As Filed with the Securities and Exchange Commission on May 19, 2004. Registration No. 333- ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ---------- FORM F-6 REGISTRATION STATEMENT under THE SECURITIES ACT OF 1933 For Depositary Shares Evidenced by American Depositary Receipts ---------- GeneMedix Plc (Exact name of issuer of deposited securities as specified in its charter) N.A. (Translation of issuer's name into English) England and Wales (Jurisdiction of incorporation or organization of issuer) THE BANK OF NEW YORK (Exact name of depositary as specified in its charter) One Wall Street, New York, N.Y. 10286 Telephone (212) 495-1784 (Address, including zip code, and telephone number, including area code, of depositary's principal executive offices) ---------- The Bank of New York ADR Division One Wall Street, 29th Floor New York, NY 10286 Telephone (212)-495-1784 (Address, including zip code, and telephone number, including area code, of agent for service) It is proposed that this filing become effective under Rule 466 |_| immediately upon filing |_| on (Date) at (Time) If a separate statement has been filed to register the deposited shares, check the following box. |_| CALCULATION OF REGISTRATION FEE ==================================================================================================================================== Proposed maximum Proposed maximum Amount of Title of each class of Amount Aggregate price aggregate registration Securities to be registered to be registered per unit (1) offering price (1) fee - ------------------------------------------------------------------------------------------------------------------------------------ American Depositary Shares evidenced by American 100,000,000 $.05 $5,000,000 $633.50 Depositary Receipts, each American Depositary Share American evidencing one common share of GeneMedix Plc Depositary Shares ==================================================================================================================================== (1) Estimated solely for the purpose of calculating the registration fee. Pursuant to Rule 457(k), such estimate is computed on the basis of the maximum aggregate fees or charges to be imposed in connection with the issuance of American Depositary Receipts evidencing American Depositary Shares. The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective, on such date as the Commission, acting pursuant to said Section 8(a), may determine. ================================================================================ The Prospectus consists of the proposed form of American Depositary Receipt included as Exhibit A to the form of Deposit Agreement filed as Exhibit (a) to this Registration Statement, which is incorporated herein by reference. -2- PART I INFORMATION REQUIRED IN PROSPECTUS Item 1. Description of the Securities to be Registered CROSS REFERENCE SHEET Item Number and Caption Location in Form of American Depositary Receipt Filed Herewith as Prospectus (1) Name and address of Depositary Introductory Paragraph (2) Title of American Depositary Receipts and Face of American Depositary Receipt, top center identity of deposited securities Terms of Deposit: (i) The amount of deposited securities Face of American Depositary Receipt - upper right represented by one unit of American corner Depositary Shares (ii) The procedure for voting, if any, the Paragraphs (15) and (16) deposited securities (iii) The collection and distribution of Paragraphs (12), (14) and (15) dividends (iv) The transmission of notices, reports Paragraphs (11), (15) and (16) and proxy soliciting material (v) The sale or exercise of rights Paragraph (13) (vi) The deposit or sale of securities Paragraphs (12) and (17) resulting from dividends, splits or plans of reorganization (vii) Amendment, extension or termination of Paragraphs (20) and (21) the Deposit Agreement (viii) Rights of holders of receipts to Paragraph (11) inspect the transfer books of the Depositary and the list of holders of receipts (ix) Restrictions upon the right to deposit Paragraphs (2), (3), (4), (5), (6) and (8) or withdraw the underlying securities -3- Item Number and Caption Location in Form of American Depositary Receipt Filed Herewith as Prospectus (x) Limitation upon the liability of the Paragraphs (13) and (18) Depositary (3) Fees and Charges Paragraph (7) Item 2. Available Information Item Number and Caption Location in Form of American Depositary Receipt Filed Herewith as Prospectus 2(a) Statement that GeneMedix Plc furnishes the Paragraph (11) Commission with certain public reports and documents required by foreign law or otherwise under Rule 12g3-2(b) under the Securities Exchange Act of 1934 and that such reports and documents can be inspected by holders of American Depositary Receipts and copied at public reference facilities maintained by the Commission in Washington, D.C. -4- PART II INFORMATION NOT REQUIRED IN PROSPECTUS Item 3. Exhibits (1) Form of Deposit Agreement (including the form of American Depositary Receipt), dated as of [Date], among GeneMedix Plc (the "Issuer"), The Bank of New York, as Depositary (the "Depositary"), and each Owner and holder from time to time of American Depositary Receipts ("ADRs") issued thereunder. (4) Opinion of Emmet, Marvin & Martin, LLP, counsel for the Depositary, as to the legality of the securities being registered. Item 4. Undertakings (a) The Depositary hereby undertakes to make available at the principal office of the Depositary in the United States, for inspection by holders of the ADRs, any reports and communications received from the Issuer which are both (1) received by the Depositary as the holder of the deposited securities and (2) made generally available to the holders of the underlying securities by the Issuer. (b) The Depositary hereby undertakes to notify each registered holder of an ADR at least thirty days before any change in the fee schedule. -5- SIGNATURES Pursuant to the requirements of the Securities Act of 1933, The Bank of New York, on behalf of the legal entity created by the Deposit Agreement, dated as of [Date], among GeneMedix Plc, The Bank of New York, as Depositary, and each Owner and holder of an American Depositary Receipt issued thereunder certifies that it has reasonable grounds to believe that all the requirements for filing on Form F-6 are met and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in The City of New York, State of New York, on May 19, 2004. By: THE BANK OF NEW YORK, as Depositary By: \s\ Andrew Zelter ------------------------ Name: Andrew Zelter Title: Managing Director -6- Pursuant to the requirements of the Securities Act of 1933, GeneMedix Plc has caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in England and Wales on May 19, 2004. GENEMEDIX PLC By: /s/ Julian Attfield ---------------------------- Name: Julian Attfield Title: Principal Financial & Accounting Officer Each of the undersigned hereby constitutes and appoints Paul Edwards and Julian Attfield, each acting severally, his true and lawful attorneys-in-fact, each with power of substitution, in his name, place and stead, in any and all capacities, to sign any or all amendments, including post-effective amendments, and supplements to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that said attorneys-in-fact, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by or on behalf of the following persons in the capacities indicated on May 19, 2004. Name Title - ---- ----- /s/ Dr. Kim Tan Chairman and Non-Executive Director - -------------------------------- Dr. Kim Tan /s/ P.M. Edwards Director (Principal Executive Officer) - -------------------------------- Paul Edwards /s/ Julian Attfield Director (Principal Financial and Accounting Officer) - -------------------------------- Julian Attfield /s/ Dr. Hong-Hoi Ting Director - -------------------------------- Dr. Hong-Hoi Ting /s/ Steve Harris Non-Executive Director - -------------------------------- Steve Harris /s/ Gordon Mylchreest Non-Executive Director - -------------------------------- Gordon Mylchreest /s/ Fong Kwok Jen Non-Executive Director - -------------------------------- Fong Kwok Jen /s/ Mark R. Saunders Authorized Representative in the United States - -------------------------------- Mark R. Saunders 405 Lexington Avenue, 45th Floor New York, New York 10174 -7- INDEX TO EXHIBITS Exhibit Number - ------- (1) Form of Deposit Agreement, dated as of [Date], among the Issuer, the Depositary and each Owner and holder from time to time of ADRs issued thereunder. (4) Opinion of Emmet, Marvin & Martin, LLP, counsel for the Depositary, as to the legality of the securities being registered. -8-