SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-K


     X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES  EXCHANGE
       ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2000, OR

       TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM ____ TO _____.


                         Commission File Number: 0-20199

                              EXPRESS SCRIPTS, INC.
             (Exact name of registrant as specified in its charter)

              Delaware                               43-1420563
    (State or other jurisdiction        (I.R.S. employer identification no.)
  of incorporation or organization)

   13900 Riverport Dr., Maryland Heights, Missouri          63043
      (Address of principal executive offices)            (Zip Code)


       Registrant's telephone number, including area code: (314) 770-1666

       Securities registered pursuant to Section 12(b) of the Act:

                                      None

           Securities registered pursuant to Section 12(g) of the Act:

                      Class A Common Stock, $0.01 par value
                                (Title of Class)

     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes X No ___

     Indicate by check mark if disclosure of delinquent  filers pursuant to Item
405 of Regulation of S-K is not contained herein, and will not be contained,  to
the  best  of  Registrant's   knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. [X]

     The  aggregate   market  value  of   Registrant's   voting  stock  held  by
non-affiliates  as of January 31, 2001, was  $3,582,603,430  based on 38,600,441
such shares held on such date by non-affiliates  and the last sale price for the
Class A Common Stock on such date of $92.8125 as reported on the Nasdaq National
Market. Solely for purposes of this computation, the Registrant has assumed that
all directors and executive  officers of the  Registrant  are  affiliates of the
Registrant  and  has  assumed  that  NYLIFE  LLC  is  not  an  affiliate  of the
Registrant.  On such date,  NYLIFE  LLC was the  beneficial  owner of  8,120,000
shares of the  Registrant's  Class A Common  Stock,  having an aggregate  market
value of $753,637,500.

Common stock outstanding as of January 31, 2001:    38,786,311  Shares Class A

                       DOCUMENTS INCORPORATED BY REFERENCE

     Part  III  incorporates  by  reference  portions  of the  definitive  proxy
statement for the  Registrant's  2001 Annual Meeting of  Stockholders,  which is
expected to be filed with the Securities and Exchange  Commission not later than
120  days  after  the   registrant's   fiscal  year  ended  December  31,  2000.

     Information  that we have  included or  incorporated  by  reference in this
Annual Report on Form 10-K, and  information  that may be contained in our other
filings with the  Securities and Exchange  Commission  (the "SEC") and our press
releases or other  public  statements,  contain or may  contain  forward-looking
statements.  Please refer to a discussion of our forward looking  statements and
associated risks in "Item 1 --Forward  Looking  Statements and Associated Risks"
in this Annual Report on Form 10-K.


                                     PART I
                                   THE COMPANY
Item 1 - Business

Industry Overview

     Prescription  drug costs are the fastest  growing  component of health care
costs in the  United  States.  The U.S.  Health  Care  Financing  Administration
("HCFA")  estimates that  prescription  drugs accounted for  approximately 8% of
U.S.  health care  expenditures  in 1998, and are expected to increase to 11% by
2008. U.S.  prescription drug sales for 1998 were  approximately  $90.6 billion,
and HCFA projects  continued sales increases at an average annual growth rate of
approximately  11% through  2008,  compared to an average  annual growth rate of
approximately  6% for total  health care costs  during this  period.  Based upon
information  in our  1999  Annual  Drug  Trend  report,  described  below  under
"--Clinical  Support",  we estimate  that average drug  spending will grow at an
annual rate of 15% from 2000 through 2004 and average per member drug spend will
grow at a  compound  annual  rate of 15% from 1995  through  2004,  and that per
member drug spend in 2004 will be  approximately  $760  compared to $387 in 1999
and $216 in 1995. Factors underlying this trend include:

o    increases in research and development  expenditures by drug  manufacturers,
     resulting in many new drug  introductions

o    a  shorter  U.S.  Food  and  Drug  Administration  approval  cycle  for new
     pharmaceuticals

o    high prices for new  "blockbuster"  drugs

o    an aging population

o    increased demand for prescription  drugs due to increased disease awareness
     by patients, effective direct-to-consumer advertising by drug manufacturers
     and a growing reliance on medication in lieu of lifestyle changes

     This trend  creates a  significant  challenge  for HMOs,  health  insurers,
employers  and unions that  provide a drug  benefit as part of the health  plans
they offer to members of their respective organizations. Certain of these health
benefit  providers,  or  "payors",  engage  the  services  of  pharmacy  benefit
management ("PBM") companies to help them provide a cost-effective  drug benefit
as part of their health plan and to better understand the impact of prescription
drug utilization on their overall health care expenditures.

     In general, PBMs coordinate the distribution of outpatient  pharmaceuticals
through a combination of benefit-management services, including retail drug card
programs, mail pharmacy services and formulary management programs. PBMs emerged
during the late 1980s by combining  traditional  pharmacy claims  processing and
mail pharmacy services to create an integrated  product offering that could help
manage the  prescription  drug  benefit  for  payors.  During  the early  1990s,
numerous  PBMs were  created,  with some  providers  offering  a  comprehensive,
integrated  package  of  services.  There  are an  estimated  60 PBMs  serving a
population of approximately 180 million members and processing approximately 2.5
billion  prescriptions  annually.  The PBM industry processed  approximately $98
billion  worth of  prescriptions  in 2000.  The three  largest  PBMs account for
approximately 55% of prescription volume or member lives.

     The  services  offered by the more  sophisticated  PBMs have  broadened  to
include disease management  programs,  compliance  programs,  outcomes research,
drug therapy management programs and sophisticated data analysis.

Company Overview

     We are the third  largest PBM in North  America.  We are  independent  from
pharmaceutical manufacturer ownership, and believe our independence is important
as it allows  us to make  unbiased  formulary  recommendations  to our  clients,
balancing both clinical efficacy and cost.

     We provide a full range of pharmacy benefit management services,  including
retail drug card programs,  mail pharmacy  services,  drug formulary  management
programs and other clinical management programs for approximately  19,000 client
groups  that  include  HMOs,   health  insurers,   third-party   administrators,
employers,  union-sponsored  benefit plans and government health programs. As of
January 1, 2001,  some of our largest  clients  include  Aetna U.S.  Healthcare,
Oxford  Health  Plans,  Blue Cross Blue  Shield of  Massachusetts,  the State of
Georgia, Blue Shield of California and Mutual of Omaha.

     As of January 1, 2001, our PBM services were provided to approximately 43.5
million  members in the United  States  and Canada who were  enrolled  in health
plans  sponsored by our clients.  In computing the number of members we serve we
make certain estimates and adjustments.  We believe different PBMs use different
factors in making these  estimates and  adjustments.  We also believe,  however,
that these  numbers  are a  reasonable  approximation  of the  actual  number of
members served by us.

         Our PBM services include:

          o    network  pharmacy  management,  mail pharmacy  services,  benefit
               design   consultation,   drug   utilization   review,   formulary
               management  programs,  disease management,  medical and drug data
               analysis services, and compliance and therapy management programs
               for our clients

          o    market  research  programs  for  pharmaceutical  manufacturers

          o    medical information  management  services,  which include outcome
               assessments, the development of data warehouses combining medical
               claims and prescription drug claims,  and sophisticated  decision
               support tools to evaluate disease specific  interventions on cost
               and  quality,   through  our  wholly-owned   subsidiary  Practice
               Patterns  Science,  Inc. ("PPS")

          o    informed decision  counseling services through our Express Health
               LineSM division

         Our non-PBM services include:


          o    infusion therapy  services  through our wholly owned  subsidiary,
               Express   Scripts    Infusion    Services

          o    distribution of  pharmaceuticals  requiring  special  handling or
               packaging  through our wholly owned  subsidiary  Express  Scripts
               Specialty Distribution Services

     Our  revenues are  primarily  generated  from the delivery of  prescription
drugs  through  our  contractual  network of retail  pharmacies,  mail  pharmacy
services and infusion therapy  services.  In 2000, 1999 and 1998,  revenues from
the delivery of prescription  drugs to our members  represented 94.1%, 93.4% and
98.2% of our total revenues,  respectively.  Revenues from services, such as the
administration of contracts between our clients and the clients' retail pharmacy
networks,  market research programs,  the sale of medical information management
services,  the sale of informed decision  counseling  services and our Specialty
Distribution Services comprised the remainder of our revenues.

     Prescription  drugs are  dispensed  to members of the health plans we serve
primarily  through  networks of retail  pharmacies that are under  non-exclusive
contract with us and through five mail pharmacy  service centers that we operate
out of leased facilities. More than 55,000 retail pharmacies,  representing more
than 99% of all United States retail  pharmacies,  participate in one or more of
our networks. In 2000, we processed approximately 241.8 million network pharmacy
claims and 15.2 million mail  pharmacy  prescriptions,  with an estimated  total
drug spending of $11.2 billion,  excluding  United  HealthCare  ("UHC")  network
pharmacy claims of 57.8 million having an estimating total drug spending of $2.7
billion.  Our contract with UHC expired on May 31, 2000 and we transitioned  the
UHC membership to another provider throughout 2000.

     We were incorporated in Missouri in September 1986, and were reincorporated
in Delaware in March 1992. Our principal  executive offices are located at 13900
Riverport Drive, Maryland Heights, Missouri 63043. Our telephone number is (314)
770-1666.

Products and Services

Pharmacy Benefit Management Services

     Overview.   Our  PBM  services   involve  the   management   of  outpatient
prescription  drug usage to foster high quality,  cost-effective  pharmaceutical
care through the application of managed care principles and advanced information
technologies.  We offer our PBM services to our clients in the United States and
Canada. Our PBM services include:

          o    retail network pharmacy administration

          o    mail pharmacy services

          o    benefit plan design consultation

          o    formulary administration

          o    electronic point-of-sale claims processing

          o    drug utilization review

          o    the development of advanced formulary  compliance and therapeutic
               intervention programs

          o    therapy management services such as prior authorization,  therapy
               guidelines,  step  therapy  protocols  and  formulary  management
               interventions

          o    sophisticated   management  information  reporting  and  analytic
               services

          o    outcomes   assessments,   the   development  of  data  warehouses
               combining  medical  claims  and  prescription  drug  claims,  and
               sophisticated decision support tools to evaluate disease specific
               interventions on cost and quality

          o    informed decision counseling

          o    drug    information     through    our     DrugDigest.org     and
               express-scripts.com websites

     During 2000, 98.7% of our revenues were derived from PBM services, compared
to 98.5% and 97.9%  during  1999 and 1998,  respectively.  The  number of retail
pharmacy network claims processed and mail pharmacy claims processed,  excluding
UHC, has increased to 241.8 million and 15.2 million  claims,  respectively,  in
2000, from 57.8 million and 2.8 million claims,  respectively,  in 1996.  During
1999 and 1998,  we processed  211.3  million,  excluding  UHC, and 113.2 million
retail pharmacy network claims,  respectively,  and 10.6 million and 7.4 million
mail pharmacy claims, respectively.

     Retail Pharmacy Network Administration.  We contract with retail pharmacies
to provide  prescription  drugs to members of the pharmacy benefit plans managed
by us. In the United States,  these pharmacies  typically  discount the price at
which they will provide drugs to members in return for  designation as a network
pharmacy.  We manage  four  nationwide  networks  in the United  States that are
responsive to client preferences  related to cost containment and convenience of
access for members.  We also manage over 400 networks of pharmacies that we have
designed to meet the  specific  needs of some of our larger  clients or that are
under direct  contract with our managed care clients.  We manage one  nationwide
network in Canada.

     All retail pharmacies in our pharmacy networks  communicate with us on-line
and in real time to process  prescription  drug claims.  When a member of a plan
presents  his or her  identification  card at a network  pharmacy,  the  network
pharmacist sends the specified claim data in an industry-standard format through
our  systems,  which  process the claim and respond to the  pharmacy,  typically
within one or two seconds. The electronic processing of the claim involves:

          o    confirming  the  member's  eligibility  for  benefits  under  the
               applicable   health   benefit  plan  and  the  conditions  to  or
               limitations  of  coverage,  such as the amount of  copayments  or
               deductibles  the member must pay

          o    performing  a concurrent  drug  utilization  review  analysis and
               alerting  the  pharmacist  to  possible  drug   interactions  and
               reactions or other indications of inappropriate prescription drug
               usage

          o    updating  the  member's  prescription  drug claim record

          o    if the claim is accepted, confirming to the pharmacy that it will
               receive payment for the drug dispensed

     Mail  Pharmacy.  We  operate  five mail  pharmacies,  located  in  Maryland
Heights,   Missouri;   Tempe,  Arizona;   Albuquerque,   New  Mexico;  Bensalem,
Pennsylvania;  and  Troy,  New  York.  These  pharmacies  provide  members  with
convenient  access to maintenance  medications  and enable our clients and us to
control drug costs through  operating  efficiencies  and economies of scale.  In
addition,  through our mail service pharmacies we are directly involved with the
prescriber  and  member,  and are  generally  able to achieve a higher  level of
generic substitutions and therapeutic interventions than can be achieved through
the retail pharmacy networks.

     Benefit Plan Design and Consultation.  We offer  consultation and financial
modeling  to assist our clients in  selecting  a benefit  plan design that meets
their needs for member  satisfaction  and cost control.  The most common benefit
design options we offer to our clients are:

          o    financial  incentives and reimbursement  limitations on the drugs
               covered by the plan,  including drug formularies,  flat dollar or
               percentage of prescription cost copayments, deductibles or annual
               benefit  maximum

          o    generic drug substitution incentives

          o    incentives or requirements  to use only network  pharmacies or to
               order certain drugs only by mail

          o    reimbursement limitations on the number of days' supply of a drug
               that can be obtained

The selected  benefit  design is entered into our electronic  claims  processing
system,  which  applies the plan design  parameters  as claims are submitted and
enables our clients and us to monitor the financial performance of the plan.

     Formulary Development,  Compliance and Therapy Management.  Formularies are
lists of drugs for which coverage is provided under the applicable plan. We have
over 10 years of  formulary  development  expertise  and an  extensive  clinical
pharmacy department.

     Our foremost  consideration  in the  formulary  development  process is the
clinical appropriateness of the drug, not the cost of the drug. In developing
formularies,  we first perform a rigorous  therapeutic  assessment of the drug's
clinical  effectiveness.  After  the  clinical  recommendation  is  made,  it is
evaluated  on an economic  basis.  No drug is added to the  formulary  until our
National Pharmacy & Therapeutics  Committee,  a panel composed of 17 independent
physicians, our Chief Medical Officer and five of our pharmacists,  approves it.
This panel does not consider any information regarding the discount or formulary
fee  arrangement  that might be negotiated  with the  manufacturer in making its
clinical  recommendation.  This ensures that the clinical  recommendation is not
affected by the purchasing arrangement.

     We  administer  a number of  different  formularies  for our  clients  that
identify  preferred  drugs whose use is encouraged or required  through  various
benefit design features.  Historically, many clients have selected a plan design
that  includes an open  formulary in which all drugs are covered by the plan and
preferred  drugs,  if any,  are merely  recommended.  Other  options  consist of
restricted formularies, in which various financial or other incentives exist for
the  selection  of preferred  drugs over their  non-preferred  counterparts,  or
closed formularies, in which benefits are available only for drugs listed on the
formulary. Formulary preferences can be encouraged:

          o    by restricting the formulary  through plan design features,  such
               as tiered  copayments,  which  require the member to pay a higher
               amount for a non-preferred drug

          o    through prescriber education programs, in which we or the managed
               care client  actively seek to educate the  prescribers  about the
               formulary preferences

          o    through  our  drug  choice  management  program,  which  actively
               promotes  therapeutic  and  generic  interchanges  to  clinically
               appropriate cost-effective products to reduce drug costs

     We also provide formulary  compliance services to our clients. For example,
if the doctor has not prescribed the preferred  drug on a client  formulary,  we
notify the pharmacist through our claims processing system. The pharmacist or we
can then contact the doctor to attempt to obtain the doctor's  consent to switch
the   prescription  to  the  preferred   product.   The  doctor  has  the  final
decision-making  authority  in  prescribing  the  medication.  The  doctor  will
consider the recommended  substitution in light of the patient's medical history
and approve or deny the substitution.  We also offer innovative proprietary drug
utilization  review and  clinical  intervention  programs  to assist  clients in
managing  compliance with the prescribed  drug therapy by identifying  potential
and inappropriate prescribing practices.

     Information Reporting and Analysis and Disease Management Programs. Through
the use of sophisticated  information and reporting systems,  we are better able
to manage the  prescription  drug benefit.  We are able to analyze  prescription
drug data to identify cost trends and budget for expected drug costs,  to assess
the financial  impact of plan design  changes and to assist  clients to identify
costly  utilization  patterns  through an  on-line  prescription  drug  decision
support  tool  called  ProActSM.  This  service  allows  our  clients to analyze
prescription drug data on-line.

     In  addition,  our PPS  subsidiary  builds  sophisticated  data  warehouses
combining medical claims, prescription drug claims, and clinical laboratory data
to provide  decision  support  to the  health  care  industry.  Proprietary  PPS
applications  enable  users to quickly  evaluate  shifts in  medical  conditions
afflicting  membership and the  effectiveness of  interventions  from a cost and
quality  of  care  perspective.  PPS  users  can  evaluate  the  impact  of  new
prescription  drugs  on the  cost  and  results  of  treating  specific  medical
conditions.  Working with leading  health care  organizations,  PPS continues to
push the  sophistication  of data  warehouses  and the  applications  to provide
insight into the subtleties of health care delivery.

     We offer disease management and education programs to assist health benefit
plans and our members in managing  the total health care costs  associated  with
certain diseases,  such as asthma,  diabetes and cardiovascular  disease.  These
programs  are based upon the premise  that  patient and  provider  behavior  can
positively  influence  medical  outcomes and reduce overall  medical  costs.  We
identify  patients  who may  benefit  from these  programs  through  claims data
analysis or self-enrollment. We conduct risk stratification surveys to establish
a plan of care for individual program participants. We provide patient education
primarily through a series of telephone and written  communications  with nurses
and  pharmacists,  and both providers and patients receive progress reports on a
regular basis. We conduct outcome surveys to analyze the clinical,  personal and
economic impact of the program.

     Electronic  Claims  Processing  System.  Our electronic  claims  processing
system enables us to implement sophisticated  intervention programs to assist in
managing  prescription  drug  utilization.  The  system can be used to alert the
pharmacist to generic  substitution and therapeutic  intervention  opportunities
and formulary  compliance  issues,  or to  administer  prior  authorization  and
step-therapy  protocol programs at the time a claim is submitted for processing.
Our  claims  processing  system  also  creates a  database  of drug  utilization
information  that can be accessed both at the time the prescription is dispensed
and also on a retrospective  basis to analyze utilization trends and prescribing
patterns for more intensive management of the drug benefit.

     Informed  Decision  Counseling.  We offer health care  decision  counseling
services  through our Express  Health  LineSM  division.  This service  allows a
member to call a toll-free telephone number and discuss health care matters with
a care counselor. The care counselor utilizes on-line decision support protocols
and other guidelines to provide the member  information to assist them in making
an informed decision in seeking appropriate treatment.  Records of each call are
kept on-line for future reference.  This service is available 24 hours a day and
staffed by registered nurses. Some multilingual capabilities and service for the
hearing impaired are also available.  The care counselors make a follow-up phone
call  to  determine  the  outcome  of the  initial  call  and  offer  additional
assistance  if needed.  Member  satisfaction  and cost savings  associated  with
redirections  to appropriate  care levels are measured  through a combination of
member surveys and system reports.

     Consumer Health and Medical Information. In the summer of 1999, we launched
an  Internet  site,   DrugDigest.org  to  provide  a  comprehensive   source  of
non-commercial,   fact-based  drug  information.   DrugDigest  currently  has  a
comprehensive  portfolio of consumer-friendly  drug information.  This portfolio
includes  information about adverse drug interactions,  drug side effects,  drug
administration  tips, and other  information  useful in helping  Express Scripts
members and their health care professionals make informed medication  decisions.
In the coming  year,  DrugDigest  will  expand  its  coverage  of  prescription,
over-the-counter, and herbal medications. The information and features available
in  our  web-based   ExpressChoice  will  allow  enrollees  to  examine  a  more
personalized  version of DrugDigest  that will include  information  about their
enrollment  benefits  and drug costs  and will  generally,  allow  members and
clients  to  more  effectively  manage  their  pharmacy  benefit.  Finally,  the
DrugDigest  team is  expanding  their  activities  into disease  management.  By
tightly coupling pharmaceutical and medical information, members will experience
an even deeper  understanding  of how their  medications  impact  their  overall
medical care.

Non-PBM Services

     In addition to PBM services,  we also provide  non-PBM  services  including
specialty  distribution services and outpatient infusion therapy to our clients.
During 2000, 1.3% of our revenues were derived from non-PBM  services,  compared
to 1.5% and 2.1% during  1999 and 1998,  respectively.  This  slight  decline is
partially due to the inclusion of Diversified  Pharmaceutical  Services  ("DPS")
for a full year in 2000  versus  only nine  months of 1999 and as a result of an
increase  in PBM  revenues  due to  the  conversion  of  clients  from  networks
contracted by our client to one  contracted by us. The decline from 1998 to 1999
is due to the acquisitions of ValueRx and DPS, which significantly increased our
PBM service revenues.

     Express  Scripts  Specialty  Distribution  Services.  We provide  specialty
distribution  services  by  assisting  pharmaceutical   manufacturers  with  the
distribution  of,  and  creation  of a database  of  information  for,  products
requiring special handling/packaging,  products targeted to a specific physician
or patient  population  and  products  distributed  to  indigent  patients.  Our
services   may   include   eligibility,    fulfillment,   inventory,   insurance
verification/authorization and reimbursement. These services are provided in our
Maryland Heights, Missouri facility located next to our Corporate Headquarters.

     Express Scripts  Infusion  Services.  We provide  infusion therapy services
which involve the  administration of prescription  drugs and other products to a
patient by  catheter,  feeding tube or  intravenously,  through our wholly owned
subsidiary,  IVTx,  Inc.,  operating  under the name  Express  Scripts  Infusion
Services.  Our clients benefit from outpatient infusion therapy services because
the length of hospital  stays can be reduced.  Rather  than  receiving  infusion
therapy in a hospital, we provide infusion therapy services to patients at home,
in a physician's office or in a free-standing  center operated by a managed care
organization  or  other  entity.  We have  facilities  supporting  our  infusion
services  operations  in Houston,  Texas;  Irvine,  Texas;  Columbia,  Maryland;
Maryland Heights, Missouri;  Columbia,  Missouri;  Springfield,  New Jersey; and
West Chester, Pennsylvania.

     Segment Information.  Information regarding our segments appears in Note 12
of the notes to our consolidated financial
statements, which is incorporated by reference herein.

Suppliers

     We maintain an extensive inventory in our mail pharmacies of brand name and
generic  pharmaceuticals.  If a drug is not in our  inventory,  we can generally
obtain it from a supplier  within one or two  business  days.  We  purchase  our
pharmaceuticals  either  directly  from  manufacturers  or through  wholesalers.
During 2000,  approximately  60.0% of our pharmaceutical  purchases were through
one  wholesaler,  most  of  which  were  brand  name  pharmaceuticals.   Generic
pharmaceuticals are generally purchased directly from manufacturers.  We believe
that   alternative   sources  of  supply  for  most   generic   and  brand  name
pharmaceuticals are readily available.

Clients

     We are a major  provider  of PBM  services to the  managed  care  industry,
including several large HMOs, government plans and large employers.  Some of our
largest  managed care clients are Aetna U.S.  Healthcare,  Inc.,  Oxford  Health
Plans,  Blue Cross Blue Shield of  Massachusetts  and Blue Shield of California.
Some of our largest  employer  groups include the State of Georgia and the State
of New York Empire Plan  Prescription  Drug  Program  (through a  subcontracting
relationship  with CIGNA  HealthCare).  We also market our PBM services  through
preferred  provider  organizations,   group  purchasing  organizations,   health
insurers, third-party administrators of health plans and union-sponsored benefit
plans.

     In  connection  with our 1999  acquisition  of  Diversified  Pharmaceutical
Services  ("DPS"),  we acquired the contract to serve  approximately 9.5 million
UHC  members.  The  contract  with UHC expired on May 31,  2000.  We developed a
migration plan to transition the UHC members to their new provider through 2000.
We believe the  termination  and  transition of this contract did not materially
adversely affect our business and results of operations.

Medicare Prescription Drug Coverage

     The federal  Medicare  program  provides a  comprehensive  medical  benefit
program  for  individuals  age 65 and over.  Today  Medicare  covers  only a few
outpatient  prescription drugs. Key policy makers on both sides of the political
aisle have  proposed  changes to the  Medicare  program  that would result in at
least partial  coverage for most  outpatient  prescription  drugs.  The Medicare
population  is  large,  and  prescription  drug  utilization  among  seniors  is
substantially higher on average than that of other age groups.

     Many of the Medicare  prescription  drug proposals  lack important  details
regarding  the   administration   of  the  plan.  We  believe  that  a  Medicare
prescription  drug  benefit  could  provide  us with  substantial  new  business
opportunities,  but at the same time any such  program  could  adversely  affect
other  aspects of our  business.  For example,  some of our clients sell medical
policies to seniors that provide a prescription drug benefit that we administer.
Other clients provide a prescription  drug benefit to their retirees.  Depending
on the plan that is ultimately  adopted,  a Medicare  prescription  drug benefit
could make such policies or plans less valuable to seniors,  adversely affecting
that segment of our business. While we believe that there could be opportunities
for new business  under a Medicare  plan that would more than offset any adverse
effects, we can give no assurance that this would be the case.

Joint Venture and Acquisitions

     On February 22, 2001, we announced  that we entered into an agreement  with
AdvancePCS and  Merck-Medco  to form RxHub LLC  ("RxHub").  RxHub is intended to
develop  an  electronic   exchange   enabling   physicians  who  use  electronic
prescribing technology to link to pharmacies, PBMs and health plans, which their
patients use. The company is designed to operate as a utility for the conduit of
information  among all parties engaging in electronic  prescribing.  We will own
one-third of the equity of RxHub (as will each of the other two  founders),  and
have  committed  to  invest up to $20  million  over the next  five  years  with
approximately  $6 million  committed for 2001. We will record our  investment in
RxHub under the equity  method of  accounting,  which  requires  our  percentage
interest  in RxHub's  results to be recorded in our  Consolidated  Statement  of
Operations.  RxHub will be operated to cover its expected operating costs and to
return the cost of capital to the founders.

     As previously  announced the  shareholders of Centre  d'autorisation  et de
paiement des services de sante, a leading  Quebec-based PBM commonly referred to
as CAPSS,  accepted an offer made by our Canadian subsidiary,  ESI Canada, Inc.,
to acquire all of the  outstanding  shares of CAPSS,  subject to satisfaction of
certain  conditions,  for approximately  CAN$25 million  (approximately  US$16.5
million). The transaction, which will be accounted for under the purchase method
of  accounting,  will be funded with our operating cash flow. We expect to close
the  transaction  during  March 2001 and it will add  approximately  1.5 million
lives to ESI Canada's  membership  base.  The  transaction is not expected to be
dilutive to earnings in 2001 and is expected to be slightly accretive in 2002.

     On April 1, 1999, we acquired DPS from SmithKline  Beecham  Corporation and
one of its affiliates for $715 million in cash,  which reflects a purchase price
adjustment for closing working capital and  transaction  costs.  The acquisition
positioned  us as the  third  largest  PBM in  North  America  in terms of total
members and provided us with one of the largest managed care membership bases of
any PBM.  In  addition,  the  acquisition  provides  us with  enhanced  clinical
capabilities, systems and technologies.

     On April 1, 1998, we acquired the PBM business  known as "ValueRx" from HCA
- - The HealthCare  Corporation  (formerly known as  Columbia/HCA  Healthcare) for
approximately $460 million in cash. Historically, while ValueRx, like us, served
all segments of the PBM market, we primarily focused on managed care and smaller
self-funded plan sponsors, and ValueRx concentrated on health insurance carriers
and large employer and union groups.

Company Operations

     General. We operate five mail pharmacies and eight member  service/pharmacy
help desk call  centers out of leased  facilities.  Electronic  pharmacy  claims
processing  takes place at our Maryland  Heights,  Missouri  and Tempe,  Arizona
facilities,  which are  maintained,  managed  and  operated by  Electronic  Data
Systems  ("EDS"),  or at facilities owned by EDS. At our Canadian  facility,  we
have  sales and  marketing,  client  services,  pharmacy  help  desk,  clinical,
provider relations and certain management information systems capabilities.

     Sales and Marketing. We market and sell our PBM services in the United
States primarily through an internal staff of sales directors and sales managers
located throughout the United States. The sales representatives are supported by
a staff of  client  service  representatives,  clinical  pharmacy  managers  and
business analyst  consultants who focus on assisting our clients in managing the
rising trend in pharmacy  costs.  Marketing and sales in Canada are conducted by
representatives  located in  Mississauga,  Ontario.  Although we cross-sell  our
infusion   services  to  our  PBM  clients,   Infusion  Services  and  Specialty
Distribution Services also employ personnel to sell these specific products.

     Member  Services.  Although we sell our  services to clients,  the ultimate
recipient of many of our  services are the members of health plans  sponsored by
our clients. We believe,  therefore,  that client satisfaction is dependent upon
member  satisfaction.  Members can call us  toll-free,  24 hours a day, 7 days a
week, to obtain  information about their prescription drug plan from our trained
member service representatives.

     Provider  Relations.  Our  Provider  Relations  group  is  responsible  for
contracting  and  administering  our pharmacy  networks.  To  participate in our
retail pharmacy  networks,  pharmacies must meet certain  qualifications and are
periodically  required to represent to us that their  applicable state licensing
requirements are being maintained and that they are in good standing. Pharmacies
can contact our various pharmacy help desks toll-free,  24 hours a day, 7 days a
week, for information and assistance in filling  prescriptions  for members.  In
addition,  our Provider Relations group audits pharmacies in the retail pharmacy
networks to determine compliance with the terms of the contract with our clients
or us.

     Clinical Support. Our Health Management Services division employs
clinical  pharmacists,  data  analysts  and  outcomes  researchers  who  provide
technical support for our PBM services.  These staff members assist in providing
high level  clinical  pharmacy  services  such as  formulary  development,  drug
information  programs,  clinical  interventions with physicians,  development of
drug therapy  guidelines and the evaluation of drugs for inclusion in clinically
sound therapeutic intervention programs.

     The Health Management  Services division conducts specific data analyses to
evaluate drug therapies,  and analyzes and prepares reports on clinical pharmacy
data for our clients.  For example, in June 2000 we released our 1999 Drug Trend
Report,  marking our fourth consecutive year of publishing such a report.  Based
on a large  sample  of our  membership  base,  the  report  examines  trends  in
pharmaceutical  utilization and cost and the factors that underlie those trends.
The  division  also  evaluates  pharmacy  plan design  strategies  and  clinical
offerings   and   conducts   outcomes   research   studies   to  inform   client
decision-making.

     Information  Systems.  Our  Information  Systems  department  supports  our
pharmacy claims processing systems and other management information systems that
are essential to our operations.  Uninterrupted  point-of-sale electronic retail
pharmacy claims processing is a significant  operational requirement for us. All
claims are presently processed through systems which are maintained, managed and
operated by EDS at our Maryland Heights,  Missouri  facility and Tempe,  Arizona
facility, or at facilities owned by EDS, who maintains certain computer hardware
for us at its  facility in Plano,  Texas.  Disaster  recovery  services  for all
systems are provided  through our EDS services  agreement.  We have  substantial
capacity for growth in our claims processing facilities.

Competition

     We believe the primary  competitive  factors in each of our  businesses are
price,  quality of  service  and scope of  available  services.  We believe  our
principal  competitive  advantages  are  our  independence  from  pharmaceutical
manufacturer ownership, our strong managed care and employer group customer base
which  supports the  development  of more  sophisticated  PBM services,  and our
commitment to provide flexible and distinctive service to our clients.

     There are other PBMs in the United  States,  most of which are smaller than
us and offer  their  services  on a local or  regional  basis.  We do,  however,
compete  with a number  of  large,  national  companies,  including  Merck-Medco
Managed  Care,  L.L.C.,  a  subsidiary  of Merck & Co.,  Inc.,  ("Merck-Medco");
AdvancePCS and  CaremarkRx,  Inc.; as well as large health  insurers and certain
HMOs which have their own PBM capabilities. Several of these other companies may
have  greater  financial,  marketing  and  technological  resources  than us. In
addition,  a competitor that is owned by a pharmaceutical  manufacturer may have
pricing  advantages  that are  unavailable  to us and  other  independent  PBMs.
However, we believe our independence from pharmaceutical  manufacturer ownership
allows us to make unbiased formulary  recommendations to our clients,  balancing
both clinical efficacy and cost.

     Consolidation  has been, and may continue to be, an important factor in all
aspects of the pharmaceutical  industry,  including the PBM segment.  We believe
the size of our  membership  base  provides us with the  necessary  economies of
scale to compete effectively in a consolidating market.

     Some of our PBM services,  such as disease  management  services,  informed
decision  counseling  services  and  medical  information  management  services,
compete with those being offered by  pharmaceutical  manufacturers,  other PBMs,
large  national  companies,   specialized   disease  management   companies  and
information  service  providers.  Our non-PBM  services compete with a number of
large national companies as well as with local providers.

Government Regulation

     Various  aspects of our  businesses  are governed by federal and state laws
and  regulations.  Since  sanctions may be imposed for violations of these laws,
compliance  is a  significant  operational  requirement.  We  believe  we are in
substantial  compliance  with all existing  legal  requirements  material to the
operation  of our  businesses.  There are,  however,  significant  uncertainties
involving the  application of many of these legal  requirements to our business.
In addition, there are numerous proposed health care laws and regulations at the
federal and state levels,  many of which could adversely  affect our business or
financial  position.  We are unable to predict what additional  federal or state
legislation or regulatory  initiatives  may be enacted in the future relating to
our  business  or the health care  industry in general,  or what effect any such
legislation  or  regulations  might have on us. We cannot  provide any assurance
that federal or state  governments  will not impose  additional  restrictions or
adopt interpretations of existing laws that could have a material adverse affect
on our business or financial position.

     Pharmacy Benefit Management Regulation Generally. Certain federal and state
laws and  regulations  affect or may affect  aspects of our PBM business.  Among
these are the following:

     FDA Regulation. The U.S. Food and Drug Administration ("FDA") generally has
authority to regulate drug promotional materials that are disseminated "by or on
behalf of" a drug  manufacturer.  In January,  1998, the FDA issued a Notice and
Draft  Guidance  regarding  its intent to regulate  certain drug  promotion  and
switching activities of pharmacy benefit managers that are controlled,  directly
or indirectly, by drug manufacturers. The position taken by the FDA in the Draft
Guidance was that  promotional  materials used by an independent  PBM or managed
care  organization  may  be  subject  to  FDA  regulation   depending  upon  the
circumstances, including the nature of the relationship between the PBM, the HMO
and the  manufacturer.  We, along with various other parties,  submitted written
comments  to the FDA  regarding  the  basis  for FDA  regulation  of PBM and HMO
activities.  It was our position that,  while the FDA may have  jurisdiction  to
regulate  drug   manufacturers,   the  Draft  Guidance  went  beyond  the  FDA's
jurisdiction.  After  extending  the  comment  period due to  numerous  industry
objections  to the proposed  Draft,  the FDA withdrew the Draft  Guidance in the
fall of 1998,  stating that it would  reconsider  the basis for such a Guidance.
The FDA has not addressed the issue since the withdrawal.  However, there can be
no assurance  that the FDA will not again  attempt to assert  jurisdiction  over
certain aspects of our PBM business in the future and, in such event, the impact
could  materially  adversely  affect  our  operations,   business  or  financial
position.

     Anti-Remuneration/Fraud  and Abuse Laws. Federal law prohibits, among other
things,  an entity from paying or receiving,  subject to certain  exceptions and
"safe harbors," any  remuneration to induce the referral of individuals  covered
by federally  funded  health care  programs,  including  Medicare,  Medicaid and
CHAMPUS or the purchase (or the arranging for or  recommending  of the purchase)
of items or services  for which  payment may be made under  Medicare,  Medicaid,
CHAMPUS or other federally-funded health care programs. Several states also have
similar  laws that are not  limited to services  for which  Medicare or Medicaid
payment may be made. State laws vary and have been  infrequently  interpreted by
courts or regulatory  agencies.  Sanctions for violating these federal and state
anti-remuneration  laws may include imprisonment,  criminal and civil fines, and
exclusion from participation in the Medicare and Medicaid programs.

     The federal statute has been interpreted  broadly by courts,  the Office of
Inspector  General  ("OIG") within the Department of Health and Human  Services,
and administrative bodies. Because of the federal statute's broad scope, federal
regulations establish certain "safe harbors" from liability.  Safe harbors exist
for  certain  properly  reported  discounts   received  from  vendors,   certain
investment  interests,  certain properly  disclosed  payments made by vendors to
group purchasing  organizations,  and certain discount and payment  arrangements
between PBMs and HMO risk contractors  serving Medicaid and Medicare members.  A
practice  that does not fall within a safe harbor is not  necessarily  unlawful,
but may be subject to scrutiny and  challenge.  In the absence of an  applicable
exception or safe harbor,  a violation of the statute may occur even if only one
purpose of a payment  arrangement is to induce  patient  referrals or purchases.
Among the practices that have been identified by the OIG as potentially improper
under the statute are certain  "product  conversion  programs" in which benefits
are given by drug  manufacturers  to  pharmacists  or physicians  for changing a
prescription  (or  recommending  or  requesting  such a change) from one drug to
another. Such laws have been cited as a partial basis, along with state consumer
protection laws discussed below, for investigations and multi-state  settlements
relating  to  financial  incentives  provided  by drug  manufacturers  to retail
pharmacies in connection with such programs.

     To our  knowledge,  these  anti-remuneration  laws have not been applied to
prohibit PBMs from receiving amounts from drug  manufacturers in connection with
drug purchasing and formulary management programs,  to therapeutic  intervention
programs conducted by independent PBMs, or to the contractual relationships such
as those we have with certain of our clients. In late 1999, it was reported that
the U.S.  Attorney's  Office in Philadelphia had issued subpoenas to Merck-Medco
and PCS (now AdvancePCS), both PBMs, and Schering-Plough Corp., a pharmaceutical
manufacturer.  We have not been served with any such subpoena,  nor are we privy
to  information  concerning the scope of  information  being  requested by these
subpoenas.  However,  the U.S.  Attorney's  Office has been quoted to the effect
that one issue being  investigated  is whether certain  practices  engaged in by
those PBMs violate certain anti-remuneration statutes. We believe that we are in
substantial  compliance  with the legal  requirements  imposed  by such laws and
regulations,  and  we  believe  that  there  are  material  differences  between
drug-switching  programs that have historically been challenged under these laws
and the  programs we offer to our  clients.  However,  there can be no assurance
that we will  not be  subject  to  scrutiny  or  challenge  under  such  laws or
regulations. Any such challenge could have a material adverse effect on us.

     ERISA  Regulation.  The  Employee  Retirement  Income  Security Act of 1974
("ERISA")  regulates  certain  aspects of employee  pension  and health  benefit
plans,   including  self-funded  corporate  health  plans  with  which  we  have
agreements to provide PBM services.  We believe that the conduct of our business
is not  generally  subject  to the  fiduciary  obligations  of  ERISA,  and  our
agreements with our clients support this contention by providing that we are not
the fiduciary of the applicable  plan.  However,  there can be no assurance that
the U.S. Department of Labor, which is the agency that enforces ERISA, would not
assert that the  fiduciary  obligations  imposed by the statute apply to certain
aspects of our operations.

     In addition to its fiduciary  provisions,  ERISA imposes civil and criminal
liability  on service  providers to health  plans and certain  other  persons if
certain forms of illegal remuneration are made or received.  These provisions of
ERISA are  similar,  but not  identical,  to the health  care  anti-remuneration
statutes discussed in the immediately  preceding section;  in particular,  ERISA
lacks the statutory and regulatory "safe harbor"  exceptions  incorporated  into
the health  care  statute.  Like the health  care  anti-remuneration  laws,  the
corresponding  provisions of ERISA are broadly written and their  application to
particular cases is often uncertain. We have implemented policies, which include
disclosure to health plan sponsors  with respect to any  commissions  paid by us
that might fall within the scope of such provisions,  and accordingly believe we
are in substantial  compliance with these provisions of ERISA.  However,  we can
provide no  assurance  that our  policies in this  regard  would be found by the
appropriate enforcement authorities to meet the requirements of the statute.

     Proposed Changes in Canadian  Healthcare  System. In Canada, the provincial
health plans  provide  universal  coverage for basic health care  services,  but
prescription  drug coverage under the government  plans is provided only for the
elderly  and the  indigent.  In late  1997,  a  proposal  was made by a  federal
government  health care task force to include  coverage for  prescription  drugs
under the provincial  health insurance plans,  which was endorsed by the federal
government's  Health  Minister.  This  report was  advisory  in nature,  and not
binding upon the federal or provincial  governments.  We believe this initiative
is dormant at the present time, and we are unable to determine the likelihood of
adoption of the proposal in the future.

     Numerous  state  laws  and  regulations  also  affect  aspects  of our  PBM
business. Among these are the following:

     Comprehensive  PBM  Regulation.  Although  no state has passed  legislation
regulating PBM activities in a comprehensive  manner,  such legislation has been
introduced  previously  in a number of states,  and  currently  in  Georgia.  In
addition,   certain  quasi-regulatory   organizations,   such  as  the  National
Association of Boards of Pharmacy  ("NABP",  an  organization of state boards of
pharmacy),  the National  Association  of Insurance  Commissioners  ("NAIC",  an
organization  of state  insurance  regulators),  and the  National  Committee on
Quality  Assurance  ("NCQA",  an  accreditation  organization)  are  considering
proposals to regulate PBMs and/or PBM activities,  such as formulary development
and  utilization  management.  While the  actions of the NABP and NAIC would not
have the force of law, they may influence  states to adopt any  requirements  or
model acts they  promulgate.  In addition,  standards  established by NCQA could
materially impact us directly as a PBM, and indirectly through the impact on our
health plan clients.

     Consumer  Protection  Laws. Most states have consumer  protection laws that
have been the basis for investigations and multi-state  settlements  relating to
financial  incentives  provided by drug  manufacturers  to retail  pharmacies in
connection with drug switching programs.  In addition,  pursuant to a settlement
agreement  entered into with seventeen  states on October 25, 1995,  Merck-Medco
Managed Care, LLC ("Medco"),  the PBM subsidiary of pharmaceutical  manufacturer
Merck & Co.,  agreed to have  pharmacists  affiliated  with Medco  mail  service
pharmacies  disclose to  physicians  and  patients the  financial  relationships
between  Merck,  Medco,  and the mail  service  pharmacy  when such  pharmacists
contact physicians seeking to change a prescription from one drug to another. We
believe that our contractual  relationships  with drug  manufacturers and retail
pharmacies  do  not  include  the  features  that  were  viewed  by  enforcement
authorities as problematic in these settlement agreements. However, no assurance
can be given that we will not be subject to scrutiny or  challenge  under one or
more of these laws.

     Network  Access  Legislation.  A  majority  of states now have some form of
legislation affecting our ability to limit access to a pharmacy provider network
or removal of a network provider. Such legislation may require us or our clients
to admit any retail  pharmacy  willing to meet the plan's  price and other terms
for network participation ("any willing provider"  legislation);  or may provide
that a provider  may not be removed  from a network  except in  compliance  with
certain  procedures  ("due process"  legislation).  We have not been  materially
affected by these statutes.

     Legislation  Affecting  Plan Design.  Some states have enacted  legislation
that  prohibits  certain types of managed care plan  sponsors from  implementing
certain restrictive design features, and many states have introduced legislation
to regulate various aspects of managed care plans, including provisions relating
to the pharmacy benefit.  For example,  some states, under so-called "freedom of
choice" legislation, provide that members of the plan may not be required to use
network  providers,  but must  instead be provided  with  benefits  even if they
choose to use  non-network  providers.  Other  states have  enacted  legislation
purporting to prohibit health plans from offering members  financial  incentives
for use of mail service  pharmacies.  Legislation  has been  introduced  in some
states to prohibit or restrict therapeutic intervention,  or to require coverage
of all FDA approved drugs.  Other states mandate coverage of certain benefits or
conditions,  and  require  health  plan  coverage  of  specific  drugs if deemed
medically  necessary by the prescribing  physician.  Such  legislation  does not
generally apply to us directly, but it may apply to certain of our clients, such
as HMOs and health  insurers.  If such legislation were to become widely adopted
and broad in scope,  it could have the effect of limiting the economic  benefits
achievable  through pharmacy benefit  management.  This development could have a
material adverse effect on our business.

     Licensure Laws.  Many states have licensure or registration  laws governing
certain types of ancillary health care organizations,  including PPOs, TPAs, and
companies  that provide  utilization  review  services.  The scope of these laws
differs  significantly  from state to state, and the application of such laws to
the activities of pharmacy benefit managers often is unclear. We have registered
under such laws in those  states in which we have  concluded,  after  discussion
with the appropriate state agency,  that such registration is required.  Because
of  increased  regulatory  requirements  on some  of our  managed  care  clients
affecting  prior  authorization  of drugs before  coverage is approved,  we have
obtained  utilization  review  licenses in selected  states  through our new ESI
Utilization Management Co. In addition, accreditation agencies' requirements for
managed care  organizations may also affect those delegated  services we provide
to such organizations.

     Legislation Affecting Drug Prices. Some states have adopted so-called "most
favored nation" legislation providing that a pharmacy participating in the state
Medicaid  program  must give the state the best  price that the  pharmacy  makes
available to any third party plan.  Such  legislation  may adversely  affect our
ability to  negotiate  discounts in the future from  network  pharmacies.  Other
states have enacted  "unitary  pricing"  legislation,  which  mandates  that all
wholesale  purchasers  of drugs  within  the  state be given  access to the same
discounts and incentives.  Such  legislation has been introduced in the past but
not enacted in Missouri,  Arizona,  Pennsylvania,  New York, and New Mexico, all
states where we operate mail service pharmacies. Such legislation, if enacted in
a state where one of our mail service  pharmacies  is located,  could  adversely
affect our ability to negotiate  discounts on our purchase of prescription drugs
to be dispensed by our mail service pharmacies.

     In addition,  various  federal and state Medicaid  agencies have raised the
issue of how average  wholesale  price ("AWP") is calculated.  AWP is a standard
pricing unit used  throughout  the industry,  as well as by us, as the basis for
calculating  drug prices under our health plans and  pharmacies and rebates with
pharmaceutical  manufacturers.  Changes to the standard have been suggested that
could alter the calculation of drug prices for federal  programs.  We are unable
to predict whether any such changes will be adopted,  and if so, if such changes
would have a material adverse impact on our financial operations.

     Regulation of Financial Risk Plans. Fee-for-service prescription drug plans
are generally not subject to financial regulation by the states. However, if the
PBM  offers to  provide  prescription  drug  coverage  on a  capitated  basis or
otherwise  accepts  material  financial  risk in providing the benefit,  laws in
various  states may regulate  the plan.  Such laws may require that the party at
risk establish reserves or otherwise demonstrate financial responsibility.  Laws
that may apply in such cases include insurance laws, HMO laws or limited prepaid
health  service plan laws. In those cases in which we have contracts in which we
are  materially  at risk to provide  the  pharmacy  benefit,  we believe we have
complied with all applicable laws.

     Many of the state laws described above may be preempted in whole or in part
by ERISA,  which  provides  for  comprehensive  federal  regulation  of employee
benefit  plans.  However,  the scope of ERISA  preemption  is  uncertain  and is
subject  to  conflicting  court  rulings,  and we  provide  services  to certain
clients, such as governmental  entities,  that are not subject to the preemption
provisions  of ERISA.  Other state laws may be invalid in whole or in part as an
unconstitutional  attempt by a state to regulate  interstate  commerce,  but the
outcome of  challenges  to these laws on this basis is  uncertain.  Accordingly,
compliance  with state laws and  regulations  remains a significant  operational
requirement for us.

     Mail  Pharmacy  Regulation.  Our mail  service  pharmacies  are  located in
Arizona, Missouri, New Mexico, New York and Pennsylvania, and we are licensed to
do business  as a pharmacy in each such state.  Many of the states into which we
deliver pharmaceuticals have laws and regulations that require out-of-state mail
service pharmacies to register with, or be licensed by, the board of pharmacy or
similar  regulatory body in the state.  These states  generally  permit the mail
service  pharmacy to follow the laws of the state  within which the mail service
pharmacy  is  located,  although  two  states  require  that  we also  employ  a
pharmacist  licensed in that state.  We have  registered our pharmacies in every
state in which such registration is required.

     Other statutes and regulations affect our mail service operations.  Federal
statutes  and  regulations  govern  the  labeling,  packaging,  advertising  and
adulteration of prescription drugs and the dispensing of controlled  substances.
The Federal Trade  Commission  requires mail order sellers of goods generally to
engage in truthful  advertising,  to stock a reasonable supply of the product to
be sold,  to fill mail orders within  thirty days,  and to provide  clients with
refunds  when  appropriate.  The United  States  Postal  Service  has  statutory
authority to restrict the  transmission of drugs and medicines  through the mail
to a degree that could have an adverse effect on our mail service operations.

     Regulation of Informed Decision Counseling and Disease Management Services.
Our health care decision support counseling and disease management  programs are
affected  by many of the same types of state laws and  regulations  as our other
activities.  In addition,  all states  regulate the practice of medicine and the
practice of  nursing.  We do not believe our  informed  decision  counseling  or
disease management  activities constitute either the practice of medicine or the
practice of nursing. However, there can be no assurance that a regulatory agency
in one or more states may not assert a contrary  position,  and we are not aware
of any controlling legal precedent for services of this kind.

     Privacy and Confidentiality Legislation. Most of our activities involve the
receipt  or use  of  confidential,  medical  information  concerning  individual
members.  In addition,  we use aggregated  and anonymized  data for research and
analysis  purposes.  Regulations  have been  proposed at the  federal  level and
legislation has been proposed,  and in some cases enacted,  in several states to
restrict the use and disclosure of confidential medical information. To date, no
such legislation has been enacted that adversely  impacts our ability to provide
our services,  but there can be no assurance  that federal or state  governments
will not enact  legislation,  impose  restrictions or adopt  interpretations  of
existing laws that could have a material adverse effect on our operations.

     In December 2000, the Department of Health and Human Services  issued final
privacy   regulations,   pursuant  to  the  Health  Insurance   Portability  and
Accountability Act of 1996 ("HIPAA"), which impose extensive restrictions on the
use and disclosure of individually  identifiable  health  information by certain
entities. We will be required to comply with certain aspects of the regulations.
We have  retained a consulting  firm to assist us in assessing the steps we will
have to take in complying with these  regulations,  which provide for a two year
implementation  period.  While this  assessment is not yet complete,  we believe
compliance with these regulations will have a significant impact on our business
operations.  We have not yet  completed an assessment of the costs we will incur
in complying with these  regulations,  and can give no assurance that such costs
will not be material to us.

     Even without new legislation and beyond the final federal regulations,
individual  health plan sponsor customers could prohibit us from including their
patients'  medical  information in our various  databases of medical data.  They
could also prohibit us from offering  services that involve the  compilation  of
such information.

     Non-PBM  Regulatory  Environment.  Our  non-PBM  activities  operate  in  a
regulatory environment that is quite similar to that of our PBM activities.

     Regulation of Infusion  Therapy  Services.  Our infusion  therapy  services
business  is subject to many of the same or similar  federal  and state laws and
regulations  affecting  our  pharmacy  benefit  management  business,  including
anti-remuneration,  physician self-referral, and other fraud and abuse type laws
and  regulations.  In addition,  some states  require that providers of infusion
therapy  services be  licensed.  We are  licensed  as a home  health  agency and
pharmacy in Texas, as a residential service agency and pharmacy in Maryland, and
as a pharmacy in New Jersey,  Missouri,  Arizona and  Pennsylvania.  We are also
licensed as a non-resident pharmacy in various states. We believe that we are in
substantial compliance with such licensing requirements.

     The  Joint  Commission  on   Accreditation   of  Healthcare   Organizations
("JCAHO"), a non-profit, private organization, has established written standards
for health care  organizations and home care services,  including  standards for
services  provided  by home  infusion  therapy  companies.  All of our  infusion
therapy facilities have received JCAHO accreditation,  which allows us to market
infusion  therapy services to Medicare and Medicaid  programs.  If we expand our
home  infusion  therapy  services  to other  states or to  Medicare  or Medicaid
programs,  we  may  be  required  to  comply  with  other  applicable  laws  and
regulations.

     Future  Regulation.  We are unable to predict  accurately  what  additional
federal or state  legislation  or regulatory  initiatives  may be enacted in the
future  relating to our  businesses or the health care  industry in general,  or
what effect any such  legislation or regulations  might have on us. There can be
no  assurance  that  federal or state  governments  will not  impose  additional
restrictions  or adopt  interpretations  of  existing  laws  that  could  have a
material adverse effect on our business or financial position.

Service Marks and Trademarks

     We, and our  subsidiaries,  have  registered  the  service  marks  "Express
Scripts",  "PERx",  "ExpressTherapeutics",  "IVTx",  "PERxCare",  "RxWorkbench",
"PTE",   "InformRX",   "M.U.S.I.C.",   "ValueRx",   "Value  Health,   Inc."  and
"Diversified", among others, with the United States Patent and Trademark Office.
Our rights to these  marks will  continue  so long as we comply  with the usage,
renewal filing and other legal  requirements  relating to the renewal of service
marks.  We are in the  process of applying  for  registration  of several  other
trademarks  and  service  marks.  If we are  unable  to  obtain  any  additional
registrations,  we believe  there  would be no  material  adverse  effect on our
business.

Insurance

     Our PBM operations,  including the dispensing of pharmaceutical products by
our mail service  pharmacies,  and the services  rendered in connection with our
disease management and informed decision  counseling  services,  and our non-PBM
operations,  such as the products and services  provided in connection  with our
infusion  therapy  programs  (including the associated  nursing  services),  may
subject  us to  litigation  and  liability  for  damages.  We  believe  that our
insurance protection is adequate for our present business operations,  but there
can be no  assurance  that we will be able  to  maintain  our  professional  and
general  liability  insurance  coverage  in the  future or that  such  insurance
coverage will be available on  acceptable  terms or adequate to cover any or all
potential  product or professional  liability  claims.  A successful  product or
professional  liability  claim in excess of our insurance  coverage,  or one for
which an exclusion from coverage  applies,  could have a material adverse effect
upon our financial position or results of operations.

Employees

     As of February 1, 2001, we employed a total of 5,259  employees in the U.S.
and 87 employees in Canada.  Approximately 652 of the U.S. employees are members
of collective bargaining units.  Specifically,  we employ members of the Service
Employees International Union at our Bensalem, Pennsylvania facility, members of
the United Auto Workers Union at our Farmington Hills,  Michigan  facility,  and
members of the United Food and Commercial Workers Union at our Albuquerque,  New
Mexico facility.  We believe our relationships with our employees and our unions
are good.

Executive Officers of the Registrant

     Pursuant to General Instruction G(3) of the Annual Report on Form 10-K, the
information  regarding our executive officers required by Item 401 of Regulation
S-K is hereby included in Part I of this report.

         Our  executive  officers  and  their  ages as of March  1,  2001 are as
follows:

            Name             Age                  Position

  Barrett A. Toan             53    Chairman of the Board,
                                    President and Chief Executive
                                    Officer
  David A. Lowenberg          51    Chief Operating Officer
  Terrence D. Arndt           57    Senior Vice President of Marketing
  Stuart L. Bascomb           59    Executive Vice President - Sales
                                    and Provider Relations and
                                    Director
  Thomas M. Boudreau          49    Senior Vice President, General
                                    Counsel and Secretary
  Mabel F. Chen               58    Senior Vice President and
                                    Director of Site Operations
  Edward J. Tenholder         49    Senior Vice President and Chief
                                    Information Systems Officer
  Mark O. Johnson             47    Senior Vice President of
                                    Integration and Administration
  Linda L. Logsdon            53    Executive Vice President of
                                    Health Management Services
  George Paz                  45    Senior Vice President and Chief
                                    Financial Officer
  Joseph W. Plum              53    Vice President and Chief
                                    Accounting Officer

     Mr. Toan was elected  Chairman of the Board of Directors in November  2000,
Chief  Executive  Officer in March 1992 and  President and a director in October
1990.

     Mr. Lowenberg was elected Express Scripts,  Inc.'s Chief Operating  Officer
in September  1999, and served as our Director of Site  Operations  from October
1994 until September 1999.

     Mr.  Arndt  joined  Express  Scripts,  Inc.  and was  elected  Senior  Vice
President of Marketing in April 1999.  Prior to joining Express  Scripts,  Inc.,
Mr. Arndt was President and Chief Operating Officer of EDI USA from July 1997 to
April 1999. Mr. Arndt served as Vice President of Business  Development for Card
Establishment  Services,  a former  division of  CitiBank,  owned by the firm of
Welsh, Carson, Anderson and Stowe, from July 1994 to July 1997.

     Mr.  Bascomb  was  elected  Executive  Vice  President  in March 1989 and a
director in January 2000.  Mr.  Bascomb has served as Executive Vice President -
Sales  and  Provider  Relations  since May 1996 and  served  as Chief  Financial
Officer and Treasurer from March 1992 until May 1996.

     Mr.  Boudreau  was  elected  Senior  Vice  President,  General  Counsel and
Secretary in October 1994. He has served as General Counsel since June 1994.

     Ms. Chen was elected Senior Vice President and Director of Site  Operations
in November  1999.  From March 1996 until November 1999, Ms. Chen served as Vice
President and General Manager of Express  Scripts,  Inc.'s Tempe facility.  From
January 1995 until joining Express  Scripts,  Ms. Chen served as the Director of
Medicaid for the State of Arizona.

     Mr.  Tenholder  was elected  Senior Vice  President  and Chief  Information
Systems  Officer in  December  2000.  Mr.  Tenholder  served as  Executive  Vice
President and Chief Operating  Officer of Blue Cross and Blue Shield of Missouri
from  October  1997 to  December  2000.  From April 1994 to  October  1997,  Mr.
Tenholder was Senior Vice  President,  Client  Services and  Operations of Right
Choice Managed Care, Inc.

     Mr.  Johnson  joined  Express  Scripts,  Inc.  and was elected  Senior Vice
President of Integration in May 1999, and has served as Senior Vice President of
Integration  and  Administration  since February 2000.  Prior to joining Express
Scripts,  Inc.,  Mr.  Johnson  served as President of DPS from May 1998 to April
1999 and Senior Vice President, Client Service and Sales of DPS from May 1997 to
May 1998.  From August 1996 to May 1997,  Mr.  Johnson was  President  and Chief
Executive  Officer of American  Day  Treatment  Center,  Inc. and also served as
Executive Vice President, Operations and Chief Operating Officer from March 1992
to August 1996.

     Ms.  Logsdon was elected  Executive  Vice  President  of Health  Management
Services in May 1999, and served as Senior Vice  President of Health  Management
Services from May 1997 until May 1999.  Ms.  Logsdon served as Vice President of
Demand and  Disease  Management  from  November  1996  until May 1997.  Prior to
joining  Express  Scripts,  Inc. in November  1996,  Ms.  Logsdon served as Vice
President  of  Corporate   Services  and  Chief  Operating   Officer  of  United
HealthCare's Midwest Companies-GenCare/Physicians Health Plan/MetraHealth, a St.
Louis-based health maintenance organization, from February 1995 to October 1996.

     Mr. Paz joined Express Scripts,  Inc. and was elected Senior Vice President
and Chief Financial  Officer in January 1998.  Prior to joining Express Scripts,
Inc.,  Mr. Paz was a partner  in the  Chicago  office of Coopers & Lybrand  from
December 1995 to December 1997.

     Mr. Plum was elected Vice President in October 1994 and has served as Chief
Accounting Officer since March 1992 and Corporate Controller since March 1989.

Forward Looking Statements and Associated Risks

     Information  that we have  included or  incorporated  by  reference in this
Annual Report on Form 10-K, and  information  that may be contained in our other
filings with the SEC and our press releases or other public statements,  contain
or may contain  forward-looking  statements.  These  forward-looking  statements
include,  among others,  statements of our plans,  objectives,  expectations  or
intentions.

     Our forward-looking statements involve risks and uncertainties.  Our actual
results  may differ  significantly  from those  projected  or  suggested  in any
forward-looking  statements.  We do not  undertake  any  obligation  to  release
publicly any revisions to such  forward-looking  statements to reflect events or
circumstances  occurring  after the date hereof or to reflect the  occurrence of
unanticipated  events.  Factors  that  might  cause such a  difference  to occur
include, but are not limited to:

          o    risks  associated  with our ability to maintain  internal  growth
               rates,  or to  control  operating  or capital  costs

          o    continued  pressure on margins  resulting from client demands for
               enhanced   service   offerings  and  higher   service   levels

          o    competition,  including  price  competition,  and our  ability to
               consummate  contract  negotiations with prospective  clients,  as
               well as competition from new competitors  offering  services that
               may in whole or in part replace  services  that we now provide to
               our customers

          o    adverse  results  in  regulatory  matters,  the  adoption  of new
               legislation or regulations  (including increased costs associated
               with  compliance with new laws and  regulations,  such as privacy
               regulations   under  the   Health   Insurance   Portability   and
               Accountability  Act  (HIPAA)),  more  aggressive  enforcement  of
               existing   legislation  or  regulations,   or  a  change  in  the
               interpretation of existing legislation or regulations

          o    the  possible  termination  of  contracts  with  key  clients  or
               providers

          o    the   possible   loss  of   relationships   with   pharmaceutical
               manufacturers, or changes in pricing, discount or other practices
               of pharmaceutical manufacturers

          o    adverse results in litigation

          o    risks associated with our leverage and debt service obligations

          o    risks  associated  with our  ability to  continue  to develop new
               products,  services and delivery  channels

          o    developments in the health care industry, including the impact of
               increases in health care costs,  changes in drug  utilization and
               cost patterns and  introductions  of new drugs

          o    risks  associated  with  our financial  commitment  relating  to
               the  RxHub venture

          o    other risks  described  from time to time in our filings with the
               SEC

These and other relevant factors,  including any other  information  included or
incorporated by reference in this Report,  and information that may be contained
in our other filings with the SEC, should be carefully considered when reviewing
any  forward-looking  statement.  The occurrence of any of the following  risks,
among  others,  could  materially  adversely  affect  our  business,  results of
operations and financial condition.

Failure to Maintain Internal Growth Rates, or to Control Operating or Capital
Costs, Could Adversely Affect Our Business

     We have experienced  rapid internal growth over the past several years. Our
ability to maintain this internal  growth rate is dependent  upon our ability to
attract new  clients,  achieve  growth in the  membership  base of our  existing
clients as well as cross-sell additional services to our existing clients. If we
are  unable to  continue  our  client  and  membership  growth,  and  manage our
operating and capital costs,  our results of operations  and financial  position
could be materially adversely affected.

Competition in the PBM Industry Could Reduce Our Client Membership and Our
Profit Margins

     Pharmacy benefit management is a very competitive business. Our competitors
include large and  well-established  companies that may have greater  financial,
marketing and  technological  resources than we do. One major  competitor in the
PBM business, Merck-Medco is a large pharmaceutical manufacturer, which may give
them  purchasing  or  other  advantages  over us by  virtue  of  this  ownership
structure,  and  enable  them to  succeed  in taking  away some of our  clients.
Consolidation in the PBM industry, such as the recently completed acquisition of
PCS,  Inc. by Advance  Paradigm,  Inc.,  may also lead to increased  competition
among a smaller  number of large PBM companies.  Competition  may also come from
other  sources  in  the  future,  including  from  Internet-based   connectivity
companies. We cannot predict what effect, if any, these new competitors may have
on the marketplace or on our business.

     Over the last several  years intense  competition  in the  marketplace  has
caused many PBMs, including us, to reduce the prices charged to clients for core
services and share a larger portion of the formulary  fees and related  revenues
received from  pharmaceutical  manufacturers  with clients.  This combination of
lower pricing and increased  revenue  sharing,  as well as increased  demand for
enhanced service  offerings and higher service levels,  has caused our operating
margins to  decline.  We expect to  continue  marketing  our  services to larger
clients, who typically have greater bargaining power than smaller clients.  This
might create continuing  pressure on our margins.  We can give no assurance that
new services  provided to these clients will fully  compensate for these reduced
margins.

Changes in State and Federal Regulations Could Restrict Our Ability to Conduct
Our Business

     Numerous  state and federal  laws and  regulations  affect our business and
operations. The categories include, but are not necessarily limited to:

          o    health care fraud and abuse laws and regulations,  which prohibit
               certain  types of  referral  and other  payments

          o    the  Employee   Retirement   Income   Security  Act  and  related
               regulations,  which  regulate  many  health care plans

          o    proposed   comprehensive   state  PBM   legislation

          o    consumer  protection  laws and  regulations

          o    network  pharmacy access laws,  including "any willing  provider"
               and "due  process"  legislation,  that  regulate  aspects  of our
               pharmacy network contracts

          o    legislation imposing benefit plan design
               restrictions,  which limit how our clients can design  their drug
               benefit plans

          o    various  licensure  laws,  such as managed  care and third  party
               administrator   licensure   laws

          o    drug pricing legislation,
               including  "most favored  nation"  pricing and "unitary  pricing"
               legislation

          o    mail pharmacy laws and regulations o privacy and
               confidentiality  laws and regulations,  including those under the
               Federal Health Insurance  Portability and  Accountability  Act of
               1996 ("HIPAA")

          o    Medicare prescription drug coverage proposals o
               other Medicare and Medicaid reimbursement regulations

          o    potential  regulation  of the PBM  industry by the U.S.  Food and
               Drug Administration

          o    pending legislation  regarding  importation of drug products into
               the United States

These and other regulatory  matters are discussed in more detail under "Business
- - Government Regulation" above.

     We believe we are operating our business in substantial compliance with all
existing  legal  requirements  material to the operation of our business.  There
are,  however,  significant  uncertainties  regarding the application of many of
these legal  requirements  to our business,  and we cannot provide any assurance
that a  regulatory  agency  charged  with  enforcement  of any of these  laws or
regulations  will not interpret them  differently or, if there is an enforcement
action brought against us, that our interpretation  would prevail.  In addition,
there are numerous  proposed  healthcare laws and regulations at the federal and
state levels,  many of which could materially  affect our ability to conduct our
business or adversely affect our results of operations. We are unable to predict
what additional  federal or state  legislation or regulatory  initiatives may be
enacted in the future  relating to our  business or the  healthcare  industry in
general, or what affect any such legislation or regulations might have on us.

     We are aware  through  reports in the press and other  sources  that a U.S.
Assistant  Attorney General in Philadelphia is conducting an investigation  into
certain  practices of PBMs.  These reports have  indicated  that some of our PBM
competitors have received subpoenas in connection with this investigation during
1999.  We have not  received a subpoena or been  requested to testify or produce
documents in connection with this  investigation.  Press reports indicate that a
possible subject of the investigation is contractual  relationships  between the
PBMs and  pharmaceutical  manufacturers.  We cannot predict what effect, if any,
this investigation may ultimately have on us or on the PBM industry generally.

     In December 2000, the Department of Health and Human Services  issued final
privacy   regulations,   pursuant  to  the  Health  Insurance   Portability  and
Accountability Act of 1996 ("HIPAA"), which impose extensive restrictions on the
use and disclosure of individually  identifiable  health  information by certain
entities. We will be required to comply with certain aspects of the regulations.
We have  retained a consulting  firm to assist us in assessing the steps we will
have to take in complying with these  regulations,  which provide for a two year
implementation  period.  While this  assessment is not yet complete,  we believe
compliance with these regulations will have a significant impact on our business
operations.  We have not yet  completed an assessment of the costs we will incur
in complying with these  regulations,  and can give no assurance that such costs
will not be material to us.

     The federal  Medicare  program  provides a  comprehensive  medical  benefit
program  for  individuals  age 65 and  over,  but  currently  covers  only a few
outpatient  prescription drugs. Currently key policy makers on both sides of the
political aisle have proposed various changes to the Medicare program that would
result in at least partial coverage for most prescription drugs. We believe that
a Medicare  prescription  drug benefit  could  provide us with  substantial  new
business  opportunities,  but at the same time any such program could  adversely
affect other  aspects of our business.  For  instance,  some of our clients sell
medical  policies to seniors  that provide a  prescription  drug benefit that we
administer. Other clients provide a prescription drug benefit to their retirees.
Depending on the plan that is ultimately  adopted, a Medicare  prescription drug
benefit could make such  policies or plans less  valuable to seniors,  adversely
affecting  that  segment of our  business.  While we believe that there would be
opportunities for new business under a Medicare plan that would more than offset
any adverse effects, we can give no assurance that this would be the case.

Failure to Retain Key Clients and Network Pharmacies Could Adversely Affect Our
Business and Limit Our Access to Retail Pharmacies

     We currently  provide PBM services to  approximately  19,000 client groups.
Our acquisitions  have diversified our client base and reduced our dependence on
any single client. Our top 10 clients, measured as of January 1, 2001, represent
approximately  29% of our total membership base, but no single client represents
more than  approximately  5% of our membership  base. Our contracts with clients
generally  do not have terms of longer than three years and, in some cases,  are
terminable  by either  party on  relatively  short  notice.  Our larger  clients
generally  distribute  requests  for  proposals  and seek  bids  from  other PBM
providers in advance of the expiration of their  contracts.  If several of these
large  clients  elect not to extend their  relationship  with us, and we are not
successful in generating sales to replace the lost business, our future business
and operating results could be materially  adversely affected.  In addition,  we
believe the managed care industry is undergoing substantial  consolidation,  and
another  party that is not our client  could  acquire  some of our managed  care
clients.  In such case, the likelihood  such client would renew its PBM contract
with us could be reduced.

     More than 55,000 retail  pharmacies,  which  represent more than 99% of all
United States  retail  pharmacies,  participate  in one or more of our networks.
However,  the top 10 retail pharmacy chains represent  approximately  38% of the
55,000  pharmacies,   with  these  pharmacy  chains   representing  even  higher
concentrations in certain areas of the United States.  Our contracts with retail
pharmacies, which are non-exclusive, are generally terminable by either party on
relatively  short  notice.  If one or more of the top pharmacy  chains elects to
terminate its relationship with us, our members' access to retail pharmacies and
our business could be materially adversely affected. In addition, large pharmacy
chains  either own PBMs today,  or could attempt to acquire a PBM in the future.
Ownership of PBMs by retail pharmacy chains could have material  adverse effects
on our  relationships  with such pharmacy chains and on our business and results
of operations.

Loss of  Relationships  with  Pharmaceutical  Manufacturers  and  Changes in the
Regulation  of Discounts and  Formulary  Fees  Provided to Us by  Pharmaceutical
Manufacturers Could Decrease Our Profits

     We  maintain   contractual   relationships  with  numerous   pharmaceutical
manufacturers that provide us with:

          o    discounts at the time we purchase the drugs to be dispensed  from
               our mail pharmacies

          o    formulary fees based upon sales of drugs from our mail pharmacies
               and through pharmacies in our retail networks

          o    administrative fees based upon the development and maintenance of
               formularies which include the particular manufacturer's products

These  fees  are  all  commonly  referred  to as  formulary  fees  or  formulary
management fees.

     We also provide  various  services for, or services which are funded wholly
or partially by, pharmaceutical manufacturers. These services include:

          o    compliance programs,  which involve instruction and counseling of
               patients  concerning the  importance of compliance  with the drug
               treatment regimen prescribed by their physician

          o    therapy management programs,  which involve education of patients
               having specific diseases, such as asthma and diabetes, concerning
               the management of their condition

          o    market  research  programs  in which we  provide  information  to
               manufacturers concerning drug utilization patterns

These arrangements are generally  terminable by either party on relatively short
notice. If several of these arrangements are terminated or materially altered by
the  pharmaceutical  manufacturers,  our  operating  results could be materially
adversely affected. In addition,  formulary fee programs, as well as some of the
services we provide to the pharmaceutical  manufacturers,  have been the subject
of debate in  federal  and state  legislatures  and  various  other  public  and
governmental  forums.  Changes  in  existing  laws or  regulations  or in  their
interpretations  of existing laws or  regulations or the adoption of new laws or
regulations  relating to any of these programs,  may materially adversely affect
our business.

Pending and Future  Litigation Could Materially  Affect Our  Relationships  with
Pharmaceutical Manufacturers or Subject Us to Significant Monetary Damages

     Since 1993, retail pharmacies have filed over 100 separate lawsuits against
drug  manufacturers,  wholesalers and certain PBMs,  challenging brand name drug
pricing practices under various state and federal antitrust laws. The plaintiffs
alleged,  among other things,  that the manufacturers  had offered,  and certain
PBMs had  knowingly  accepted,  discounts and rebates on purchases of brand name
prescription  drugs that violated the Federal  Sherman Act.  Some  manufacturers
settled certain of these actions, including a Sherman Act case brought on behalf
of a  nationwide  class of  retail  pharmacies.  The  class  action  settlements
generally  provided for commitments by the  manufacturers  in their  discounting
practices  to retail  pharmacies.  The  defendants  who did not  settle  won the
Sherman Act class action on a directed verdict.  With respect to the cases filed
by plaintiffs who opted out of the class action,  some drug  manufacturers  have
settled  certain  of these  actions,  but such  settlements  are not part of the
public record. The Robinson-Patman Act cases are still pending.

     We are not  currently a party to any of these  proceedings.  To date, we do
not believe any of these  settlements  have had a material adverse effect on our
business.  However,  we  cannot  provide  any  assurance  that the  terms of the
settlements  will not  materially  adversely  affect us in the future or that we
will not be made a party to any separate lawsuit. In addition, we cannot predict
the outcome or possible ramifications to our business of the Robinson-Patman Act
cases (see Item 3 - Legal Proceedings).

     We are also  subject to risks  relating to  litigation  and  liability  for
damages in  connection  with our PBM  operations,  including  the  dispensing of
pharmaceutical  products  by our  mail  pharmacies,  the  services  rendered  in
connection  with our  formulary  management  and  informed  decision  counseling
services,  and our non-PBM  operations,  including  the  products  and  services
provided in connection  with our infusion  therapy  programs (and the associated
nursing  services).  We believe our  insurance  protection  is adequate  for our
present  operations.  However,  we cannot  provide any assurance that we will be
able to maintain our professional and general  liability  insurance  coverage in
the future or that such insurance coverage will be available on acceptable terms
to cover any or all  potential  product  or  professional  liability  claims.  A
successful  product or  professional  liability claim in excess of our insurance
coverage could have a material adverse effect on our business.

Our Leverage  and Debt  Service  Obligations  Could  Impede Our  Operations  and
Flexibility

     As of December 31, 2000, our net debt to net capitalization ratio is 32.7%,
which means that the amount of our outstanding  debt is significant  compared to
the net book value of our assets,  and we have substantial  interest expense and
future repayment obligations. As of December 31, 2000, we had total consolidated
debt of approximately  $396.4 million.  We may incur additional  indebtedness in
the future.

     Our level of debt and the limitations  imposed on us by our debt agreements
could have important consequences, including the following:

          o    we will  have to use a portion  of our cash flow from  operations
               for debt service rather than for our operations

          o    we may from time to time  incur  indebtedness  under  our  credit
               facility, which is subject to a variable interest rate, making us
               vulnerable to increases in interest rates

          o    we could be less able to take advantage of  significant  business
               opportunities,  such as acquisition  opportunities,  and react to
               changes in market or industry conditions

          o    we could be more  vulnerable  to  general  adverse  economic  and
               industry conditions

          o    we  may  be  disadvantaged  compared  to  competitors  with  less
               leverage

     Furthermore,  our ability to satisfy our  obligations,  including  our debt
service  requirements,  will be dependent upon our future  performance.  Factors
which  could  affect  our  future  performance   include,   without  limitation,
prevailing economic conditions and financial,  business and other factors,  many
of which are beyond our control and which affect our business and operations.

     Our bank credit  facility  is secured by the  capital  stock of each of our
existing and subsequently  acquired domestic  subsidiaries,  excluding  Practice
Patterns Science, Inc., Great Plains Reinsurance Co., ValueRx of Michigan, Inc.,
Diversified NY IPA, Inc., and Diversified Pharmaceutical Services (Puerto Rico),
Inc., and 65% of the stock of our foreign subsidiaries. If we are unable to meet
our obligations under this bank credit facility,  these creditors could exercise
their rights as secured parties and take possession of the pledged capital stock
of these  subsidiaries.  This would  materially  adversely affect our results of
operations and financial condition.

Failure to Continue to Develop New Products,  Services and Delivery Channels May
Adversely Affect Our Business

     We  operate  in a  highly  competitive  environment.  We,  as  well  as our
competitors, continually develop new products and services to assist our clients
in managing  the pharmacy  benefit.  If we are  unsuccessful  in  continuing  to
develop innovative products and services, our ability to attract new clients and
retain existing clients may suffer.

     Technology is also an important  component of our business,  as we continue
to utilize new and better  channels,  such as the Internet,  to communicate  and
interact with our clients, members and business partners. If our competitors are
more successful than us in employing this technology, our ability to attract new
clients, retain existing clients and operate efficiently may suffer.

Efforts to Reduce  Health Care Costs and Alter Health Care  Financing  Practices
Could Adversely Affect Our Business

     Efforts are being made in the United  States to control  health care costs,
including prescription drug costs, in response to, among other things, increases
in prescription  drug  utilization  rates and drug prices.  If these efforts are
successful  or  if  prescription   drug  utilization   rates  were  to  decrease
significantly,  our  business  and  results of  operations  could be  materially
adversely affected.

     We have  designed our business to compete  within the current  structure of
the U.S.  health  care  system.  Changing  political,  economic  and  regulatory
influences may affect health care financing and reimbursement  practices. If the
current health care financing and  reimbursement  system changes  significantly,
our  business  could be  materially  adversely  affected.  Congress is currently
considering proposals to reform the U.S. health care system. These proposals may
increase governmental involvement in health care and PBM services, and otherwise
change the way our clients do business.  Health care  organizations may react to
these  proposals and the  uncertainty  surrounding  them by reducing or delaying
purchases of cost control  mechanisms and related  services that we provide.  We
cannot predict what effect,  if any,  these  proposals may have on our business.
Other  legislative  or  market-driven  changes in the health care system that we
cannot anticipate could also materially adversely affect our business.

Our  Commitment  to Invest in RxHub  Could  Impede Our  Ability to Pursue  Other
Opportunities

     We  have  entered  into a  joint  venture  agreement  with  AdvancePCS  and
Merck-Medco  to form  RxHub,  which is  designed to operate as a utility for the
conduit of information between  pharmacies,  PBMs and health plans. In doing so,
we have  committed  to invest up to $20 million over the next five years to fund
the venture.  Committing  our future cash flow to this  investment  my limit our
ability to invest in other opportunities.

Item 2 - Properties

     We operate our United States and Canadian PBM and non-PBM businesses out of
leased facilities throughout the United States and Canada.

          PBM Facilities                      Non-PBM Facilities
     Maryland Heights, Missouri          Maryland Heights, Missouri
        Earth City, Missouri                 Columbia, Missouri
           Tempe, Arizona                       Irvine, Texas
       Bloomington, Minnesota                  Houston, Texas
       Bensalem, Pennsylvania                Columbia, Maryland
           Troy, New York                  Springfield, New Jersey
     Farmington Hills, Michigan          West Chester, Pennsylvania
      Albuquerque, New Mexico
       Horsham, Pennsylvania
        Mississauga, Ontario

     Our Maryland  Heights,  Missouri  facility  houses our  corporate  offices.
Express Scripts Infusion Services and Specialty  Distribution Services corporate
offices are also located at our Maryland Heights,  Missouri facility.  Specialty
Distribution  Services is  operated  out of our  facility  in Maryland  Heights,
Missouri.  We believe our facilities have been generally well maintained and are
in good  operating  condition.  Our existing  facilities  contain  approximately
1,300,000 square feet in area, in the aggregate.

     We own and lease computer systems at the processing  centers. In late 1999,
we entered  into a five year  agreement  with EDS to outsource  our  information
systems operations. Under the terms of the agreement, EDS has responsibility for
operating  and  maintaining  the  computer   systems.   Our  software  for  drug
utilization  review and other  products has been  developed  internally by us or
purchased under perpetual,  nonexclusive  license agreements with third parties.
Our computer  systems at each site are  extensively  integrated and share common
files through  local and wide area  networks.  Uninterruptable  power supply and
diesel  generators allow our computers,  telephone  systems and mail pharmacy at
each  major site to  continue  to  function  during a power  outage.  To protect
against  loss of data and extended  downtime,  we store  software and  redundant
files at both  on-site  and  off-site  facilities  on a  regular  basis and have
contingency operation plans in place. We cannot, however,  provide any assurance
that our  contingency or disaster  recovery plans would  adequately  address all
relevant issues.


Item 3 - Legal Proceedings

     As discussed in detail in our Quarterly  Report on Form 10-Q for the period
ended June 30, 1998, filed with the Securities and Exchange Commission on August
13, 1998 (the "Second Quarter,  1998 10-Q"),  we acquired all of the outstanding
capital stock of Value Health,  Inc., a Delaware  corporation  ("Value Health"),
and Managed  Prescription  Network,  Inc., a Delaware  corporation  ("MPN") from
HCA-The Healthcare Corporation (formerly, "Columbia HCA/HealthCare Corporation")
("HCA") and its affiliates on April 1, 1998 (the  "Acquisition").  Value Health,
MPN and/or their  subsidiaries  (collectively,  the "Acquired  Entities"),  were
party to various legal proceedings,  investigations or claims at the time of the
Acquisition.  The effect of these actions on our future financial results is not
subject to reasonable  estimation because considerable  uncertainty exists about
the  outcomes.   Nevertheless,  in  the  opinion  of  management,  the  ultimate
liabilities  resulting  from any such  lawsuits,  investigations  or claims  now
pending  should not  materially  affect  our  consolidated  financial  position,
results of operations or cash flows. A brief  description of the most notable of
the proceedings follows:

     Bash, et al. v. Value Health,  Inc., et al., No. 3:97cv2711  (JCH)(D.Conn.)
("Bash"). On December 15, 1995, a purported shareholder class action lawsuit was
filed by Irwin Bash and Leykin,  Hyman & Bash  Associates  in the United  States
District  Court  for  the  District  of  New  Mexico  against  Diagnostek,  Inc.
("Diagnostek"),  Nunzio P. DeSantis,  William Baron,  and Courtland  Miller (all
former Diagnostek officers).  Also named as defendants in Bash are Value Health,
Inc. ("Value  Health"),  Robert E. Patricelli,  William J. McBride and Steven J.
Shulman (certain of Value Health's former officers).  The Bash Complaint asserts
that  Value  Health  and  certain  other  defendants  made  false or  misleading
statements  to the public in  connection  with  Value  Health's  acquisition  of
Diagnostek in 1995, and that  Diagnostek and certain of its former  officers and
directors made false or misleading statements concerning its financial condition
prior to the  acquisition  by Value Health.  The Bash  Complaint  asserts claims
under the  Securities  Act of 1933 and the  Securities  Exchange Act of 1934, as
well as common law claims, and seeks  certification of a class consisting of all
persons  (with  certain  exclusions)  who  purchased or  otherwise  acquired (a)
Diagnostek  common stock from March 27, 1994  through  July 28, 1995;  (b) Value
Health common stock pursuant to a Proxy and Prospectus and merger in which their
Diagnostek shares were converted into Value Health shares;  and (c) Value Health
common stock from March 27, 1995 through  November 7, 1995.  The Bash  Complaint
does not specify the amount of damages  sought.  On March 26,  1996,  the former
Diagnostek  officers filed a motion  seeking  either  dismissal of the case or a
transfer to the District of Connecticut, where the earlier-filed Freedman action
(discussed  below) was pending.  In the late summer of 1997, the Bash plaintiffs
filed an Amended  Complaint that deleted those  allegations that overlapped with
the  allegations  contained in an earlier  lawsuit filed against  Diagnostek and
certain of its former officers.  A formal order approving the settlement of this
earlier lawsuit was entered by the United States District Court for the District
of New Mexico on November 21,  1997.  In  addition,  defendants  filed a renewed
motion to transfer the action to Connecticut. On October 24, 1997, an answer was
filed on  behalf of Value  Health,  Diagnostek,  and the  former  directors  and
officers of Value Health who had been named as defendants. On November 28, 1997,
the New Mexico court entered an order transferring the action to Connecticut. On
February 4, 1998,  the court  ordered that  plaintiffs  in the Freedman  action,
discussed  below,  share all discovery  obtained from the  defendants  and third
parties in their lawsuit with the  plaintiffs in the Bash lawsuit.  On March 17,
1998,  the  defendants  filed a motion  to  consolidate  this  lawsuit  with the
Freedman lawsuit  discussed below, and the court granted the motion on April 24,
1998.

     Freedman,  et al.  v.  Value  Health,  Inc.,  et  al.,  No.  3:95  CV  2038
(JCH)(D.Conn).  On September 22 and 25, 1995,  two related  lawsuits  were filed
against Value Health and certain other  defendants in the United States District
Court  for the  District  of  Connecticut.  On  February  16,  1996,  a  single,
consolidated class action complaint was filed covering both suits (the "Freedman
Complaint"), naming as defendants Value Health, Robert E. Patricelli, William J.
McBride,  Steven J.  Shulman,  David M. Wurzer,  David J.  McDonnell,  Walter J.
McNerny,  Rodman W. Moorhead,  III, Constance P. Newman, and John L. Vogelstein,
all former Value Health  directors and  officers,  and Nunzio P.  DeSantis,  the
former president of Diagnostek. The Freedman Complaint alleges that Value Health
and certain other  defendants made false or misleading  statements to the public
in  connection  with Value  Health's  acquisition  of  Diagnostek  in 1995.  The
Freedman  Complaint  asserts  claims  under the  Securities  Act of 1933 and the
Securities  Exchange Act of 1934, and seeks  certification of a class consisting
of all persons (with certain  exceptions)  who purchased  shares of Value Health
common  stock  during  the  period  March 27,  1995 (the  date  certain  adverse
developments  were disclosed by Value Health).  The Freedman  Complaint does not
specify the amount of damages sought.  On March 17, 1998, the defendants filed a
motion to consolidate  this lawsuit with the Bash lawsuit,  discussed above, and
the motion was granted on April 24, 1998.

     In the consolidated Bash and Freedman action, the court granted plaintiffs'
motions for class  certification  and  certified a class  consisting  of (i) all
persons who  purchased or otherwise  acquired  shares of Value Health during the
period from April 3, 1995,  through and  including  November 7, 1995,  including
those who acquired shares in connection with the Diagnostek merger; and (ii) all
persons who  purchased or otherwise  acquired  shares of  Diagnostek  during the
period from March 27, 1995,  through and including July 28, 1995. Fact discovery
in the consolidated lawsuit is complete,  and expert discovery will be completed
over the course of the next several  months.  Motions for summary  judgment were
filed by both the plaintiffs and the defendants, and a hearing on the motions is
scheduled for February 28, 2001. No trial date has been set.

     In connection with the  Acquisition,  HCA has agreed to defend and hold the
Company and its affiliates  (including  Value Health)  harmless from and against
any  liability  that may  arise  in  connection  with  either  of the  foregoing
proceedings.  Consequently,  the  Company  does not  believe  it will  incur any
material liability in connection with the foregoing matters.

     In addition,  in the  ordinary  course of our  business,  there have arisen
various  legal  proceedings,  investigations  or claims now pending  against our
subsidiaries unrelated to the Acquisition and us. The effect of these actions on
future  financial  results  is not  subject  to  reasonable  estimation  because
considerable uncertainty exists about the outcomes. Nevertheless, in the opinion
of  management,  the  ultimate  liabilities  resulting  from any such  lawsuits,
investigations or claims now pending will not materially affect our consolidated
financial position, results of operations or cash flows.

     Since 1993, retail pharmacies have filed over 100 separate lawsuits against
drug  manufacturers,  wholesalers and certain PBMs,  challenging brand name drug
pricing practices under various state and federal antitrust laws. The plaintiffs
alleged,  among other things,  that the manufacturers  had offered,  and certain
PBMs had  knowingly  accepted,  discounts and rebates on purchases of brand name
prescription  drugs  that  violated  the  federal   Robinson-Patman   Act.  Some
plaintiffs also filed claims against the drug manufacturers and drug wholesalers
alleging a  conspiracy  not to discount  pharmaceutical  drugs in  violation  of
Section 1 of the Sherman Act, and these claims were certified as a class action.
Some of the drug  manufacturers  settled  both the Sherman Act and the  Robinson
Patman claims against them. The class action Sherman Act  settlements  generally
provide that the  manufacturers  will not refuse to pay  discounts or rebates to
retail pharmacies based on their status as such. Settlements with plaintiffs who
opted out of the class are not part of the public record.  The drug manufacturer
and  wholesaler  defendants in the class action who did not settle went to trial
and were dismissed by the court on a motion for directed verdict. That dismissal
was affirmed by the Court of Appeals for the Seventh Circuit.  One aspect of the
case was remanded to the trial court and has now been dismissed.  Plaintiffs who
opted out of the class  action  will  still  have the  opportunity  to try their
Sherman Act claims in separate  lawsuits.  The class  action did not involve the
Robinson-Patman claims, so many of those matters are still pending. We are not a
party to any of these  proceedings.  To date, we do not believe any  settlements
have had a material adverse effect on our business.  However,  we cannot provide
any assurance that the terms of the  settlements  will not materially  adversely
affect us in the future. In addition,  we cannot predict the outcome or possible
ramifications  to our business of the cases in which the  plaintiffs  are trying
their claims separately, and we cannot provide any assurance that we will not be
made a party to any such separate lawsuits in the future.

Item 4 - Submission of Matters to a Vote of Security Holders

     No matters were  submitted to a vote of security  holders during the fourth
quarter of 2000.

                                     PART II

Item 5 - Market For Registrant's Common Equity and Related Stockholder Matters

     Market Price of and Dividends on the Registrant's Common Equity and Related
Stockholder Matters

     Market  Information.  Our  Class A Common  Stock is  traded  on the  Nasdaq
National  Market  ("Nasdaq")  tier of The Nasdaq  Stock  Market under the symbol
"ESRX".  The high and low prices, as reported by the Nasdaq, are set forth below
for the periods indicated.

                                Fiscal Year 2000            Fiscal Year 1999
Class A Common Stock           High          Low           High           Low
     First Quarter         $   67.0000   $   28.5000   $  105.5000  $   59.1250
     Second Quarter            66.6250       34.6250       91.0000      55.0000
     Third Quarter             78.0000       56.2500       92.3750      61.5000
     Fourth Quarter           107.0000       63.7500       88.6875      44.3750

     Our Class B Common Stock has no established public trading market and there
are no shares outstanding as of December 31, 2000.

     Holders.  As of January 31, 2001,  there were 403 stockholders of record of
our Class A Common Stock. We estimate there are approximately  30,000 beneficial
owners of the Class A Common Stock.

     Dividends.  The Board of Directors  has not declared any cash  dividends on
our common stock since the initial public offering.  The Board of Directors does
not currently  intend to declare any cash dividends in the  foreseeable  future.
The terms of our  existing  credit  facility and the  indenture  under which our
public debt was issued contain certain restrictions on our ability to declare or
pay cash dividends.

     Recent Sales of Unregistered Securities

         None.

Item 6 - Selected Financial Data

The following  selected  financial data should be read in  conjunction  with the
Consolidated  Financial  Statements,  including the related  notes,  and "Item 7
- --Management's  Discussion  and Analysis of Financial  Condition  and Results of
Operations".




                                                                        Year Ended December 31,

(in thousands, except per share data)             2000(2)        1999(3)        1998(4)         1997           1996
                                                                                             
- -----------------------------------------------------------------------------------------------------------------------
Statement of Operations Data:
Revenues:
   Revenues                                     $ 6,776,441    $ 4,285,104    $ 2,824,872    $ 1,230,634    $   773,615
   Other revenues                                    10,423          3,000              -              -              -
                                               ------------------------------------------------------------------------
                                                  6,786,864      4,288,104      2,824,872      1,230,634        773,615
                                               -------------------------------------------------------- ---------------
Costs and expenses:
   Cost of revenues                               6,247,192      3,826,905      2,584,997      1,119,167        684,882
   Selling, general and administrative              339,460        294,194        148,990         62,617         49,103
   Non-recurring charges                                  -         30,221          1,651              -              -
                                               ------------------------------------------------------------------------
                                                  6,586,652      4,151,320      2,735,638      1,181,784        733,985
                                               ------------------------------------------------------------------------
Operating income                                    200,212        136,784         89,234         48,850         39,630
Other (expense) income, net                        (204,680)       128,682        (12,994)         5,856          3,450
                                               ------------------------------------------------------------------------
(Loss) income before income taxes                    (4,468)       265,466         76,240         54,706         43,080
Provision for income taxes                            3,553        108,098         33,566         21,277         16,932
                                               ------------------------------------------------------------------------
(Loss) income before extraordinary loss              (8,021)       157,368         42,674         33,429         26,148
Extraordinary loss on early retirement of
    debt                                             (1,105)        (7,150)             -              -              -
                                           ------------------------------------------------------------------------
Net (loss) income                               $    (9,126)   $   150,218    $    42,674    $    33,429    $    26,148
                                               ========================================================================
Basic earnings per share:(1)
  Before extraordinary loss                     $      (0.21)  $       4.36   $       1.29   $       1.02   $       0.81
  Extraordinary loss on early retirement of
      debt                                             (0.03)         (0.20)             -            -              -
                                               -------------------------------------------------------------------------
  Net (loss) income                             $      (0.24)  $       4.16   $       1.29   $       1.02   $       0.81
                                               =========================================================================
Diluted earnings per share:(1)
  Before extraordinary loss                     $      (0.21)  $       4.25   $       1.27   $       1.01   $       0.80
  Extraordinary loss on early retiremen of
      debt                                             (0.03)         (0.19)             -            -              -
                                               -------------------------------------------------------------------------
  Net (loss) income                             $      (0.24)  $       4.06   $       1.27   $       1.01   $       0.80
                                               =========================================================================
Weighted average shares outstanding:(1)
   Basic                                             38,196         36,095         33,105         32,713         32,160
   Diluted(5)                                        38,196         37,033         33,698         33,122         32,700

- ------------------------------------------------------------------------------------------------------------------------
Balance Sheet Data:
Cash and cash equivalents                       $    53,204    $   132,630    $   122,589    $    64,155    $    25,211
Working capital                                    (117,775)       (34,003)       117,611        166,062        128,259
Total assets                                      2,276,664      2,487,311      1,095,461        402,508        300,425
Debt:
   Short-term debt                                        -              -         54,000              -              -
   Long-term debt                                   396,441        635,873        306,000              -              -
Stockholders' equity                                705,244        699,482        249,694        203,701        164,090
- -----------------------------------------------------------------------------------------------------------------------
Selected Data:
Pharmacy benefit covered lives(6)                    43,500         48,000         23,500         12,300         10,000
Annual drug spending(7)                         $13,874,691    $11,160,389    $ 4,495,088    $ 2,486,380    $ 1,635,890
Network pharmacy claims processed                   299,584        273,909        113,177         73,164         57,838
Mail pharmacy prescriptions filled                   15,183         10,608          7,426          3,899          2,770
EBITDA(8)                                       $   278,827    $   208,651    $   115,683    $    59,320    $    46,337
Cash flows provided by operating activities     $   245,910    $   214,059    $   126,574    $    52,391    $    29,863
Cash flows (used in) investing activities       $   (73,578)   $  (759,576)   $  (426,052)   $   (16,455)   $   (64,808)
Cash flows (used in) provided by
   financing activities                         $  (251,627)   $   555,450    $   357,959    $     3,033    $    48,652
- -----------------------------------------------------------------------------------------------------------------------
<FN>

(1) Earnings  per  share  and  weighted  average  shares  outstanding  have been
    restated to reflect the two-for-one stock split effective October 30, 1998.
(2) Includes a  non-cash  write-off  of  $165,207  ($103,089  net of tax) of our
    investment  in  PlanetRx.  Includes an ordinary  gain of $1,500 ($926 net of
    tax) on the  restructuring of our interest rate swap  agreements.  Excluding
    these amounts, our basic and diluted earnings per share before extraordinary
    loss would have been $2.46 and $2.41, respectively.
(3) Includes the  acquisition  of DPS  effective  April 1, 1999.  Also  includes
    non-recurring operating charges and a one-time non-operating gain of $30,221
    ($18,188  net of tax) and  $182,930  ($112,037  net of  tax),  respectively.
    Excluding  these  amounts,  our basic and diluted  earnings per share before
    extraordinary loss would have been $1.76 and $1.72, respectively.
(4) Includes the acquisition of ValueRx effective April 1, 1998. Also includes a
    non-recurring  charge of $1,651 ($1,002 net of tax).  Excluding this charge,
    our basic and  diluted  earnings  per share would have been $1.32 and $1.30,
    respectively.
(5) In  accordance  with FAS 128,  basic  weighted  average  shares were used to
    calculate  2000  diluted  EPS as the 2000 net  loss and the  actual  diluted
    weighted  average  shares (39,033 as of December 31, 2000) cause diluted EPS
    to be anti-dilutive.
(6) Reflects the addition or loss of members to arrive at January 1, 2001, 2000,
    1999, 1998 or 1997 membership.  In computing the number of lives we serve we
    make  certain  estimates  and  adjustments.  We believe  different  PBMs use
    different  factors  in  making  these  estimates  and  adjustments.  We also
    believe,  however, that these numbers are a reasonable  approximation of the
    actual number of lives served by us.
(7) Drug  spending  is a measure  of the gross  aggregate  dollar  value of drug
    expenditures  of all programs  managed by us. The difference  between annual
    drug spending and revenue reported by us is the combined effect of excluding
    from reported revenues:

          o    the drug ingredient cost for those clients that have  established
               their own pharmacy networks

          o    the expenditures  for drugs of those companies on  formulary-only
               programs managed by us

          o    the   co-pay   portion   of  drug   expenditures   that  are  the
               responsibility   of  members  of  health  plans  serviced  by  us

     Therefore,  drug spending provides a common basis to quantify the drug
     expenditures managed by a company.  Drug spend, however, is not an accepted
     reporting  measurement under generally accepted  accounting  principles and
     should not be considered as an alternative to revenue.

(8) EBITDA  is  earnings  before  other  income  (expense),   interest,   taxes,
    depreciation and  amortization,  or operating  income plus  depreciation and
    amortization.  EBITDA is presented because it is a widely accepted indicator
    of a company's ability to incur and service indebtedness.  EBITDA,  however,
    should not be considered as an  alternative  to net income,  as a measure of
    operating  performance,  as an  alternative  to cash flow or as a measure of
    liquidity.  In addition,  our  calculation of EBITDA may not be identical to
    that used by other companies.
</FN>


Item 7 - Management's Discussion and Analysis of Financial Condition and Results
of Operations

OVERVIEW

     We  derive  our  revenues  primarily  from  the  sale of  pharmacy  benefit
management  ("PBM")  services in the United States and Canada.  Our PBM revenues
generally include  administrative fees,  dispensing fees and ingredient costs of
pharmaceuticals dispensed from retail pharmacies included in one of our networks
or from one of our mail  pharmacies,  and the  associated  costs are recorded in
cost of revenues (the "Gross  Basis").  Where we only  administer  the contracts
between our clients and the clients' network  pharmacies,  we record as revenues
only the administrative fee we receive from our activities (the "Net Basis"). We
also derive PBM revenues from the sale of informed decision  counseling services
through our Express Health LineSM division,  and the sale of medical information
management services (which include the development of data warehouses to combine
medical  claims  and  prescription  drug  claims),  disease  management  support
services  and quality and  outcomes  assessments  through our Health  Management
Services  ("HMS")  division  and  Practice   Patterns   Science,   Inc.  ("PPS")
subsidiary.

     Non-PBM  revenues are derived from  administrative  fees received from drug
manufacturers  for the dispensing or distribution of  pharmaceuticals  requiring
special handling or packaging through our Express Scripts Specialty Distribution
Services subsidiary  ("SDS").  Non-PBM revenues are also generated from the sale
of  pharmaceuticals  for and the provision of infusion  therapy services through
our Express Scripts Infusion Services subsidiary.

     Reflecting  the  addition  of new client  groups at  January  1, 2001,  our
membership was approximately 43.5 million members compared to approximately 38.5
million  members  as of  January 1, 2000,  representing  a 13.0%  increase.  The
membership  count  excludes 9.5 million  members at January 1, 2000 served under
the United  HealthCare  ("UHC")  contract,  which  expired on May 31,  2000.  We
developed a migration  plan to transition  the UHC members to their new provider
throughout 2000. The migration is now complete.  The increase in membership from
January 1, 2000 is due in part to the  addition of new clients such as the State
of Georgia.  Additionally,  we continue to develop new products and services for
sale to  existing  clients  and  pharmaceutical  manufacturers  and  expand  the
services  provided to existing clients.  During 2000,  approximately 6.3 million
members  began  utilizing  expanded  services  that  provide  for more  advanced
formulary  management  and the addition of mail and network  services where only
one or two of these  services were  previously  utilized.  In 1999, we increased
membership by approximately 15.0 million members from 23.5 million members as of
January 1, 1999,  representing  a 63.8%  increase.  This  increase  excludes the
impact of approximately  9.5 million UHC members added during 1999. The increase
from January 1, 1999 is primarily due to our second major  acquisition  on April
1, 1999,  discussed  below. The increase in membership in 1998 was primarily due
to the purchase of ValueRx on April 1, 1998. In computing the number of lives we
serve we make certain  estimates and adjustments.  We believe different PBMs use
different  factors in making these estimates and  adjustments.  We also believe,
however, that these numbers are a reasonable  approximation of the actual number
of lives served by us.

     As  previously  discussed,  on  April  1,  1999,  we  acquired  Diversified
Pharmaceutical  Services,  Inc. and Diversified  Pharmaceutical Services (Puerto
Rico)  Inc.   (collectively,   "DPS"),   from  SmithKline  Beecham   Corporation
("SmithKline  Beecham") and SmithKline Beecham  InterCredit BV for approximately
$715 million,  which  includes a purchase price  adjustment for closing  working
capital and transaction  costs. On April 1, 1998, we consummated our first major
acquisition by acquiring Value Health,  Inc. and Managed  Prescription  Network,
Inc.  (collectively,  "ValueRx"),  the  PBM  operations  of  HCA-The  Healthcare
Corporation (formerly, "Columbia/HCA Healthcare Corporation"), for approximately
$460 million in cash, which includes  transaction costs and executive management
severance costs of  approximately  $6.7 million and $8.3 million,  respectively.
Consequently,  our operating results include those of DPS from April 1, 1999 and
ValueRx from April 1, 1998.  The net assets  acquired  from DPS and ValueRx have
been  recorded at their  estimated  fair value,  resulting in  $754,236,000  and
$278,113,000 of goodwill,  respectively,  that is being amortized over 30 years.
Both  acquisitions  have  been  accounted  for  under  the  purchase  method  of
accounting.



RESULTS OF OPERATIONS

REVENUES


                                                               Year Ended December 31,
                                                        Increase/
(in thousands)                               2000       (Decrease)      1999        Increase        1998
                                                                                 
- --------------------------------------------------------------------------------------------------------------
Gross Basis revenues                     $    6,483,866      61.8%  $    4,007,077       46.1%  $   2,742,485
Net Basis revenues                              204,531      (3.6)%        212,217      837.9%         22,626
Other revenues                                   10,423     247.4%           3,000          nm              -
                                        ----------------------------------------------------------------------
  Total PBM revenues                          6,698,820      58.7%       4,222,294       52.7%      2,765,111
  Non-PBM revenues                               88,044      33.8%          65,810       10.1%         59,761
                                        ----------------------------------------------------------------------
    Total revenues                       $    6,786,864      58.3%  $    4,288,104       51.8%  $   2,824,872
                                        ======================================================================
nm  = not meaningful



     Our growth in PBM  revenues  during  2000 over 1999 is  primarily  due to a
combination  of the following  factors:  the  conversion  of historical  Express
Scripts and DPS clients to our own retail pharmacy networks; higher utilization;
increased  membership;  the  conversion  of certain  clients  to a  manufacturer
formulary  management  program in which we derive an administrative  fee for our
services,  which is recorded in revenue, from a program whereby amounts received
from  pharmaceutical  manufacturers  are  recorded  as a  reduction  of  cost of
revenues;  higher drug  ingredient  costs  resulting  from price  increases  for
existing drugs and new drugs introduced into the  marketplace;  and DPS revenues
being  reported  for all of 2000  compared  to only nine  months of 1999.  These
increases were slightly  offset by the reduction in Net Basis revenues  received
under the UHC  contract  since its  termination  in May 2000.  Our growth in PBM
revenues  during 1999 over 1998 is primarily due to the inclusion of ValueRx for
the full  twelve  months  of 1999  compared  to only nine  months  of 1998,  the
inclusion  of DPS for nine  months of 1999,  increased  member  utilization  and
higher drug ingredient  costs resulting from price increases for existing drugs,
new drugs  introduced  into the  marketplace  and changes in therapeutic mix and
dosage.

     Revenues for network pharmacy claims increased $1,813,434,000, or 59.6%, in
2000 over 1999 and $1,039,588,000, or 51.8%, in 1999 over 1998. Network pharmacy
claims  processed  increased  9.4% to 299,584,000 in 2000 over 1999. The average
revenue per network pharmacy claim increased 46.4% to $16.28 over 1999 primarily
as a result of the increased rate of historical  Express Scripts and DPS clients
moving from retail pharmacy networks contracted by the clients to one contracted
by us. As previously  discussed  under  "--Overview",  we record the  associated
revenues for clients  utilizing our retail pharmacy networks on the Gross Basis,
therefore this shift to our retail pharmacy  networks results in increased Gross
Basis  revenues.  During  1999,  network  pharmacy  claims  processed  increased
273,909,000  over 1998. The average revenue per network pharmacy claim decreased
37.2% in 1999 from 1998  primarily  due to the  acquisition  of DPS,  as the DPS
contracts  required us to record  revenue on the Net Basis  which  substantially
reduces the average  revenue per network  pharmacy  claim.  Excluding  DPS,  the
average revenue per network pharmacy claim increased 8.2% over 1998.

     Mail pharmacy services  revenues and mail pharmacy  services  prescriptions
filled increased $631,914,000,  or 56.1% and 4,575,000, or 43.1%,  respectively,
during 2000 over 1999.  These increases are primarily due to the addition of new
members with high mail  utilization  rates,  the  cross-selling of mail pharmacy
services  and  increased  utilization  by existing  members.  Revenues  for mail
pharmacy  services  increased  $389,244,000,  or  52.8%,  in 1999 over 1998 as a
result of the growth in mail pharmacy claims processed of 3,182,000, or 42.8% in
1999 over 1998. These increases are primarily due to the acquisitions of ValueRx
and DPS,  increased  utilization by existing  members as well as the addition of
new members.  The average revenue per mail pharmacy claim increased 9.1% in 2000
over 1999 and 7.0% in 1999 over 1998  primarily  due to higher  drug  ingredient
costs as stated above.

     Other  revenue  increased  $7,423,000  during  2000  over  1999 due to fees
received under our agreement with PlanetRx.com, Inc. ("PlanetRx"),  which became
effective in December 1999. Effective July 5, 2000 we restructured our agreement
with  PlanetRx  in  exchange  for  a  one-time   cash  payment  of   $8,000,000.
Approximately  $3,700,000 of the payment  represents  amounts earned through the
second  quarter  of 2000,  the  remaining  $4,300,000  represents  a fee for the
termination of the prior  contract.  No additional cash payments will be paid to
us under the restructured agreement.

     The increase in revenue for non-PBM  services  during 2000 compared to 1999
is primarily due to additional  volume within SDS resulting  from a new contract
that took effect during the fourth  quarter of 1999. The increase in revenue for
non-PBM services in 1999 is primarily due to additional  business within SDS and
continued changes in the product mix sold in our Infusion Services business that
resulted in higher drug ingredient  costs. This increase was partially offset by
the  reduction  in  revenue  from  our  managed  vision   business  due  to  the
restructuring of this operation during 1999.



COSTS AND EXPENSES


                                                               Year Ended December 31,
(in thousands)                               2000        Increase       1999        Increase        1998
                                                                                 
- --------------------------------------------------------------------------------------------------------------
    PBM cost of revenues                 $    6,186,415      63.9%  $    3,774,618       48.6%  $   2,540,360
         Percentage of total PBM revenues         92.4%                      89.4%                      91.9%
    Non-PBM cost of revenues                     60,777      16.2%          52,287       17.1%         44,637
         Percentage of non-PBM revenues           69.0%                      79.5%                      74.7%
                                            ------------------------------------------------------------------
   Total Cost of revenues                     6,247,192      63.2%       3,826,905       48.0%      2,584,997
        Percentage of total revenues              92.0%                      89.2%                      91.5%

   Selling, general and administrative          272,049      17.5%         231,543       78.0%        130,116
        Percentage of total revenues               4.0%                       5.4%                       4.6%

   Depreciation and amortization(1)              67,411       7.6%          62,651      231.9%         18,874
        Percentage of total revenues               1.0%                       1.5%                       0.7%

   Non-recurring expenses                             -         nm          30,221    1,730.5%          1,651
       Percentage of total revenues                0.0%                       0.7%                       0.1%
                                        ----------------------------------------------------------------------
   Total costs and expenses              $    6,586,652      58.7%  $    4,151,320       51.7%  $   2,735,638
                                        ======================================================================
       Percentage of total revenues               97.1%                      96.8%                      96.8%

<FN>

     (1) Represents  depreciation and amortization  expense included in selling,
general and  administrative  expenses on our  Statement of  Operations.  Cost of
revenues, above, also includes depreciation and amortization expense on property
and equipment of $11,204,  $9,216 and $7,575 for the years ended 2000,  1999 and
1998, respectively.
</FN>
nm  = not meaningful


     Our cost of revenues for PBM services as a percentage of total PBM revenues
has increased  during 2000 over 1999 primarily due to converting both historical
Express Scripts and DPS clients from pharmacy networks  contracted by the client
to one contracted by us, for which we record the drug ingredient cost in cost of
revenues (see further discussion under "--Overview"), continued margin pressures
due to pricing,  and  changes in the product  mix.  These  increases  in cost of
revenues  were   partially   offset  by  increases  in  amounts   received  from
pharmaceutical  manufacturers for our formulary management programs during 2000.
Cost of  revenues  for PBM  services  as a  percentage  of  total  PBM  revenues
decreased  in 1999  from  1998  primarily  due to the  acquisition  of  DPS,  as
discussed above, DPS recorded  revenues under the Net Basis.  Excluding DPS, the
gross margin  percentage  for the year ended December 31, 1999 decreased to 7.4%
from 8.1% for the year ended December 31, 1998. The decrease is primarily due to
the  conversion of historical  Express  Scripts  clients from pharmacy  networks
contracted by the client to one contracted by us, lower drug ingredient  margins
resulting from changes in therapeutic  mix, lower pricing offered to clients and
increased  formulary  management  revenue sharing  partially offset by improving
margins from our HMS business.

     Cost of revenues for non-PBM services  decreased as a percentage of non-PBM
revenues in 2000 from 1999 primarily due to additional volume of business within
SDS, which represents a larger percentage of non-PBM  revenues,  where we record
as  revenue  only  our  administrative   fee  for  distributing   pharmaceutical
manufacturers'  products.  SDS has  also  been  able to  derive  operating  cost
efficiencies  as a result of the increase in volume  serviced under the contract
that took effect in the fourth  quarter of 1999,  as  discussed  above.  Cost of
revenues for non-PBM services increased as a percentage of non-PBM revenues over
1998  primarily  due to the continued  change in product mix sold,  resulting in
additional costs of approximately $2,141,000. In addition, cost of revenues from
SDS  increased  88.9% over 1998 as a result of  establishing  a new  facility to
support a larger operation.

     Selling,  general and administrative  expenses,  excluding depreciation and
amortization,   increased   $40,506,000,   or  17.5%,  in  2000  over  1999  and
$101,427,000, or 78.0%, in 1999 over 1998. The increase in 2000 is primarily due
to expenditures  required to expand the operational and  administrative  support
functions to enhance management of the pharmacy benefit as well as the inclusion
of DPS for a full twelve  months  during  2000  versus nine months of 1999.  The
increase in 1999 is primarily  due to our  acquisition  of DPS,  costs  incurred
during the  integration  of DPS and  ValueRx,  costs  incurred  in  funding  our
information  technology  enhancements,  costs required to expand the operational
and  administrative  support  functions  to enhance  management  of the pharmacy
benefit,  and the  inclusion of ValueRx for a full twelve  months.  During 2000,
1999  and  1998,  we  capitalized  $36,518,000,   $15,997,000  and  $10,244,000,
respectively,  in new systems  development  costs.  However,  as a percentage of
total  revenues,   selling,  general  and  administrative  expenses,   excluding
depreciation and amortization,  for 2000 decreased to 4.0% from 5.4% in 1999 and
4.6% in 1998 due to converting clients to networks contracted by us.

     Depreciation  and  amortization  increased during 2000 over 1999 due to the
expansion of our operations and enhancement of our information systems to better
serve  our  clients.  This  increase  was  slightly  offset by the  decrease  in
amortization  of customer  contracts  as a result of the UHC  customer  contract
intangible  asset being fully amortized  during 2000. The remaining  increase in
2000  was  primarily  due to the  acquisition  of  DPS,  as 1999  only  included
amortization  of the DPS goodwill and other  intangible  assets for nine months.
Depreciation and amortization  substantially increased during 1999 over 1998 due
to the  acquisitions of DPS and ValueRx.  During 2000, we recorded  amortization
expense for  goodwill and other  intangible  assets of  $53,638,000  compared to
$53,297,000 in 1999 and $12,183,000 in 1998.

     During 1999, we recorded the following items in our Consolidated  Statement
of Operations in the non-recurring charges line (there were no such items during
2000):

                    o    During  the  second  quarter  of 1999,  we  incurred  a
                         $9,400,000   charge  for  the   consolidation   of  our
                         Plymouth,  Minnesota  facility  into  our  Bloomington,
                         Minnesota  facility.  In  December  1999 and  September
                         2000, the associated  accrual was reduced by $2,301,000
                         and  $44,000,  primarily  as a result of  subleasing  a
                         portion of the unoccupied space. The consolidation plan
                         included  the   relocation  of  all  employees  at  the
                         Plymouth  facility  to the  Bloomington  facility  that
                         began in August 1999, with completion delayed until the
                         first  quarter of 2001.  Included  in the  charge  were
                         anticipated   cash    expenditures   of   approximately
                         $4,779,000  for  lease  termination  fees  and  rent on
                         unoccupied  space  to be paid  through  April  2001 and
                         anticipated    non-cash    charges   of   approximately
                         $2,276,000 for the write-down of leasehold improvements
                         and furniture and fixtures. The charge does not include
                         any costs  associated  with the physical  relocation of
                         the employees.

                    o    During   December   1999,   we   recorded   a   pre-tax
                         restructuring charge of $2,633,000  associated with the
                         outsourcing  of our computer  operations  to Electronic
                         Data Systems Corporation.  The principal actions of the
                         plan  included  cash   expenditures  of   approximately
                         $2,148,000  for the  transition  of 51 employees to the
                         outsourcer   and   the   elimination   of   contractual
                         obligations  of ValueRx,  which had no future  economic
                         benefit to us, and  non-cash  charges of  approximately
                         $485,000 due to the reduction in the carrying  value of
                         certain  capitalized  software  to its  net  realizable
                         value.  This  plan  was  completed  during  the  second
                         quarter of 2000 when remaining cash payments were made.

                    o    Also  in   December   1999,   we   recorded  a  pre-tax
                         restructuring   charge  of  $969,000   associated  with
                         restructuring our PPS majority-owned subsidiary and the
                         purchase  of  the   remaining  PPS  common  stock  from
                         management.  The charge consisted of cash  expenditures
                         of $559,000 relating to stock compensation  expense and
                         $410,000 of  severance  payments to 9  employees.  This
                         plan was completed in January 2000.

                    o    In   conjunction   with  the  sale  of  the  assets  of
                         YourPharmacy.com,  Inc.  to  PlanetRx,  we  recorded  a
                         $19,520,000  stock  compensation   charge  relating  to
                         former  YourPharmacy.com  employees.  The amount of the
                         charge was determined using the initial public offering
                         price of $16 per share for PlanetRx common stock.


OTHER INCOME (EXPENSE), NET

     Our interest expense, net has decreased $14,775,000 during 2000 compared to
1999. The decrease is a result of utilizing the  $299,378,000  proceeds from our
June 1999 common stock  offering to repay a portion of our credit  facility,  as
well as utilizing  $344,131,000  of our own cash to pay-down our credit facility
from June 1999 through December 31, 2000.  Associated with the prepayment of our
loans  during  2000,  we recorded an ordinary  gain in interest  expense of $1.5
million due to the  restructuring  of our  interest  rate swap  agreements  (see
"--Market Risk").  Additionally,  we have repurchased  $10,115,000 of our Senior
Notes as of  December  31,  2000  (see  "--Liquidity  and  Capital  Resources").
Interest  expense,  net  increased in 1999 over 1998  primarily  due to the debt
incurred to purchase DPS (see "--Liquidity and Capital Resources").

     During 2000, we recorded a $165,207,000  ($103,089,000 net of tax) non-cash
impairment  charge on our  investment  in PlanetRx  common  stock as the loss in
value was deemed to be other than temporary. Any unrealized loss associated with
recording our investment in PlanetRx at current market value previously recorded
in  stockholders'  equity was  written off to the current  period  earnings,  in
addition to any  additional  charges  necessary to write-off  our  investment in
accordance  with  Financial   Accounting  Standards  Board  Statement  No.  115,
"Accounting   for   Certain   Investments   in  Debt  and  Equity   Securities".
Additionally, during 2000, we made charitable donations of 200,000 shares of our
PlanetRx  common  stock  (after  giving  effect to the  December 4, 2000 8-for-1
reverse stock split) and realized selling,  general and  administrative  expense
related to the donation of approximately $713,000.  Therefore,  our ownership of
PlanetRx as of December  31, 2000  consists of  approximately  1,096,000  common
shares, or 17.8%, of PlanetRx common shares  outstanding (after giving effect to
the December 4, 2000 8-for-1 reverse stock split) which are carried at no value.

     During 1999, we recognized a one-time non-cash gain of $182,930,000 related
to the sale of the assets of  YourPharmacy.com,  Inc.  in  exchange  for a 19.9%
ownership interest in PlanetRx.

PROVISION FOR INCOME TAXES

     Our effective tax rate for 2000 is a negative  79.5% compared to a positive
40.7% for 1999. Excluding the tax effect of the marketable  securities write-off
and the ordinary gain on the  restructuring  of our swaps (see  "--Liquidity and
Capital  Resources")  in  2000,  and the  one-time  gain  (see  "--Other  Income
(Expense),  Net") and  non-recurring  items (see "--Cost and Expenses") in 1999,
our effective  tax rates would have been 40.9% and 43.7% for 2000 and 1999.  Our
effective  tax rates also  decreased in 1999 to 40.7% from 44.0% in 1998.  These
decreases are primarily due to the reduction in the non-deductible  goodwill and
customer contract  amortization  expense associated with the ValueRx acquisition
as a  percentage  of income  before  income  taxes.  The  goodwill  and customer
contract  amortization  for the DPS  acquisition  is  deductible  for income tax
purposes due to the filing of an Internal Revenue Code ss.338(h)(10) election.

NET INCOME AND EARNINGS PER SHARE

     Our net income decreased  $159,344,000,  or 106.1%,  in 2000 from 1999, and
increased $107,544,000, or 252.0%, in 1999 over 1998. Net income was
affected by the following one-time items:

         Year Ended December 31, 2000

                    o    A  non-cash  impairment  charge  during  the second and
                         fourth   quarters   of   2000   totaling   $165,207,000
                         ($103,089,000  net of  tax)  relating  to our  PlanetRx
                         investment (see "--Other Income (Expense), Net")

                    o    An  extraordinary  loss on the early retirement of debt
                         due to the write-off of deferred  financing fees during
                         the  third  and  fourth   quarters  of  2000   totaling
                         $1,790,000   ($1,105,000   net  of  tax)  discussed  in
                         "--Liquidity and Capital Resources"

                    o    An ordinary gain in the amount of $1,500,000  ($926,000
                         net of tax) on the  restructuring  of our interest rate
                         swap agreements related to the early retirement of debt
                         in the third quarter of 2000 (see "--Market Risk") Year
                         Ended December 31, 1999

                    o    Non-recurring   charges   discussed   in  "--Cost   and
                         Expenses" totaling $30,221,000 ($18,188,000 net of tax)

                    o    One-time gain of $182,930,000 ($112,037,000 net of tax)
                         discussed in "--Other Income (Expense), Net"

                    o    An  extraordinary  loss on the early retirement of debt
                         during the second and third  quarters of 1999  totaling
                         $11,642,000 ($7,150,000 net of tax)

     Excluding  these  one-time  items  and  excluding  financing  costs  on the
temporary debt  associated with the acquisition of DPS after assuming our equity
and Senior Notes  offerings had been  completed on April 1, 1999, net income for
2000 would have been $94,142,000, or $2.46 per basic share and $2.41 per diluted
share,  compared to $63,519,000,  or $1.81 per basic share and $1.77 per diluted
share for 1999, respectively.

     Basic and diluted  weighted  average shares  outstanding for 2000 increased
5.8% and 3.1%, respectively,  over 1999. The increase for both basic and diluted
shares  outstanding is primarily related to the exercise of stock options during
2000.

LIQUIDITY AND CAPITAL RESOURCES

     During 2000,  net cash  provided by  operations  increased  $31,851,000  to
$245,910,000  from  $214,059,000  in 1999.  This  increase is  primarily  due to
increased  profitability,  excluding the effect of the non-cash write-off of our
investment in PlanetRx stock (see "--Other Income (Expense), Net"), and bringing
our  inventory  levels down after  increasing  our  inventory  during the fourth
quarter of 1999 for our mail  pharmacies'  anticipation  of  potentially  higher
demand due to our members' Year 2000 concerns.

     Days sales outstanding ("DSO") increased slightly to 31.2 days at
December 31, 2000 from 27.7 days at December  31,  1999,  but is still down from
36.9 days at December 31, 1998 due to the  acquisition  of DPS.  Gross  revenues
must be used to  calculate  DSO due to the impact of the Gross Basis  versus the
Net Basis of recording revenues,  as discussed in "--Overview" and "--Revenues".
The  accounts  receivable  balance  includes  the  cost  of  the  pharmaceutical
dispensed,  which may not be included  in  revenues,  as  required by  generally
accepted  accounting  principles,  based on the  contractual  terms  embedded in
client and pharmacy  contracts.  The  following  table  presents our DSO for the
years ended:




                                                               December 31,
(in thousands)                               2000                  1999                 1998
                                                                            
- ---------------------------------------------------------------------------------------------------
Total revenues                           $    6,786,864        $    4,288,104        $   2,824,872
Client/pharmacy pass through                  2,812,150             3,570,108              726,960
                                        ----------------      ----------------      ---------------
Gross revenues                           $    9,599,014        $    7,858,212        $   3,551,832
                                        ================      ================      ===============
Average monthly gross receivables        $      818,551        $      597,160        $     359,423
                                        ================      ================      ===============
DSO                                              31.2                  27.7                  36.9
                                        ================      ================      ===============


     Our allowance for doubtful accounts has increased $5,396,000,  or 31.2%, to
$22,677,000 at December 31, 2000 from $17,281,000 at December 31, 1999 primarily
due to increased reserves for infusion services business.  As a percentage of at
risk   receivables   (which   represent   receivables  for  which  there  is  no
corresponding payable obligation),  the allowance for doubtful accounts was 3.2%
at December 31, 2000  compared to 2.6% at December 31, 1999 and 3.9% at December
31, 1998. The  percentage  reduction from December 31, 1998 to December 31, 1999
is attributable to the final adjustment,  in accordance with generally  accepted
accounting  principles,  to the ValueRx  opening  balance  sheet  allowance  for
doubtful  accounts  and  goodwill  based upon the actual  collection  of ValueRx
receivables.

     Our  investment  in  net  working  capital  decreased  significantly  to  a
$117,775,000  deficit from a  $34,003,000  deficit as of December 31, 1999 and a
$117,611,000 excess as of December 31, 1998. This reduction in 2000 is primarily
due to  our  reduction  in  cash  through  our  capital  expenditures  and  debt
prepayments (discussed below) as well as timing of collections and payments.

     We previously  announced that we anticipated  our cash flow from operations
would be temporarily  reduced due to the  termination of the UHC contract during
the  third  quarter  of 2000.  We  subsequently  negotiated  a  revision  to the
previously  announced  transition  plan with UHC which  extended the  transition
period and delayed the  anticipated  temporary cash reduction  through the first
quarter of 2001.  The  transition  of UHC members was  completed by December 31,
2000. We expect to fund the remaining  payables  associated with the termination
of the UHC contract in 2001 primarily with operating cash flow. We will continue
to utilize our operating cash flows for future debt prepayments,  possible stock
repurchases,   integration  costs,   technology  initiatives  and  other  normal
operating cash needs as we deem appropriate.

     Our capital  expenditures in 2000 increased  $43,260,000,  or 117.1%,  over
1999  primarily  due  to our  concerted  effort  to  invest  in our  information
technology  to enhance the  services  provided  to our  clients,  the  continued
renovation  of our St.  Louis  operations  facilities  and  integration  related
activities as a result of our acquisitions.  We expect to continue  investing in
technology  that will provide  efficiencies  in  operations,  manage  growth and
enhance  the  service  provided  to  our  clients.  We  expect  to  fund  future
anticipated capital  expenditures  primarily with operating cash flow or, to the
extent  necessary,  with  working  capital  borrowings  under  our $300  million
revolving  credit facility,  discussed  below. The $13,105,000  increase in 1999
capital  expenditures over 1998 was due to the  aforementioned  items as well as
the completion of our corporate headquarters.

     During  September  2000, we sold our  Albuquerque,  New Mexico property and
building for  $7,806,000.  These assets were then leased back from the purchaser
over a  period  of 10  years  with  the  option  to  extend  the  terms up to an
additional 10 years.  The resulting lease is being accounted for as an operating
lease, and the resulting deferred gain of $4,136,000 is being amortized over the
10 year life of the lease.

     During 2000, we utilized our own  internally  generated  cash to repay $100
million on our bank revolving credit facility  (described below), to prepay $130
million of our Term A loans (described below), to repurchase  $10,115,000 of our
Senior Notes on the open market and to repurchase  790,000 shares of our Class A
Common Stock for  $30,247,000.  As of December 31, 2000,  we have  repurchased a
total of 1,265,000 shares of our Class A Common Stock under the stock repurchase
program that we announced on October 25, 1996.  Our Board of Directors  approved
the repurchase of up to 2,500,000 shares, and placed no limit on the duration of
the program.  Additional  debt repayments or common stock  repurchases,  if any,
will be made in such amounts and at such times as we deem appropriate based upon
prevailing  market and business  conditions,  subject to  restrictions  on stock
repurchases  contained  in our bank  credit  facility  and the  Indenture  which
governs our Senior Notes.

     We have a credit  facility with a commercial  bank syndicate  consisting of
$155 million of Term A loans and a $300 million revolving credit facility.  As a
result  of the  prepayment  of our Term A loans  noted  above,  we  recorded  an
extraordinary  charge during 2000 for the deferred  financing fees in the amount
of $1,105,000,  net of tax. The  prepayments  on the Term A loans  eliminate the
scheduled  principal  payments for fiscal years 2001,  2002 and a portion of the
scheduled  principal  payment for fiscal year 2003.  Beginning in March 2003, we
are  required  to  make  annual  principal  payments  on  the  Term A  loans  of
$26,750,000 in 2003,  $62,700,000  in 2004 and  $65,550,000 in 2005. The capital
stock of each of our existing and subsequently  acquired domestic  subsidiaries,
excluding  PPS,  Great  Plains  Reinsurance  Co.,  ValueRx  of  Michigan,  Inc.,
Diversified NY IPA, Inc. and Diversified  Pharmaceutical Services (Puerto Rico),
Inc.,  and 65% of the stock of our  foreign  subsidiaries  have been  pledged as
collateral for the credit facility.

     Our credit  facility  requires us to pay interest  quarterly on an interest
rate spread based on several London  Interbank  Offered Rates  ("LIBOR") or base
rate  options.  Using a LIBOR  spread,  the Term A loans had an interest rate of
7.52% on December 31,  2000.  During 2000,  the LIBOR  interest  rate spread was
reduced to 1.0% based upon  calculations  set forth in our credit  facility.  To
alleviate  interest  rate  volatility,  we have entered  into two separate  swap
arrangements,  which are discussed in "--Market Risk" below. The credit facility
contains covenants that limit the indebtedness we may incur,  dividends paid and
the amount of annual  capital  expenditures.  The  covenants  also  establish  a
minimum  interest  coverage ratio, a maximum leverage ratio, and a minimum fixed
charge  coverage  ratio.  In  addition,  we are required to pay an annual fee of
0.25%, payable in quarterly installments, on the unused portion of the revolving
credit  facility  ($300 million at December 31, 2000).  At December 31, 2000, we
are in compliance with all covenants associated with the credit facility.

     In June 1999, we issued $250 million of 9.625% Senior Notes due 2009, which
require interest to be paid semi-annually on June 15 and December 15. The Senior
Notes are callable at specified  prepayment premiums beginning in June 2004. The
Senior Notes are  unconditionally  and jointly and  severally  guaranteed by our
wholly-owned domestic subsidiaries other than PPS, Great Plains Reinsurance Co.,
ValueRx  of  Michigan,   Inc.,   Diversified  NY  IPA,  Inc.,  and   Diversified
Pharmaceutical  Services (Puerto Rico),  Inc. During the second quarter of 2000,
we  repurchased  $10,115,000  of  our  Senior  Notes  on  the  open  market  for
$10,150,000, which includes $385,000 of accrued interest.

     We regularly review potential  acquisitions and affiliation  opportunities.
We believe that  available  cash  resources,  bank  financing or the issuance of
additional  common  stock  could  be  used to  finance  future  acquisitions  or
affiliations.  However,  there can be no assurance we will make new acquisitions
or affiliations in 2001 or thereafter.

OTHER MATTERS

     On February 22, 2001, we announced  that we entered into an agreement  with
AdvancePCS and  Merck-Medco  to form RxHub LLC  ("RxHub").  RxHub is intended to
develop  an  electronic   exchange   enabling   physicians  who  use  electronic
prescribing technology to link to pharmacies, PBMs and health plans, which their
patients use. The company is designed to operate as a utility for the conduit of
information  among all parties engaging in electronic  prescribing.  We will own
one-third of the equity of RxHub (as will each of the other two  founders),  and
have  committed  to  invest up to $20  million  over the next  five  years  with
approximately  $6 million  committed for 2001. We will record our  investment in
RxHub under the equity  method of  accounting,  which  requires  our  percentage
interest  in RxHub's  results to be recorded in our  Consolidated  Statement  of
Operations.  RxHub will be operated to cover its expected operating costs and to
return the cost of capital to the founders.

     As previously  announced the  shareholders of Centre  d'autorisation  et de
paiement des services de sante, a leading  Quebec-based PBM commonly referred to
as CAPSS,  accepted an offer made by our Canadian subsidiary,  ESI Canada, Inc.,
to acquire all of the  outstanding  shares of CAPSS,  subject to satisfaction of
certain  conditions,  for approximately  CAN$25 million  (approximately  US$16.5
million). The transaction, which will be accounted for under the purchase method
of  accounting,  will be funded with our operating cash flow. We expect to close
the  transaction  during  March 2001 and it will add  approximately  1.5 million
lives to ESI Canada's  membership  base.  The  transaction is not expected to be
dilutive to earnings in 2001 and is expected to be slightly accretive in 2002.

     Prior to November 7, 2000, NYLife Healthcare Management, Inc., a subsidiary
of New York Life Insurance Company, owned all of our outstanding shares of Class
B Common  Stock.  On  November  7,  2000,  NYLife  Healthcare  Management,  Inc.
exchanged  each  outstanding  share of Class B Common Stock for one share of our
Class A Common Stock and then immediately distributed such shares to NYLIFE LLC,
another  subsidiary  of New York Life.  Consequently,  on November  7, 2000,  we
reacquired all of our outstanding  Class B Common Stock and currently hold it as
treasury shares.  Immediately  following the exchange and distribution to NYLIFE
LLC,  NYLIFE LLC  completed  the sale of 6,900,000  shares of our Class A Common
Stock to the public  through a  secondary  offering.  Contemporaneous  with this
stock  offering,  the Express  Scripts  Automatic  Exchange  Security  Trust,  a
closed-end  investment  company that is not  affiliated  with us, sold 3,450,000
investment units to the public. Upon maturity of the investment units, the Trust
may deliver up to  3,450,000  shares of our Class A Common Stock owned by NYLIFE
LLC to the holders of the investment units. We did not receive any proceeds from
the secondary offering or the offering by the Trust.

     At December 31,  2000,  NYLIFE LLC owned shares of our Class A Common Stock
representing  approximately 20.8% of the combined voting power of all classes of
our common  stock,  which  includes the right to vote  3,450,000  Class A Common
Stock that the Trust may deliver upon  exchange of the Trust  issued  investment
units.  New York Life has  agreed on behalf of itself and its  subsidiaries,  to
vote  these  3,450,000  shares of our  Class A Common  Stock  prior to  delivery
thereof by the Trust to the  holders of the Trust  investment  units in the same
proportion and to the same effect as the votes cast by our other stockholders at
any meeting of stockholders,  subject to the following exceptions: New York Life
has agreed to vote its  8,120,000  shares  (which  includes the above  described
3,450,000 shares) in favor of the slate of nominees for directors recommended by
our Board of Directors for election by  stockholders  (provided that, so long as
New York Life is  entitled to  representation  on the Board of  Directors,  such
slate  includes  New York  Life's  nominees)  and the  adoption  of the  Express
Scripts, Inc.2000 Long-Term Incentive Plan.

     In  June  1998,   Financial   Accounting  Standards  Board  Statement  133,
"Accounting for Derivative  Instruments and Hedging  Activities" ("FAS 133") was
issued.  FAS 133 requires all  derivatives  to be recognized as either assets or
liabilities  in the statement of financial  position and measured at fair value.
In addition, FAS 133 specifies the accounting for changes in the fair value of a
derivative  based  on the  intended  use of the  derivative  and  the  resulting
designation.  The effective  date for FAS 133 was  originally  effective for all
fiscal  quarters of fiscal years  beginning  after June 15, 1999.  However,  the
Financial  Accounting Standards Board has deferred the effective date so that it
will begin for all fiscal  quarters  of fiscal  years  beginning  after June 15,
2000,  and will be  applicable  to our first  quarter of fiscal  year 2001.  Our
present  interest rate swaps (see "-Market  Risk") will be considered  cash flow
hedges. Accordingly, the fair value of the swaps will be reported on the balance
sheet  as an asset  or  liability.  The  corresponding  unrealized  gain or loss
representing  the  effective  portion  of these  hedges  will be  recognized  in
stockholders'   equity  and  other  comprehensive  income  and  any  changes  in
unrealized  gains or losses from the  initial  measurement  date  related to the
ineffective portion of the hedges will be recognized in earnings concurrent with
the interest expense on our underlying variable rate debt. If we had adopted FAS
133 as of December  31, 2000,  we would have  recorded  the  unrealized  loss of
$991,000 as a liability and a decrease in stockholders' equity.

     In  December  1999,  the SEC issued  Staff  Accounting  Bulletin  No.  101,
"Revenue Recognition in Financial Statements" ("SAB 101"). In June 2000, the SEC
issued SAB 101B to defer the effective date for  implementation of SAB 101 until
the fourth quarter of fiscal 2000. In addition, Emerging Issues Task Force Issue
99-19,  "Recording  Revenue Gross as a Principal  versus Net as an Agent" ("EITF
99-19") was issued in July 2000 with  implementation  required no later than the
fourth quarter of fiscal 2000. SAB 101 and EITF 99-19 summarize certain views in
applying  generally  accepted  accounting  principles to revenue  recognition in
financial  statements.  The  necessary  adjustments  to our revenue  recognition
policies  in order to comply with SAB 101 and EITF 99-19 did not have a material
effect on our financial statements.

     In December 2000, the Department of Health and Human Services  issued final
privacy   regulations,   pursuant  to  the  Health  Insurance   Portability  and
Accountability Act of 1996 ("HIPAA"), which impose extensive restrictions on the
use and disclosure of individually  identifiable  health  information by certain
entities. We will be required to comply with certain aspects of the regulations.
We have  retained a consulting  firm to assist us in assessing the steps we will
have to take in complying with these  regulations,  which provide for a two year
implementation  period.  While this  assessment is not yet complete,  we believe
compliance with these regulations will have a significant impact on our business
operations.  We have not yet  completed an assessment of the costs we will incur
in complying with these  regulations,  and can give no assurance that such costs
will not be material to us.

IMPACT OF INFLATION

     Changes  in  prices   charged  by   manufacturers   and   wholesalers   for
pharmaceuticals  affect our revenues and cost of revenues. To date, we have been
able to recover  substantially  all price  increases  from our clients under the
terms of our agreements,  although under selected  arrangements in which we have
performance  measurements  on drug costs with our clients we could be  adversely
affected by inflation in drug costs if the result is an overall  increase in the
cost of the drug plan to the client. To date,  changes in pharmaceutical  prices
have not had a significant adverse affect on us.

MARKET RISK

     In conjunction with the prepayment of the Term A loans, we restructured our
existing  interest rate swap  agreements,  reducing the notional  amounts of the
swaps to a combined $100 million as of December 31, 2000. We received $2,397,000
to restructure our swap agreements,  of which  $1,500,000  ($926,000 net of tax)
was  recognized  against  interest  expense as an ordinary  gain  related to the
prepayment  of debt and the  remaining  $897,000  has been  deferred and will be
amortized over the remaining term of the loans.

     Our first interest rate swap agreement became effective during 1998 and has
a notional  principal  amount of $49  million  with a fixed rate of  interest of
5.88% per annum,  plus the interest rate spread of 1.0% as of December 31, 2000.
Under the restructured  agreement,  the notional principal amount will reduce to
approximately $47 million in April 2001 until maturing in October 2001.

     Our second interest rate swap agreement  became  effective  during 2000 and
has a notional  principal amount of $51 million with a fixed rate of interest of
6.25% per annum,  plus the interest rate spread of 1.0% as of December 31, 2000.
Under the restructured agreement, the notional principal amount will increase to
approximately $53 million in April 2001, to approximately $98 million in October
2001 and to $100 million in April 2002.  Beginning  in April 2003,  the notional
principal  amount  will be  reduced  to $60  million  and in April  2004 will be
reduced to $20 million until maturing in April 2005.

     As a result, we have, in effect,  converted 64.5% of our variable rate debt
to fixed rate debt under our credit facility at December 31, 2000.  Beginning in
October 2000, we have converted  approximately $100 million of our variable rate
debt to fixed rate debt until April 2003 when the notional amount reduces to $60
million and April 2004 when the notional amount reduces to $20 million.

     Interest  rate risk is  monitored on the basis of changes in the fair value
and a sensitivity analysis is used to determine the impact interest rate changes
will have on the fair value of the interest rate swaps,  measuring the change in
the net present  value  arising from the change in the interest  rate.  The fair
value of the swaps are then  determined by calculating  the present value of all
cash flows  expected  to arise  thereunder,  with  future  interest  rate levels
implied from prevailing mid-market yields for money-market instruments, interest
rate futures and/or prevailing mid-market swap rates. Anticipated cash flows are
then  discounted on the  assumption of a  continuously  compounding  zero-coupon
yield  curve.  A 10 basis point  decline in interest  rates at December 31, 2000
would have caused the fair value of the swaps to decrease by $434,000, resulting
in a liability with a fair value of $1,425,000.

Item 7A.  Quantitative and Qualitative Disclosures About Market Risk.
- --------------------------------------------------------------------

     Response to this item is included in Item 7  "Management's  Discussion  and
Analysis of Financial Condition and Results of Operations--Market Risk" above.

Item 8 - Consolidated Financial Statements and Supplementary Data

                        Report of Independent Accountants

To the Board of Directors and
Stockholders of Express Scripts, Inc.


In our  opinion,  the  consolidated  financial  statements  listed  in the index
appearing  under  Item  14(a)(1)  on page 65  present  fairly,  in all  material
respects,  the financial position of Express Scripts,  Inc. and its subsidiaries
at December  31, 2000 and 1999,  and the results of their  operations  and their
cash flows for each of the three years in the period ended  December 31, 2000 in
conformity with accounting principles generally accepted in the United States of
America. In addition, in our opinion, the financial statement schedule listed in
the index  appearing  under  Item  14(a)(2)  on page 65 present  fairly,  in all
material  respects,  the  information set forth therein when read in conjunction
with the related consolidated  financial statements.  These financial statements
and  financial  statement  schedule  are  the  responsibility  of the  Company's
management;  our  responsibility  is to express  an  opinion on these  financial
statements and financial  statement  schedule based on our audits.  We conducted
our audits of these statements in accordance with auditing  standards  generally
accepted in the United States of America, which require that we plan and perform
the audit to obtain reasonable  assurance about whether the financial statements
are free of material misstatement. An audit includes examining, on a test basis,
evidence  supporting the amounts and  disclosures  in the financial  statements,
assessing the  accounting  principles  used and  significant  estimates  made by
management,  and evaluating the overall  financial  statement  presentation.  We
believe that our audits provide a reasonable basis for our opinion.


/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
St. Louis, Missouri
February 5, 2001,  except as to the first two
   paragraphs of Note 2 which are as
   of February 22, 2001



CONSOLIDATED BALANCE SHEET


                                                                                                December 31,
(in thousands, except share data)                                                         2000                1999
                                                                                                     
- ------------------------------------------------------------------------------------------------------------------------
Assets
Current assets:
   Cash and cash equivalents                                                           $      53,204       $     132,630
   Receivables, net                                                                          802,790             783,086
   Inventories                                                                               110,053             113,248
   Deferred taxes                                                                             22,180              32,248
   Prepaid expenses and other current assets                                                   9,942               5,143
                                                                                   --------------------------------------
        Total current assets                                                                 998,169           1,066,355
                                                                                   --------------------------------------
Investment in marketable securities                                                                -             150,365
Property and equipment, net                                                                  147,709              97,573
Goodwill, net                                                                                967,017             982,496
Other intangible assets, net                                                                 157,094             183,420
Other assets                                                                                   6,655               7,102
                                                                                   --------------------------------------
        Total assets                                                                   $   2,276,644       $   2,487,311
                                                                                   ======================================

Liabilities and Stockholders' Equity
Current liabilities:
   Claims and rebates payable                                                          $     878,622       $     850,630
   Accounts payable                                                                           94,407             112,731
   Accrued expenses                                                                          142,915             136,997
                                                                                   --------------------------------------
        Total current liabilities                                                          1,115,944           1,100,358
Long-term debt                                                                               396,441             635,873
Other liabilities                                                                             59,015              51,598
                                                                                   --------------------------------------
        Total liabilities                                                                  1,571,400           1,787,829
                                                                                   --------------------------------------

Commitments and Contingencies (Notes 3, 6 and 8)

Stockholders' equity:
   Preferred stock, $0.01 par value, 5,000,000 shares authorized, and no shares
      issued and outstanding                                                                       -                   -
   Class A Common Stock, $0.01 par value, 150,000,000 shares authorized,
      39,044,000 and 23,981,000 shares issued and outstanding, respectively                      390                 240
   Class B Common Stock, $0.01 par value, 31,000,000 shares authorized,
      no shares and 15,020,000 shares issued and outstanding, respectively                         -                 150
   Additional paid-in capital                                                                441,387             418,921
   Unearned compensation under employee compensation plans                                   (13,676)                  -
   Accumulated other comprehensive income                                                        (97)             (9,521)
   Retained earnings                                                                         287,414             296,540
                                                                                   --------------------------------------
                                                                                             715,418             706,330
   Class A Common Stock in treasury at cost, 270,000 and 465,000 shares,
      respectively                                                                           (10,174)             (6,848)
                                                                                   --------------------------------------
        Total stockholders' equity                                                           705,244             699,482
                                                                                   --------------------------------------
        Total liabilities and stockholders' equity                                     $   2,276,644       $   2,487,311
                                                                                   ======================================


See accompanying Notes to Consolidated Financial Statements.



CONSOLIDATED STATEMENT OF OPERATIONS



                                                                                Year Ended December 31,
(in thousands, except per share data)                                 2000                1999                1998
                                                                                                 
- -------------------------------------------------------------------------------------------------------------------------
Revenues:
   Revenues                                                       $    6,776,441      $    4,285,104      $    2,824,872
   Other revenues                                                         10,423               3,000                   -
                                                               ----------------------------------------------------------
                                                                       6,786,864           4,288,104           2,824,872
                                                               ----------------------------------------------------------
Costs and expenses:
   Cost of revenues                                                    6,247,192           3,826,905           2,584,997
   Selling, general and administrative                                   339,460             294,194             148,990
   Non-recurring                                                               -              30,221               1,651
                                                               ----------------------------------------------------------
                                                                       6,586,652           4,151,320           2,735,638
                                                               ----------------------------------------------------------
Operating income                                                         200,212             136,784              89,234
                                                               ----------------------------------------------------------
Other income (expense):
   Interest income                                                         8,430               5,762               7,236
   Interest expense                                                      (47,903)            (60,010)            (20,230)
   Write-off of marketable securities                                   (165,207)                  -                   -
   Gain on sale of assets                                                      -             182,930                   -
                                                               ----------------------------------------------------------
                                                                        (204,680)            128,682             (12,994)
                                                               ----------------------------------------------------------
(Loss) income before income taxes                                         (4,468)            265,466              76,240
Provision for income taxes                                                 3,553             108,098              33,566
                                                               ----------------------------------------------------------
(Loss) income before extraordinary loss                                   (8,021)            157,368              42,674
Extraordinary loss on early retirement of debt,
   net of taxes                                                           (1,105)             (7,150)                  -
                                                               ----------------------------------------------------------
Net (loss) income                                                 $       (9,126)     $      150,218      $       42,674
                                                               ==========================================================

Basic earnings per share:
   Before extraordinary loss                                      $       (0.21)      $         4.36      $         1.29
   Extraordinary loss on early retirement of debt                         (0.03)               (0.20)                  -
                                                               ----------------------------------------------------------
   Net (loss) income                                              $       (0.24)      $         4.16      $         1.29
                                                               ==========================================================
Weighted average number of common shares
   outstanding during the period - Basic EPS                              38,196              36,095              33,105
                                                               ==========================================================

Diluted earnings per share:
   Before extraordinary loss                                      $       (0.21)      $         4.25      $         1.27
   Extraordinary loss on early retirement of debt                         (0.03)               (0.19)                  -
                                                               ----------------------------------------------------------
   Net (loss) income                                              $       (0.24)      $         4.06      $         1.27
                                                               ==========================================================
Weighted average number of common shares
   outstanding during the period - Diluted EPS                            38,196              37,033              33,698
                                                               ==========================================================


See accompanying Notes to Consolidated Financial Statements



CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY

- -------------------------------------------------------------------------------


                               Number of Shares                                               Amount
                              -------------------  -------------------------------------------------------------------------------
                                                                                Unearned
                                                                              Compensation  Accumulated
                             Class A   Class B   Class A  Class B  Additional    Under         Other
                             Common    Common    Common    Common   Paid-in     Employee   Comprehensive Retained Treasury
(in thousands)               Stock     Stock      Stock    Stock    Capital  Compensation     Income     Earnings    Stock   Total
                                                                                 Plans
                                                                                      
- -------------------------------------------------  --------------------------------------------------------------------------------
Balance at December 31, 1997   9,238     7,510    $   93   $   75    $106,901   $     -     $  (27)    $103,64   $(6,989) $203,701
                              -------------------  ---------------------------------------------------------------------------------
  Comprehensive income:
    Net income                     -         -         -        -           -         -          -      42,674         -    42,674
    Other comprehensive
       income,
     Foreign currency
       translation
       adjustment                  -         -         -        -           -         -        (47)          -         -       (47)
                              -------------------   --------------------------------------------------------------------------------
  Comprehensive income             -         -         -        -           -         -        (47)      42,674        -    42,627
  Issuance of stock dividend   9,239     7,510        92       75        (167)        -          -           -         -         -
  Exercise of stock options      133         -         1        -       2,020         -          -           -         -     2,021
  Tax benefit relating to
    employee
    stock options                  -         -         -        -       1,345         -          -           -         -     1,345
                              --------------------   -------------------------------------------------------------------------------
Balance at December 31, 1998  18,610    15,020       186      150     110,099         -        (74)     146,322   (6,989)  249,694
                              --------------------   -------------------------------------------------------------------------------
  Comprehensive income:
    Net income                     -         -         -        -           -         -          -      150,218        -   150,218
    Other comprehensive
       income,
     Foreign currency
       translation
       adjustment                  -         -         -        -           -         -        108           -         -       108
     Unrealized loss on
       investment,
       net of taxes                -         -         -        -           -         -     (9,555)          -         -    (9,555)
                              --------------------   -------------------------------------------------------------------------------
  Comprehensive income             -         -         -        -           -         -     (9,447)     150,218        -   140,771
  Issuance of common stock     5,175         -        52        -     299,326         -          -           -         -   299,378
  Common stock issued under
    employee plans                10         -         -        -         551         -          -           -         -       551
  Exercise of stock options      186         -         2        -       5,744         -          -           -        141    5,887
  Tax benefit relating to
    employee
    stock options                  -         -         -        -       3,201         -          -           -         -     3,201
                              --------------------   -------------------------------------------------------------------------------
Balance at December 31, 1999   23,981    15,020      240      150     418,921         -      (9,521)    296,540    (6,848) 699,482
                              --------------------   -------------------------------------------------------------------------------
  Comprehensive income:
    Net loss                       -         -         -        -           -         -          -       (9,126)        -   (9,126)
    Other comprehensive
        income,
     Foreign currency
        translation
        adjustment                 -         -         -        -           -         -         (131)         -         -     (131)
     Recognition of prior
        period
        unrealized loss on
        investment                 -         -         -        -           -         -        9,555          -         -    9,555
                              --------------------    ------------------------------------------------------------------------------
  Comprehensive income (loss)      -         -         -        -           -         -        9,424      (9,126)              298
  Conversion of Class B
    Common Stock
    to Class A Common Stock   15,020   (15,020)       150    (150)          -         -           -            -                 -
  Treasury stock acquired          -         -         -        -           -         -           -            -   (30,247)(30,247)
  Common stock issued under
    employee plans                43         -         -        -       9,031   (15,160)          -            -     7,607   1,478
  Amortization of unearned
    compensation
    under employee plans           -         -         -        -           -     1,484           -            -        -    1,484
  Exercise of stock options        -         -         -        -      (2,021)        -           -            -    19,314  17,293
  Tax benefit relating to
    employee
    stock options                  -         -         -        -      15,456         -           -            -        -   15,456
                              ----------------------   -----------------------------------------------------------------------------
Balance at December 31, 2000  39,044         -       $ 390   $  -    $441,387   $(13,676)   $     (97)   $287,414 $(10,174)$705,244
                              ======================   =============================================================================



See accompanying Notes to Consolidated Financial Statements



CONSOLIDATED STATEMENT OF CASH FLOWS

- -------------------------------------------------------------------------------



                                                                                Year Ended December 31,
(in thousands)                                                        2000                1999                1998
                                                                                                    
- -----------------------------------------------------------------------------------------------------------------------------------
Cash flows from operating activities:
   Net (loss) income                                                 $    (9,126)        $   150,218         $    42,674
   Adjustments to reconcile net income to net cash
     Provided by operating activities:
       Depreciation and amortization                                      78,615              71,867              26,449
       Deferred income taxes                                             (42,092)             76,217              10,068
       Bad debt expense                                                   12,843               4,989               4,583
       Write-off of marketable securities                                165,207                   -                   -
       Gain on sale of assets, net of cash paid                                -            (185,650)                  -
       Non-recurring charges, net of cash paid                                 -              22,281               1,467
       Tax benefit relating to employee stock options                     15,456               3,201               1,345
       Extraordinary loss on early retirement of debt                      1,790              11,642                   -
       Other, net                                                          4,521               2,164                 609
       Changes in operating assets and liabilities, net of
         changes resulting from acquisitions:
           Receivables                                                   (35,286)           (217,977)            (35,083)
           Inventories                                                     3,103             (54,059)            (15,417)
           Other current and non-current assets                              745              (2,177)                756
           Claims and rebates payable                                     29,806             279,714             107,660
           Other current and non-current liabilities                      20,328              51,629             (18,537)
                                                               -----------------------------------------------------------
Net cash provided by operating activities                                245,910             214,059             126,574
                                                               -----------------------------------------------------------

Cash flows from investing activities:
   Purchases of property and equipment                                   (80,218)            (36,958)            (23,853)
   Proceeds from sale of property and equipment                            8,831                   -                   -
   Acquisitions, net of cash acquired                                          -            (722,618)           (460,137)
   Short-term investments                                                 (2,191)                  -              57,938
                                                               -----------------------------------------------------------
Net cash (used in) investing activities                                  (73,578)           (759,576)           (426,052)
                                                               -----------------------------------------------------------

Cash flows from financing activities:
   Repayment of long-term debt                                          (240,069)         (1,015,000)                  -
   Proceeds from long-term debt                                                -           1,290,950             360,000
   Treasury stock acquired                                               (30,247)                  -                   -
   Net proceeds from issuance of common stock                                  -             299,378                   -
   Deferred financing fees                                                     -             (26,316)             (4,062)
   Cash received from employee stock-based plans                          18,689               6,438               2,021
                                                               -----------------------------------------------------------
Net cash (used in) provided by financing activities                     (251,627)            555,450             357,959
                                                               -----------------------------------------------------------

Effect of foreign currency translation adjustment                           (131)                108                 (47)
                                                               -----------------------------------------------------------

Net (decrease) increase in cash and cash equivalents                     (79,426)             10,041              58,434
Cash and cash equivalents at beginning of year                           132,630             122,589              64,155
                                                               ------------------------------------------------------------
Cash and cash equivalents at end of year                             $    53,204         $   132,630         $   122,589
                                                               ============================================================

Supplemental data:
Cash paid during the year for:
   Restructuring charges                                             $     3,318         $     4,683         $       184
   Income taxes                                                           30,814               1,080              17,202
   Interest                                                               48,172              61,607              13,568



See accompanying Notes to Consolidated Financial Statements


NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

- -------------------------------------------------------------------------------

1.       Summary of significant accounting policies

     Organization  and  operations.  We  are  one of  the  largest  full-service
pharmacy benefit  management  ("PBM")  companies  independent of  pharmaceutical
manufacturer  ownership in North America.  We provide health care management and
administration  services on behalf of clients  that include  health  maintenance
organizations,  health  insurers,  third-party  administrators,   employers  and
union-sponsored benefit plans. Our fully integrated PBM services include network
claims processing,  mail pharmacy services,  benefit design  consultation,  drug
utilization review, formulary management,  disease management,  medical and drug
data analysis services,  medical information  management services (which include
the development of data  warehouses to combine  medical claims and  prescription
drug  claims),  disease  management  support  services  and outcome  assessments
through our Health  Management  Services division and Practice Patterns Science,
Inc. ("PPS")  subsidiary,  and informed decision counseling services through our
Express Health LineSM  division.  We also provide non-PBM services which include
distribution  services  through  our  Express  Scripts  Specialty   Distribution
Services subsidiary ("SDS"),  infusion therapy services through our wholly-owned
subsidiary IVTx,  Inc.,  operating as Express Scripts  Infusion  Services,  and,
prior to September 1, 1998,  provided  managed vision care programs  through our
wholly-owned subsidiary Express Scripts Vision Corporation.

     Basis of presentation.  The consolidated  financial  statements include our
accounts  and  those  of all  our  wholly-owned  subsidiaries.  All  significant
intercompany accounts and transactions have been eliminated.  The preparation of
the consolidated  financial statements conforms to generally accepted accounting
principles in the U.S., and requires us to make estimates and  assumptions  that
affect  the  reported  amounts  of  assets  and  liabilities  at the date of the
financial  statements and the reported  amounts of revenues and expenses  during
the  reporting  period.  Actual  amounts  could differ from those  estimates and
assumptions.

     Cash and cash equivalents.  Cash and cash equivalents  include cash on hand
and  investments  with original  maturities of three months or less. In 1999, we
changed banking  relationships  resulting in certain cash disbursement  accounts
being  maintained  by banks not holding our cash  concentration  accounts.  As a
result, cash disbursement accounts carrying negative balances of $83,691,000 and
$113,732,000  have been  reclassified  to claims and rebates payable at December
31, 2000 and 1999, respectively.

     Accounts receivable. As of December 31, 2000 and 1999, unbilled receivables
were  $394,205,000  and  $354,370,000,  respectively.  Unbilled  receivables are
billed to  clients  typically  within 30 days based on the  contractual  billing
schedule agreed upon with the client.  As of December 31, 2000 and 1999, we have
allowances for doubtful accounts of $22,677,000 and $17,281,000, respectively.

     Inventories. Inventories consist of prescription drugs and medical supplies
that are stated at the lower of first-in first-out cost or market.

     Property and  equipment.  Property and  equipment is carried at cost and is
depreciated using the straight-line  method over estimated useful lives of seven
years for furniture,  five years for equipment and purchased  computer  software
and three years for personal computers.  Leasehold improvements are amortized on
a  straight-line  basis  over the term of the  lease or the  useful  life of the
asset,  if shorter.  Expenditures  for  repairs,  maintenance  and  renewals are
charged to income as incurred. Expenditures which improve an asset or extend its
estimated useful life are capitalized.  When properties are retired or otherwise
disposed of, the related cost and accumulated  depreciation are removed from the
accounts and any gain or loss is included in income.

     Software development costs. Research and development  expenditures relating
to the  development  of software  to be  marketed to clients,  or to be used for
internal  purposes,  are charged to expense until  technological  feasibility is
established.  Thereafter, the remaining software production costs up to the date
of general  release to  customers,  or to the date placed into  production,  are
capitalized and included as Property and Equipment.  During 2000, 1999 and 1998,
$36,518,000,  $15,997,000  and  $10,244,000 in software  development  costs were
capitalized,  respectively, primarily due to the integration of our acquisitions
and enhancements to our information  systems.  Capitalized  software development
costs  amounted to  $81,933,000  and  $42,353,000 at December 31, 2000 and 1999,
respectively.  Amortization of the capitalized  amounts commences on the date of
general  release  to  customers,  or the date  placed  into  production,  and is
computed on a  product-by-product  basis using the straight-line method over the
remaining  estimated  economic life of the product but not more than five years.
Reductions,  if any, in the carrying value of capitalized  software costs to net
realizable value are expensed.  Amortization  expense in 2000, 1999 and 1998 was
$6,535,000, $3,810,000 and $1,968,000, respectively.

     Marketable  securities.  All  investments  not  included  as cash  and cash
equivalents  are  accounted  for  under  Financial  Accounting  Standards  Board
Statement  ("FAS") 115,  "Accounting for Certain  Investments in Debt and Equity
Securities."  Available-for-sale securities are reported at fair value, which is
based upon quoted market prices,  with unrealized gains and losses,  net of tax,
reported as a component of other  comprehensive  income in stockholders'  equity
until recognized.  Unrealized losses are recognized as expense when a decline in
fair value is determined to be other than temporary.

     Goodwill.  Goodwill is amortized on a straight-line basis over periods from
10 to 30 years.  The  amount  reported  is net of  accumulated  amortization  of
$71,348,000  and  $36,317,000  at  December  31,  2000 and  1999,  respectively.
Amortization expense,  included in selling, general and administrative expenses,
was  $35,031,000,  $28,203,000  and  $7,863,000 for the years ended December 31,
2000, 1999 and 1998, respectively.

     Other  intangible  assets.  Other  intangible  assets include,  but are not
limited to, customer  contracts,  non-compete  agreements and deferred financing
fees and are amortized on a straight-line basis over periods from 2 to 20 years.
The amount  reported  is net of  accumulated  amortization  of  $55,954,000  and
$34,918,000 at December 31, 2000 and 1999,  respectively.  Amortization  expense
for customer contracts and non-compete  agreements included in selling,  general
and administrative expenses was $18,607,000,  $25,094,000 and $4,320,000 for the
years ended December 31, 2000, 1999 and 1998, respectively. Amortization expense
for  deferred  financing  fees  included  in interest  expense  was  $2,391,000,
$2,241,000,  and $609,000 for the years ended December 31, 2000,  1999 and 1998,
respectively.

     Contractual  agreements.  We have entered  into  corporate  alliances  with
certain of our clients  whereby  shares of our Class A Common Stock were awarded
as advance discounts to the clients. We account for these agreements as follows:

         Between  December  15,  1995 and  November  20,  1997 - For  agreements
         entered into between these dates, we utilize the provisions of FAS 123,
         "Accounting  for  Stock-Based  Compensation,"  which  requires that all
         stock issued to  nonemployees  be accounted for based on the fair value
         of  the  consideration  received  or  the  fair  value  of  the  equity
         instruments  issued.  We have  adopted  FAS 123 as it  relates to stock
         issued or to be issued  under client  alliances  based on fair value at
         the date the agreement was consummated.

          Subsequent  to  November  20, 1997 - In November  1997,  the  Emerging
          Issues Task Force ("EITF") of the Financial Accounting Standards Board
          ("FASB")  reached a  consensus  that the  value of equity  instruments
          issued  for  consideration  other  than  employee  services  should be
          initially  determined  on the  date on which a "firm  commitment"  for
          performance  first exists by the  provider of goods or services.  Firm
          commitment is defined as a commitment pursuant to which performance by
          a provider of goods or services  is probable  because of  sufficiently
          large disincentives for nonperformance.  The consensus must be applied
          for all new  arrangements and  modifications of existing  arrangements
          entered into from November 20, 1997.  The consensus only addresses the
          date upon  which  fair  value is  determined  and does not  change the
          accounting based upon fair value as prescribed by FAS 123. We have not
          entered into any such arrangements subsequent to November 20, 1997.

     Shares  issued  on the  effective  date of the  contractual  agreement  are
considered  outstanding  and  included in basic and diluted  earnings  per share
computations  when issued.  Shares  issuable  upon the  satisfaction  of certain
conditions  are  considered  outstanding  and  included  in basic  and  dilutive
earnings per share computation when all necessary conditions have been satisfied
by the end of the period. If all necessary conditions have not been satisfied by
the end of the period,  the number of shares  included in the dilutive  earnings
per share  computation  is based on the number of shares,  if any, that would be
issuable  if the end of the  reporting  period  were the end of the  contingency
period and if the  result  would be  dilutive.  The value of the shares of stock
awarded as advance  discounts  is  recorded as a deferred  cost and  included in
other intangible assets. The deferred cost is recognized in selling, general and
administrative expenses over the period of the contract.

     Impairment  of  long  lived  assets.   We  evaluate   whether   events  and
circumstances have occurred that indicate the remaining estimated useful life of
long  lived  assets,  including  goodwill,  may  warrant  revision  or that  the
remaining  balance  of an  asset  may not be  recoverable.  The  measurement  of
possible  impairment  is based on the  ability to recover  the balance of assets
from expected future operating cash flows on an undiscounted  basis.  Impairment
losses, if any, would be determined based on the present value of the cash flows
using discount rates that reflect the inherent risk of the underlying  business.
In our opinion,  other than the write-down of long-lived  assets associated with
our  facilities  consolidation  and  computer  operations  outsourcing,  no such
impairment existed as of December 31, 2000 or 1999 (see Note 6).

     Derivative financial  instruments.  We have entered into interest rate swap
agreements in order to manage  exposure to interest rate risk. We do not hold or
issue derivative financial  instruments for trading purposes.  The interest rate
swaps are designated as a hedge of our variable interest rate payments.  Amounts
received or paid are accrued as interest  receivable  or payable and as interest
income or expense. The fair values of interest rate swap agreements are based on
market  prices.  The  fair  values  represent  the  estimated  amount  we  would
receive/pay  to  terminate  the  agreements  taking into  consideration  current
interest rates.

     In  June  1998,  the  FASB  issued  FAS  133,  "Accounting  for  Derivative
Instruments  and Hedging  Activities".  FAS 133 requires all  derivatives  to be
recognized  as either  assets  or  liabilities  in the  statement  of  financial
position and to measure those  instruments at fair value.  In addition,  FAS 133
specifies the accounting for changes in the fair value of a derivative  based on
the intended use of the derivative and the resulting designation.  The effective
date for FAS 133 was  originally  effective  for all fiscal  quarters  of fiscal
years beginning after June 1, 1999. However, the FASB has deferred the effective
date so that it will begin for all fiscal  quarters  of fiscal  years  beginning
after June 15, 2000,  and will be applicable to our first quarter of fiscal year
2001. Our present  interest rate swaps (see Note 5) will be considered cash flow
hedges. Accordingly, the change in the fair values of the swaps will be reported
on the balance sheet as an asset or liability. The corresponding unrealized gain
or loss representing the effective portion of these hedges will be recognized in
stockholders'   equity  and  other  comprehensive  income  and  any  changes  in
unrealized  gain or loss  from  the  initial  measurement  date  related  to the
ineffective portion of the hedges will be recognized in earnings concurrent with
the interest expense on our underlying variable rate debt. If we had adopted FAS
133 as of  December  31,  2000,  we would have  recorded an  unrealized  loss of
$991,000 as a liability and a decrease in stockholders' equity during 2000.

     Fair value of financial  instruments.  The carrying  value of cash and cash
equivalents,  accounts receivable and accounts payable  approximated fair values
due to the short-term  maturities of these  instruments.  The fair value,  which
approximates  the carrying  value,  of our Credit  Facility was estimated  using
either  quoted  market  prices or the current  rates offered to us for debt with
similar  maturity.  The fair value of the swaps (a  liability of $991,000 and an
asset of  $6,867,000 at December 31, 2000 and 1999,  respectively)  was based on
quoted market prices, which reflect the present values of the difference between
estimated future fixed rate payments and future variable rate receipts. The fair
value of our senior note facility ($245,882,000 and $255,000,000 at December 31,
2000 and 1999, respectively) was estimated based on quoted market prices.

     Revenue   recognition.    Revenues   from   dispensing   prescription   and
non-prescription  medical  products from our mail  pharmacies  are recorded upon
shipment.  Revenue  from  sales  of  prescription  drugs  by  pharmacies  in our
nationwide  network and pharmacy claims processing  revenues are recognized when
the claims are processed. When we dispense pharmaceuticals from our mail service
pharmacies to members of health  benefit plans  sponsored by our clients or when
we have an  independent  contractual  obligation  to pay  our  network  pharmacy
providers  for  benefits  provided to members of our clients'  pharmacy  benefit
plans, we include  payments from plan sponsors for these benefits as revenue and
ingredient  costs or payments to these  pharmacy  providers  in cost of revenues
(the "Gross Basis").  If we are merely  administering the plan sponsors' network
pharmacy  contracts we record only the administrative or dispensing fees derived
from our contracts with the plan sponsors as revenue (the "Net Basis").

     Management services provided to drug manufacturers include various services
relating to administration of manufacturer rebate programs. Revenues relating to
these  services are  recognized as earned based upon  detailed drug  utilization
data.  Rebates payable to customers in accordance with the applicable  contracts
are excluded from revenues and expenses.

     Retail pharmacy and mail pharmacy revenues are recognized based upon actual
scripts adjudicated and therefore require no estimation.

     In December 1999, the  Securities  and Exchange  Commission  ("SEC") issued
Staff Accounting Bulletin No. 101, "Revenue Recognition in Financial Statements"
("SAB 101").  In June 2000,  the SEC issued SAB 101B to defer the effective date
for  implementation  of SAB 101 until the  fourth  quarter  of fiscal  2000.  In
addition,  EITF Issue 99-19,  "Recording Revenue Gross as a Principal versus Net
as an Agent" ("EITF 99-19") was issued in July 2000 with implementation required
no later  than  the  fourth  quarter  of  fiscal  2000.  SAB 101 and EITF  99-19
summarize certain views in applying generally accepted accounting  principles to
revenue recognition in financial  statements.  The necessary  adjustments to our
revenue recognition  policies in order to comply with SAB 101 and EITF 99-19 did
not have a material effect on our financial statements.

     Cost of revenues.  Cost of revenues includes product costs, pharmacy claims
payments  and other  direct  costs  associated  with  dispensing  prescriptions,
including shipping and handling and non-prescription medical products and claims
processing operations, offset by fees received from pharmaceutical manufacturers
in connection with our drug  purchasing and formulary  management  programs.  We
estimate fees receivable from pharmaceutical  manufacturers on a quarterly basis
converting total  prescriptions  dispensed to estimated rebatable scripts (i.e.,
those  prescriptions  with  respect to which we are  contractually  entitled  to
submit claims for rebates)  multiplied by the contractually  agreed manufacturer
rebate amount.  Estimated fees receivable from pharmaceutical  manufacturers are
recorded  when  we  determine  them to be  realizable,  and  realization  is not
dependent  upon future  pharmaceutical  sales.  Estimates  are revised  once the
actual  rebatable   scripts  are  calculated  and  rebates  are  billed  to  the
manufacturer.

     Income taxes.  Deferred tax assets and liabilities are recognized  based on
temporary  differences between financial statement basis and tax basis of assets
and liabilities using presently enacted tax rates.

     Earnings per share. Basic earnings per share is computed using the weighted
average number of common shares outstanding during the period.  Diluted earnings
per share is computed in the same  manner as basic  earnings  per share but adds
the number of additional  common shares that would have been outstanding for the
period if the potential  dilutive common shares had been issued.  The difference
between  the number of  weighted  average  shares  used in the basic and diluted
calculation  for all years are  outstanding  stock  options  and stock  warrants
(833,000,  938,000  and  593,000  in 2000,  1999 and  1998,  respectively),  any
unvested shares and shares issuable  pursuant to employee elected deferral under
the executive deferred compensation plan (3,000 in 2000) and restricted stock we
have issued (1,000 in 2000), all calculated under the "treasury stock" method in
accordance with FAS 128,  "Earnings Per Share". Due to the net loss in 2000, all
potentially dilutive common shares have been excluded due to anti-dilution.

     Foreign currency translation.  The financial statements of ESI Canada, Inc.
are translated  into U.S.  Dollars using the exchange rate at each balance sheet
date for assets and  liabilities and a weighted  average  exchange rate for each
period for revenues, expenses, gains and losses. The functional currency for ESI
Canada,  Inc. is the local currency and cumulative  translation  adjustments are
recorded  within  the other  comprehensive  income  component  of  stockholders'
equity.

     Employee stock-based compensation. We account for employee stock options in
accordance with Accounting  Principles Board No. 25 ("APB 25"),  "Accounting for
Stock Issued to Employees." Under APB 25, we apply the intrinsic value method of
accounting and, therefore,  have not recognized compensation expense for options
granted, because options have only been granted at a price equal to market value
at the time of grant.  During  1996,  FAS 123 became  effective  for us. FAS 123
prescribes the  recognition of  compensation  expense based on the fair value of
options determined on the grant date. However,  FAS 123 grants an exception that
allows  companies  currently  applying APB 25 to continue using that method.  We
have,  therefore,  elected to continue applying the intrinsic value method under
APB 25. For  companies  that choose to continue  applying  the  intrinsic  value
method,  FAS 123  mandates  certain pro forma  disclosures  as if the fair value
method had been utilized (see Note 10).

     Comprehensive  income.  Other  than  net  income,  our  two  components  of
comprehensive income are changes in the foreign currency translation adjustments
and  unrealized  losses  on  available-for-sale  securities.  We have  displayed
comprehensive income within the Statement of Changes in Stockholders' Equity.

     Segment  reporting.  The relative  segment  information is derived from the
management  approach which designates the internal  organization that is used by
management  for making  operating  decisions  and assessing  performance  as the
source of our reportable segments (see Note 12).

2.       Changes in business

     Joint  venture.  On February 22, 2001, we announced that we entered into an
agreement with AdvancePCS and Merck-Medco to form RxHub LLC ("RxHub").  RxHub is
intended  to  develop  an  electronic   exchange  enabling  physicians  who  use
electronic prescribing technology to link to pharmacies,  PBMs and health plans,
which their  patients  use.  The company is designed to operate as a utility for
the conduit of information among all parties engaging in electronic prescribing.
We will own  one-third  of the  equity  of RxHub  (as will each of the other two
founders),  and have  committed  to invest up to $20 million  over the next five
years with  approximately  $6 million  committed  for 2001.  We will  record our
investment in RxHub under the equity method of  accounting,  which  requires our
percentage  interest  in RxHub's  results  to be  recorded  in our  Consolidated
Statement of Operations.  RxHub will be operated to cover its expected operating
costs and to return the cost of capital to the founders.

     Acquisitions.   As  previously   announced  the   shareholders   of  Centre
d'autorisation et de paiement des services de sante, a leading  Quebec-based PBM
commonly  referred  to  as  CAPSS,  accepted  an  offer  made  by  our  Canadian
subsidiary, ESI Canada, Inc., to acquire all of the outstanding shares of CAPSS,
subject to satisfaction of certain conditions,  for approximately CAN$25 million
(approximately  US$16.5 million).  The transaction,  which will be accounted for
under the purchase method of accounting,  will be funded with our operating cash
flow.  We expect  to close the  transaction  during  March  2001 and it will add
approximately 1.5 million lives to ESI Canada's membership base. The transaction
is not  expected  to be  dilutive  to  earnings  in 2001 and is  expected  to be
slightly accretive in 2002.

     On  April  1,  1999,   we  completed   our   acquisition   of   Diversified
Pharmaceutical  Services,  Inc. and Diversified  Pharmaceutical Services (Puerto
Rico) Inc.  (collectively,  "DPS"),  from  SmithKline  Beecham  Corporation  and
SmithKline  Beecham  InterCredit BV (collectively,  "SB") for approximately $715
million,  which includes a purchase price adjustment for closing working capital
and transaction costs. We filed an Internal Revenue Code ss.338(h)(10) election,
making  amortization  expense of  intangible  assets,  including  goodwill,  tax
deductible.  We used  approximately $48 million of our own cash and financed the
remainder of the purchase price and related acquisition costs.

     The  acquisition  has been  accounted  for  using  the  purchase  method of
accounting.  The  results  of  operations  of  DPS  have  been  included  in the
consolidated  financial  statements  and PBM segment  since  April 1, 1999.  The
purchase  price has been  allocated  based on the  estimated  fair values of net
assets  acquired at the date of the  acquisition.  The excess of purchase  price
over tangible net assets acquired has been allocated to other intangible  assets
consisting  of  customer  contracts  in the amount of  $129,500,000  which began
amortizing  in 1999 using the  straight-line  method over the  estimated  useful
lives of 2 to 20 years and goodwill in the amount of $754,236,000 which is being
amortized using the  straight-line  method over the estimated  useful life of 30
years.  In  conjunction  with  the  acquisition,   DPS  retained  the  following
liabilities:

(in thousands)
- -----------------------------------------------------------------
Fair value of assets acquired                  $     1,028,848
Cash paid for the capital stock                       (714,678)
                                          -----------------------
         Liabilities retained                  $       314,170
                                          =======================

     The  following  unaudited pro forma  information  presents a summary of our
combined  results  of  operations  and  those of DPS as if the  acquisition  had
occurred at the beginning of the period presented,  along with certain pro forma
adjustments to give effect to amortization of goodwill, other intangible assets,
interest  expense  on  acquisition  debt and  other  adjustments.  The pro forma
financial information is not necessarily indicative of the results of operations
as they would have been had the transaction  been effected on the assumed date,
nor is it an indication of trends in future results.

                                            Year Ended December
                                                    31,
(in thousands, except per share data)               1999
- ------------------------------------------------------------------
Total revenues                                     $  4,353,470
Income before extraordinary loss                        158,423
Extraordinary loss                                       (7,150)
                                            ----------------------
Net income                                         $    151,273
                                            ======================
Basic earnings per share
    Before extraordinary loss                      $       4.39
    Extraordinary loss                                    (0.20)
                                            ----------------------
    Net income                                     $       4.19
                                            ======================
Diluted earnings per share
    Before extraordinary loss                      $       4.28
    Extraordinary loss                                    (0.19)
                                            ----------------------
    Net income                                     $       4.09
                                            ======================

     As  previously  disclosed,  on  April  1,  1998,  we  acquired  all  of the
outstanding capital stock of Value Health, Inc. Managed  Prescriptions  Network,
Inc.  (collectively  known as  "ValueRx")  from HCA-The  Healthcare  Corporation
(formerly,  "Columbia/HCA  Healthcare  Corporation  ")  for  approximately  $460
million. Consequently, our operating results include those of ValueRx from April
1, 1998.  The net assets  acquired  from  ValueRx  have been  recorded  at their
estimated  fair value,  resulting  in  $278,113,000  of  goodwill  that is being
amortized  over 30 years and  $57,653,000 of other  intangible  assets which are
being  amortized  over 2 to 20 years.  This  acquisition  has been accounted for
under the purchase method of accounting.

     Sale of assets. On August 31, 1999, we, along with  YourPharmacy.com,  Inc.
("YPC"),  our wholly-owned  subsidiary,  entered into an Asset  Contribution and
Reorganization  Agreement (the  "Contribution  Agreement")  with  PlanetRx,  PRX
Holdings,  Inc.  ("Holdings"),  and PRX Acquisition Corp.  ("Acquisition  Sub").
Pursuant  to the  Contribution  Agreement,  YPC  agreed  to  contribute  certain
operating  assets  constituting  its  e-commerce  business in  prescription  and
non-prescription  drugs and health and beauty aids to  Holdings in exchange  for
19.9% of the post-initial public offering common equity of Holdings (the "IPO"),
and PlanetRx was also to assume certain obligations of YPC.  Simultaneously with
this  transaction,  Acquisition  Sub was to merge  into  PlanetRx  and  PlanetRx
shareholders  would  receive  stock in Holdings,  which would change its name to
"PlanetRx.com,  Inc."  As a result  of the  transactions,  YPC  would be a 19.9%
shareholder  in the  new  PlanetRx  (formerly  Holdings),  which  would  conduct
business as an Internet pharmacy.

     On  October  13,  1999,  the  transactions  described  in the  Contribution
Agreement were  consummated,  YPC received  10,369,990  unregistered  shares, or
19.9%, of the common equity of PlanetRx, and PlanetRx assumed options granted to
YPC employees which converted into options to purchase approximately 1.8 million
shares of PlanetRx  common stock. In connection with the IPO, we also executed a
180 day lock-up  agreement that prevented us from selling our shares until April
10, 2000. The consummation of the transaction occurred immediately preceding the
closing of  PlanetRx's  IPO of common  stock.  Based on the IPO price of $16 per
share, YPC received consideration valued at $165,920,000. We recorded a one-time
gain during 1999 (in other income) of  $182,930,000  on the  transaction,  and a
one-time  stock  compensation  expense  during 1999  (included in  non-recurring
expenses)  of  $19,520,000  relating  to the  YPC  employee  stock  options.  We
accounted  for this  investment  in PlanetRx on the cost method and reported our
investment  on the balance  sheet under the caption  "investment  in  marketable
securities" at fair value in accordance with FAS 115 (see Note 1).

     As  part  of  our  agreement,  PlanetRx  was to  pay  us an  annual  fee of
$11,650,000 and  reimbursement  for certain expenses of $3,000,000 over a 5 year
term,  which  could  be  extended  to 10 years  if we meet  certain  performance
measures.  Additionally,  we were eligible to receive an  incremental  fee based
upon the number of our  members who placed  their  first order for  prescription
drug or non-prescription  merchandise with PlanetRx. We recorded $10,423,000 and
$3,000,000  of  revenue  during  2000 and 1999,  respectively.  We also  reduced
selling and general  administrative  expenses by  $1,500,000  and  $750,000  for
reimbursement of certain  expenses  relating to our Internet  initiative  during
2000 and 1999, respectively.

     Effective  July 5, 2000, we  restructured  our  agreement  with PlanetRx in
exchange for a one-time cash payment of $8 million.  Approximately  $3.7 million
of the payment represents amounts earned through the second quarter of 2000, the
remaining  $4.3  million  represents  a fee for  the  termination  of the  prior
contract.  No additional cash payments will be paid to us under the restructured
agreement.

     During 2000,  we recorded a non-cash  impairment  charge to  write-off  our
investment in PlanetRx  common stock as the loss in value was deemed to be other
than temporary.  Therefore,  any unrealized losses associated with recording our
investment  in  PlanetRx  at  current  market  value  that  we had  recorded  in
stockholders'  equity  were  written  off to the  current  period  earnings,  in
addition to any  additional  charges  necessary  to  write-off  our  investment.
Additionally,  during 2000 we donated approximately 200,000 shares (after giving
effect to the  8-for-1  reverse  stock  split on  December  4, 2000) of PlanetRx
common stock and  realized  expenses  related to the  donation of  approximately
$713,000.  At December 31, 2000 we own  approximately  1,096,000  shares  (after
giving  effect to the  8-for-1  reverse  stock  split on  December  4,  2000) of
PlanetRx which are carried at no value.

3.       Contractual agreements

     Effective  January 1, 1996,  we  executed a  multi-year  contract  with The
Manufacturers  Life Insurance Company  ("Manulife"),  to provide PBM services in
Canada.  Under  the terms of the  agreement,  we are the  exclusive  third-party
provider of PBM  services to  Manulife's  Canadian  clients.  We will also issue
shares of our Class A Common Stock as an advance discount to Manulife based upon
achievement of certain volumes of Manulife pharmacy claims we process. No shares
will be issued until after the fourth year of the agreement.  The shares will be
issued based on volumes reached in years four through six. We anticipate issuing
no more than 474,000  shares to Manulife over a period up to the first six years
of the agreement. Except for certain exemptions from registration under the 1933
Act,  any  shares  issued to  Manulife  cannot be  traded  until  they have been
registered  under the 1933 Act and any  applicable  state  securities  laws.  In
accordance  with the  terms of the  agreement,  no stock has been  issued  since
inception.

     If Manulife has not exercised an early termination option at the end of the
sixth or tenth year of the  agreement,  we will  issue at each of those  times a
ten-year warrant as an advance discount to purchase up to approximately  237,000
additional  shares of our Class A Common Stock  exercisable at 85% of the market
price at those times.  The actual  number of shares for which such warrant is to
be issued is based on the volume of Manulife  pharmacy claims we process in year
six and year ten, respectively.

     Pursuant to an agreement with Coventry  Corporation,  an operator of health
maintenance  organizations  located principally in Pennsylvania and Missouri, on
January 3, 1995,  we issued  50,000 shares of Class A Common Stock as an advance
discount to Coventry in a private placement.  These shares were valued at $13.69
per share, the split-adjusted per share market value of our Class A Common Stock
on November 22, 1994,  which was the date the agreement was  consummated and the
obligation of the parties became unconditional. No revision of the consideration
for the transaction  occurred between November 22, 1994 and January 3, 1995. The
shares issued to Coventry were being amortized over a six-year period.  However,
due to Coventry  extending  the  agreement  for only two years  instead of three
years, as discussed  below,  the estimated  useful life of the shares issued has
been reduced to five years and ended in 1999.  Amortization expense was $171,000
for each of the years ended December 31, 1999 and 1998, respectively. Except for
certain  exemptions from registration under the 1933 Act, these shares cannot be
traded  until they have been  registered  under the 1933 Act and any  applicable
state securities laws.

     Effective  January 1, 1998,  Coventry  renewed the agreement for a two-year
term through December 31, 1999. As part of the agreement,  we issued warrants as
an advance  discount  to  purchase an  additional  50,000  shares of our Class A
Common  Stock,  exercisable  at 90% of the market  value at the time of renewal.
During 1998,  we expensed the advance  discount,  which  represented  10% of the
market value.

4.       Property and equipment

     Property and equipment, at cost, consists of the following:

                                                       December 31,
(in thousands)                                   2000             1999
- ----------------------------------------------------------------------------
Land                                      $         400     $       2,051
Building                                              -             3,076
Furniture                                        18,210            12,873
Equipment                                        87,515            64,204
Computer software                               101,075            55,054
Leasehold improvements                           14,594             9,922
                                         -----------------------------------
                                                221,794           147,180
Less accumulated depreciation and
   amortization                                  74,085            49,607
                                         -----------------------------------
                                          $     147,709     $      97,573
                                         ===================================

5.       Financing

         Long-term debt consists of:



                                                                        December 31,
(in thousands)                                                  2000                    1999
                                                                               
- -----------------------------------------------------------------------------------------------------
Revolving credit facility due March 31, 2005 with an
   interest rate of 7.94% at December 31, 1999                $          -            $     100,000
Term A loans due March 31, 2005 with an interest rate of
   7.52% and 7.94% at December 31, 2000 and 1999, and a
   deferred interest rate swap gain of $847 at December 31,
   2000                                                            155,847                  285,000
9.625% Senior Notes due June 15, 2009, net of an
   unamortized discount of $1,024 and $1,146, and an
   unamortized interest rate lock of $1,733 and $2,019             240,594                  250,873
                                                            -----------------------------------------
Total long-term debt                                          $    396,441            $     635,873
                                                            =========================================


     We have a credit  facility with a commercial  bank syndicate which consists
of $155 million of Term A loans and a $300 million  revolving  credit  facility.
During 2000, we utilized $130 million of our own  internally  generated  cash to
prepay a portion of our Term A loans. As a result of the prepayment, we recorded
an  extraordinary  charge  during 2000 for the  deferred  financing  fees in the
amount of $1,790,000 ($1,105,000 net of tax). The prepayment on the Term A loans
eliminated the scheduled  principal  payments for fiscal years 2001,  2002 and a
portion of the scheduled  principal  payment for fiscal year 2003.  Beginning in
March 2003,  we are  required to make  annual  principal  payments on the Term A
loans of $26,750,000 in 2003,  $62,700,000 in 2004 and  $65,550,000 in 2005. The
capital  stock  of each  of our  existing  and  subsequently  acquired  domestic
subsidiaries,  excluding PPS, Great Plains Reinsurance Co., ValueRx of Michigan,
Inc., Diversified NY IPA, Inc. and Diversified  Pharmaceutical  Services (Puerto
Rico), Inc., and 65% of the stock of our foreign  subsidiaries have been pledged
as collateral for the credit facility.

     The credit  facility  requires us to pay interest  quarterly on an interest
rate spread based on several London  Interbank  Offered Rates  ("LIBOR") or base
rate options.  To alleviate  interest rate volatility,  we have entered into two
separate swap  arrangements,  which are  discussed  below.  The credit  facility
contains covenants that limit the indebtedness we may incur,  dividends paid and
the amount of annual  capital  expenditures.  The  covenants  also  establish  a
minimum  interest  coverage ratio, a maximum leverage ratio, and a minimum fixed
charge  coverage  ratio.  In  addition,  we are required to pay an annual fee of
0.25%, payable in quarterly installments, on the unused portion of the revolving
credit  facility  ($300 million at December 31, 2000).  At December 31, 2000, we
are in compliance with all covenants associated with the credit facility.

     In June 1999, we issued $250 million of 9.625% Senior Notes due 2009, which
require interest to be paid semi-annually on June 15 and December 15. The Senior
Notes are callable at specified  prepayment premiums beginning in June 2004. The
Senior Notes are  unconditionally  and jointly and  severally  guaranteed by our
wholly-owned domestic subsidiaries other than PPS, Great Plains Reinsurance Co.,
ValueRx  of  Michigan,   Inc.,   Diversified  NY  IPA,  Inc.,  and   Diversified
Pharmaceutical  Services (Puerto Rico),  Inc. During the second quarter of 2000,
we  repurchased  $10,115,000  of  our  Senior  Notes  on  the  open  market  for
$10,150,000, which includes $385,000 of accrued interest.

     The  following  represents  the  schedule  of  current  maturities  for our
long-term debt (in thousands):

             Year Ended December 31,
- --------------------------------------------------------
2001                                 $              -
2002                                                -
2003                                           26,750
2004                                           62,700
2005                                           65,550
                                 -----------------------
                                     $        155,000
                                 =======================

     In conjunction with the prepayment of the Term A loans, we restructured our
existing  interest rate swap  agreements,  reducing the notional  amounts of the
swaps to a combined $100 million as of December 31, 2000. We received $2,397,000
to restructure our swap agreements,  of which  $1,500,000  ($926,000 net of tax)
was  recognized  against  interest  expense as an ordinary  gain  related to the
prepayment  of debt and the  remaining  $897,000 has been  deferred and is being
amortized  over the remaining  term of the loans.  Under the  restructured  swap
agreements,  we have,  in effect,  converted  approximately  $100 million of our
variable rate debt to fixed rate debt until April 2003 when the notional  amount
reduces to $60 million and April 2004 when the  notional  amount  reduces to $20
million.

     During 1999,  we entered  into an interest  rate lock with  Bankers'  Trust
Company  related to our offering of $250 million Senior Notes.  Upon issuance of
the Senior  Notes,  we received  $2,135,000,  which is being  amortized  against
interest expense over the term of the Senior Notes. Interest expense was reduced
by $286,000 and $116,000 during 2000 and 1999, respectively.

6.       Corporate restructuring

     During the  second  quarter of 1999,  we  recorded a pre-tax  restructuring
charge  of  $9,400,000  associated  with  the  consolidation  of  our  Plymouth,
Minnesota facility into our Bloomington,  Minnesota  facility.  In December 1999
and  September  2000,  the  associated  accrual  was reduced by  $2,301,000  and
$44,000,  primarily as a result of subleasing a portion of the unoccupied space.
The consolidation  plan includes the relocation of all employees at the Plymouth
facility to the Bloomington  facility that began in August 1999, with completion
delayed  until the first  quarter of 2001 from the  previously  disclosed  third
quarter of 2000.  Included  in the  restructuring  charge are  anticipated  cash
expenditures of approximately  $4,779,000 for lease termination fees and rent on
unoccupied  space (which  payments  will continue  through April 2001,  when the
lease expires) and anticipated non-cash charges of approximately  $2,276,000 for
the  write-down  of leasehold  improvements  and  furniture  and  fixtures.  The
restructuring  charge does not include any costs  associated  with the  physical
relocation of the employees.

     During  December  1999,  we  recorded  a  pre-tax  restructuring  charge of
$2,633,000  associated  with  the  outsourcing  of our  computer  operations  to
Electronic Data Systems Corporation.  The principal actions of the plan included
cash expenditures of approximately $2,148,000 for the transition of 51 employees
to the  outsourcer and the  elimination  of  contractual  obligations of ValueRx
which  had  no  future  economic   benefit  to  us,  and  non-cash   charges  of
approximately  $485,000 due to the  reduction  in the carrying  value of certain
capitalized  software to its net realizable value. The plan was completed during
the second quarter of 2000 when all cash payments were made.

     Also in  December  1999,  we  recorded  a pre-tax  restructuring  charge of
$969,000 associated with restructuring our PPS majority-owned subsidiary and the
purchase of the remaining PPS common stock from management.  The charge consists
of cash  expenditures  of $559,000  relating to stock  compensation  expense and
$410,000 of severance payments to 9 employees (of which $133,000 was paid during
December 1999). This plan was completed in January 2000.




                               Balance at                                   Balance at                                  Balance at
                              December 31,        1999          1999       December 31,        2000         2000       December 31,
(in thousands)                    1998          Charges        Usage           1999         Reversals       Usage          2000
                                                                                                    
- -----------------------------------------------------------------------------------------------------------------------------------
Non-cash
Write-down of long-lived
     assets                     $      531     $    2,761    $    3,264      $       28     $        -    $        -     $       28
Cash
Employee transition costs
                                       232          1,725           365           1,592              -         1,592              -
Stock compensation                       -            559             -             559              -           559              -
Lease termination fees and
     rent                                -          5,656         4,318           1,338             44         1,167            127
                             ------------------------------------------------------------------------------------------------------
                                $      763     $   10,701    $    7,947      $    3,517     $       44    $    3,318     $      155
                             ======================================================================================================


     All of the  restructuring  charges  which  include  tangible  assets  to be
disposed  of are  written  down to their  net  realizable  value,  less  cost of
disposal.  We expect recovery to approximate its cost of disposal.  Considerable
management  judgment is necessary to estimate  fair value;  accordingly,  actual
results could vary from such estimates.

7.       Income taxes

     The income tax provision consists of the following:




                                                                          Year Ended December 31,
(in thousands)                                              2000                    1999                   1998
                                                                                                
- ------------------------------------------------------------------------------------------------------------------------
Current provision:
   Federal                                               $   40,515              $   26,933              $   20,171
   State                                                      5,668                   4,190                   3,049
   Foreign                                                     (538)                    758                     278
                                                   ---------------------------------------------------------------------
      Total current provision                                45,645                  31,881                  23,498
                                                   ---------------------------------------------------------------------
Deferred provision:
   Federal                                                  (37,757)                 68,627                   8,694
   State                                                     (4,335)                  7,590                   1,374
                                                   ---------------------------------------------------------------------
      Total deferred provision                              (42,092)                 76,217                  10,068
                                                   ---------------------------------------------------------------------
Total current and deferred provision                     $    3,553              $  108,098              $   33,566
                                                   =====================================================================



         Income taxes included in the Consolidated Statement of Operations are:



                                                                          Year Ended December 31,
(in thousands)                                              2000                    1999                   1998
                                                                                                
- ------------------------------------------------------------------------------------------------------------------------
Continuing operations                                    $    3,553              $  108,098              $   33,566
Extraordinary loss on early retirement of debt                 (685)                 (4,492)                      -
                                                   ---------------------------------------------------------------------
                                                         $    2,868              $  103,606              $   33,566
                                                   =====================================================================



         A  reconciliation  of the  statutory  federal  income  tax rate and the
effective  tax rate follows (the effect of foreign  taxes on the  effective  tax
rate for 2000, 1999 and 1998 is immaterial):



                                                                          Year Ended December 31,
                                                            2000                    1999                   1998
                                                                                                   
- ------------------------------------------------------------------------------------------------------------------------
Statutory federal income tax rate                           35.0%                   35.0%                   35.0%
State taxes, net of federal benefit                          3.3                     3.6                     3.8
Non-deductible amortization of goodwill and
   customer contracts                                     (103.6)                    1.8                     4.9
Other, net                                                 (14.2)                    0.3                     0.3
                                                   ---------------------------------------------------------------------
Effective tax rate                                         (79.5)%                  40.7%                   44.0%
                                                   =====================================================================


         The deferred tax assets and  deferred tax  liabilities  recorded in the
consolidated balance sheet are as follows:




                                                                    December 31,
(in thousands)                                              2000                    1999
                                                                          
- -------------------------------------------------------------------------------------------------
Deferred tax assets:
   Allowance for doubtful accounts                      $     9,087             $     5,744
   Accrued expenses                                          16,203                  23,864
   Depreciation and property differences                          -                   7,112
   Non-compete agreements                                     2,292                   2,008
   Net operating loss carryforward                            2,975                   7,829
   Unrealized loss on investments                                 -                   6,000
   Other                                                      2,366                     693
                                                   ----------------------------------------------
     Gross deferred tax assets                               32,923                  53,250
                                                   ----------------------------------------------
Deferred tax liabilities:
   Gain on sale of assets                                         -                 (62,987)
   Depreciation and property differences                    (17,799)                      -
   Goodwill and customer contract amortization
                                                            (15,026)                 (7,942)
   Other                                                     (2,341)                   (985)
                                                   ----------------------------------------------
     Gross deferred tax liabilities                         (35,166)                (71,914)
                                                   ----------------------------------------------
Net deferred tax liabilities                            $    (2,243)            $   (18,664)
                                                   ==============================================


8.       Commitments and contingencies

     During  September  2000, we sold our  Albuquerque,  New Mexico property and
building for  $7,806,000.  These assets were then leased back from the purchaser
over a  period  of 10  years  with  the  option  to  extend  the  terms up to an
additional 10 years.  The resulting lease is being accounted for as an operating
lease, and the resulting deferred gain of $4,136,000 is being amortized over the
10 year life of the lease.

     We have entered into noncancellable  agreements to lease certain office and
distribution  facilities  with  remaining  terms from one to ten  years.  Rental
expense under the office and  distribution  facilities  leases in 2000, 1999 and
1998 was  $12,041,000,  $11,147,000  and  $3,876,000,  respectively.  The future
minimum lease payments due under noncancellable  operating leases are as follows
(in thousands):


             Year Ended December 31,
- --------------------------------------------------------
                      2001               $     13,702
                      2002                     13,140
                      2003                     12,980
                      2004                     13,007
                      2005                     12,722
                   Thereafter                  34,333
                                    --------------------
                                         $     99,884
                                    ====================

     For  the  year  ended  December  31,  2000,   approximately  60.0%  of  our
pharmaceutical   purchases  were  through  one  wholesaler.   We  believe  other
alternative  sources are readily available and that no other concentration risks
exist at December 31, 2000.

     In the ordinary course of business  (which includes the business  conducted
by DPS and ValueRx  prior to acquiring  them on April 1, 1999 and April 1, 1998,
respectively), various legal proceedings,  investigations or claims pending have
arisen against us and our  subsidiaries  (ValueRx and DPS continue to be a party
to  proceedings  that  arose  prior to their  April 1,  1998 and  April 1,  1999
respective  acquisition  dates). The effect of these actions on future financial
results is not subject to reasonable estimation because considerable uncertainty
exists  about  the  outcomes.   Nevertheless,   in  our  opinion,  the  ultimate
liabilities  resulting  from any such  lawsuits,  investigations  or claims  now
pending  are not  expected  to  materially  affect  our  consolidated  financial
position, results of operations or cash flows.


9.       Common stock

     Prior to November 7, 2000, NYLife Healthcare Management, Inc., a subsidiary
of New York Life Insurance Company, owned all of our outstanding shares of Class
B Common  Stock.  On  November  7,  2000,  NYLife  Healthcare  Management,  Inc.
exchanged  each  outstanding  share of Class B Common Stock for one share of our
Class A Common Stock and then immediately distributed such shares to NYLIFE LLC,
another  subsidiary  of New York Life.  Consequently,  on November  7, 2000,  we
reacquired all of our outstanding  Class B Common Stock and currently hold it as
treasury shares.  Immediately  following the exchange and distribution to NYLIFE
LLC,  NYLIFE LLC  completed  the sale of 6,900,000  shares of our Class A Common
Stock to the public  through a  secondary  offering.  Contemporaneous  with this
stock  offering,  the Express  Scripts  Automatic  Exchange  Security  Trust,  a
closed-end  investment  company that is not  affiliated  with us, sold 3,450,000
investment units to the public. Upon maturity of the investment units, the Trust
may deliver up to  3,450,000  shares of our Class A Common Stock owned by NYLIFE
LLC to the holders of the investment units. We did not receive any proceeds from
the secondary offering or the offering by the Trust.

     At December 31,  2000,  NYLIFE LLC owned shares of our Class A Common Stock
representing  approximately 20.8% of the combined voting power of all classes of
our common  stock,  which  includes the right to vote  3,450,000  Class A Common
Stock that the Trust may deliver upon  exchange of the Trust  issued  investment
units.  New York Life has  agreed on behalf of itself and its  subsidiaries,  to
vote  these  3,450,000  shares of our  Class A Common  Stock  prior to  delivery
thereof by the Trust to the  holders of the Trust  investment  units in the same
proportion and to the same effect as the votes cast by our other stockholders at
any meeting of stockholders,  subject to the following exceptions: New York Life
has agreed to vote its  8,120,000  shares  (which  includes the above  described
3,450,000 shares) in favor of the slate of nominees for directors recommended by
our Board of Directors for election by  stockholders  (provided that, so long as
New York Life is  entitled to  representation  on the Board of  Directors,  such
slate  includes  New York  Life's  nominees)  and the  adoption  of the  Express
Scripts, Inc. 2000 Long-Term Incentive Plan.

     As of December 31, 2000, we have repurchased a total of 1,265,000 shares of
our Class A Common Stock under the open-market stock repurchase
program  we  announced  on October  25,  1996,  of which,  790,000  shares  were
repurchased  during 2000.  Approximately  766,000  shares have been utilized for
stock option  exercises  and 219,000  shares have been  utilized for  restricted
stock awards during 2000.  Our Board of Directors  approved the repurchase of up
to  2,500,000  shares,  and  placed  no limit on the  duration  of the  program.
Additional  purchases,  if any,  will be in such amounts and at such times as we
deem appropriate based upon prevailing market and business  conditions,  subject
to  certain  restrictions  on stock  repurchases  contained  in our bank  credit
facility and the Indenture covering our Senior Notes.

     As of December  31,  2000,  approximately  4,659,000  shares of our Class A
Common Stock have been reserved for issuance to organizations with which we have
signed  contractual  agreements (see Note 3) and for employee benefit plans (see
Note 10).

     In June 1999, we consummated our offering of 5,175,000  shares of our Class
A Common  Stock at a price of $61 per share.  The net  proceeds of  $299,378,000
were used to retire the $150 million senior  subordinated bridge credit facility
and a portion of the Term B loans under the $1.05 billion credit facility.

     In October 1998, we announced a two-for-one  stock split of our Class A and
Class B Common Stock for  stockholders of record on October 20, 1998,  effective
October 30,  1998.  The split was effected in the form of a dividend by issuance
of one additional share of Class A Common Stock for each share of Class A Common
Stock  outstanding  and one  additional  share of Class B Common  Stock for each
share of Class B Common  Stock  outstanding.  The  earnings  per  share  and the
weighted average number of shares outstanding for basic and diluted earnings per
share  have  been  adjusted  for the  stock  split  except  on the  Consolidated
Statement of Changes in Stockholders' Equity.

10.      Employee benefit plans and stock-based compensation plans

     Retirement  savings  plan.  We  offer  all of  our  full-time  employees  a
retirement  savings  plan under  Section  401(k) of the Internal  Revenue  Code.
Employees may elect to enter a written salary  deferral  agreement under which a
maximum of 15% of their salary,  subject to aggregate  limits required under the
Internal  Revenue  Code,  may be  contributed  to the plan. We match 100% of the
first 4% of the employees'  compensation  contributed to the Plan. For the years
ended  December  31,  2000,  1999  and  1998,  we had  contribution  expense  of
approximately $4,718,000, $3,604,000 and $1,751,000, respectively.

     Employee stock purchase plan. In December 1998, our Board of Directors
approved  an  employee  stock  purchase  plan,  effective  March 1,  1999,  that
qualifies  under  Section  423 of the  Internal  Revenue  Code and  permits  all
employees,  excluding certain management level employees,  to purchase shares of
our Class A Common Stock.  Participating employees may elect to contribute up to
10% of their  salary  to  purchase  common  stock  at the end of each six  month
participation  period at a purchase  price equal to 85% of the fair market value
of our Class A Common Stock at the end of the participation  period. During 2000
and 1999,  approximately  32,000 and 10,000  shares of our Class A Common  Stock
were issued  under the plan,  respectively.  Class A Common  Stock  reserved for
future employee purchases under the plan is 209,000 at December 31, 2000.

     Deferred compensation plan. In December 1998, the Compensation Committee of
the Board of Directors approved a non-qualified  deferred compensation plan (the
"Executive  Deferred  Compensation  Plan"),  effective  January  1,  1999,  that
provides  benefits payable to eligible key employees at retirement,  termination
or death.  Benefit  payments are funded by a combination of  contributions  from
participants and us.  Participants  become fully vested in our  contributions on
the third  anniversary of the end of the plan year for which the contribution is
credited to their account.  For 2000, our  contribution  was equal to 6% of each
qualified  participant's total annual  compensation,  with 25% being invested in
our Class A Common  Stock and the  remaining  being  allocated  to a variety  of
investment   options.  We  incurred   approximately   $89,000  and  $224,000  of
compensation expense in 2000 and 1999,  respectively.  In addition,  we recorded
$797,000 of compensation  expense in 1998 as a past service  contribution  which
was equal to 8% of each  participant's  total annual cash  compensation  for the
period of the participant's past service with us in a senior executive capacity.
At December 31, 2000,  50,000  shares of Class A Common Stock have been reserved
for future issuance under the plan.

     Stock-based  compensation  plans.  In August  2000,  the Board of Directors
adopted  the Express  Scripts,  Inc.  2000  Long-Term  Incentive  Plan which was
subsequently  amended in February  2001 (as  amended,  the "2000  LTIP"),  which
provides  for the  grant of  various  equity  awards to our  officers,  Board of
Directors and key employees selected by the Compensation  Committee of the Board
of Directors.  The 2000 LTIP is subject to approval of our  stockholders.  As of
December 31, 2000, 271,000 shares of Class A Common Stock have been reserved for
issuance  under  this  plan.  During  2000,  we  granted  approximately  219,000
restricted shares of Class A Common Stock,  issued from shares held in treasury,
under the 2000 LTIP to certain of our officers and  employees.  These shares are
subject to various cliff-vesting periods from three to ten years with provisions
allowing for accelerated vesting based upon specific performance criteria. Prior
to vesting,  these  restricted  shares are subject to  forfeiture  to us without
consideration  upon  termination  of  employment  under  certain  circumstances.
Approximately 6,600 shares have been forfeited as of February 28, 2001. Unearned
compensation of $14,841,000  relating to the restricted shares has been recorded
as a  separate  component  of  stockholders'  equity and is being  amortized  to
non-cash compensation expense over the estimated vesting periods.

     As a result of the  Board's  adoption  of the 2000  LTIP,  and  subject  to
stockholder  approval  of the 2000 LTIP,  no  additional  awards will be granted
under  either of our 1992 amended and  restated  stock  option plans  (discussed
below) or under our 1994  amended and  restated  Stock  Option  Plan  (discussed
below).  However,  these plans are still in existence  as there are  outstanding
grants under these plans.

     In April 1992,  we adopted a stock option plan that we amended and restated
in 1995 and amended in 1999, which provided for the grant of nonqualified  stock
options and incentive  stock options to our officers and key employees  selected
by the Compensation Committee of the Board of Directors. In June 1994, the Board
of Directors  adopted the Express  Scripts,  Inc.  1994 Stock Option Plan,  also
amended and  restated in 1995 and amended in 1997,  1998 and 1999.  Under either
plan,  the exercise price of the options was not less than the fair market value
of the  shares  at the time of  grant,  and the  options  typically  vest over a
five-year period from the date of grant.

     In April  1992,  we also  adopted a stock  option plan that was amended and
restated  in 1995 and  amended in 1996 and 1999 that  provided  for the grant of
nonqualified stock options to purchase 48,000 shares to each director who is not
an employee of ours or our affiliates.  In addition, the second amendment to the
plan gave each non-employee  director who was serving in such capacity as of the
date of the second amendment the option to purchase 2,500 additional shares. The
second amendment  options will vest over three years. The plan provides that the
options  vest over a two-,  three- or  five-year  period  from the date of grant
depending upon the circumstances of the grant.

     We apply APB 25 and related  interpretations  in accounting  for our plans.
Accordingly,  compensation cost has been recorded based upon the intrinsic value
method of accounting  for  restricted  stock and no  compensation  cost has been
recognized  for our stock options  plans.  Had  compensation  cost for our stock
option based  compensation  plans been determined based on the fair value at the
grant dates for awards under those plans  consistent with the method  prescribed
by FAS 123, our net income and earnings per share would have been reduced to the
pro  forma  amounts  indicated  below.  Note  that  due to the  adoption  of the
methodology  prescribed  by FAS 123,  the pro forma  results  shown  below  only
reflect the impact of options  granted in 2000,  1999 and 1998.  Because  future
options may be granted and vesting typically occurs over a five year period, the
pro forma impact shown for 2000, 1999 and 1998 is not necessarily representative
of the impact in future years.

(in thousands, except per share data)  2000           1999           1998
- -----------------------------------------------------------------------------
Net income
   As reported                   $    (9,126)   $   150,218    $    42,674
   Pro forma                         (19,796)       142,753         38,585

Basic earnings per share
   As reported                   $     (0.24)   $      4.16    $      1.29
   Pro forma                           (0.52)          3.95           1.16

Diluted earnings per share
   As reported                   $     (0.24)   $      4.06    $      1.27
   Pro forma                           (0.52)          3.86           1.14

         The fair value of options  granted  (which is amortized to expense over
the option vesting period in determining the pro forma impact),  is estimated on
the date of grant using the Black-Scholes multiple option-pricing model with the
following weighted average assumptions:

                                   2000             1999        1998
- ---------------------------------------------------------------------------
Expected life of option          1-6 years      2-7 years     2-7 years
Risk-free interest rate          6.0%-6.7%      4.6%-6.3%     4.1%-5.9%
Expected volatility of stock      56%-60%          59%           44%
Expected dividend yield             None           None          None

         A summary of the status of our fixed stock  option plans as of December
31, 2000,  1999 and 1998,  and changes during the years ending on those dates is
presented below.







                                               2000                         1999                        1998
                                      ---------------------------------------------------------------------------------------
                                                    Weighted-Average            Weighted-Average             Weighted-Average
                                                      Exercise                  Exercise Price                 Exercise
                                                       Price                                                    Price
(share data in thousands)                Shares                      Shares                        Shares
                                                                                              
- -----------------------------------------------------------------------------------------------------------------------------
Outstanding at beginning of year          3,286        $ 35.24        2,780        $ 28.02          1,702       $ 17.21
Granted                                     891          48.06          843          60.43          1,866         40.65
Exercised                                  (777)         22.32         (196)         30.28           (133)        14.71
Forfeited/Cancelled                        (176)         48.55         (141)         50.35           (655)        38.82
                                      -------------               -------------                 ------------
Outstanding at end of year                3,224          41.16        3,286          35.24          2,780         28.02
                                      =============               =============                 ============

Options exercisable at year end           1,262                       1,391                           800
                                      =============               =============                 ============
Weighted-average fair value of
  options granted during the year      $  21.69                    $  32.40                      $  18.07
                                      =============               =============                 ============


         The following table  summarizes  information  about fixed stock options
outstanding at December 31, 2000:





                                           Options Outstanding                                Options Exercisable
                       ------------------------------------------------------------    ----------------------------------

      Range of
   Exercise Prices           Number         Weighted-Average                                Number       Weighted-Average
   (share data in        Outstanding at        Remaining        Weighted-Average         Exercisable     Exercise Price
     thousands)             12/31/00        Contractual Life     Exercise Price          at 12/31/00
                                                                                             
- ---------------------- ------------------- ------------------- --------------------    ----------------- ----------------
   $  3.25 - 17.00                  515                5.84            $    13.89               433            $  13.44
     20.81 - 35.63                  789                6.71                 28.88               412               27.81
     38.31 - 51.63                1,005                7.70                 44.59               152               48.17
     54.88 - 67.38                  721                8.54                 58.66               237               58.99
     70.16 - 88.56                  194                7.83                 80.63                28               80.82
                       -------------------                                             -----------------
   $  3.25 - 88.56                3,224                7.26            $    41.16             1,262            $  32.35
                       ===================                                             =================



11.      Condensed consolidating financial statements

     Our Senior Notes are unconditionally  and jointly and severally  guaranteed
by  our  wholly-owned   domestic  subsidiaries  other  than  PPS,  Great  Plains
Reinsurance  Co.,  ValueRx of Michigan,  Inc.,  Diversified  NY IPA,  Inc.,  and
Diversified  Pharmaceutical  Services  (Puerto Rico),  Inc.  Separate  financial
statements of the Guarantors are not presented as we have determined them not to
be material to  investors.  Therefore,  the  following  condensed  consolidating
financial information has been prepared using the equity method of accounting in
accordance  with the  requirements  for  presentation  of such  information.  We
believe  that  this  information,   presented  in  lieu  of  complete  financial
statements for each of the guarantor subsidiaries, provides sufficient detail to
allow  investors  to  determine  the  nature  of the  assets  held  by,  and the
operations  of,  each of the  consolidating  groups.  As of January 1, 2000,  we
undertook an internal  corporate  reorganization  to eliminate  various entities
whose existence was deemed to be no longer necessary,  including,  among others,
ValueRx,  and to create  several  new  entities to conduct  certain  activities,
including SDS and ESI Mail Pharmacy Service, Inc. ("ESI MPS"). Consequently, the
assets, liabilities and operations of ValueRx are incorporated into those of the
issuer, Express Scripts, Inc. and the assets,  liabilities and operations of SDS
and ESI MPS are incorporated into those of the Guarantors for 2000.


Condensed Consolidating Balance Sheet
- --------------------------------------------------------------------------------



                                                    Express
(in thousands)                                   Scripts, Inc.     Guarantors   Non-Guarantors        Eliminations    Consolidated
                                                                                                      
- -----------------------------------------------------------------------------------------------------------------------------------
As of December 31, 2000
Current assets                                     $   755,995     $   236,311      $     5,863      $         -     $   998,169
Property and equipment, net                            120,754          24,724            2,231                -         147,709
Investments in subsidiaries                            866,561               -            2,261         (868,822)              -
Intercompany                                          (216,039)        223,144           (7,105)               -               -
Goodwill, net                                          251,139         711,062            4,816                -         967,017
Other intangible assets, net                            55,175         101,640              279                -         157,094
Other assets                                            77,505         (73,162)           2,312                -           6,655
                                                 --------------- ---------------- ---------------- --------------- ----------------
    Total assets                                   $ 1,911,091     $ 1,223,719      $    10,657      $  (868,822)    $ 2,276,644
                                                 =============== ================ ================ =============== ================

Current liabilities                                $   630,888     $   478,583      $     6,473      $         -     $ 1,115,944
Long-term debt                                         396,441               -                -                -         396,441
Other liabilities                                      125,264         (64,514)          (1,735)               -          59,015
Stockholders' equity                                   758,497         809,650            5,919         (868,822)        705,244
                                                 --------------- ---------------- ---------------- --------------- ----------------
    Total liabilities and stockholders' equity     $ 1,911,091     $ 1,223,719      $    10,657      $  (868,822)    $ 2,276,644
                                                 =============== ================ ================ =============== ================

As of December 31, 1999
Current assets                                     $   549,374     $   509,702      $     7,279      $         -     $ 1,066,355
Property and equipment, net                             39,036          55,776            2,761                -          97,573
Investments in subsidiaries                            725,468               -            2,261         (727,729)              -
Investments in marketable securities                         -         150,365                -                -         150,365
Intercompany                                           463,438        (463,241)            (197)               -               -
Goodwill, net                                              168         976,759            5,569                -         982,496
Other intangible assets, net                            22,458         160,901               61                -         183,420
Other assets                                            13,179          (6,493)             563             (147)          7,102
                                                 --------------- ---------------- ---------------- --------------- ----------------
    Total assets                                   $ 1,813,121     $ 1,383,769      $    18,297      $  (727,876)    $ 2,487,311
                                                 =============== ================ ================ =============== ================

Current liabilities                                $   527,312     $   563,457      $     9,589      $         -     $ 1,100,358
Long-term debt                                         635,873               -                -                -         635,873
Other liabilities                                       83,365         (33,018)           1,251                -          51,598
Stockholders' equity                                   566,571         853,330            7,457         (727,876)        699,482
                                                 --------------- ---------------- ---------------- --------------- ----------------
    Total liabilities and stockholders' equity     $ 1,813,121     $ 1,383,769      $    18,297      $  (727,876)    $ 2,487,311
                                                 =============== ================ ================ =============== ================




Condensed Consolidating Statement of Operations
- -------------------------------------------------------------------------------



                                                    Express
(in thousands)                                   Scripts, Inc.     Guarantors     Non-Guarantors      Eliminations    Consolidated
                                                                                                      
- -----------------------------------------------------------------------------------------------------------------------------------
Year ended December 31, 2000
Total revenues                                     $ 4,262,854     $ 2,512,197      $    11,813      $         -     $ 6,786,864
Operating expenses                                   4,159,946       2,411,737           14,969                -       6,586,652
                                                 ----------------------------------------------------------------------------------
   Operating income (loss)                             102,908         100,460           (3,156)               -         200,212
Write-off of marketable securities                           -        (165,207)               -                -        (165,207)
Interest (expense) income                              (39,506)            (12)              45                -         (39,473)
                                                 ----------------------------------------------------------------------------------
   Income (loss) before tax effect                      63,402         (64,759)          (3,111)               -          (4,468)
Income tax provision (benefit)                          25,935         (21,079)          (1,303)               -           3,553
                                                 ----------------------------------------------------------------------------------
   Income (loss) before extraordinary loss              37,467         (43,680)          (1,808)               -          (8,021)
Extraordinary loss on early
   retirement of debt                                   (1,105)              -                -                -          (1,105)
                                                 ----------------------------------------------------------------------------------
   Net income (loss)                               $    36,362     $   (43,680)     $    (1,808)     $         -     $    (9,126)
                                                 ==================================================================================

Year ended December 31, 1999
Total revenues                                     $ 2,257,952     $ 1,989,237      $    40,915      $         -     $ 4,288,104
Operating expenses                                   2,140,144       1,971,696           39,480                -       4,151,320
                                                 ----------------------------------------------------------------------------------
   Operating income                                    117,808          17,541            1,435                -         136,784
Gain on sale of assets                                       -         182,930                -                -         182,930
Interest (expense) income                              (54,700)            292              160                -         (54,248)
                                                 ----------------------------------------------------------------------------------
   Income before tax provision                          63,108         200,763            1,595                -         265,466
Income tax provision                                    34,799          72,031            1,268                -         108,098
                                                 ----------------------------------------------------------------------------------
   Income before extraordinary loss                     28,309         128,732              327                -         157,368
Extraordinary loss on early
   retirement of debt                                   (7,150)              -                -                -          (7,150)
                                                 ----------------------------------------------------------------------------------
   Net income                                      $    21,159     $   128,732      $       327      $         -     $   150,218
                                                 ==================================================================================

Year ended December 31, 1998
Total revenues                                     $ 1,646,807     $ 1,167,387      $    10,678      $         -     $ 2,824,872
Operating expenses                                   1,584,731       1,139,387           11,520                -       2,735,638
                                                 ----------------------------------------------------------------------------------
   Operating income (loss)                              62,076          28,000             (842)               -          89,234
Interest (expense) income                              (13,943)            846              103                -         (12,994)
                                                 ----------------------------------------------------------------------------------
   Income (loss) before tax provision                   48,133          28,846             (739)               -          76,240
Income tax provision                                    17,903          15,377              286                -          33,566
                                                 ----------------------------------------------------------------------------------
   Net income (loss)                               $    30,230     $    13,469      $    (1,025)     $         -     $    42,674
                                                 ==================================================================================



Condensed Consolidating Statement of Cash Flows
- -------------------------------------------------------------------------------


                                                    Express
(in thousands)                                   Scripts, Inc.     Guarantors     Non-Guarantors      Eliminations    Consolidated
                                                                                                      
- -----------------------------------------------------------------------------------------------------------------------------------
Year ended December 31, 2000
Net cash (used in) provided by
  operating activities                             $  (313,023)    $   567,294      $    (8,214)     $      (147)    $   245,910
                                                 ----------------------------------------------------------------------------------

Cash flows from investing activities:
  Purchase of property and equipment                  (107,171)         27,215             (262)               -         (80,218)
  Proceeds from sales of property
     and equipment                                       8,831               -                -                -           8,831
  Other                                                 (2,191)              -                -                -          (2,191)
                                                 ----------------------------------------------------------------------------------
Net cash (used in) provided by
  investing activities                                (100,531)         27,215             (262)               -         (73,578)
                                                 ----------------------------------------------------------------------------------

Cash flows from financing activities:
  Repayment of long-term debt                         (240,069)              -                -                -        (240,069)
  Treasury stock acquired                              (30,247)              -                -                -         (30,247)
  Other                                                 18,689               -                -                -          18,689
  Net transactions with parent                         689,901        (697,226)           7,178              147               -
                                                 ----------------------------------------------------------------------------------
Net cash provided by (used in)
  financing activities                                 438,274        (697,226)           7,178              147        (251,627)
                                                 ----------------------------------------------------------------------------------
Effect of foreign currency
  translation adjustment                                  (131)              -                -                -            (131)
                                                 ----------------------------------------------------------------------------------

Net increase (decrease) in cash and
  cash equivalents                                      24,589        (102,717)          (1,298)               -         (79,426)
Cash and cash equivalents at beginning
  of year                                              123,722           4,198            4,710                -         132,630
                                                 ----------------------------------------------------------------------------------
Cash and cash equivalents at end of year           $   148,311     $   (98,519)     $     3,412      $         -     $    53,204
                                                 ==================================================================================

Year ended December 31, 1999
Net cash provided by (used in)
  operating activities                             $   229,381     $   (24,216)     $     8,747      $       147     $   214,059
                                                 ----------------------------------------------------------------------------------

Cash flows from investing activities:
  Purchase of property and equipment                   (23,656)        (12,652)            (650)               -         (36,958)
  Acquisitions, net of cash acquired                         -        (716,735)          (5,883)               -        (722,618)
                                                 ----------------------------------------------------------------------------------
Net cash (used in) provided by
  investing activities                                 (23,656)       (729,387)          (6,533)               -        (759,576)
                                                 ----------------------------------------------------------------------------------

Cash flows from financing activities:
  Repayment of long-term debt                       (1,015,000)              -                -                -      (1,015,000)
  Proceeds from long-term debt                       1,290,950               -                -                -       1,290,950
  Net proceeds from issuance of
     common stock                                      299,378               -                -                -         299,378
  Deferred financing fees                              (26,316)              -                -                -         (26,316)
  Other                                                  6,438               -                -                -           6,438
  Net transactions with parent                        (755,474)        754,976              645             (147)              -
                                                 ----------------------------------------------------------------------------------
Net cash (used in) provided by
  financing activities                                (200,024)        754,976              645             (147)        555,450
                                                 ----------------------------------------------------------------------------------

Effect of foreign currency
  translation adjustment                                   108               -                -                -             108
                                                 ----------------------------------------------------------------------------------

Net increase in cash and
  cash equivalents                                       5,809           1,373            2,859                -          10,041
Cash and cash equivalents at beginning
  of year                                              117,913           2,825            1,851                -         122,589
                                                 ----------------------------------------------------------------------------------
Cash and cash equivalents at end of year           $   123,722     $     4,198      $     4,710      $         -     $   132,630
                                                 ==================================================================================


12.      Segment information

     We are  organized on the basis of services  offered and have  determined we
have two reportable segments: PBM services and non-PBM services (defined in Note
1  "organization  and  operations").  We manage the pharmacy  benefit  within an
operating segment that encompasses a fully-integrated PBM service. The remaining
three operating service lines (IVTx, SDS and Vision) have been aggregated into a
non-PBM reporting segment.

     The following table presents  information about the reportable segments for
the years ended December 31:



(in thousands)                              PBM            Non-PBM         Total
                                                                  
- ------------------------------------------------------------------------------------------
2000
Total revenues                             $   6,698,820    $      88,044  $   6,786,864
Depreciation and amortization expense             77,830              785         78,615
Interest income                                    8,430                -          8,430
Interest expense                                  47,898                5         47,903
Income before income taxes                       (19,666)          15,198         (4,468)
Total assets                                   2,227,348           49,296      2,276,644
Capital expenditures                              78,065            2,153         80,218
- ------------------------------------------------------------------------------------------
1999
Total revenues                             $   4,222,294    $      65,810  $   4,288,104
Depreciation and amortization expense             71,156              711         71,867
Interest income                                    5,761                1          5,762
Interest expense                                  60,001                9         60,010
Income before income taxes                       259,182            6,284        265,466
Total assets                                   2,479,746            7,565      2,487,311
Capital expenditures                              35,895            1,063         36,958
- ------------------------------------------------------------------------------------------
1998
Total revenues                             $   2,765,111    $      59,761  $   2,824,872
Depreciation and amortization expense             25,466              983         26,449
Interest income                                    7,235                1          7,236
Interest expense                                  20,218               12         20,230
Income before income taxes                        70,107            6,133         76,240
Total assets                                   1,068,715           26,746      1,095,461
Capital expenditures                              23,432              421         23,853
- ------------------------------------------------------------------------------------------


13.      Quarterly financial data (unaudited)

- --------------------------------------------------------------------------------



                                                                               Quarters
                                               -------------------------------------------------------------------------
(in thousands, except per share data)                First           Second(1)          Third(2)          Fourth(3)
                                                                                               
- ------------------------------------------------------------------------------------------------------------------------
Fiscal 2000
Total revenues                                      $ 1,475,509        $ 1,653,367       $ 1,736,489       $ 1,921,499
Cost of revenues                                      1,343,063          1,515,964         1,603,650         1,784,515
Selling, general and administrative                      83,371             87,421            82,687            85,981
Operating income                                         49,075             49,982            50,152            51,003
Extraordinary loss on early retirement
    of debt                                                   -                  -              (898)             (207)
                                               -------------------------------------------------------------------------
Net income (loss)                                   $    21,432        $   (74,177)      $    23,875       $    19,744
                                               =========================================================================

Basic earnings per share:
    Before extraordinary loss                       $     0.56         $    (1.96)       $     0.64        $     0.52
    Extraordinary loss on early retirement
       of debt                                                -                  -            (0.02)            (0.01)
                                               -------------------------------------------------------------------------
    Net income (loss)                               $     0.56         $    (1.96)       $     0.62        $     0.51
                                               =========================================================================

Diluted earnings per share:(4)
    Before extraordinary loss                       $     0.55         $    (1.96)       $     0.63        $     0.51
    Extraordinary loss on early retirement
       of debt                                                -                  -            (0.02)            (0.01)
                                               -------------------------------------------------------------------------
    Net income (loss)                               $     0.55         $    (1.96)       $     0.61        $     0.50
                                               =========================================================================

<FN>

(1) Includes  a  non-cash  write-off  of  $155,500  ($97,032  net of tax) on our
    investment  in  PlanetRx.  Excluding  this  amount,  our basic  and  diluted
    earnings per share would have been $0.60 and $0.59, respectively.
(2) Includes an ordinary  gain of $1,500 ($926 net of tax) on the  restructuring
    of our interest rate swap agreements.  Excluding this amount,  our basic and
    diluted earnings per share before  extraordinary items would have been $0.62
    and $0.61, respectively.
(3) Includes  a  non-cash  write-off  of  $9,707  ($6,057  net  of  tax)  on our
    investment  in  PlanetRx.  Excluding  this  amount,  our basic  and  diluted
    earnings per share would have been $0.68 and $0.66, respectively.
(4) In  accordance  with FAS 128,  basic  weighted  average  shares were used to
    calculate  second  quarter  2000  diluted EPS as the net loss and the actual
    diluted  weighted  average shares (38,507 as of June 30, 2000) cause diluted
    EPS to be anti-dilutive.
</FN>





- ------------------------------------------------------------------------------------------------------------------------
                                                                               Quarters
                                               -------------------------------------------------------------------------
(in thousands, except per share data)                First           Second(1)           Third            Fourth(2)
                                                                                               
- ------------------------------------------------------------------------------------------------------------------------
Fiscal 1999
Total revenues                                      $   899,087        $   996,749       $ 1,083,496       $ 1,308,772
Cost of revenues                                        823,647            869,989           958,987         1,174,282
Selling, general and administrative                      46,440             81,897            78,761            87,096
Operating income                                         29,000             35,463            45,748            26,573
Extraordinary loss on early retirement
    of debt                                                   -             (6,597)             (553)                -
                                               -------------------------------------------------------------------------
Net income                                          $    13,543        $       421       $    16,995       $   119,259
                                               =========================================================================

Basic earnings per share:
    Before extraordinary loss                       $     0.41         $     0.20        $     0.46        $     3.10
    Extraordinary loss on early retirement
       of debt                                                -             (0.19)            (0.02)                 -
                                               -------------------------------------------------------------------------
    Net income                                      $     0.41         $     0.01        $     0.44        $     3.10
                                               =========================================================================

Diluted earnings per share:
    Before extraordinary loss                       $     0.40         $     0.20        $     0.45        $     3.03
    Extraordinary loss on early retirement
       of debt                                                -             (0.19)            (0.02)                 -
                                               -------------------------------------------------------------------------
    Net income                                      $     0.40         $     0.01        $     0.43        $     3.03
                                               =========================================================================
<FN>

(1) Includes the  acquisition  of DPS effective  April 1, 1999.  Also includes a
    non-recurring operating charge of $9,400 ($5,773 net of tax). Excluding this
    amount, our basic and diluted earnings per share before  extraordinary items
    would have been $0.38 and $0.37, respectively.
(2) Includes  non-recurring  operating charges and a one-time non-operating gain
    of  $20,821  ($12,415  net of  tax)  and  $182,903  ($112,037  net of  tax),
    respectively.  Excluding these amounts,  our basic and diluted  earnings per
    share  before   extraordinary   items  would  have  been  $0.51  and  $0.50,
    respectively.

</FN>



Item 9 - Changes in and  Disagreements  with Accountants on Accounting
          and Financial Disclosure

         None.

                                    PART III

Item 10 - Directors and Executive Officers of the Registrant

     The  information  required by this item will be  incorporated  by reference
from our definitive  Proxy Statement for our 2001 Annual Meeting of Stockholders
to be filed pursuant to Regulation 14A (the "Proxy Statement") under the heading
"I. Election of Directors";  provided that the Compensation  Committee Report on
Executive  Compensation,  the Audit Committee  Report and the performance  graph
contained in the Proxy Statement shall not be deemed to be incorporated  herein;
and  further  provided  that some of the  information  regarding  our  executive
officers  required by Item 401 of Regulation  S-K has been included in Part I of
this report.

Item 11 - Executive Compensation

     The  information  required by this item will be  incorporated  by reference
from  the  Proxy  Statement  under  the  headings   "Directors'   Compensation,"
"Compensation  Committee  Interlocks and Insider  Participation"  and "Executive
Compensation."

Item 12 - Security Ownership of Certain Beneficial Owners and Management

     The  information  required by this item will be  incorporated  by reference
from the Proxy  Statement  under the  headings  "Security  Ownership  of Certain
Beneficial Owners and Management."

Item 13 - Certain Relationships and Related Transactions

     The  information  required by this item will be  incorporated  by reference
from the Proxy Statement under the heading  "Certain  Relationships  and Related
Transactions."

                                     PART IV

Item 14 - Exhibits, Financial Statement Schedules and Reports on Form 8-K

(a)  Documents filed as part of this Report

    (1)  Financial Statements

              The  following   report  of   independent   accountants   and  our
         consolidated  financial  statements are contained in this Report on the
         page indicated

                                                                    Page No. In
                                                                     Form 10-K
                                                                 ---------------

         Report of Independent Accountants                              38

         Consolidated Balance Sheet as of
             December 31, 2000 and 1999                                 39

         Consolidated Statement of Operations
             for the years ended December 31, 2000,
             1999 and 1998                                              40

         Consolidated Statement of Changes in
             Stockholders' Equity for the years ended
             December 31, 2000, 1999 and 1998                           41

         Consolidated Statement of Cash Flows for
             the years ended December 31, 2000,
             1999 and 1998                                              42

         Notes to Consolidated Financial Statements                     43

    (2) The following  financial  statement schedule is contained in this Report
on the page indicated.

                                                                    Page No. In
         Financial Statement Schedule:                               Form 10-K
                                                                  --------------

         VIII.  Valuation and Qualifying Accounts
                   and Reserves for the years ended
                   December 31, 2000, 1999 and 1998                     69

              All other schedules are omitted because they are not applicable or
         the  required  information  is  shown  in  the  consolidated  financial
         statements or the notes thereto.

    (3)  List of Exhibits

         See Index to Exhibits on pages 70 - 75

(b)  Reports on Form 8-K


                           (i)      On  October  17,  2000,  we filed a  Current
                                    Report on Form 8-K,  dated  October 17, 2000
                                    under  Items  5 and  7,  regarding  a  press
                                    release  we  issued   concerning  our  third
                                    quarter 2000 financial performance.

                           (ii)     On  October  18,  2000,  we filed a  Current
                                    Report on Form 8-K,  dated  October 17, 2000
                                    under Items 5 and 7,  regarding an amendment
                                    to  the  employment  agreement  between  the
                                    Company  and Mr.  Toan,  our  President  and
                                    Chief Executive Officer.

                           (iii)    On  October  31,  2000,  we filed a  Current
                                    Report on Form 8-K,  dated  October 31, 2000
                                    under Item 5,  regarding our 1999 Drug Trend
                                    Report dated June 2000.


                                   SIGNATURES

         Pursuant to the  requirements  of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned thereunto duly authorized.

                                        EXPRESS SCRIPTS, INC.


February 26, 2001                   By:  /s/ Barrett A. Toan
                                         Barrett A. Toan, President
                                         and Chief Executive Officer


     Pursuant to the  requirements of the Securities  Exchange Act of 1934, this
report  has  been  signed  below  by the  following  persons  on  behalf  of the
registrant and in the capacities and on the dates indicated.

Signature                    Title                             Date

/s/ Barrett A. Toan          President,                        February 26, 2001
Barrett A. Toan              Chief Executive
                             Officer and
                             Chairman of the Board
                             Of Directors

/s/ George Paz               Senior Vice President and         February 26, 2001
George Paz                   Chief Financial Officer

/s/ Joseph W. Plum           Vice President and                February 26, 2001
Joseph W. Plum               Chief Accounting Officer

/s/ Stuart L. Bascomb        Director                          February 26, 2001
Stuart L. Bascomb

/s/ Gary G. Benanav          Director                          February 26, 2001
Gary G. Benanav

/s/ Frank J. Borelli         Director                          February 27, 2001
Frank J. Borelli

/s/ Barbara B. Hill          Director                          February 23, 2001
Barbara B. Hill

                             Director
Richard A. Norling

/s/ Seymour Sternberg        Director                          February 28, 2001
Seymour Sternberg

/s/ Howard L. Waltman        Director                          February 27, 2001
Howard L. Waltman

/s/ Norman Zachary           Director                          February 26, 2001
Norman Zachary




                              EXPRESS SCRIPTS, INC.
         Schedule VIII - Valuation and Qualifying Accounts and Reserves
                  Years Ended December 31, 2000, 1999 and 1998


        Col. A                Col. B                     Col. C                     Col. D             Col. E
- ----------------------     ------------     -------------------------------     --------------     -------------
                                                        Additions
                                            -------------------------------
                              Balance           Charges          Charges                               Balance
                                at             to Costs         to Other                               at End
                             Beginning            and              and                                   of
      Description            of Period         Expenses         Accounts         (Deductions)          Period
                                                                              
- ----------------------     ------------     -------------    --------------     --------------     -------------

Allowance for Doubtful
Accounts Receivable

Year Ended 12/31/98        $  4,801,563     $   4,583,008    $    9,570,069(1)  $    1,148,356     $  17,806,284
Year Ended 12/31/99        $ 17,806,284     $   4,989,041    $     (937,616)(2) $    4,576,997     $  17,280,712
Year Ended 12/31/00        $ 17,280,712     $  12,843,253    $   (1,370,986)(3) $    6,075,618     $  22,677,361

<FN>

(1)  Represents the opening  balance sheet for our April 1, 1998  acquisition of
ValueRx.
(2)  Represents the opening balance sheet adjustment for ValueRx and the opening
     balance sheet for our April 1, 1999 acquisition of DPS.
(3)  Represents the opening balance sheet adjustment for DPS.

</FN>


                                INDEX TO EXHIBITS
            (Express Scripts, Inc. - Commission File Number 0-20199)


Exhibit
Number          Exhibit

2.1(2)         Stock Purchase  Agreement by and among SmithKline  Beecham
               Corporation,   SmithKline  Beecham  InterCredit  BV  and  Express
               Scripts,  Inc., dated as of February 9, 1999, and certain related
               Schedules,  incorporated  by  reference to Exhibit No. 2.1 to the
               Company's Current Report on Form 8-K filed February 18, 1999.

2.2            Asset Contribution and Reorganization  Agreement dated August
               31, 1999 by and among PlanetRx.com, Inc., PRX Holdings, Inc., PRX
               Acquisition, Corp., YourPharmacy.com,  Inc., and Express Scripts,
               Inc.  (incorporated  by  reference  to  the  Exhibit  No.  2.1 to
               PlanetRx's   Registration  Statement  on  Form  S-1,  as  amended
               (Registration Number 333-82485)).

3.1            Certificate  of  Incorporation  of the Company,  as amended,
               incorporated  by  reference  to Exhibit No. 3.1 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1999.

3.2(1)         Third Amended and Restated Bylaws, as amended.

4.1            Form of Certificate for Class A Common Stock, incorporated by
               reference  to  Exhibit  No.  4.1  to the  Company's  Registration
               Statement  on Form S-1 filed  June 9, 1992  (Registration  Number
               33-46974).

4.2            Indenture,  dated as of June 16,  1999,  among the  Company,
               Bankers Trust Company, as trustee,  and Guarantors named therein,
               incorporated  by  reference  to Exhibit No. 4.4 to the  Company's
               Registration   Statement   on  Form  S-4  filed  August  4,  1999
               (Registration Number 333-83133).

4.3            Supplemental  Indenture,  dated as of October  6,  1999,  to
               Indenture dated as of June 16, 1999,  among the Company,  Bankers
               Trust  Company,   as  trustee,   and  Guarantors  named  therein,
               incorporated  by  reference  to Exhibit No. 4.3 to the  Company's
               Annual Report on Form 10-K for the year ending December 31, 1999.

4.4            Second Supplemental Indenture,  dated as of July 19, 2000, to
               Indenture dated as of June 16, 1999,  among the Company,  Bankers
               Trust  Company,   as  trustee,   and  Guarantors  named  therein,
               incorporated  by  reference  to Exhibit No. 4.4 to the  Company's
               Quarterly  Report on Form  10-Q for the  quarter  ended  June 30,
               2000.

4.5            Stockholder  and  Registration  Rights  Agreement dated as of
               October 6, 2000  between the Company and New York Life  Insurance
               Company,  incorporated  by  reference  to Exhibit  No. 4.2 to the
               Company's  Amendment No. 1 to Registration  Statement on Form S-3
               filed October 17, 2000 (Registration Number 333-47572).

4.6            Asset Acquisition  Agreement dated October 17, 2000,  between
               NYLIFE Healthcare Management,  Inc., the Company,  NYLIFE LLC and
               New York Life  Insurance  Company,  incorporated  by reference to
               Exhibit  No.  4.3  to  the  Company's  amendment  No.  1  to  the
               Registration  Statement  on  Form  S-3  filed  October  17,  2000
               (Registration Number 333-47572).

10.1           Lease Agreement dated March 3, 1992, between Riverport, Inc.
               and Douglas Development  Company--Irvine Partnership in commendam
               and the Company,  incorporated  by reference to Exhibit No. 10.21
               to the  Registration  Statement  on Form S-1  filed  June 9, 1992
               (Registration Number 33-46974).

10.2           First  Amendment  to Lease  dated as of December  29,  1992,
               between Sverdrup/MDRC Joint Venture and the Company, incorporated
               by  reference  to Exhibit No.  10.13 to the  Company's  Quarterly
               Report on Form 10-Q for the quarter ending June 30, 1993.

10.3           Second Amendment to Lease dated as of May 28, 1993,  between
               Sverdrup/MDRC  Joint  Venture and the  Company,  incorporated  by
               reference to Exhibit No. 10.14 to the Company's  Quarterly Report
               on Form 10-Q for the quarter ending June 30, 1993.

10.4           Third  Amendment  to Lease  entered  into as of October  15,
               1993, by and between Sverdrup/MDRC Joint Venture and the Company,
               incorporated  by reference to Exhibit No. 10.69 to the  Company's
               Annual Report on Form 10-K for the year ending 1993.

10.5           Fourth Amendment to Lease dated as of March 24, 1994, by and
               between Sverdrup/MDRC Joint Venture and the Company, incorporated
               by reference to Exhibit No. 10.70 to the Company's  Annual Report
               on Form 10-K for the year ending 1993.

10.6           Fifth  Amendment  to Lease made and  entered  into June 30,
               1994,  between  Sverdrup/MDRC  Joint  Venture  and  the  Company,
               incorporated  by  reference  to  Exhibit  10.1  to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1994.

10.7           Sixth  Amendment  to Lease made and entered into January 31,
               1995,  between  Sverdrup/MDRC  Joint  Venture  and  the  Company,
               incorporated  by reference to Exhibit No. 10.70 to the  Company's
               Annual Report on Form 10-K for the year ending 1994.

10.8           Seventh  Amendment to Lease dated as of August 14, 1998,  by
               and between Duke Realty Limited  Partnership,  by and through its
               general partner, Duke Realty Investments,  Inc., and the Company,
               incorporated  by reference  to Exhibit No. 10.3 to the  Company's
               Quarterly  Report on Form 10-Q for the quarter  ending  September
               30, 1998.

10.9           Eighth  Amendment to Lease dated as of August 14,  1998,  by
               and between Duke Realty Limited  Partnership,  by and through its
               general partner, Duke Realty Investments,  Inc., and the Company,
               incorporated  by reference  to Exhibit No. 10.4 to the  Company's
               Quarterly  Report on Form 10-Q for the quarter  ending  September
               30, 1998.

10.10          Ninth  Amendment to Lease dated as of February 19, 1999, by
               and between Duke Realty Limited  Partnership,  by and through its
               general partner, Duke Realty Investments,  Inc., and the Company,
               incorporated  by reference to Exhibit No. 10.29 to the  Company's
               Annual Report on Form 10-K/A for the year ending 1998.

10.11(3)       Express Scripts, Inc. 1992 Stock Option Plan, incorporated
               by reference to Exhibit No. 10.23 to the  Registration  Statement
               on Form S-1 filed June 9, 1992 (Registration Number 33-46974).

10.12(3)       Express  Scripts,  Inc.  Stock  Option  Plan for  Outside
               Directors,  incorporated by reference to Exhibit No. 10.24 to the
               Registration   Statement   on  Form  S-1   filed   June  9,  1992
               (Registration Number 33-46974).

10.13(3)       Express Scripts, Inc. 1994 Stock Option Plan, incorporated
               by  reference  to Exhibit  No.  10.4 to the  Company's  Quarterly
               Report on Form 10-Q for the quarter ending June 30, 1994.

10.14(3)       Amended and Restated Express  Scripts,  Inc. 1992 Employee
               Stock Option Plan, incorporated by reference to Exhibit No. 10.78
               to the  Company's  Annual Report on Form 10-K for the year ending
               1994.

10.15(3)       First  Amendment  to Express  Scripts,  Inc.  Amended and
               Restated  1992 Stock  Option Plan  incorporated  by  reference to
               Exhibit D to the Company's Proxy Statement dated April 22, 1999.

10.16(3)       Second  Amendment to Express  Scripts,  Inc.  Amended and
               Restated  1992 Stock  Option Plan  incorporated  by  reference to
               Exhibit F to the Company's Proxy Statement dated April 22, 1999.

10.17(3)       Amended and Restated  Express  Scripts,  Inc. Stock Option
               Plan for Outside Directors,  incorporated by reference to Exhibit
               No.  10.79 to the  Company's  Annual  Report on Form 10-K for the
               year ending 1994.

10.18(3)       First  Amendment  to Express  Scripts,  Inc.  Amended and
               Restated   1992  Stock   Option   Plan  for   Outside   Directors
               incorporated  by  reference to Exhibit A to the  Company's  Proxy
               Statement dated April 9, 1996.

10.19(3)       Second  Amendment to Express  Scripts,  Inc.  Amended and
               Restated   1992  Stock   Option   Plan  for   Outside   Directors
               incorporated  by  reference to Exhibit G to the  Company's  Proxy
               Statement dated April 22, 1999.

10.20(3)       Amended and Restated  Express  Scripts,  Inc.  1994 Stock
               Option Plan incorporated by reference to Exhibit No. 10.80 to the
               Company's Annual Report on Form 10-K for the year ending 1994.

10.21(3)       First  Amendment  to Express  Scripts,  Inc.  Amended and
               Restated  1994 Stock  Option Plan  incorporated  by  reference to
               Exhibit A to the Company's Proxy Statement dated April 16, 1997.

10.22(3)       Second  Amendment to Express  Scripts,  Inc.  Amended and
               Restated  1994 Stock  Option Plan  incorporated  by  reference to
               Exhibit A to the Company's Proxy Statement dated April 21, 1998.

10.23(3)       Third  Amendment  to Express  Scripts,  Inc.  Amended and
               Restated  1994 Stock  Option Plan,  incorporated  by reference to
               Exhibit C to the Company's Proxy Statement dated April 22, 1999.

10.24(3)       Fourth  Amendment to Express  Scripts,  Inc.  Amended and
               Restated  1994 Stock  Option Plan,  incorporated  by reference to
               Exhibit E to the Company's Proxy Statement dated April 22, 1999.

10.25(3)       Express  Scripts,  Inc.  2000 Long Term  Incentive  Plan,
               incorporated  by  reference  to Exhibit No. 4.3 to the  Company's
               Registration Statement on Form S-8, filed with the Securities and
               Exchange  Commission  on  August  9,  2000  (Registration  Number
               333-43336).

10.26(3)       Express  Scripts,   Inc.  Employee  Stock  Purchase  Plan
               incorporated  by  reference  to Exhibit No. 4.1 to the  Company's
               Registration  Statement  on Form  S-8  filed  December  29,  1998
               (Registration Number 333-69855).

10.27(3)       Express  Scripts,  Inc.  Executive  Deferred  Compensation
               Plan, as amended, incorporated by reference to Exhibit No 10.1 to
               the  Company's  Quarterly  Report  on From  10-Q for the  quarter
               ending June 30, 2000.

10.28(3)       Employment  Agreement  effective  as of  April  1,  1999,
               between  Barrett  A.  Toan  and  the  Company,   incorporated  by
               reference to Exhibit No. 10.1 to the Company's  Quarterly  Report
               on Form 10-Q for the quarter ending March 31, 1999.

10.29(3)       Amendment to the Employment  Agreement between the Company
               and Barrett A. Toan,  incorporated  by  reference  to Exhibit No.
               10.1 to the  Company's  Current  Report on Form 8-K dated October
               17, 2000 and filed October 18, 2000.

10.30(3)       Form of Severance  Agreement dated as of January 27, 1998,
               between the Company and each of the following individuals: Stuart
               L.  Bascomb,  Thomas  M.  Boudreau,  Linda L.  Logsdon,  David A.
               Lowenberg,  George Paz,  Terrence D. Arndt (agreement dated as of
               May 26,  1999),  Mabel Chen  (agreement  dated as of Novemebr 23,
               1999),  Mark O. Johnson  (agreement dated as of May 26, 1999) and
               Edward J.  Tenholder  (dated  December 4, 2000)  incorporated  by
               reference to Exhibit No. 10.70 to the Company's  Annual Report on
               Form 10-K for the year ending December 31, 1997.

10.31          Credit  Agreement  dated  as of April 1,  1999  among  the
               Company,  the Lenders listed therein,  Credit Suisse First Boston
               as lead  Arranger,  Administrative  Agent and  Collateral  Agent,
               Bankers  Trust  Company  as  Syndication  Agent,  BT Alex.  Brown
               Incorporated as  Co-Arranger,  The First National Bank of Chicago
               as   Co-Documentation   Agent,   and  Mercantile  Bank,  N.A.  as
               co-Documentation Agent,  incorporated by reference to Exhibit No.
               10.8 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending June 30, 1999.

10.32          Amendment  No.1 to Credit  Agreement  dated as of April 1,
               1999 among the Company, the Lenders listed therein, Credit Suisse
               First Boston as Lead Arranger,  Administrative Agent and BT Alex.
               Brown  Incorporated  as  Co-Arranger,  The First National Bank of
               Chicago as  Co-Documentation  Agent, and Mercantile Bank, N.A. as
               Co-Documentation Agent,  incorporated by reference to Exhibit No.
               10.1 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending September 30, 1999.

10.33          Amendment No. 2 to Credit  Agreement  dated as of April 1,
               1999 among the Company, the Lenders listed therein, Credit Suisse
               First  Boston  as  Lead   Arranger,   Administrative   Agent  and
               Collateral Agent,  Bankers Trust Company as Syndication Agent, BT
               Alex. Brown Incorporated as Co-Arranger,  The First National Bank
               of Chicago as  Co-Documentation  Agent, and Mercantile Bank, N.A.
               as Co-Documentation  Agent,  incorporated by reference to Exhibit
               No. 10.2 to the Company's  Quarterly  Report on Form 10-Q for the
               quarter ending September 30, 1999.

10.34          Amendment No. 3 and Waiver to Credit  Agreement dated as of
               April 1, 1999 among the  Company,  the  Lenders  listed  therein,
               Credit Suisse First Boston as Lead Arranger, Administrative Agent
               and Collateral Agent, Bankers Trust Company as Syndication Agent,
               BT Alex.  Brown  Incorporated as Co-Arranger,  The First National
               Bank of Chicago as  Co-Documentation  Agent, and Mercantile Bank,
               N.A. as  Co-Documentation  Agent,  incorporated  by  reference to
               Exhibit No. 10.3 to the Company's  Quarterly  Report on Form 10-Q
               for the quarter ending September 30, 1999.

10.35          Subsidiary  Guaranty dated as of April 1, 1999, in favor of
               Credit  Suisse First Boston as  Collateral  Agent and the Lenders
               listed in the Credit Agreement, by the following parties: Managed
               Prescription  Network,  Inc.,  Value Health,  Inc.,  IVTx,  Inc.,
               Express  Scripts  Vision Corp.,  ESI/VRx Sales  Development  Co.,
               HealthCare  Services,  Inc., MHI, Inc.,  ValueRx,  Inc.,  ValueRx
               Pharmacy  Program,  Inc.,  Diversified  Pharmaceutical  Services,
               Inc., ESI OnLine, Inc.,  incorporated by reference to Exhibit No.
               10.9 to the  Company's  Quarterly  Report  on Form  10-Q  for the
               quarter ending June 30, 1999.

10.36          Company Pledge  Agreement dated as of April 1, 1999, by the
               Company  in favor of Credit  Suisse  First  Boston as  Collateral
               Agent  and  the   Lenders   listed  in  the   Credit   Agreement,
               incorporated  by reference to Exhibit No. 10.10 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1999.

10.37          Subsidiary  Pledge Agreement dated as of April 1, 1999, in
               favor of Credit Suisse First Boston as  Collateral  Agent and the
               Lenders listed in the Credit Agreement, by the following parties:
               ESI Canada Holdings,  Inc., Value Health,  Inc.,  ValueRx,  Inc.,
               incorporated  by reference to Exhibit No. 10.11 to the  Company's
               Quarterly  Report on Form 10-Q for the  quarter  ending  June 30,
               1999.

10.38          International  Swap  Dealers   Association,   Inc.  Master
               Agreement dated as of April 3, 1998,  between the Company and The
               First  National  Bank of Chicago,  incorporated  by  reference to
               Exhibit No. 10.6 to the Company's  Quarterly  Report on Form 10-Q
               for the quarter ending June 30, 1998.

10.39          Swap Transaction Confirmation Agreement between the Company
               and Bankers Trust Company  dated June 17, 1999,  incorporated  by
               reference to Exhibit No. 10.5 to the Company's  Quarterly  Report
               on Form 10-Q for the quarter ending September 30, 1999.

10.40(4)       Agreement dated June 19, 2000 by and among the Company and
               PlanetRx.com, Inc., incorporated by reference to Exhibit No. 7 to
               Schedule 13D dated June 19, 2000 (filed June 29, 2000),  filed by
               the Company with respect to PlanetRx.com, Inc.

10.41          Amended and Restated  Investor's  Rights Agreement dated as
               of June 3, 1999, incorporated by reference to the Exhibit No. 4.2
               to  PlanetRx's  Registration  Statement  on Form S-1,  as amended
               (Registration Number 333-82485).

10.42          Amendment  of  Amended  and  Restated   Investor's  Rights
               Agreement   dated  as  of  October   13,   1999  by  and  between
               PlanetRx.com,  Inc. and YourPharmacy.com,  Inc.  (incorporated by
               reference  to Exhibit 4 to  Schedule  13D dated  October 21, 1999
               filed  October 22,  1999)  filed by Express  Scripts,  Inc.  with
               respect to PlanetRx.com, Inc. (File No. 000-27437).

12.1(1)        Computation of Ratios of Earnings to Fixed Charges.

21.1(1)        List of Subsidiaries.

23.1(1)        Consent of PricewaterhouseCoopers LLP.

[FN]

1    Filed herein.
2    The Company agrees to furnish supplementally a copy of any omitted schedule
     to this agreement to the Commission upon request.
3    Management contract or compensatory plan or arrangement.
4    Confidential treatment was granted for certain portions of this exhibit.
</FN>