AMENDMENT

         This agreement, dated July 11, 1997, by and between IntegraMed America,
Inc.,  a  Delaware  Corporation  with its  principal  place of  business  at One
Manhattanville Road, Purchase,  New York 10577 ("INMD"),  Reproductive  Sciences
Medical Center, Inc., a California professional corporation,  with its principal
place of business at 4150 Regents Row, Suite 280, LaJolla, California ("PC") and
Dr. Samuel H. Wood, M.D.,  Ph.D., an individual  having a post office address at
P.O. Box 1208, Rancho Sante Fe, California 92067 ("Physician"),  is an amendment
to the Management Agreement ("Management  Agreement"),  Personal  Responsibility
Agreement ("PR Agreement") and Asset Purchase Agreement ("Asset  Agreement") all
dated June 6, 1997, between the parties.

         WHEREAS,  INMD has  received  a certain  anecdotal  reports  which make
allegations  impugning the operation of the IVF Laboratory at Pomerado  Hospital
and

         WHEREAS,  INMD has  disclosed  to PC and  Physician  the nature of such
allegations and both PC and Physician unequivocally refute them; and

         WHEREAS,   INMD  has   communicated  to  Physician  and  PC  that  such
allegations,  if true,  would be  material  to the  validity  of the  management
Agreement and PR Agreement; and

         WHEREAS,  PC and  Physician  wish to provide  assurance to INMD, in the
form of written representations.

         Now, therefore, INMD, PC and Physician agree as follows:

         1.       The Management Agreement, PR Agreement and Asset Agreement are
                  hereby amended to include the following  representation  by PC
                  and Physician:

                  a.       PC and Physician have not been advised or informed of
                           any  facts,   circumstances,   or  allegations   that
                           indicate,  suggest  or imply  that  the  Reproductive
                           Sciences  Center at Pomerado  Hospital was closed for
                           any reason other than purely administrative decisions
                           by the Pomerado Hospital;

                  b.       PC and  Physician  have  no  knowledge  or any  facts
                           suggesting, nor have they been advised by any person,
                           entity or  governmental  unit,  that the operation of
                           the  IVF  Laboratory  at  Pomerado  Hospital,  or the
                           operation  of the  Reproductive  Sciences  Center  at
                           Pomerado  Hospital  (during the period that Physician
                           was medical  Director) is, or will be, the subject of
                           any  investigation  by any  governmental  officer  or
                           unit, licensing or regulatory agency,  administrative
                           or judicial tribunal, insurance department or entity,
                           SART or ASRM.








                  c.       Physician  and PC have no  knowledge,  and are not in
                           possession   of   any   facts   or    representations
                           suggesting,  that there is any  impediment  to the PC
                           and/or Physician's securance of Licensure as a tissue
                           bank, clinical laboratory or andrology  laboratory at
                           the  Facilities  (as  such  term is  utilized  in the
                           Management Agreement).

                  d.       Physician  and PC have no  knowledge,  and are not in
                           possession   of   any   facts   or    representations
                           suggesting,   that  during  the   operation   of  the
                           Reproductive  Sciences  Center at  Pomerado  Hospital
                           there   has  been  any   improper   record   keeping,
                           mishandling  of any tissue or specimens or failure to
                           obtain appropriate  consent,  by Dr. Wood (Physician)
                           Catherine Adams and/or Linda Anderson,  except to the
                           extent that,  as with any  laboratory or IVF Program,
                           there  is a  potential  for an  occasional  claim  of
                           negligence or medical malpractice in the treatment of
                           an individual patient or specimen.

                  e.       The Physician  and PC have no knowledge,  and are not
                           in  possession  of  any  facts  suggesting  that  the
                           Physician  or PC have  engaged  in any  insurance  or
                           billing irregularities.

         2.       The  Parties  agree  that  the  representations  contained  in
                  paragraph 1(a) - (e) are material to the Management Agreement,
                  PR Agreement and Asset Agreement.

         3.       PC  and  Physician   acknowledge   that  the  obtaining,   and
                  maintaining of the licensures  referred to in Section 4.6.7 of
                  the   Management   Agreement  are  a  material  term  of  such
                  management  Agreement  and that any  federal  or state  agency
                  action which limits,  revokes suspends, or fails to renew such
                  licensure(s) shall be treated as a "Professional  Disciplinary
                  Action"   and  shall  be  governed  by  Section  8.2  of  such
                  Management Agreement,  as if it were a suspension,  revocation
                  or  non-renewal  of a  physician's  authorization  to practice
                  medicine.

         4.       The parties agree that failure to obtain at least  provisional
                  licensures as  delineated  in Section 4.6.7 of the  Management
                  Agreement  within  six  months of the date  hereof  shall be a
                  material breach, by the PC, of the Management Agreement.

         5.       This  Agreement  shall be  considered in addition to the terms
                  and conditions of the Management  Agreement,  PR Agreement and
                  Asset Agreement and shall be read in connection therewith.







         IN WITNESS  WHEREOF,  this  Amendment  has been  executed,  by original
signatures on a faxed copy, by the parties hereto,  as of the day and year first
above written.

INTEGRAMED AMERICA, INC.

By:      /s/Gerardo Canet
         --------------------------------------
         Gerardo Canet, Chief Executive Officer

REPRODUCTIVE SCIENCES MEDICAL CENTER, INC.

By:      /s/Samuel H. Wood
         --------------------------------------
         Samuel H. Wood, M.D., Ph.D., President