EXHIBIT 4.2

                           HEMISPHERx BIOPHARMA, INC.
                      (FORMERLY HEM PHARMACEUTICALS CORP.)
              AMENDED AND RESTATED 1992 EMPLOYEE STOCK OPTION PLAN

1. Administration of Plan

This plan is intended to provide for the grant of incentive  stock  options,  as
defined in Section 422 of the  Internal  Revenue  code of 1986,  as amended (the
"Code"),  to employees of HEM  Pharmaceuticals  Corp.  (the  "Company")  and its
subsidiaries from time to time, and for the grant of non-qualified stock options
to employees,  directors,  consultants and others whose efforts are important to
the success of the Company.  This Plan shall be  administered  by a committee of
the Board of  Directors,  consisting of at least three  "disinterested  persons"
within the meaning of SEC Rule 16b-3 (the  "Option  Committee").  Subject to the
provisions  of Section 13, the Option  Committee is  authorized to interpret the
Plan, to prescribe,  amend and rescind rules and regulations relating to it, and
to make all other determinations necessary or advisable for its administration.

2. Shares Covered by Plan

Options  may be  granted  under the Plan  while  the Plan is in  effect  for the
purchase of not in excess of 92,160(1) shares of the Common Stock,  $.001(1) par
value ("Common Stock"),  of the Company.  Shares covered by unexercised  options
which are no longer  exercisable  for any reason shall be available for issuance
under  options  granted  hereunder  for  purposes  of  computing  the  foregoing
limitation unless the Plan has been terminated.  Shares delivered on exercise of
options may be made available  from  authorized and unissued stock or from stock
held in the Treasury of the Company.

3. Eligibility

All employees, directors,  consultants and others whose efforts are important to
the success of the Company shall be eligible to receive options under this Plan;
provided,  that incentive  stock options may be granted only to employees of the
Company or its corporate subsidiaries.

4. Allotment of Options and Number of Shares.

The allotment of options among the eligible grantees, the number of shares to be
covered by each option to be granted,  and the  designation of options as either
incentive  stock options or  non-qualified  stock options shall be determined by
the Option Committee.




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5. Option Agreements; Terms of Options.

Each grantee to whom an option is granted  shall enter into a written  agreement
with the Company setting forth the terms and conditions of the option granted to
him,  which  agreement may contain such terms,  condition and  restrictions  not
inconsistent with the terms of the Plan as the Option Committee shall approve in
each case.

6. Option Price.

The price to be paid by a grantee who exercises an option shall be determined by
the Option  Committee  but  except in the case of  substituted  options  granted
pursuant  to  Section  11 shall  in no event be less  than (a) in the case of an
incentive  stock  option,  the fair market value of the Common Stock on the date
such option is granted,  or (b) in the case of a non-qualified stock option, 50%
of the fair market value of the Common Stock on the date such option is granted.

7. Duration and Rate of Exercise of Options.

The option  period shall be fixed by the Option  Committee but in any event each
option shall by its terms be  exercisable  no later than the  expiration  of ten
years from the date such option is granted.

The Option  Committee  shall  determine  the rate at which each option  shall be
exercisable.

The Option  Committee  shall  determine the manner in which each option shall be
exercisable  and the  timing  and  form of the  purchase  price  to be paid by a
grantee upon the exercise of an option under the Plan. To the extent provided in
the option agreement, payment of the purchase price may be in cash, part in cash
and part by personal  promissory note or in whole or in part by the surrender of
a whole  number of shares of  previously  issued  Common  Stock of the  Company.
Previously  issued  shares of Common  Stock  shall be  accepted as payment in an
amount equal to the then fair market value of the surrendered shares.

8. Nontransferability of Options.

Each  option  granted  under  the Plan to any  person  shall by its terms not be
transferable  by  him  otherwise  than  by  will  or the  laws  of  descent  and
distribution, and shall be exercisable during his lifetime only by him.



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9. Rights of a Stockholder.

An optionee  shall have no rights as a  stockholder  with  respect to any shares
covered by his  options  until he shall have become the holder of record of such
shares, and no adjustment shall be made, except adjustments  pursuant to section
10 hereof, for dividends (ordinary or extraordinary, whether in cash, securities
or other  property) or  distributions  or other rights in respect of such shares
for which the record date is prior to the date on which he shall have become the
holder of record thereof.

10. Effect of Change in Stock Subject to the Plan.

If there is any change in the shares of Common Stock of the Company  through the
declaration of stock dividends or through  recapitalizations  resulting in stock
split-ups or  combinations  or exchanges of shares or  otherwise,  the number of
shares available for options, the exercise price of outstanding options, and the
number of shares  subject to any option shall be  appropriately  adjusted by the
Option Committee,  and in their discretion,  in such cases,  fractional parts of
shares may be disregarded.

11. Grant of Options in Connection with Certain Acquisitions.

The  Option  Committee  may grant  options  under the Plan in  substitution  for
options  granted  under  plans of  other  employers,  if such  grant  occurs  in
connection with a corporate merger, consolidation,  separation,  reorganization,
or liquidation to which the Company or any of its subsidiaries is a party, or by
reason of the  acquisition  of property or stock of another  corporation  by the
Company  or  any  of its  subsidiaries,  provided  that  such  transaction  is a
transaction  to which  Section  424(a) of the Code  applies.  The  Stock  Option
Committee may impose such terms and  conditions  upon the grant of any incentive
stock option under this Section as are necessary to ensure that the substitution
will qualify under said Section 424(a) and will not constitute a modification of
the  option  under  Section  424(h) of the Code,  even  though  any such term or
condition  would  otherwise be  inconsistent  with the  provisions of this Plan.
Options  granted under the  provisions of this Section may be granted at a price
less than the fair market  value of the Common  Stock on the date such option is
granted,  so long as the ratio of the option  price to the fair market  value of
the Common  Stock is no more  favorable  to the  optionee  than the ratio of the
option  price to the fair  market  value of the stock  subject to the old option
immediately before such substitution.  Except as otherwise specifically provided
in the agreement  setting forth the terms and conditions of such an option,  the
provisions  of this Plan shall govern any options  granted  under this  Section.
Nothing in this Section  shall be deemed to authorize




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the  grant of  options  under  the Plan for a number  of shares in excess of the
number set forth in Section 2.

12. Use of Proceeds.

The proceeds received by the Company from the sale of stock pursuant to the Plan
may be used for general corporate purposes.

13. Amendment and Discontinuance.

The Board of  Directors  may from time to time alter or suspend  and at any time
discontinue the Plan.  However, no action of the Board of Directors may, without
approval  of the  stockholders,  increase  the  maximum  number  of shares to be
offered for sale under  options in the  aggregate  (other than  according to the
terms of Section 10 above),  modify the provisions of Section 3 hereof regarding
eligibility,  reduce the purchase price at which shares may be offered  pursuant
to options  (other  than  according  to the terms of  Section  10) or extend the
expiration date of the Plan; nor may any action of the Board of Directors or the
stockholders  alter or impair an optionee's rights under any outstanding  option
previously  granted  under the Plan,  without  the  consent of the holder of the
option.

14. Effective Date and Termination Date.

This Plan and any amendment thereto requiring  stockholder approval shall become
effective  upon the date of its  adoption  by the Board of  Directors,  subject,
however to approval by the  stockholders  of the Company within twelve months of
such date.  The Plan shall  remain in effect  until  terminated  by the Board of
Directors,  but not later  than ten years  after the date the Plan is  initially
adopted by the Board of Directors, or is approved by the shareholders, whichever
first occurs.

December 3, 1992.

Note (1): Plan amended to reflect stock splits consisting of a 2.17015:1 Reverse
Stock Split  effected  on May 9, 1994 and a 2:1 Forward  Stock Split on November
30, 1994.  Also reflects a change in par value to $.001 per share effective June
29, 1994.