Exhibit 3(i)(a)
                            CERTIFICATE  OF  DESIGNATION
                            ----------------------------

                    OF  SERIES  A  PARTICIPATING  PREFERRED  STOCK
                    ----------------------------------------------

                                        OF
                                        --

                           INCYTE  PHARMACEUTICALS,  INC.
                           ------------------------------



     We, Roy A. Whitfield, the Chief Executive Officer, and Elias Lee Bendekgey,
the  Secretary,  of  Incyte  Pharmaceuticals,  Inc., a corporation organized and
existing  under  the General Corporation Law of the State of Delaware, DO HEREBY
CERTIFY:

     That pursuant to the authority conferred upon the Board of Directors by the
Certificate of Incorporation of the Corpo-ration, the said Board of Directors on
September  25,  1998,  adopted  the  following  resolution  creating a series of
250,000 shares of Preferred Stock designated as Series A Participating Preferred
Stock:

     RESOLVED,  that  pursuant to the authority vested in the Board of Directors
of  the  Corporation  in  accordance  with the  provisions of its Certificate of
Incorporation,  a  series of Preferred Stock of the Corporation be and it hereby
is  created,  and  that  the  designation  and  amount  thereof  and the powers,
preferences  and  relative,  participating, optional and other special rights of
the  shares of such series, and the  qualifications, limitations or restrictions
thereof  are  as  follows:

     1.     Designation  and  Amount.  The  shares  of  such  series  shall  be
            ------------------------
designated  as  "Series  A  Participating  Preferred Stock," par value $.001 per
share, and the number of shares constituting such series shall be 250,000.  Such
number  of  shares  may  be increased or decreased by resolution of the Board of
Directors;  provided,  that  no  decrease  shall  reduce the number of shares of
Series  A Participating Preferred Stock to a number less than that of the shares
then  outstand-ing  plus  the  number  of  shares  issuable  upon  exercise  of
outstanding  rights,  options  or  warrants  or  upon  conversion of outstanding
securities  issued  by  the  Corporation.

     2.     Dividends  and  Distributions.
            -----------------------------

     (A)     Subject  to  the  prior  and  superior rights of the holders of any
shares of any series of Preferred Stock ranking prior and superior to the shares
of Series A Participating Preferred Stock with respect to dividends, the holders
of shares of Series A Participating Preferred Stock in preference to the holders
of  shares  of  Common Stock, par value $.001 per share (the "Common Stock"), of
the  Corporation and any other junior stock, shall be entitled to receive, when,
as  and if declared by the Board of Directors out of funds legally available for
the  purpose,  quarterly  dividends  payable  in cash on the first day of March,
June,  September  and  December  in  each year (each such date being referred to
herein  as  a  "Quarterly  Dividend  Payment  Date"),  commencing  on  the first
Quarterly  Dividend Payment Date after the first issuance of a share or fraction
of  a  share  of  Series  A Participating Preferred Stock in an amount per share
(rounded to the nearest cent) equal to the greater of (a) $25.00, or (b) subject
to the provision for adjustment hereinafter set forth, 1,000 times the aggregate
per  share amount of all cash dividends, and 1,000 times the aggregate per share
amount  (payable in kind) of all non-cash dividends or other distributions other
than  a  dividend  payable  in  shares  of Common Stock or a subdivision  of the
outstanding shares of Common Stock (by reclassification  or otherwise), declared
on the Common Stock, since the immediately preceding  Quarterly Dividend Payment
Date,  or,  with respect to the first Quarterly Dividend Payment Date, since the
first  issu-ance  of any share or fraction of a share of Series A  Participating
Preferred  Stock.  In  the  event  the  Corporation  shall at any time after the
close  of  business  on  October  13,  1998  (the "Rights Declaration Date") (i)
declare  any  dividend  on  Common Stock payable in shares of Common Stock, (ii)
subdivide the outstanding  Common Stock, or (iii) combine the outstanding Common
Stock  into  a smaller number of shares, by reclassifica-tion or otherwise, then
in  each  such  case  the  amount  to  which  holders  of  shares  of  Series  A
Participating  Preferred  Stock  were  entitled  immediately prior to such event
under  clause  (b)  of  the preceding sentence shall be adjusted by  multiplying
such  amount  by  a  fraction  the numerator of which is the number of shares of
Common  Stock  outstanding  immediately after such event and the  denominator of
which  is the number of shares of Common Stock that were outstanding immediately
prior  to  such  event.

     (B)     The  Corporation  shall  declare a dividend or distribu-tion on the
Series  A  Participating  Preferred  Stock  as  provided  in paragraph (A) above
immediately  after  it  declares  a dividend or distribution on the Common Stock
(other than a dividend payable in shares of Common Stock); provided that, in the
event  no  dividend or distribution shall have been declared on the Common Stock
during  the  period  between  any  Quarterly  Dividend Payment Date and the next
subsequent  Quarterly  Dividend  Payment Date, a dividend of $25.00 per share on
the  Series  A  Participating   Preferred Stock shall nevertheless be payable on
such  subsequent  Quarterly  Dividend  Payment  Date.

     (C)     Dividends  shall  begin to accrue and be cumu-lative on outstanding
shares  of  Series  A  Participating Preferred Stock from the Quarterly Dividend
Payment  Date  next  preceding  the  date  of  issue  of such shares of Series A
Participating  Preferred  Stock unless the date of issue of such shares is prior
to  the record date for the first Quarterly Dividend Payment Date, in which case
dividends  on  such  shares shall begin to accrue from the date of issue of such
shares, or unless the date of issue is a Quarterly Dividend Payment Date or is a
date  after the record date for the determination of holders of shares of Series
A  Participating  Preferred  Stock  entitled to receive a quarterly dividend and
before  such  Quarterly  Dividend  Payment  Date  in either of which events such
dividends  shall  begin to accrue and be cumulative from such Quarterly Dividend
Payment  Date.  Accrued but unpaid dividends shall not bear interest.  Dividends
paid  on  the shares of Series A Participating Preferred Stock in an amount less
than  the total amount of such dividends at the time accrued and payable on such
shares  shall  be  allocated  pro  rata on a share-by-share basis among all such
shares  at  the  time outstanding.  The Board of Directors may fix a record date
for  the  determination of holders of shares of Series A Participating Preferred
Stock  entitled  to  receive  payment  of  a  dividend  or distribution declared
thereon, which record date shall be no more than 30 days prior to the date fixed
for  the  payment  thereof.

     3.     Voting  Rights.  The  holders  of  shares  of Series A Participating
            --------------
Preferred  Stock  shall  have  the  following  voting  rights:

          (A)     Subject  to  the  provision  for  adjustment  here-inafter set
forth,  each  share of Series A Partici-pating Preferred Stock shall entitle the
holder  thereof  to  1,000  votes  on  all  matters  submitted  to a vote of the
stockholders of the Corporation.  In the event the Corporation shall at any time
after  the  Rights  Declaration  Date  (i)  declare any dividend on Common Stock
payable  in  shares of Common Stock, (ii) subdivide the outstanding Common Stock
into  a  greater number of shares, or (iii) combine the outstanding Common Stock
into  a smaller number of shares, by reclassification or otherwise, then in each
such  case  the number of votes per share to which holders of shares of Series A
Participating  Preferred  Stock  were  entitled  immediately prior to such event
shall  be  adjusted  by  multiplying  such number by a fraction the numerator of
which is the number of shares of Common Stock outstanding immediately after such
event  and  the  denominator  of  which  is the number of shares of Common Stock
outstanding  immediately  prior  to  such  event.

          (B)     Except  as  otherwise  provided  herein, in the Certificate of
Incorporation  or  by  law,  the  holders  of  shares  of Series A Participating
Preferred  Stock and the holders of shares of Common Stock and any other capital
stock of the Corporation having general voting rights shall vote together as one
class  on  all  matters submitted to a vote of stockholders of the Corporation.

          (C)     (i)  If  at  any  time dividends on any Series A Participating
Preferred  Stock  shall  be  in  arrears  in  an  amount  equal to six quarterly
dividends  thereon,  the  holders of the Series A Participating Preferred Stock,
voting as a separate series from all other series of Preferred Stock and classes
of  capital  stock,  shall  be  entitled  to  elect  two members of the Board of
Directors  in  addition  to  any Directors elected by any other series, class or
classes  of securities and the authorized number of Directors will automatically
be  increased  by  two.  Promptly  thereafter,  the  Board  of Directors of this
Corporation  shall,  as  soon  as  may be practicable, call a special meeting of
holders  of  Series  A Participating Preferred Stock for the purpose of electing
such members of the Board of Directors.  Said special meeting shall in any event
be  held  within  45  days  of  the  occurrence  of  such  arrearage.

          (ii)  During  any  period  when  the holders of Series A Participating
Preferred  Stock,  voting as a separate series, shall be entitled and shall have
exercised  their right to elect two Directors, then and during such time as such
right  continues  (a) the then authorized number of Directors shall be increased
by  two,  and the holders of Series A Participating Preferred Stock, voting as a
separate series, shall be entitled to elect the additional Directors so provided
for, and (b) each such additional Director shall not be a member of any existing
class  of  the Board of Directors, but shall serve until the next annual meeting
of  stockholders  for  the  election of Directors, or until his or her successor
shall  be  elected  and  shall  qualify,  or until his or her right to hold such
office  terminates  pursuant  to  the  provisions  of  this  Section  3(C).

          (iii)  A  Director elected pursuant to the terms hereof may be removed
with  or  without cause by the holders of Series A Participating Preferred Stock
entitled  to  vote  in  an  election  of  such  Director.

          (iv)  If,  during any interval between annual meetings of stockholders
for  the  election  of Directors and while the holders of Series A Participating
Preferred  Stock  shall be entitled to elect two Directors, there are fewer than
two  such  Directors in office by reason of resignation, death or removal, then,
promptly  thereafter, the Board of Directors shall call a special meeting of the
holders  of  Series  A  Participating Preferred Stock for the purpose of filling
such vacancy(ies) and such vacancy(ies) shall be filled at such special meeting.
Such special meeting shall in any event be held within 45 days of the occurrence
of  any  such  vacancy(ies).

          (v)  At  such  time as the arrearage is fully cured, and all dividends
accumulated  and  unpaid on any shares of Series A Participating Preferred Stock
outstanding  are  paid,  and, in addition thereto, at least one regular dividend
has  been  paid  subsequent  to curing such arrearage, the term of office of any
Director  elected  pursuant to this Section 3(C), or his or her successor, shall
automatically  terminate,  and  the  authorized  number  of  Directors  shall
automatically  decrease  by  two, and the rights of the holders of the shares of
the  Series  A Participating Preferred Stock to vote as provided in this Section
3(C)  shall  cease, subject to renewal from time to time upon the same terms and
conditions.

          (D)     Except  as  set  forth herein or as otherwise provided by law,
holders  of  Series A Participating Preferred Stock shall have no special voting
rights  and  their  consent shall not be required (except to the extent they are
entitled to vote with holders of Common Stock and any other capital stock of the
Corporation  having  general  voting  rights as set forth herein) for taking any
corporate  action.

     4.     Certain  Restrictions.
            ---------------------

     (A)     Whenever  quarterly  dividends or other divi-dends or distributions
payable  on  the Series A Participating Preferred Stock as provided in Section 2
are  in  arrears,  thereafter  and  until  all  accrued and unpaid dividends and
distributions,  whether  or  not  declared,  on shares of Series A Participating
Preferred  Stock outstanding shall have been paid in full, the Corporation shall
not

          (i)  declare  or pay dividends on, make any other distributions on, or
redeem  or  purchase  or otherwise acquire for consideration any shares of stock
ranking  junior  (either  as  to  dividends  or upon liquidation, dissolution or
winding  up)  to  the  Series  A  Participating  Preferred  Stock;

          (ii)  declare  or  pay dividends on or make any other distributions on
any  shares  of  stock  ranking  on  a  parity  (either  as to dividends or upon
liqui-dation,  dissolution  or  winding  up)  with  the  Series  A Participating
Preferred  Stock  except  dividends  paid ratably on the Series A  Participating
Preferred  Stock  and all such parity stock on which dividends are payable or in
arrears  in  proportion   to  the total amounts to which the holders of all such
shares  are  then  entitled;

          (iii)  redeem  or  purchase  or  otherwise  acquire  for consideration
shares  of  any  stock  ranking  on  a  parity  (either  as to dividends or upon
liquida-tion,  dissolution  or  winding  up)  with  the  Series A  Participating
Preferred  Stock  provided that the Corporation may at any time redeem, purchase
or  otherwise  acquire shares of any such parity stock in exchange for shares of
any  stock  of  the   Corporation ranking junior (either as to dividends or upon
dissolution,  liquidation or winding up) to the Series A Participating Preferred
Stock;  or

          (iv)  purchase  or  otherwise  acquire for consideration any shares of
Series  A  Participating  Preferred  Stock  or  any shares of stock ranking on a
parity with the Series A Participating Preferred Stock except in accordance with
a  purchase  offer made in writing or by publication (as determined by the Board
of  Directors)  to  all  holders  of such shares upon such terms as the Board of
Directors,  after  consideration  of  the  respective annual  dividend rates and
other  relative  rights  and  preferences  of the respective series and classes,
shall  determine in good faith will result in fair and equitable treatment among
the  respective  series  or  classes.

     (B)     The Corporation shall not permit any subsidi-ary of the Corporation
to  purchase  or  otherwise acquire for consideration any shares of stock of the
Corporation  unless  the Corporation could, under paragraph (A) of this  Section
4,  purchase  or otherwise  acquire such shares at such time and in such manner.

     5.     Reacquired  Shares.  Any shares of Series A Participating  Preferred
            ------------------
Stock  purchased  or  otherwise  acquired  by  the  Corporation  in  any  manner
whatsoever shall be retired and canceled promptly after the acquisition thereof.
All  such  shares  shall  upon their cancellation become authorized but unissued
shares  of  Preferred  Stock  and  may  be  reissued  as part of a new series of
Preferred  Stock  to  be  created  by  resolution or resolutions of the Board of
Directors,  subject  to  the   conditions and restrictions on issuance set forth
herein.

     6.     Liquidation,  Dissolution  or  Winding  Up.
            ------------------------------------------

     (A)     Upon  any  liquidation  (voluntary  or  otherwise),  dissolution or
winding  up  of the Corporation, no distribution shall be made to the holders of
shares  of  stock  ranking  junior  (either as to dividends or upon liquidation,
dissolution or winding up) to the Series A Participating Preferred Stock unless,
prior  thereto,  the holders of shares of Series A Participating Preferred Stock
shall  have  received  per  share,  the  greater of $1,000.00 or 1,000 times the
payment  made  per  share  of  Common Stock, plus an amount equal to accrued and
unpaid  dividends  and  distributions   thereon, whether or not declared, to the
date  of  such  payment  (the "Series A Liquidation Preference").  Following the
payment of the full amount of the Series A Liquidation Preference, no additional
distributions  shall  be made to the holders of shares of Series A Participating
Preferred  Stock  unless,  prior  thereto, the holders of shares of Common Stock
shall  have received an amount per share (the "Common Adjustment")  equal to the
quotient  obtained  by  dividing (i) the Series A Liquidation Preference by (ii)
1,000  (as   appropriately  adjusted  as  set forth in subparagraph (C) below to
reflect  such  events as stock splits, stock dividends and recapitalization with
respect  to  the  Common  Stock)  (such  number  in clause (ii), the "Adjustment
Number").  Following  the payment of the full amount of the Series A Liquidation
Preference  and  the  Common Adjustment in respect of all  outstanding shares of
Series  A  Participating Preferred Stock and Common Stock, respectively, holders
of Series A  Participating Preferred Stock and holders of shares of Common Stock
shall  receive their ratable and proportionate  share of the remaining assets to
be  distributed  in the ratio of the Adjustment Number to 1 with respect to such
Preferred  Stock  and  Common  Stock,  on  a  per  share  basis,   respectively.

     (B)     In  the  event  there are not sufficient assets available to permit
payment  in  full  of  the  Series A Liquida-tion Preference and the liquidation
preferences  of  all  other  series  of Preferred Stock, if any, which rank on a
parity  with  the  Series  A  Partici-pating Preferred Stock then such remaining
assets  shall  be  distributed  ratably  to the holders of such parity shares in
proportion  to their respective liquidation preferences.  In the event there are
not  sufficient   assets  available  to  permit  payment  in  full of the Common
Adjustment,  then  such  remaining  assets  shall be distributed  ratably to the
holders  of  Common  Stock.

     (C)     In  the  event  the  Corporation shall at any time after the Rights
Declaration  Date (i) declare any divi-dend on Common Stock payable in shares of
Common  Stock, (ii) subdivide the outstanding Common Stock, or (iii) combine the
outstanding  Common  Stock into a smaller number of shares, by  reclassification
or otherwise, then in each such case the Adjustment Number in effect immediately
prior to such event shall be adjusted by multiplying such Adjustment Number by a
fraction  the   numerator  of  which  is  the  number  of shares of Common Stock
outstanding   immediately  after  such event and the denominator of which is the
number  of  shares  of  Common Stock that were outstanding immedi-ately prior to
such  event.

     7.     Consolidation,  Merger,  etc.  In  case  the Corporation shall enter
            ----------------------------
into  any  consolidation,  merger, combination or other transaction in which the
shares  of  Common  Stock  are  exchanged  for  or  changed  into other stock or
securities,  cash and/or any other property, then in any such case the shares of
Series  A  Partici-pating  Preferred  Stock  shall at the same time be similarly
exchanged  or  changed  in  an  amount  per  share (subject to the provision for
adjustment  hereinafter  set forth) equal to 1,000 times the aggregate amount of
stock, securities, cash and/or any other property (payable in kind), as the case
may  be,  into  which  or  for  which  each  share of Common Stock is changed or
exchanged.  In  the  event  the  Corporation  shall at any time after the Rights
Declaration  Date  (i) declare any dividend on Common Stock payable in shares of
Common Stock, (ii) sub-divide the outstanding Common Stock, or (iii) combine the
outstanding Common Stock into a smaller number of shares, then in each such case
the  amount  set forth in the preceding sentence with respect to the exchange or
change  of shares of Series A Participating Preferred Stock shall be adjusted by
multiplying  such  amount  by a fraction the numerator of which is the number of
shares  of  Common  Stock  outstanding   immediately  after  such  event and the
denominator  of  which  is  the  number  of  shares  of  Common  Stock  that are
outstanding  immediately  prior  to  such  event.

     8.     Redemption.  The  shares  of Series A Partici-pating Preferred Stock
            ----------
shall  not  be  redeemable.

     9.     Ranking.  The  Series  A  Participating  Pre-ferred Stock shall rank
            -------
junior  to  all  other  series  of  the  Corporation's Preferred Stock as to the
payment  of  dividends  and the distribu-tion of assets, unless the terms of any
such  series  shall  provide  otherwise.

     10.     Amendment.  The  Certificate of Incorporation and the Bylaws of the
             ---------
Corporation  shall  not  be further amended in any manner which would materially
alter  or  change  the  powers,  preferences  or  special rights of the Series A
Participating  Preferred  Stock  so  as  to  affect  them  adversely without the
affirmative vote of the holders of at least 66-2/3% of the outstanding shares of
Series  A  Participating  Preferred  Stock  voting  separately  as  a  class.

     11.     Fractional  Shares.  Series  A Participating Preferred Stock may be
             ------------------
issued  in fractions of a share which shall entitle the holder, in proportion to
such  holder's  fractional shares, to exercise voting rights, receive dividends,
participate  in  distributions  and  to  have the benefit of all other rights of
holders  of  Series  A  Participating  Preferred  Stock.

     IN WITNESS WHEREOF, we have executed and subscribed this Certificate and do
affirm  the  foregoing as true under the penalties of perjury as of the 25th day
of  September,  1998.



                                   \s\  Roy  A.  Whitfield
                           -------------------------------
                                    Roy  A.  Whitfield
          Chief  Executive  Officer


Attest:



                         \s\  Elias  Lee  Bendekgey
                -----------------------------------
     Elias  Lee  Bendekgey
     Secretary