SEVERANCE AGREEMENT


         THIS  AGREEMENT  is made as of August 19, 1996 by and between  BioTime,
Inc., a California corporation  (hereinafter referred to as the "Company"),  and
Lawrence Cohen (hereinafter referred to as "Cohen").

                              W I T N E S S E T H:


         WHEREAS,  Cohen is  presently a director of the Company and is employed
by the Company in the capacity of Chairman of the Board; and

         WHEREAS,  Cohen  desires to retire from the Company and the Company and
Cohen  desire to  implement  certain  arrangements  in  connection  with Cohen's
retirement from the Company.

         NOW,   THEREFORE,   in   consideration  of  the  terms  and  conditions
hereinafter set forth, the parties hereto agree as follows:


         1. Stock  Options.  The Company  hereby  grants to Cohen stock  options
("Options")  to purchase up to 25,000 of the  Company's  Common  Shares,  no par
value  ("Shares") at an exercise price of $14.88 per Share. All such Options are
granted  pursuant to and shall be governed by the  Company's  1992 Stock  Option
Plan, as amended,  and by that certain Stock Option Agreement  between the Cohen
and the Company in the form attached as EXHIBIT A. The grant of Options to Cohen
under this Agreement is subject to the express  condition that Cohen execute and
deliver the Stock Option Agreement.

                  (a)  Exercise  Period and  Expiration  of  Options.  The Stock
Option  Agreement  shall provide,  among other things,  that the Options granted
under this Section 1 shall not become exercisable unless and until vested.  Such
Options  shall vest and thereby  become  exercisable  ninety (90) days after the
date of this Agreement if (i) concurrently  with Cohen's  execution and delivery
of this Agreement,  his wife, Donna Cohen,  shall have executed and delivered to
the Company that certain Stock Lock-Up Agreement in the form attached as EXHIBIT
B, and (ii) no breach or default by Cohen or Donna Cohen  under this  Agreement,
the Stock Option  Agreement or the Stock Lock-Up  Agreement shall have occurred.
The Stock Option Agreement shall provide,  among other things,  that the Options
shall expire on the earliest to occur of: (A) two years after the date of grant;
and (B) any breach or default by Cohen or Donna Cohen under this Agreement,  the
Stock Option Agreement or the Stock Lock-Up Agreement.

         2. Resignation.  Cohen hereby resigns as a director,  officer (Chairman
of the Board) and employee of BioTime.

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         3.  Severance  Compensation.  As  severance  compensation,  the Company
agrees to pay to Cohen the  unpaid  portion  of his  salary  and other  benefits
payable  to him under the terms of his  Employment  Agreement,  dated  April 25,
1994, through April 24, 1997,  provided that Cohen fully and faithfully performs
and complies with all of his agreements and  obligations  under this  Agreement,
and Donna Cohen  fully and  faithfully  performs  and  complies  with all of her
agreements and obligations under the Stock Lock-Up Agreement; provided, however,
that the  provisions of Section 6.8 of Cohen's  Employment  Agreement  shall not
apply in the event that a "Change in Control"  as defined  therein  occurs;  and
provided,  further, that Cohen agrees that the unpaid portion of his salary plus
other cash  benefits  payable for the  remainder  of the term of his  Employment
Agreement (ie. through April 24, 1997) is $42,500.

         4.  Confidentiality.  In the course of serving as an officer,  director
and employee of the Company,  the Company has disclosed to Cohen,  and Cohen may
otherwise  have  obtained  knowledge  of or access to,  trade  secrets and other
proprietary and  confidential  information  concerning the Company,  the Company
products, financial condition, research and development plans, and other matters
pertaining to the Company's business ("Confidential Information").  Cohen agrees
to treat and hold all Confidential  Information as secret and confidential,  and
to apply strict  standards  of care to maintain the secrecy of the  Confidential
Information.  In this regard,  Consultant  agrees not to copy or  reproduce  any
Confidential  Information  and not to disclose the contents of any  Confidential
Information  to any person or entity,  other than  officers and directors of the
Company.  Cohen further agrees to return to the Company  written or other copies
(including electronic media containing Confidential  Information) of any and all
Confidential Information in Cohen's possession. The provisions of this Section 4
shall not apply to any  Confidential  Information that Cohen is obligated by law
to disclose to any court or any federal or state government agency.

         5.  Restrictions  on Certain Sales.  Cohen agrees that, for a period of
six months from the date of this Agreement, he will not, directly or indirectly,
in his own name,  in the name of any other  person or  entity,  or  through  any
account  owned or  controlled  by Cohen or over which  Cohen  holds any power to
direct the sale or other  disposition  of securities  (a) sell,  offer for sale,
transfer or exchange  any Common  Shares of the  Company,  or (b) grant,  write,
purchase or sell any call,  put or other option giving Cohen or any other person
or entity the right to sell,  or giving any other  person or entity the right to
purchase,  Common  Shares  of the  Company,  except  for  such  sales  or  other
transactions  in or  pertaining  to Common  Shares of the  Company  for which no
report,   statement,   form,  notice  or  other  document  (including,   without
limitation,  any notice  under  Rule 144 under the  Securities  Act of 1933,  as
amended  (the  "Securities  Act"),  or any  Form 4 under  Section  16(a)  of the
Securities Exchange Act of 1934, as amended (the "Exchange Act")) is required to
be filed with the Securities and Exchange Commission.

         6.  Restrictions  on  Certain  Actions.  For a period of five (5) years
commencing  on the  date of this  Agreement,  Cohen  agrees  not to (a) make any
statement  (public or private)  critical of the Company,  its management (or any
officer  or  director  of  the  Company),  technology,   products,  business  or
prospects,  (b)  recommend  that anyone sell or refrain from  purchasing  Common
Shares

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of the Company, (c) engage (directly, or indirectly through the participation in
any  group,  or  ownership  of any  direct  or  indirect  interest  in  account,
corporation,  partnership or other entity) in any short sale of Common Shares of
the  Company,  (d)  acquire,  directly  or  indirectly,  as part  of a group  or
otherwise,  beneficial  ownership of 5% or more of any outstanding  class of the
Company  equity  securities,   and  Cohen  will  not  join  in  any  group  that
beneficially  owns 5% or more of any such  class of equity  securities,  and (e)
participate  in or support any group or slate of  candidates  seeking to replace
any incumbent director of the Company.  Beneficial ownership shall be determined
under Section 13(d) of the Exchange Act and the rules promulgated thereunder.

         7.  Injunctive  Relief.  Cohen  acknowledges  that the Company would be
irreparably  harmed by the disclosure or use of any Confidential  Information in
violation  of this  Agreement.  Cohen  agrees  that,  in  addition  to all other
remedies  available  to the Company at law or in equity,  the  Company  shall be
entitled to equitable relief  enjoining any use,  appropriation or disclosure of
Confidential Information in violation of this Agreement.

         8.  Certain  Remedies  for Breach.  Cohen agrees that the Options to be
granted  under  Subsection  1 are being  granted  in  consideration  of  Cohen's
agreement to comply with the  provisions of this  Agreement and the Stock Option
Agreement,  and Donna  Cohen's  Agreement to comply with the  provisions  of the
Stock  Lock-Up  Agreement,  and  Cohen's  right  to  exercise  such  Options  is
conditioned  upon  Cohen's full  compliance  with this  Agreement  and the Stock
Option  Agreement,  and Donna  Cohen's full  compliance  with the Stock  Lock-Up
Agreement.  Because a breach of the  provisions of this  Agreement and the Stock
Lock-Up  Agreement could not adequately be compensated by money damages,  and/or
because  determination  of any monetary damages incurred by the Company would be
difficult to calculate,  in the event of a breach of this Agreement or the Stock
Lock-Up  Agreement,  the Company  shall be entitled  (in addition to, and not in
lieu of, any other right or remedy  available  to it under this  Agreement,  the
Stock Option Agreement,  and the Stock Lock-Up Agreement to cancel any or all of
the Options  granted to Cohen under this  Agreement  which have not  theretofore
been exercised in accordance with their terms and conditions.  Such cancellation
may be effected  without any  compensation to Cohen or Donna Cohen for the value
of such Options or the value of the Shares or other  securities  underlying such
Options.

         9.  Reasonable  Restrictions.  Cohen  agrees  that  the  provisions  of
Sections 4, 5 and 6 are  reasonable and necessary to protect the Company and its
business.  It is the desire and intent of the  parties  that the  provisions  of
Sections 4, 5 and 6 shall be enforced to the fullest extent  permitted under the
public policies and laws applied in each  jurisdiction  in which  enforcement is
sought.  If any restriction  contained in Sections 4, 5 and 6 shall be deemed to
be  invalid,  illegal  or  unenforceable  by  reason of the  extent or  duration
thereof,  or otherwise,  then the court making such determination shall have the
right to reduce such extent or other  provisions  hereof and in its reduced form
such restriction shall then be enforceable in the manner contemplated hereby.

         10. Release. Cohen hereby forever releases,  acquits and discharges the
Company and each officer,  director and employee of the Company from any and all
liability, whether in

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contract,  tort,  or  otherwise,  that Cohen may now have or which may hereafter
accrue,  arising  out of or  connected  with the service of Cohen as a director,
officer or employee of the Company, or as a shareholder of the Company, prior to
the date of this  Agreement.  Cohen further agrees not to participate as a party
adverse to the Company in any lawsuit or other  proceeding and not to finance or
otherwise  assist  any party  adverse  to the  Company  in any  lawsuit or other
proceeding, other than proceedings pertaining to any actual or alleged breach of
this  Agreement  or the Stock  Option  Agreement.  The  Company  hereby  forever
releases,  acquits and discharges  Cohen from any and all liability,  whether in
contract,  tort,  or  otherwise,  that the  Company  may now  have or which  may
hereafter  accrue,  arising out of or  connected  with the service of Cohen as a
director,  officer  or  employee  of the  Company,  or as a  shareholder  of the
Company,  prior to the date of this Agreement.  The Company and Cohen agree that
this  release  includes all claims of every kind and nature,  past,  present and
future, known or unknown, suspected or unsuspected.  With respect to the subject
matter of this release, the Company and Cohen expressly waive any and all rights
or claims under Section 1542 of the California Civil Code, which provides:

         "A general  release does not extend to claims  which the creditor  does
         not know or suspect to exist in his favor at the time of executing  the
         release,  which  if  known by him must  have  materially  affected  his
         settlement with the debtor."

This Section 10 shall not affect Cohen's rights to indemnification  arising from
his acting as an officer,  director or employee of the  Company,  as provided in
the  articles of  incorporation  and bylaws of the Company or Section 317 of the
California  Corporations Code. The Company's articles of incorporation authorize
the  corporation  to  indemnify  officers and  directors  to the fullest  extent
permitted under California law, and the Company agrees to so indemnify Cohen but
only to the same extent as such  indemnification  is provided to other  officers
and  directors  of the  Company;  provided,  however,  that the Company does not
presently  maintain  insurance  indemnifying  its  officers and  directors  from
liabilities arising from their acts and omissions,  and the Company shall not be
obligated to provide  Cohen with any such  insurance  even if such  insurance is
obtained for other officers and directors in the future.

         11. Tax  Withholding.  Cohen agrees that the Company may withhold  from
the severance payments all federal, state, and local income,  employment,  FICA,
SDI and other  taxes.  Cohen also  agrees to remit to the  Company on demand all
federal,  state, and local income tax withholdings arising from the grant of the
Option, as may be required by applicable law. In this regard, Cohen acknowledges
that the exercise price of the Option on the date of grant is less than the fair
market  value per share of the Shares  issuable  upon  Cohen's  exercise  of the
Option.

         12. Transfers of Restricted Shares. The Company agrees that it will not
act to materially delay or prohibit any sale of restricted  Company Shares owned
by Cohen or Donna  Cohen,  and will not  impose any fee as a  condition  of such
transfer,  provided  that  the  sale (a)  does  not  violate  the  terms of this
Agreement or the Stock Lock-Up  Agreement,  (b) is made in compliance  with Rule
144(k) under the Securities  Act, (c) does not violate  Section 10 or Section 16
of the Exchange Act or any regulation  thereunder,  and (d) does not violate the
securities or "Blue Sky" laws of any state. For the purpose of this Section, the
Company  shall not be deemed to have caused a  restriction  or delay on any sale
resulting  from  (i)  the  placement  of  a  legend  on  any  stock  certificate
restricting  sales  or  transfers  without  registration  or an  exemption  from
registration  under the Securities Act and applicable  state  securities or Blue
Sky laws,  (ii) the entry of any stop transfer  order or legend on the books and
records of the  transfer  agent of the Shares  relating to the  restrictions  on
transfer  described in (i), and (iii) any requirement  that Cohen or Donna Cohen
provide  the  transfer  agent for the  Shares  with an opinion of counsel to the
effect  that  the  proposed  sale may be made  without  registration  under  the
Securities Act or the securities or Blue Sky laws of any state.

         13.  Entire  Agreement.  The  provisions of this  Agreement,  the Stock
Option Agreement and the Stock Lock-Up Agreement constitute the entire agreement
between  Cohen  and the  Company  with  respect  to the  subject  matter of this
Agreement,  and  supersede  any  prior  oral  understanding.   No  modification,
supplement or discharge of this Agreement  shall be effective  unless in writing
and executed on behalf of the party to be charged.

         14.  Waiver.  No  waiver  by  either  party of any  condition,  term or
provision of this Agreement  shall be deemed to be a waiver of any proceeding or
succeeding  breach of the same or of any other  condition,  term or provision of
this Agreement.

         15.  Successors and Assigns.  This Agreement  shall be binding upon the
heirs,  executors,  administrators,  successors and assigns of Cohen,  and shall
inure to the benefit of the successors and assigns of the Company.

         16.   Counterparts.   This   Agreement   may  be  executed  in  several
counterparts,  each of  which  shall  be  deemed  an  original  but all of which
together shall constitute one and the same instrument.

         17. Construction.  This Agreement shall be construed in accordance with
the laws of the State of California.

         18. Notices.  Any notices or other communication  required or permitted
to be given  under  this  Agreement  shall be in  writing  and  shall be  deemed
received when  personally  delivered to the party to whom it is to be given,  or
four (4) days after  being  deposited  in the United  States  mail,  first class
certified postage prepaid, and addressed as follows:

         To the Company:                       BioTime, Inc.
                                               935 Pardee Street
                                               Berkeley, California 94710


               To Cohen:                       Lawrence Cohen
                                               3311 N.E. 26th Avenue
                                               Lighthouse Point, Florida 33064

Either party may change its address for notices by giving the other party notice
of such new address in the manner provided in this Section.

         19.  Titles and  Subtitles.  The titles or headings of the Sections and
Subsections of this Agreement are for  convenience of reference only and are not
to be considered in construing this Agreement.

         20. Severability.  If one or more provisions of this Agreement are held
to be  unenforceable  under  applicable law, each such  unenforceable  provision
shall be excluded from this Agreement and the balance of this Agreement shall be
interpreted as if each such  unenforceable  provision were so excluded,  and the
balance of this Agreement as so  interpreted  shall be enforceable in accordance
with its terms.

         IN WITNESS WHEREOF,  the parties hereto have executed this Agreement on
the day and year first above written.


                                               BIOTIME, INC.


                                    By _______________________________________
                                               Paul E. Segall, President



                                       ---------------------------------------
                                               Lawrence Cohen

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