AMENDMENT TO MANAGEMENT AGREEMENT
                                     Between
                            INTEGRAMED AMERICA, INC.
                                       and
                          MPD MEDICAL ASSOCIATES, P.C.

         THIS  AMENDMENT,  dated  as of  January  1,  1998,  to  the  MANAGEMENT
AGREEMENT,  dated as of June 2, 1997, by and between IntegraMed America, Inc., a
Delaware corporation, with its principal place of business at One Manhattanville
Road, Purchase, New York 10577 ("INMD") and MPD Medical Associates,  P.C., a New
York professional services corporation,  with its principal place of business at
200 Old Country Road, Mineola, New York 11501 ("PC").

                                    RECITALS

         WHEREAS, INMD and PC entered into a Management  Agreement,  dated as of
June 2, 1997 ["Management Agreement"]; and

         WHEREAS,  INMD has provided the full complement of services outlined in
the Management Agreement since its Effective Date (as stated therein); and

         WHEREAS, in recognition of the additional services and capital provided
to PC and its shareholder,  Gabriel San Roman,  M.D. ["San Roman"],  the parties
have agreed to increase  the Basic  Management  Fee (as such term is used in the
Management Agreement).

         NOW, THEREFORE, in consideration of the mutual covenants and agreements
herein contained and other good and valuable consideration, PC and INMD agree to
the following amendment to the Management Agreement ["Amendment"].

         1.       Section  6.3.4(a) is hereby  nullified and deleted,  effective
                  January 1, 1998 and the Basic  Management Fee of INMD shall be
                  controlled solely by the Management Agreement.

         2. Section 7.1.5 is hereby amended to read as follows:

                  7.1.5(a) for the period  between The Effective  Financial Date
                  and  December  31,  1997,  INMD shall waive  Fifteen  Thousand
                  Dollars ($15,000) ["First Monthly Waiver Amount"] of its Basic
                  Management  Fee.  For the period  between  January 1, 1998 and
                  March  31,  1998,  INMD  shall  waive  Five  Thousand  Dollars
                  ($5,000) of its Basic  Management Fee ["Second  Monthly Waiver
                  Amount"].  Commencing  with the date April 1, 1998, INMD shall
                  be entitled to its full Basic  Management  Fee.  The First and
                  Second Waiver amounts shall be inoperable, retroactive to the





                  Effective  Financial Date, if this Agreement is the subject of
                  a  material  breach by PC during  the  first  twelve  calendar
                  months  of this  Agreement  which  is not  cured  pursuant  to
                  Section 8.1.2.

                  7.1.5(b) for the first twelve (12) months after the  Effective
                  Financial Date of this  Agreement,  INMD shall, at its expense
                  provide Dr. San Roman with professional liability coverage, as
                  a named insured under INMD's professional  liability coverage,
                  which policy shall be in the minimum  amount of $1 million per
                  incident, $3 million in the aggregate, with an A carrier, on a
                  claims  made  basis  ["IntegraMed  Insurance  Period"].   This
                  coverage  shall not be a Cost of Service  of Advance  and this
                  paragraph  does not  alter  the  provisions  of  section  10.2
                  hereof.

         3. This  Amendment is made  pursuant to Section 12.5 of the  Management
Agreement.

         IN WITNESS  WHEREOF,  this  Amendment  has been executed by the parties
hereto as of the day and year first above written.


INTEGRAMED AMERICA, INC.

By:      /s/Donald S. Wood
         --------------------
         Donald S. Wood, Ph.D.
         President and Chief Operating Officer of
         Reproductive Science Center Division

MPD MEDICAL ASSOCIATES, P.C.

By:      /s/Gabriel San Roman
         -----------------------
         Gabriel San Roman, M.D.