a monthly basis a
minimum Tangible Net Worth plus Subordinated Debt of $2,000,000. Section 6.11 of
the  Loan  Agreement  as  amended  requires  that  Borrower  achieve   quarterly
profitability  beginning with the quarter ended March 31, 1996.  Section 6.13 of
the Loan Agreement as amended requires Borrower to maintain on a monthly basis a
ratio of total senior  liabilities to annualized  Earnings before Interest Taxes
Depreciation and Amortization of 3.50:1.00.  As of March 31, 1996,  Borrower was
in default  of the Loan  Agreement  for  non-compliance  of all of the  required
financial covenants, and that default continues as of this date.

         Section 2.1 of the Loan Agreement limits funds to be advanced under the
above  referenced  loan  obligation  ("Line  of  Credit")  to the  lesser of (i)
$10,000,000.00, or (ii) 85% of eligible accounts receivable minus (iii) the face
amount of all outstanding  letters of credit  (including  drawn but unreimbursed
letters  of  credit).  Pursuant  to  that  certain  Borrowing  Base  Certificate
submitted by Borrower and dated as of March 31, 1996, the total funds  available
under this formula totaled  $6,804,020.00,  as compared to the principal balance
outstanding  under the Line of Credit of  $7,750,000.00,  which sum  exceeds the
total  available funds by $945,980.00  ("Overadvance").  Section 2.2 of the Loan
Agreement  requires  Borrower  to  immediately  repay in cash the  amount of any
Overadvance.  To date,  Borrower has failed to pay the amount of  Overadvance to
Bank.

         In addition, the Line of Credit matured on April 20, 1996 at which date
all  indebtedness  owing  under the Line of Credit  became  immediately  due and
payable. To date, amounts advanced under the Line of Credit have not been paid.

         In light of the above  described  Events of Default (as set forth above
and as  defined  in the Loan  Agreement),  and  with  regard  to  those  certain



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unsecured converable senior subordinated  debentures dated November 14, 1994 and
December 5, 1994  (collectively,  the "Subordinated  Debt"),  Borrower is hereby
prohibited from making any further  payments of accrued interest or principal on
account of the  Subordinated  Debt in accordance  with the terms of section 7 of
the agreements evidencing the Subordinated Debt.

         Subject to the  immediate  cessation of  Subordinated  Debt payments as
outlined  above and  Borrower's  continued  compliance  with all other terms and
conditions of the Loan  Agreement,  Bank agrees to forbear from  exercising  its
remedies   under  the  Loan   Agreement  as  amended   until  August  15,  1996,
notwithstanding  Borrower's  existing Events of Default under the Loan Agreement
as a result of Borrower's  failure to comply with the covenants  outlined above.
By signing below,  Borrower  acknowledges  that the Loan is currently in default
and, as a result of such default, that Bank is entitled to exercise its remedies
as provided in the Loan Agreement and applicable law.  Nothing in this agreement
in any way shall  constitute  Bank's  waiver of  Borrower's  existing  Events of
Default under the Loan Agreement.  Upon  termination of the  forbearance  period
described above, without any notice to Borrower,  Bank may exercise any remedies
available to Bank under the Loan Agreement and under applicable law.

         Borrower  further  understands  and agrees that in  modifying  the Loan
Agreement,  Bank is relying upon  Borrower's  representations,  warranties,  and
agreements,  as set forth in the Loan  Agreement.  Except as expressly  modified
pursuant to this letter, the terms of the Loan Agreement remain unchanged and in
full  force and  effect.  Bank's  agreement  to  modify  the Loan  Agreement  in
accordance with the provisions set forth in this letter shall in no way obligate
Bank to make any future  modifications  to the Loan  Agreement.  Nothing in this
letter shall  constitute a satisfaction of the Borrower's  indebtedness to Bank.
The  terms of this  paragraph  apply  not only to this  letter,  but also to all
subsequent loan modifications agreements.

Very Truly Yours,

SILICON VALLEY BANK

 /s/Mitzi R. Lazich
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Mitzi R. Lazich
Vice President


By executing below, the undersigned  acknowledges and confirms the effectiveness
of this letter to amend the Loan Agreement.

MERIS LABORATORIES, INC.

 /s/William Neeley
- ------------------------
By:  William Neeley
Its:  President
Dated:  6-4-96

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