As Filed with the Securities and Exchange Commission on November 26, 2004.
                                                      Registration No. 333-
- --------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              --------------------

                                    FORM F-6
                             REGISTRATION STATEMENT
                                      under
                           THE SECURITIES ACT OF 1933
         For Depositary Shares Evidenced by American Depositary Receipts

                               -------------------

                             REGEN THERAPEUTICS PLC
   (Exact name of issuer of deposited securities as specified in its charter)

                                      N.A.
                   (Translation of issuer's name into English)

                                England and Wales
            (Jurisdiction of incorporation or organization of issuer)

                              THE BANK OF NEW YORK
             (Exact name of depositary as specified in its charter)
                      One Wall Street, New York, N.Y. 10286
                            Telephone (212) 495-1784
    (Address, including zip code, and telephone number, including area code,
                  of depositary's principal executive offices)

                              --------------------
                              The Bank of New York
                                  ADR Division
                           One Wall Street, 29th Floor
                               New York, NY 10286
                            Telephone (212)-495-1784
    (Address, including zip code, and telephone number, including area code,
                             of agent for service)

         It is proposed that this filing become effective under Rule 466
                            |_| immediately upon filing
                              |_| on (Date) at (Time)

    If a separate statement has been filed to register the deposited shares,
                          check the following box. |_|

                         CALCULATION OF REGISTRATION FEE



==================================================================================================================================

                                                                              Proposed maximum   Proposed maximum     Amount of
                 Title of each class of                       Amount           Aggregate price       aggregate      registration
              Securities to be registered                to be registered       per unit (1)     offering price (1)     fee
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                                          
American Depositary Shares evidenced by American            25,000,000               $.05            $1,250,000       $158.38
Depositary Receipts, each American Depositary Share          American
evidencing two hundred (200) ordinary shares of ReGen       Depositary
Therapeutics Plc.                                             Shares
==================================================================================================================================


(1)   Estimated  solely for the purpose of  calculating  the  registration  fee.
      Pursuant  to Rule  457(k),  such  estimate is computed on the basis of the
      maximum  aggregate  fees or charges to be imposed in  connection  with the
      issuance of American  Depositary  Receipts  evidencing American Depositary
      Shares.

The Registrant hereby amends this  Registration  Statement on such date or dates
as may be necessary to delay its effective date until the Registrant  shall file
a further amendment which specifically  states that this Registration  Statement
shall become  effective in accordance with Section 8(a) of the Securities Act of
1933 or until the registration statement shall become effective, on such date as
the Commission, acting pursuant to said Section 8(a), may determine.

- --------------------------------------------------------------------------------



      The  Prospectus  consists  of the  proposed  form of  American  Depositary
Receipt included as Exhibit A to the form of Deposit  Agreement filed as Exhibit
(1) to this Registration Statement, which is incorporated herein by reference.


                                      -2-


                                     PART I

                       INFORMATION REQUIRED IN PROSPECTUS

Item 1.  Description of the Securities to be Registered

                              CROSS REFERENCE SHEET



                                                            Location in Form of
                                                            American Depositary Receipt
         Item Number and Caption                            Filed Herewith as Prospectus
         -----------------------                            ----------------------------
                                                      
(1)      Name and address of Depositary                     Introductory Paragraph

(2)      Title of American Depositary Receipts and          Face of American Depositary Receipt, top center
         identity of deposited securities

         Terms of Deposit:

         (i)      The amount of deposited securities        Face of American Depositary Receipt - upper right
                  represented by one unit of American       corner
                  Depositary Shares

         (ii)     The procedure for voting, if any, the     Paragraphs (15) and (16)
                  deposited securities

         (iii)    The collection and distribution of        Paragraphs (12), (14) and (15)
                  dividends

         (iv)     The transmission of notices, reports      Paragraphs (11), (15) and (16)
                  and proxy soliciting material

         (v)      The sale or exercise of rights            Paragraph (13)

         (vi)     The deposit or sale of securities         Paragraphs (12) and (17)
                  resulting from dividends, splits or
                  plans of reorganization

         (vii)    Amendment, extension or termination of    Paragraphs (20) and (21)
                  the Deposit Agreement

         (viii)   Rights of holders of receipts to          Paragraph (11)
                  inspect the transfer books of the
                  Depositary and the list of holders of
                  receipts

         (ix)     Restrictions upon the right to deposit    Paragraphs (2), (3), (4), (5), (6) and (8)
                  or withdraw the underlying securities



                                      -3-




                                                            Location in Form of
                                                            American Depositary Receipt
         Item Number and Caption                            Filed Herewith as Prospectus
         -----------------------                            ----------------------------
                                                      
         (x)      Limitation upon the liability of the      Paragraphs (13) and (18)
                  Depositary

(3)      Fees and Charges                                   Paragraph (7)


Item 2.  Available Information



                                                            Location in Form of
                                                            American Depositary Receipt
         Item Number and Caption                            Filed Herewith as Prospectus
         -----------------------                            ----------------------------
                                                      
2(a)     Statement that ReGen Therapeutics Plc furnishes    Paragraph (11)
         the Commission with certain public reports and
         documents required by foreign law or otherwise
         under Rule 12g3-2(b) under the Securities
         Exchange Act of 1934 and that such reports and
         documents can be inspected by holders of
         American Depositary Receipts and copied at
         public reference facilities maintained by the
         Commission in Washington, D.C.



                                      -4-


                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 3. Exhibits

      (1) Form of Deposit Agreement  (including the form of American  Depositary
Receipt),  dated as of [Date], among ReGen Therapeutics Plc (the "Issuer"),  The
Bank of New York, as Depositary  (the  "Depositary"),  and each Owner and holder
from time to time of American Depositary Receipts ("ADRs") issued thereunder.

      (2) Form of Letter  from the  Depositary  to the  Issuer,  relating to the
Pre-release of American Depositary Receipts.

      (4) Opinion of Emmet, Marvin & Martin, LLP, counsel for the Depositary, as
to the legality of the securities being registered.

Item 4. Undertakings

      (a) The  Depositary  hereby  undertakes to make available at the principal
office of the Depositary in the United States,  for inspection by holders of the
ADRs, any reports and communications received from the Issuer which are both (1)
received by the  Depositary  as the holder of the deposited  securities  and (2)
made  generally  available to the holders of the  underlying  securities  by the
Issuer.

      (b) The Depositary  hereby  undertakes to notify each registered holder of
an ADR at least thirty days before any change in the fee schedule.


                                      -5-


                                   SIGNATURES

      Pursuant to the  requirements  of the  Securities Act of 1933, The Bank of
New York, on behalf of the legal entity created by the Deposit Agreement,  dated
as of [Date], among ReGen Therapeutics Plc, The Bank of New York, as Depositary,
and each Owner and holder of an American  Depositary  Receipt issued  thereunder
certifies  that it has reasonable  grounds to believe that all the  requirements
for filing on Form F-6 are met and has duly caused this  Registration  Statement
to be signed on its behalf by the undersigned, thereunto duly authorized, in The
City of New York, State of New York, on November 26, 2004.

                                                 By: THE BANK OF NEW YORK,
                                                     as Depositary

                                                 By: \s\ Andrew Zelter
                                                     ---------------------------
                                                     Name: Andrew Zelter
                                                     Title: Managing Director


                                      -6-


      Pursuant  to  the  requirements  of the  Securities  Act  of  1933,  REGEN
THERAPEUTICS  PLC has caused  this  Registration  Statement  to be signed on its
behalf by the undersigned,  thereunto duly authorized in England on November 26,
2004.

                                             REGEN THERAPEUTICS PLC

                                            By: \s\ Percy Lomax
                                                ---------------------
                                                Name:  Percy Lomax
                                                Title: Executive Chairman

      Each of the  undersigned  hereby  constitutes and appoints Percy Lomax and
Norman  Lott  his  true  and  lawful  attorneys-in-fact,   each  with  power  of
substitution,  in his name, place and stead, in any and all capacities,  to sign
any or all amendments,  including post-effective  amendments, and supplements to
this Registration Statement, and to file the same, with all exhibits thereto and
other  documents  in  connection  therewith,  with the  Securities  and Exchange
Commission, hereby ratifying and confirming all that said attorney-in-facts,  or
his  substitute  or  substitutes,  may lawfully do or cause to be done by virtue
hereof.

      Pursuant  to  the  requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement has been signed by or on behalf of the following persons
in the capacities indicated on November 26, 2004.

Name                                             Title
- ----                                             -----

\s\ Percy Lomax                                  Executive Chairman and Director
- -----------------------
Percy Lomax                                      (Principal Executive Officer)

\s\ Norman Lott                                  Finance Director
- -----------------------
Norman Lott                                      (Principal Financial and
                                                  Accounting Officer)

\s\ Malcolm Beveridge                            Director
- -----------------------
Malcolm Beveridge

\s\ Keith Corbin                                 Director
- -----------------------
Keith Corbin

\s\ Martin Small                                 Director
- -----------------------
Martin Small

\s\ Timothy Shilton                              Director
- -----------------------
Timothy Shilton


                                      -7-


\s\ Donald J. Puglisi                              Authorized Representative in
- -----------------------                            the United States
Donald J. Puglisi
Managing Director
Puglisi & Associates


                                      -8-


                                INDEX TO EXHIBITS

Exhibit
Number
- ------

(1)   Form of Deposit  Agreement,  dated as of  [Date],  among the  Issuer,  the
      Depositary  and each  Owner and  holder  from time to time of ADRs  issued
      thereunder.

(2)   Form  of  Letter  from  the  Depositary  to the  Issuer,  relating  to the
      Pre-release of American Depositary Receipts.

(4)   Opinion of Emmet, Marvin & Martin, LLP, counsel for the Depositary,  as to
      the legality of the securities being registered.


                                      -9-