EXHIBIT 32.1

         CERTIFICATION PURSUANT TO RULE 13A-14(b) OR RULE 15D-14(b) OF THE
         SECURITIES EXCHANGE ACT OF 1934 AND U.S.C. SECTION 1350


I, Michael A. Martino, President and Chief Executive Officer of Sonus
Pharmaceuticals, Inc. (the "Company"), certify, pursuant to Rule 13a-14(b) or
Rule 15d-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section
1350, that:

(1)      the Quarterly Report on Form 10-Q of the Company for the quarterly
         period ended September 30, 2003 (the "Report") fully complies with the
         requirements of Section 13(a) or 15(d) of the Securities Exchange Act
         of 1934 (15 U.S.C. 78m or 780(d)); and

(2)      the information contained in the Report fairly presents, in all
         material respects, the financial condition and results of operations of
         the Company.

Dated: November 14, 2003

                                      /s/ Michael A. Martino
                                      ------------------------------------------
                                      Michael A. Martino
                                      President and Chief Executive Officer