Exhibit 99.1350CERT

         Certification Pursuant to Rule 30a-2(b) under the 1940 Act and
                      Section 906 of the Sarbanes Oxley Act

Pursuant to 18 U.S.C.  ss. 1350,  the  undersigned  officer of BlackRock  Series
Fund, Inc. (the "registrant"),  hereby certifies,  to the best of his knowledge,
that the  registrant's  Report on Form N-CSR for the period ended June 30, 2008,
(the  "Report")  fully  complies  with the  requirements  of Section  15d of the
Securities Exchange Act of 1934, as amended, and that the information  contained
in the Report fairly presents, in all material respects, the financial condition
and results of operations of the registrant.

Date: August 22, 2008

/s/ Donald C. Burke
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Donald C. Burke
Chief Executive Officer (principal executive officer) of
BlackRock Series Fund, Inc.

Pursuant to 18 U.S.C.  ss. 1350,  the  undersigned  officer of BlackRock  Series
Fund, Inc. (the "registrant"),  hereby certifies,  to the best of his knowledge,
that the  registrant's  Report on Form N-CSR for the period ended June 30, 2008,
(the  "Report")  fully  complies  with the  requirements  of Section  15d of the
Securities Exchange Act of 1934, as amended, and that the information  contained
in the Report fairly presents, in all material respects, the financial condition
and results of operations of the registrant.

Date: August 22, 2008

/s/ Neal J. Andrews
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Neal J. Andrews
Chief Financial Officer (principal financial officer) of
BlackRock Series Fund, Inc.

This  certification  is being  furnished  pursuant  to Rule  30a-2(b)  under the
Investment  Company Act of 1940, as amended,  and 18 U.S.C.  Section 1350 and is
not being  filed as part of the Form  N-CSR  with the  Securities  and  Exchange
Commission.