Exhibit 10.1

                           STOCK PURCHASE AGREEMENT

                  THIS STOCK PURCHASE AGREEMENT (this "Agreement") is made as
of February 26, 1998 by and between Integra LifeSciences Corporation, a
Delaware corporation ("Integra"), and Century Medical, Inc., a Japanese
corporation (the "Purchaser").

         WHEREAS, Integra desires to sell, and the Purchaser desires to
purchase, the Preferred Shares (as such term is hereinafter defined) on the
terms and conditions hereinafter set forth.

         NOW, THEREFORE, in consideration of the mutual terms and conditions
herein contained, the parties hereto, intending to be legally bound, hereby
agree as follows:

                                  DEFINITIONS

         For all purposes of this Agreement, unless otherwise expressly
provided, (a) the terms defined in this Definitions section have the meanings
assigned to them herein and include the plural as well as the singular, (b)
all accounting terms not otherwise defined herein have the meanings assigned
under generally accepted accounting principles in the United States, (c) all
references in this Agreement to designated "Sections" and other subdivisions
are to the designated Sections and other subdivisions of the body of this
Agreement, (d) pronouns of either gender or neuter shall include, as
appropriate, the other pronoun forms, and (e) the words "herein", "hereof" and
other words of similar import refer to this Agreement as a whole and not to
any particular Article, Section or other subdivision.

         As used in this Agreement, the following definitions shall apply:

         "Action" means any action, complaint, petition, investigation, suit
or other proceeding, whether civil or criminal, in law or in equity, or before
any arbitrator or Governmental Entity.

         "Business" means the business of Integra and shall be deemed to include
any of the following incidents of such business: income, operations, condition 
(financial or other), assets, properties and liabilities.

         "Code" means the Internal Revenue Code of 1986, as amended.

         "Common Stock" means the Common Stock, $0.01 par value, of Integra.

         "Contract" means any agreement, arrangement, bond, commitment,
franchise, indemnity, indenture, instrument, lease, license or understanding,
whether or not in writing.




         "Encumbrance" means any claim, charge, easement, encumbrance, lease,
covenant, security interest, lien, option, pledge, rights of others,
restriction (whether on voting, sale, transfer, disposition or otherwise),
whether imposed by agreement, understanding, law, equity or otherwise, except
for any restrictions on transfer generally arising under any applicable United
States federal or state securities law.

         "Exchange Act" means the Securities Exchange Act of 1934, as amended.

         "GAAP" means generally accepted accounting principles in the United
States, as in effect from time to time.

         "Governmental Entity" means any government or any agency, bureau,
board, commission, court, department, official, political subdivision,
tribunal or other instrumentality of any government of or within the United
States, whether federal, state or local.

         "Law" means any constitutional provision, statute or other law, rule,
regulation, or interpretation of any Governmental Entity and any Order.

         "Loss" means any action, cost, damage, disbursement, expense,
liability, loss, deficiency, diminution in value, obligation, penalty or
settlement of any kind or nature, whether foreseeable or unforeseeable,
including but not limited to, interest or other carrying costs, penalties,
legal, accounting and other professional fees and expenses incurred in the
investigation, collection, prosecution and defense of claims and amounts paid
in settlement, that may be imposed on or otherwise incurred or suffered by the
specified Person.

         "Order" mans any decree, injunction, judgement, order, ruling,
assessment or writ of any Governmental Entity.

         "Person" means an association, a corporation, an individual, a
partnership, a trust or any other entity or organization including a
Governmental Entity.

         "SEC" means the Securities and Exchange Commission or any successor 
          entity.

         "SEC Reports" has the meaning set forth in Section 2.6.

         "Securities Act" means the Securities Act of 1933, as amended.

         "Subsidiary" means any Person in which Integra has a direct or
indirect equity ownership interest in excess of 50%.

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SECTION I.  PURCHASE AND SALE OF THE PREFERRED SHARES; CLOSING

                     1.1     Purchase and Sale of Preferred Shares.  Subject to 
the terms and conditions of this Agreement, the Purchaser shall purchase 500,000
shares of Integra's Series A Convertible Preferred Stock, par value $.01 per 
share (the "Preferred Shares") for a total purchase price of $4,000,000, in a 
maximum of two (2) installments as follows:

                             (a) the Purchaser agrees to purchase at the First 
Closing (as defined in Section 1.2(a)), and Integra agrees to sell and issue to 
the Purchaser at the First Closing, at least 250,000 Preferred Shares at the
purchase price of $8.00 per share (the "Share Price");

                             (b) the Purchaser agrees to purchase at the Second
Closing (as defined in Section 1.2(b)), and Integra agrees to sell and issue to 
the Purchaser at the Second Closing, the balance of the Preferred Shares not
purchased at the First Closing, at the Share Price; and

                             (c) the Preferred Shares shall have the rights,
preferences, privileges and restrictions set forth in the Certificate of 
Designation, Preferences and Rights of Series A Convertible Preferred Stock to 
Integra's Certificate of Incorporation attached hereto as Exhibit A (the 
"Certificate of Designation"), which shall be filed by Integra with the 
Secretary of State of the State of Delaware prior to the First Closing. The term
"Conversion Shares," as used herein, means the shares of Common Stock of Integra
issuable upon conversion of the Preferred Shares.

                     1.2     Closing.  As used herein, a "Closing" shall mean 
the closing of the issuance and sale of the Preferred Shares to the Purchaser 
hereunder, and the "Closing Date" shall mean the date on which such Closing 
takes place.

                             (a)    First Closing.  The closing of the issuance 
and sale of the Preferred Shares to the Purchaser pursuant to Section 1.1(a)
(the "First Closing") hereunder shall be held anytime during the period 
beginning April 1, 1998 and ending on April 30, 1998 ("First Closing Period") at
the offices of Integra, 105 Morgan Lane, Plainsboro, New Jersey 08536 at 
10:00 a.m., on such date during the First Closing Period as may be mutually 
agreed upon by Integra and the Purchaser. At the First Closing, Integra shall 
deliver to the Purchaser a certificate representing the Preferred Shares being 
purchased against payment of the Purchase Price therefor by check or wire 
transfer pursuant to wiring instructions given to Purchaser in writing by 
Integra as soon as practicable following the date hereof.

                             (b)  Second Closing.  The closing of the issuance 
and sale of the Preferred Shares to the Purchaser pursuant to Section 1.1(b) 
(the "Second Closing") hereunder shall be held anytime during the period 
beginning on the day after the First Closing Date and ending on June 30, 1998 
(the "Second Closing Period") at the offices of

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Integra, 105 Morgan Lane, Plainsboro, New Jersey 08536 at 10:00 a.m., on such
date during the Second Closing Period as may be mutually agreed upon by
Integra and the Purchaser. At the Second Closing, Integra shall deliver to the
Purchaser a certificate representing the Preferred Shares being purchased
against payment of the Purchase Price therefor by check or wire transfer
pursuant to wiring instructions given to Purchaser in writing by Integra as
soon as practicable following the date hereof.

                     1.3     Share Adjustment.

                             (a)  Subject to Section 1.3(b), if (i) Integra 
sells shares of its Series A Convertible Preferred Stock to any Person other 
than the Purchaser (a "Subsequent Sale") for aggregate consideration at or above
$1,000,000 and at a price per share (the "Subsequent Sale Price") of less than 
$8.00, and (ii) the price per share of Series A Convertible Preferred Stock is 
less than 1.6 times the average closing price of Integra's Common Stock for the 
10 trading days immediately prior to the Subsequent Sale (equitably adjusted for
any subdivision or combination of Integra's Common Stock) (the "Average Closing
Price"), then Integra shall issue and deliver to Purchaser, without additional
consideration, a number of shares of Integra's Series A Convertible Preferred
Stock ("Adjustment Shares") equal to the difference between (x) $4,000,000
divided by the Adjusted Purchase Price (as defined herein), and (y) 500,000.
"Adjusted Purchase Price" means the product of $5.00 times the Subsequent Sale
Price divided by the Average Closing Price. Any such Adjustment Shares shall
be delivered by Integra to the Purchaser on the later of (i) the date of the
Second Closing and (ii) five business days after the date of the Subsequent
Sale.

                             (b) Purchaser's right to obtain the price
adjustment set forth in Section 1.3(a) shall expire on the earlier of (i) June 
30, 1998, (ii) the date on which Integra sells shares of its Series A 
Convertible Preferred Stock for aggregate consideration at or above $3,000,000 
to any Person other than the Purchaser at a price per share at or above $8.00 
and (iii) the date immediately following the date of issuance by Integra to 
Purchaser of any Adjustment Shares pursuant to Section 1.3(a).

SECTION II.  REPRESENTATIONS AND WARRANTIES OF INTEGRA

                     Integra represents and warrants to the Purchaser as
follows:

                     2.1     Corporate Organization.  Integra is a corporation 
duly organized, validly existing and in good standing under the laws of the
State of Delaware. Integra and each Subsidiary has all requisite corporate power
and authority to own, operate and lease its properties and to carry on its 
business as it is now being conducted. Integra and each Subsidiary is duly 
qualified or licensed to do business and is in good standing in each 
jurisdiction in which the property owned, leased or operated by it or the nature
of the business conducted by it makes such qualification or licensing necessary,
except where its

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failure so to qualify to be licensed would not have a material adverse effect
on Integra or such Subsidiary.

                     2.2 Capitalization. On the date hereof, the authorized 
capital stock of Integra consists of 60,000,000 shares of Common Stock, and 
15,000,000 shares of Preferred Stock, par value $.01 per share. Upon the filing 
of the Certificate of Designation with the Secretary of State of Delaware, 
2,000,000 shares of Integra's Preferred Stock shall be designated as "Series A
Convertible Preferred Stock" and 13,000,000 shares of Integra's Preferred
Stock shall be undesignated. As of the date hereof, 29,903,082 shares of
Common Stock are issued and outstanding, and no shares of Preferred Stock are
issued and outstanding. All of the issued and outstanding shares of Common
Stock have been duly authorized and validly issued and are fully paid and
non-assessable. Except as stated in the SEC Reports and except for certain
commitments to issue Preferred Stock previously disclosed to the Purchaser,
there are no existing subscriptions, options, warrants, calls, commitments,
agreements, conversion or other rights of any character (contingent or
otherwise) to purchase or otherwise acquire from Integra at any time, or upon
the happening of any stated event, any shares of the capital stock of Integra.

                     2.3     Authorization. Integra has all requisite corporate
power and authority to enter into this Agreement and the Registration Rights 
Agreement in the form attached hereto as Exhibit B (the "Registration Rights 
Agreement") and to carry out its obligations hereunder and thereunder. The 
execution and delivery of this Agreement and the Registration Rights Agreement 
and the consummation of the transactions contemplated hereby and thereby have 
been duly authorized by the Board of Directors of Integra, which authorization 
remains in full force and effect and has not been modified or amended by any 
subsequent action of such Board of Directors, and no other corporate actions or 
proceedings on the part of Integra are necessary to authorize this Agreement and
the Registration Rights Agreement or the transactions contemplated hereby and
thereby. The transactions contemplated hereby will not violate any of the
provisions of Integra's Amended and Restated Certificate of Incorporation or
By-Laws, as amended. This Agreement and the Registration Rights Agreement will
constitute the valid and binding obligations of Integra, each enforceable in
accordance with its respective terms, except to the extent that enforceability
may be limited by equity, bankruptcy, insolvency and other laws of general
application affecting the rights and remedies of creditors and to the extent
the indemnification provisions contained in the Registration Rights Agreement
may be limited by applicable United States federal or state securities laws.

                     2.4     No Violation.  Except for filings under United 
States federal and state securities laws, no permit, consent, approval, 
authorization of or declaration to or filing with any Governmental Entity or 
other Person, not made or obtained, is required in connection with the execution
and delivery of this Agreement or the Registration Rights Agreement or the 
offering and issuance of the Preferred Shares and Conversion Shares. The 
execution, delivery and performance of this Agreement and the Registration 
Rights Agreement will not

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violate, result in a breach of or the acceleration of any obligation under, or
constitute a default under, any provision of any indenture, mortgage, lien,
lease, agreement, contract, instrument, order, judgment, decree, law,
ordinance or regulation to which any property of Integra is subject or by
which Integra is bound or result in the creation or imposition of any lien,
claim, charge, restriction, equity or encumbrance of and kind whatsoever upon,
or give to any other Person any interest or right in or with respect to, any
of the properties, assets, business, agreements or contracts of Integra.

                     2.5     Good Title: Valid Issuance of Securities.  Upon 
consummation of the transactions contemplated by this Agreement in accordance 
with the terms hereof, the Purchaser will acquire good title to the Preferred 
Shares. The Preferred Shares, when issued, sold and delivered in accordance with
the terms hereof for the consideration expressed herein, will be duly and 
validly issued, fully paid and nonassessable and free of restrictions on 
transfer other than restrictions on transfer under this Agreement and applicable
United States federal and state securities laws. The Conversion Shares have been
duly and validly authorized and reserved for issuance (and no further corporate 
or other action is required for the issuance of the Preferred Shares or
Conversion Shares contemplated by this Agreement) and, upon issuance in
accordance with the terms of the Certificate of Designation, shall be duly and
validly issued, fully paid and nonassessable.

                     2.6     SEC Reports.  The Common Stock is registered under 
Section 12 of the Exchange Act. Integra has provided to Purchaser a true and 
complete copy (without exhibits) of all reports filed by Integra with the 
Securities and Exchange Commission pursuant to Sections 13(a) and 14(a) of the 
Exchange Act since November 1, 1997 (collectively, the "SEC Reports"). None of 
the SEC Reports as of their respective dates contained any untrue statement of a
material fact or omitted to state a material fact required to be stated
therein or necessary to make the statements therein, in light of the
circumstances under which they were made, not misleading. All of the audited
consolidated financial statements and unaudited consolidated interim financial
statements of Integra included in the SEC Reports have been prepared in
accordance with GAAP applied on a consistent basis for the dates and during
the periods involved (except as otherwise stated in such financial statements
or, in the case of unaudited interim statements, to the extent they may not
include footnotes or may be condensed or summary statements), and fairly
present the consolidated financial position, results of operations and cash
flows of Integra as of the dates thereof and for the periods indicated therein
(subject, in the case of any unaudited interim financial statements, to normal
year end audit adjustments). Integra does not have any liability or
obligation, secured or unsecured (whether absolute, accrued, contingent or
otherwise, and whether due or to become due), which is of a nature required
under GAAP applied on a consistent basis to be included in a consolidated
balance sheet or disclosed in the notes thereto, except such liabilities and
obligations which (i) are recorded in the most recent balance sheet included
in the SEC Reports or (ii) were incurred after the date of such balance sheet
in the ordinary course of business. There has been no material adverse change
in the

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Business since December 31, 1997 other than Integra's plan to close its West
Chester, Pennsylvania facility during 1998.

                     2.7     Private Placement.  Subject to the truth and 
accuracy of the Purchaser's representations set forth in this Agreement, the 
offer, sale and issuance of the Preferred Shares and the Conversion Shares, as 
contemplated by this Agreement, are exempt from the registration requirements of
the Securities Act and from the qualification requirements of applicable United
States federal and state securities laws.

                     2.8     Legal Matters.  Except as disclosed in the SEC 
Reports, (i) there is no Order or Action pending or, to the best knowledge of 
Integra, threatened against or affecting Integra or any of its properties or 
assets that individually or when aggregated with one or more other Orders or 
Actions has or if determined adversely to the interest of Integra might 
reasonably be expected to have a material adverse effect on Integra, the 
Business, on Integra's ability to perform this Agreement, or on any aspect of 
the transactions contemplated by this Agreement, and (ii) Integra is not in
violation of any Laws, the effect of which violation would be materially
adverse to the Business.

                     2.9     Insurance.  There is in full force and effect 
insurance coverage on the assets, properties, premises, operations and personnel
of Integra in such amounts and against such risks and losses as in the opinion 
of Integra is adequate in all material respects for the business engaged in by 
Integra. All such insurance policies are in full force and effect, and Integra 
has not received a notification with respect to any material policies of their
cancellation or that they will not be renewed or that the insurance carrier
insuring same has placed any condition on renewal or cancellation which would
make the renewal or cancellation onerous.

SECTION III.         REPRESENTATIONS AND WARRANTIES OF THE PURCHASER

                     The Purchaser understands that the Preferred Shares will 
not be registered under the Securities Act on the grounds that the sale of such 
securities to the Purchaser is exempt pursuant to Section 4(2) of the Securities
Act and/or Regulation D promulgated under the Securities Act, and that the 
reliance of Integra on such exemptions is predicated in part on the Purchaser's
representations, warranties, covenants and acknowledgements set forth in this
Section 3.

                     3.1     Corporate Organization.  The Purchaser is a 
corporation duly organized and validly existing under the laws of Japan.

                     3.2     Authorization.  The Purchaser has all requisite 
corporate power and authority to enter into the Agreement and the Registration 
Rights Agreement and to carry out its obligations hereunder and thereunder and 
to purchase the Preferred Shares and Conversion

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Shares. The execution and delivery by the Purchaser of this Agreement and the
Registration Rights Agreement and the consummation of the transactions
contemplated hereby have been duly authorized by the Board of Directors of
Purchaser, which authorization remains in full force and effect and has not
been modified or amended by any subsequent action of such Board of Directors,
and no other corporate actions or proceedings on the part of the Purchaser are
necessary to authorize this Agreement and the Registration Rights Agreements
or the transactions contemplated hereby or thereby. The transactions
contemplated hereby will not violate the provisions of Purchaser's charter
documents. This Agreement and the Registration Rights Agreement will
constitute the valid and legally binding obligations of the Purchaser, each
enforceable in accordance with its respective terms, except to the extent that
enforceability may be limited by equity, bankruptcy, insolvency and other laws
of general applications affecting the rights and remedies of creditors and to
the extent the indemnification provisions contained in the Registration Rights
Agreement may be limited by applicable federal or state securities laws.

                     3.3     No Violation.  The execution, delivery and 
performance by the Purchaser of this Agreement and any related agreements or 
contemplated transactions will not violate or constitute a breach or default 
(whether upon lapse of time and/or occurrence of any act or event or otherwise) 
under the charter documents of the Purchaser, any Law to which the Purchaser is 
subject, or any Contract to which the Purchaser is a party that is material to 
the financial condition, results of operations or conduct of the business of the
Purchaser.

                     3.4     Purchase for Own Account.  This Agreement and the 
Registration Rights Agreement are made with Purchaser in reliance upon the 
Purchaser's representation to Integra that the Preferred Shares (or the 
Conversion Shares) to be acquired by the Purchaser will be acquired for 
investment for the Purchaser's own account, not as a nominee or agent, and not 
with a view to the resale or distribution of any part thereof, and that the 
Purchaser has no present intention of selling, granting any participation in, or
otherwise distributing the same, and the Purchaser will not distribute the 
Preferred Shares or Conversion Shares in violation of the Securities Act. The 
Purchaser further represents that it does not presently have any contract, 
undertaking, agreement or arrangement with any Person to sell, transfer or grant
participations to such Person or to any third person with respect to any of
the Preferred Shares (or the Conversion Shares). The Purchaser has not been
formed for the specific purpose of acquiring the Preferred Shares (or the
Conversion Shares).

                     3.5     Disclosure of Information.  The Purchaser has had 
an opportunity to review all the information it considers material for deciding 
whether to acquire the Preferred Shares (and the Conversion Shares) and to 
discuss Integra's business, management, financial affairs and the terms and 
conditions of the offering of the Preferred Shares with Integra's management 
and has had an opportunity to review Integra's facilities.

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                     3.6     Restricted Securities.  The Purchaser understands 
that the Preferred Shares (and the Conversion Shares) have not been registered 
under the Securities Act, by reason of a specific exemption from the 
registration provisions of the Securities Act which depends upon, among other 
things, the bona fide nature of the investment intent and the accuracy of the 
Purchaser's representations as expressed herein. The Purchaser understands that 
the Preferred Shares (and the Conversion Shares) are characterized as 
"restricted securities" under United States federal securities laws inasmuch as 
they are being acquired from Integra in a transaction not involving a public 
offering and that under such laws and applicable regulations such Preferred 
Shares (and the Conversion Shares) may be resold without registration under the 
Securities Act only in certain limited circumstances. The Purchaser acknowledges
that the Preferred Shares (and the Conversion Shares) must be held indefinitely
unless subsequently registered under the Securities Act or an exemption from 
such registration is available. The Purchaser is aware that, except as provided 
in the Registration Rights Agreement, Integra is not obligated to register under
the Securities Act any sale, transfer or other disposition of the Preferred
Shares or the Conversion Shares.

                     3.7     No Public Market.  The Purchaser understands that 
no public market now exists for the Preferred Shares, and that Integra has made 
no assurances that a public market will ever exist for the Preferred Shares.

                     3.8     Legends.  The Purchaser understands that the 
Preferred Shares (and the Conversion Shares), and any securities issued in 
respect thereof or exchanged therefor, may bear one or all of the following 
legends:

                             (a)    "THE SECURITIES REPRESENTED BY THIS CERTIFI-
CATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION
WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISPOSITION MAY BE
EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN
OPINION OF COUNSEL ACCEPTABLE TO THE COMPANY THAT SUCH REGISTRATION IS NOT
REQUIRED UNDER SUCH ACT."

                             (b) Any legend required by the laws (including,
without limitation, the Blue Sky laws), of any state to the extent such laws are
applicable to the shares represented by the certificate so legended.

                     3.9     Accredited Investor. The Purchaser represents that:
(a) it is an accredited investor as defined in Rule 501(a) of Regulation D 
promulgated under the Securities Act; (b) its financial situation is such that 
it can afford to bear the economic risk of holding the Preferred Shares and
Conversion Shares for an indefinite period of time and suffer complete loss of
its investment in the Preferred Shares and Conversion Shares; and (c) its
knowledge and experience in financial and business matters are such that it is
capable of

                                       9




evaluating the merits and risks of its purchase of the Preferred Shares and
Conversion Shares, as contemplated by this Agreement. Purchaser represents
that it has been advised by legal counsel in connection with the negotiation
and execution of this Agreement.

                     3.10    No Brokers or Finders.  The Purchaser has not 
incurred, and neither it nor Integra will incur, directly or indirectly, as a 
result of any action taken by the Purchaser, any liability for brokerage or 
finders' fees or agents' commissions or any similar charges in connection with 
this Agreement.

SECTION IV.  COVENANTS OF INTEGRA

                     4.1     Advise of Changes.  Until the Second Closing Date, 
Integra shall promptly advise the Purchaser in writing of (i) any event known to
Integra occurring subsequent to the date hereof which would render any 
representation or warranty of Integra contained in this Agreement, if made on or
as of the date of such event or any date prior to the Second Closing Date, 
untrue or inaccurate in any material respect (other than an event so affecting a
representation or warranty which is expressly limited to a state of facts
existing at a time prior to the occurrence of such event) or (ii) any material
adverse change in Integra's Business.

SECTION V.  CONDITIONS PRECEDENT TO THE PURCHASER'S OBLIGATIONS

                     The Purchaser's obligations to Integra under this Agreement
are subject to the fulfillment on or before each of the Closing (except as 
otherwise specified) of each of the following conditions unless waived by the 
Purchaser:

                     5.1     Representations and Warranties.  On the First and 
Second Closing Dates, the representations and warranties of Integra contained in
Section 2 hereof shall be true and correct in all material respects with the
same effect as though made on and as of the First and Second Closing Dates, 
respectively, and Integra shall have so certified to the Purchaser in writing; 
provided that the representations and warranties contained in Section 2.2 shall
be true and correct in all material respects with the same effect as though made
on and as of the Second Closing Date, subject to the issuance of Preferred 
Shares on the First Closing Date consistent with this terms of this Agreement 
and issuances of shares of Common Stock between the First and Second Closing 
Dates.

                     5.2     Performance of Covenants.  Integra shall have 
performed all covenants required to be performed by it under this Agreement 
prior to the respective Closing Date, and Integra shall have so certified to the
Purchaser in writing.

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                     5.3     Registration Rights Agreement.  On the First 
Closing Date, Integra shall have executed and delivered to the Purchaser the 
Registration Rights Agreement.

                     5.4     No Proceeding or Litigation.  No suit, action, or 
other proceeding seeking to restrain, prevent or change the transactions 
contemplated hereby or otherwise questioning the validity or legality of such 
transactions shall have been instituted by a party other than the Purchaser and 
be pending.

                     5.5     Qualifications.  All authorizations, approvals or 
permits, if any, of any Governmental Entity that are required in connection with
the lawful issuance and sale of the Preferred Shares and the Conversion Shares 
pursuant to this Agreement shall be obtained and effective as of each of the 
Closing Dates, and no such authorizations, approvals or permits shall have 
imposed a condition which in the reasonable judgement of the Purchaser is unduly
burdensome.

                     5.6     Certificate of Designation.  The Certificate of 
Designation shall be in full force and effect as of each Closing Date and will 
not have been amended or modified.

                     5.7     Financial Statements.  The Purchaser shall have 
received the most recent (as of such Closing Date) annual or quarterly 
consolidated financial statements of Integra filed with the SEC.

                     5.8     Amended and Restated Certificate of Incorporation 
and Bylaws. Integra shall have delivered to the Purchaser (i) a copy of its 
Amended and Restated Certificate of Incorporation and the Certificate of 
Designation, certified by the Secretary or an Assistant Secretary of Integra as 
of the Closing Date, and (ii) a copy of Integra's ByLaws, as amended (certified 
as of the First Closing Date by the Secretary or an Assistant Secretary of 
Integra).

SECTION VI.  CONDITIONS PRECEDENT TO INTEGRA'S OBLIGATIONS

                     The obligations of Integra to the Purchaser under this 
Agreement are subject to the fulfillment on or before each of the Closing Dates 
(unless otherwise specified), of each of the following conditions unless 
otherwise waived by Integra.

                     6.1     Representations and Warranties.  On the First and 
Second Closing Dates, the representations and warranties of the Purchaser 
contained in Section 3 hereof shall be true and correct in all material respects
with the same effect as though made on and as of such Closing Date, and the 
Purchaser shall have so certified to Integra in writing.

                     6.2     Performance.  All of the covenants, agreements and 
conditions contained in this Agreement to be performed or complied with by the 
Purchaser on or prior

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to the First and Second Closing Dates shall have been performed or complied
with, and the Purchaser shall have so certified to Integra in writing.

                     6.3     No Proceeding or Litigation.  No suit, action, or 
other proceeding seeking to restrain, prevent or change the transactions 
contemplated hereby or otherwise questioning the validity or legality of such 
transactions shall have been instituted by a party other than Integra and be 
pending.

                     6.4     Qualifications.  All authorizations, approvals or 
permits, if any, of any Governmental Entity that are required in connection with
the lawful issuance and sale of the Preferred Shares and the Conversion Shares
pursuant to this Agreement shall be obtained and effective as of each of the 
Closing Dates.

SECTION VII.         COMPLIANCE WITH SECURITIES ACT; RESTRICTIONS ON
                     TRANSFERABILITY OF THE PREFERRED SHARES AND
                     CONVERSION SHARES

                     7.1     Compliance with Securities Act.  The Preferred 
Shares and Conversion Shares shall not be transferable, except upon the
conditions specified in this Section 6, which conditions are intended to insure
compliance with the provisions of the Securities Act and applicable state
securities laws in respect of any such transfer.

                     7.2     Restrictive Legends.  The Preferred Shares, and 
each certificate representing the Preferred Shares and any Conversion Shares or 
other securities issued in respect of the Preferred Shares upon any stock split,
stock dividend, recapitalization, merger, consolidation or similar event,
shall (unless otherwise permitted by the provisions of Section 7.4 below) be
stamped or otherwise imprinted with one or all of the legends set forth in
Section 3.8 hereof.

                     7.3     Restrictions on Transferability.  The Purchaser 
shall not sell, assign, give, donate, pledge or otherwise encumber or dispose of
("Transfer") any Preferred Shares or Conversion Shares or any interest therein 
now held or hereafter acquired by it, except by operation of law or as provided 
in this Agreement. Integra shall not be required to register the Transfer of any
Preferred Shares or Conversion Shares on its books unless it shall have been
provided with an opinion of counsel satisfactory to it prior to such Transfer
to the effect that registration under the Securities Act or any applicable
state securities laws is not required in connection with the transaction
resulting in such Transfer.

                     7.4     Termination of Restrictions on Transferability. The
conditions precedent imposed by this Section 7 upon the transferability of the 
Conversion Shares shall cease and terminate when such securities shall have been
registered under the Securities Act and sold or otherwise disposed of in
accordance with the intended method of disposition by the seller or sellers
thereof set forth in the registration statement covering such securities, or

                                      12




when such securities are transferable in accordance with the provisions of
Rule 144 promulgated under the Securities Act. Whenever the conditions imposed
by this Section 7 shall terminate as hereinabove provided with respect to any
of the Conversion Shares, the holder of any such securities bearing the
legends set forth in Section 3.8 as to which such conditions shall have
terminated shall be entitled to receive from Integra, without expense (except
for the payment of any applicable transfer tax) and as expeditiously as
possible, new stock certificates not bearing such legends.

SECTION VIII.  SURVIVAL OF REPRESENTATIONS AND WARRANTIES

                     The representations and warranties set forth in Sections 
2.1, 2.2, 2.3, 2.4 and 2.5 shall survive the Closing and continue in full force 
and effect for a period of two (2) years thereafter. None of the covenants, 
agreements or the representations and warranties set forth in Sections 2.6, 2.7,
2.8 or 2.9 or Section III made herein and in the certificates delivered pursuant
thereto by the parties hereto shall survive the Closing of the transactions 
contemplated hereunder except the payment of expenses pursuant to Section 9.3
hereof.

SECTION IX.  MISCELLANEOUS

                     9.1     Arbitration.

                             (a)    All disputes arising out of or relating to 
this Agreement which cannot be settled by the parties shall promptly be 
submitted to and determined in arbitration in Princeton, New Jersey if initiated
and brought by the Purchaser, or Tokyo, Japan if initiated and brought by
Integra, by a panel of three arbitrators (unless otherwise agreed by the 
parties), of whom the Purchaser shall select one, Integra shall select one and 
the third shall be selected by the two previously selected, pursuant to the 
rules and regulations then obtaining of the American Arbitration Association. 
The decision of the arbitrators shall be final and binding upon the parties and 
judgement upon such decision may be entered in any court of competent 
jurisdiction. The party against whom an award is rendered shall pay and
discharge all reasonable costs and expenses (including reasonable attorneys'
fees) which are incurred by the other party in obtaining such award.

                             (b)    Discovery shall be allowed pursuant to the 
intendment of the United States Federal Rules of Civil Procedure and as the 
arbitrators determine appropriate under the circumstances.

                             (c) Such arbitrators shall be required to apply
the contractual provisions hereof in deciding any matter submitted to it and 
shall not have any authority, by reason of this Agreement or otherwise, to
render a decision that is contrary to the mutual intent of the parties as set 
forth in this Agreement.

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                     9.2     Successors.  Except as otherwise provided herein, 
this Agreement shall be binding upon, and shall inure to the benefit of, the 
respective successors and permitted assigns of each of the parties hereto.

                     9.3     Expenses.  The parties hereto shall each bear their
own fees and expenses and those of their respective agents and advisors, whether
or not the transactions contemplated by this Agreement are consummated.

                     9.4     Notice.  Any notice or other communications 
required or permitted hereunder shall be deemed validly given, made or served, 
when delivered personally or by telecopier (except for legal process) with a 
copy by recognized overnight delivery service, or upon receipt by the party 
entitled to receive the notice when sent by registered or certified mail, 
postage prepaid, or by a recognized overnight delivery service, addressed as 
follows or to such other address or addresses or telecopier number as may 
hereafter be furnished in writing by notice similarly given by one party to the 
other:

           To Integra:       Integra LifeSciences Corporation
                             105 Morgan Lane
                             Plainsboro, NJ 08536
                             Fax: (609) 799-3297
                             Attention: Stuart M. Essig
                                        President and Chief Executive Officer

           With a copy to:   John E. Stoddard III, Esq.
                             Drinker Biddle & Reath LLP
                             105 College Road East
                             Princeton, NJ 08542-0627
                             Fax: (609) 799-7000

           To the Purchaser: Century Medical, Inc.
                             1-6-4 Ohsaki
                             Shinagawa-ku, Tokyo 141
                             Japan
                             Fax: (03) 3491-0577
                             Attention:   Mr. Shunzo Saegusa
                                          Sr. Officer
                                          Medical Products Division

                                      14




          With a copy to:    Dale M. Araki, Esq.
                             O'Melveny & Myers LLP
                             Sanbancho KB-6 Bldg.
                             6 Sanbancho
                             Chiyoda-ku, Tokyo 102
                             Japan
                             Fax: (03) 3239-2432


Notice given by telecopier shall be deemed delivered on the day the sender
receives telecopier confirmation that such notice was received at the
telecopier number of the addressee. Notice given by mail as set forth above
shall be deemed received three days after the date the same is postmarked,
except that notice given by a recognized overnight delivery service as set
forth above shall be deemed received on the business day following the date
the same is sent.

                     9.5     Full Agreement.  This Agreement, together with the 
Exhibits attached hereto or delivered herewith, including the Registration 
Rights Agreement, set forth the entire understanding of the parties with respect
to the transactions contemplated hereby and thereby.

                     9.6     Headings.  The headings of the Sections of this 
Agreement are inserted for convenience of reference only and shall not be 
considered a part hereof.

                     9.7     Amendment.  This Agreement may be modified, amended
or changed only with the written consent of Integra and the Purchaser.

                     9.8     Public Announcements.  Any announcements or similar
publicity with respect to this Agreement or the transactions contemplated herein
shall be made at such time and in such manner as Integra and the Purchaser shall
agree, provided that any party may make any public disclosure it believes in 
good faith is required by applicable law or any listing or trading agreement
concerning its publicly-traded securities.

                     9.9     Counterparts.  This Agreement may be executed in 
one or more counterparts, each of which will be deemed to be an original copy of
this Agreement and all of which, when taken together, will be deemed to 
constitute one and the same agreement.

                     9.10  Delays or Omissions.  No delay or omission to 
exercise any right, power or remedy accruing to any party to this Agreement, 
upon any breach or default of the other party, shall impair any such right, 
power or remedy or such non-breaching party nor shall it be construed to be a 
waiver of any such breach or default, or an acquiescence therein, or of or in
any similar breach or default thereafter occurring; nor shall any waiver of

                                      15




any single breach or default be deemed a waiver of any other breach or default
theretofore or thereafter occurring.

                     9.11    Governing Law.  This Agreement shall be governed by
and construed and enforced in accordance with the laws of the State of Delaware.

                     9.12    Severability.  If any provision of this Agreement 
is determined to be invalid, illegal or unenforceable by any Governmental 
Entity, the remaining provisions of this Agreement to the extent permitted by 
Law shall remain in full force and effect provided that the essential terms and 
conditions of this Agreement for both parties remain valid, binding and 
enforceable, and that the economic and legal substance of the transactions 
contemplated is not affected in any manner materially adverse to any party. In 
the event of any such determination, the parties agree to negotiate in good 
faith to modify this Agreement to fulfill as closely as possible the original 
intent and purpose hereof. To the extent permitted by Law, the parties hereby to
the same extent waive any provision of Law that renders any provision hereof 
prohibited or unenforceable in any respect.

                 [Remainder of page intentionally left blank.]

                                      16






                     IN WITNESS WHEREOF, each of the parties hereto has fully 
executed this Agreement as of the date first set forth above.

                                       INTEGRA LIFESCIENCES CORPORATION

                                       By:/s/Andre P. Decarie
                                          -------------------
                                          Andre P. de carie
                                          Senior Vice President -- Business
                                              Development

                                       CENTURY MEDICAL, INC.

                                       By:/s/Mitsunari Suzuki
                                          -------------------
                                          Mitsunari Suzuki
                                          President and Chief Executive Officer

                                      17