AMENDMENT NO. 2 TO MANAGEMENT AGREEMENT

                                      Among

                            INTEGRAMED AMERICA, INC.

                                       AND

              REPRODUCTIVE ENDOCRINE & FERTILITY CONSULTANTS, P.A.


                                       And

                MIDWEST FERTILITY FOUNDATIONS & LABORATORY, INC.


         THIS AMENDMENT NO. 2 TO MANAGEMENT AGREEMENT ("Amendment No. 2"), dated
July 1, 1998 by and among IntegraMed America, Inc., a Delaware corporation, with
its principal place of business at One Manhattanville Road,  Purchase,  New York
10577  ("INMD")  and  Reproductive  Endocrine & Fertility  Consultants,  P.A., a
professional  association,  doing business as Reproductive  Science  Associates,
having its  principal  place of business at Two Brush Creek,  Suite 500,  Kansas
City,  Missouri 64112, and Midwest Fertility  Foundations & Laboratory,  Inc., a
Kansas  corporation,  having its principal place of business at Two Brush Creek,
Suite 500,  Kansas City,  Missouri  64112.  (Reproductive  Endocrine & Fertility
Consultants,  P.A. and Midwest  Fertility  Foundations  &  Laboratory,  Inc. are
collectively referred to as "PA").

                                    RECITALS:

         WHEREAS, INMD and PA entered into a Management Agreement dated November
1, 1995 (the "Management Agreement"), which was amended May 22, 1997 ("Amendment
No.  1"),  pursuant  to which INMD  agreed to  provide  certain  management  and
administrative services to PA; and

         WHEREAS, INMD and PA wish to amend further the Management Agreement, in
pertinent  part,  to, among other things,  (i) modify the management fee payment
and (ii)  provide for joint  responsibilities  and duties  under the  Management
Agreement, as amended.

         NOW THEREFORE,  in  consideration  of the mutual promises and covenants
herein contained, and as contained in the Management Agreement, as amended, INMD
and PA agree as follows:

         1. Section 7.1.4 of the  Management  Agreement is hereby deleted in its
entirety and the following hereby substituted therefor, effective July 1, 1998:






         "7.1.4 an additional  Service Fee equal to 20% of PDE, paid monthly but
reconciled  to PA's annual  results of  operations  evidenced by PA's  Financial
Statements;  provided, however, the first $25,000 of PDE, quarterly, shall inure
to the  benefit of PA.  INMD shall be paid 20% of all PDE in excess of  $25,000,
quarterly, during the term of this Agreement."

         2.  Paragraph 2 of  Amendment  No. 1 is hereby  deleted in its entirety
effective  July 1,  1998  and the  resultant  Section  7.3.1  of the  Management
Agreement is hereby amended by deleting the same and  substituting the following
therefor, effective July 1, 1998:

         "7.3.1 Any amounts advanced  hereunder shall be considered Service Fees
as provided for in Section 7.1 and shall be repaid by INMD retaining 55% of PA's
80% PDE allocation provided for in Section 7.1.4, after the first $25,000 of PDE
is received by PA on a quarterly basis; provided,  however, INMD agrees to delay
effecting  retention  of 55% of PA' 80% PDE in excess of $25,000 on a  quarterly
basis until January 1, 1999 in order for PA to develop a sustained profit stream
between the date hereof and January 1, 1999."

         3.  Paragraph 3 of  Amendment No 1 is hereby  deleted in its  entirety,
effective July 1, 1998 and the resultant Section 7.4 of the Management Agreement
is hereby amended by deleting the same and substituting the following therefor:

         "7.4  INMD  will  seek,  at its  sole  costs  and  expense,  with  PA's
assistance on a best-efforts  basis, a medical practice  practicing in a medical
area  complimentary  to PA's  medical  practice  ("Co-  Tenant")  to occupy  the
Facility on a co-extensive basis with PA. INMD will, after identification of and
negotiations  with  such  Co-Tenant,   establish  a  reasonable   occupancy  fee
("Occupancy  Fee") to be paid to INMD by the  Co-Tenant,  and will  establish an
appropriate  method for PA's and Co- Tenant's  sharing of INMD's  management and
administrative  services,  with Co-Tenant paying a reasonable cost ("Co-Tenant's
Prorata  Costs") for such  services and INMD  crediting  PA's Costs of Services,
monthly,  for  Co-Tenant's  Prorata Costs and Occupancy  Fee. The selection of a
Co-Tenant  shall be subject  to PA's  approval  which  will not be  unreasonably
withheld and INMD will determine  which INMD employees and services will be made
available to Co-Tenant,  all on a non-exclusive  basis,  with PA's consent which
will not be unreasonably withheld."

         4. The  Management  Agreement  is hereby  amended to add the  following
Article:

                                   "Article 13


                        JOINT DUTIES AND RESPONSIBILITIES


         13.1 FORMATION AND OPERATION OF JOINT PRACTICE  MANAGEMENT  BOARD. INMD
and  PA  will  establish  a  Joint  Practice  Management  Board  which  will  be
responsible  for  developing  management  and  administrative  policies  for the
overall  operation of PA. The Joint  Practice  Management  Board will consist of
designated  management  representative(s)  from INMD, one or more PA owners,  as
determined by PA, such other practice physicians, as appropriate. In the case of
any matter  requiring a formal  vote,  PA shall have one (1) vote and INMD shall
likewise have one (1) vote.







         13.2  DUTIES  AND  RESPONSIBILITIES  OF THE JOINT  PRACTICE  MANAGEMENT
BOARD.  The Joint Practice  Management Board shall have the following duties and
responsibilities:

                  13.2.1  ANNUAL  BUDGETS.  All  annual  capital  and  operation
         budgets  prepared  by INMD shall be subject to the  review,  amendment,
         approval and disapproval of the Joint Practice Management Board.

                  13.2.2 CAPITAL IMPROVEMENTS AND EXPANSION. Except as otherwise
         provided  herein,  any  renovation  and  expansion  plans,  and capital
         equipment  expenditures  with  respect  to PA  shall  be  reviewed  and
         approved by the Joint Practice Management Board and shall be based upon
         the  best  interests  of  PA,  and  shall  take  into  account  capital
         priorities,  economic feasibility,  physician support, productivity and
         then current market and regulatory conditions.

                  13.2.3  ADVERTISING  BUDGET.  All annual advertising and other
         marketing  budgets  prepared  by INMD shall be  subject to the  review,
         amendment,  approval and  disapproval of the Joint Practice  Management
         Board.

                  13.2.4 PATIENT FEES. The Joint Practice Management Board shall
         review and approve the fee schedule  for all  physician  and  ancillary
         services rendered by PA.

                  13.2.5 ANCILLARY SERVICES. The Joint Practice Management Board
         shall approve ancillary services rendered by PA.

                  13.2.6 PROVIDER AND PAYER  RELATIONSHIPS.  Decisions regarding
         the  establishment  or maintenance of relationship  with  institutional
         health care  providers  and payers shall be made by the Joint  Practice
         Management  Board in  consultation  with PA;  provided,  however,  that
         unanimous  consent  of PA  designated  members  of the  Joint  Practice
         Management  Board shall be  necessary  to  discontinue  any existing PA
         institutional relationship.

                  13.2.7 STRATEGIC PLANNING. The Joint Practice Management Board
         shall develop long-term strategic plans, from time to time.

                  13.2.8 PHYSICIAN HIRING.  The Joint Practice  Management Board
         shall determine,  except as otherwise  provided for herein,  the number
         and type of physicians  required for the efficient operation of PA. The
         approval of the Joint Practice  Management  Board shall be required for
         any  modifications  to  the  restrictive  covenants  contained  in  any
         physician agreement.

                  13.2.9 PROVIDER CONTRACTS. The Joint Practice Management Board
         shall  approve,  disapprove,  or amend  all  managed  care,  PPO,  HMO,
         Medicare risk and other provider contracts negotiated by INMD."

            4. All other  provisions of the  Management  Agreement and Amendment
No. 1 not in conflict with this Amendment No. 2 remain in full force and effect.





         5. This  Amendment  No. 2 may be  executed  in any  number of  separate
counterparts,  each of which shall be deemed to be an original  but all of which
together shall constitute one and the same instrument.

         IN WITNESS WHEREOF, the parties have signed this Amendment No. 2 as the
date first written above.

INTEGRAMED AMERICA, INC.



By:/s/Donald S. Wood
   ----------------------------------
   Donald S. Wood, Pd.D.,  President,
   Reproductive Science Center Division


REPRODUCTIVE ENDOCRINE & FERTILITY CONSULTANTS, P.A.



By:/s/Elwyn M. Grimes
   ---------------------------------------------
   Elwyn M. Grimes, M.D., President


MIDWEST FERTILITY FOUNDATIONS & LABORATORY, INC.



By:Elwyn M. Grimes
   ---------------------------------------------
   Elwyn M. Grimes, M.D., President