CERTIFICATE OF POWERS, DESIGNATIONS,
                      PREFERENCES AND RIGHTS OF THE SERIES
                            OF THE PREFERRED STOCK OF
                           HEMISPHERx BIOPHARMA, INC.

                                To Be Designated
                            Series E Preferred Stock

     Hemispherx  Biopharma,  Inc., a Delaware  corporation (the  "Company"),  in
accordance  Section 103 of the General  Corporation Law of the State of Delaware
("DGCL"),  by its  President,  does hereby certify that on January 31, 1997, the
Board of  Directors  of the Company by  unanimous  written  consent  pursuant to
Section 141(f) of the DGCL, duly adopted the following resolutions providing for
the  issuance  of a series of  Preferred  Stock to be  designated  the  Series E
Convertible Preferred Stock, par value $.01, and to consist of 5,000 shares:

          RESOLVED,  that  the  Company  is  authorized  to  issue a  series  of
          Preferred  Stock to be designated  the Series E Convertible  Preferred
          Stock,  $.01 par value  ("Series  E  Preferred"),  to consist of 5,000
          shares; and it is further

          RESOLVED, that the rights, privileges and limitations of each share of
          Series E Preferred shall be as follows:

     1. Issuance.  The Series of Preferred  designated as the Series E Preferred
shall consist of 5,000 shares.

     2.  Dividends.  The  holders of shares of Series E  Preferred  stock  shall
receive dividends,  when and if declared by the board of directors, out of funds
legally available for the payment of dividends,  at the rate of $60 per share in
cash (or at the option of the Company in freely tradable shares of the Company's
Common Stock,  $.01 par value ("Common Stock") based on market value at the time
the  dividend  is   declared),   payable  in  preference  to  all  other  common
shareholders and on a parity basis with respect to any other series of preferred
shares. Such dividends shall be cumulative, and no dividend shall be paid on the
shares of any other class  ranking  junior to the Series E Preferred  unless the
current annual  dividend,  and all arrears of dividends if any, on the shares of
Series E Preferred  shall have been paid, or provision  shall have been made for
the payment  thereof.  The  holders of shares of Series E Preferred  shall at no
time have any other right to further dividends of any kind.

     3. Voting  Rights  Except as required by law,  shares of Series E Preferred
shall not be entitled to vote on any matter upon which the vote,  or the consent
in  lieu  of  voting,  of  the  shareholders  is  required  including,   without
limitation, the election of directors.




     4. Rank. All Series E Preferred  shall rank (i) senior to the Common Stock,
now or hereafter  issued,  as to payment of dividends and distribution of assets
upon liquidation,  dissolution,  or winding up of the Company, whether voluntary
or  involuntary,  and (ii) on a parity with any  additional  series of preferred
stock of any class which the Board of  Directors  or the  stockholders  may from
time to time authorize,  both as to payment of dividends and as to distributions
of assets upon liquidation,  dissolution,  or winding up of the Company, whether
voluntary or involuntary.

     5. Liquidation. In the event of the dissolution, liquidation, or winding up
of the Company,  or a sale of all its assets,  whether voluntary or involuntary,
or in the event of its  insolvency,  there  shall be paid to the  holders of the
shares of Series E  Preferred  the sum of $1,000 per  share,  plus  accrued  and
unpaid dividends,  before any sums shall be paid or any assets distributed among
the holders of the Company's Common Stock. If the assets of the Company shall be
insufficient  to permit  the  payment  in full to the  holders  of the shares of
Series E  Preferred  and other  series of  preferred  stock of the  amount  thus
distributable,  then the  entire  assets  of the  Company  shall be  distributed
ratably  among the holders of Series E Preferred and the holders of other series
of preferred  stock.  After the  foregoing  payments to the holders of shares of
Series E Preferred and holders of other series of preferred stock, the remaining
assets  and  funds of the  Company  shall be  distributed  among and paid to the
holders of the Common  Stock,  share and share  alike,  in  proportion  to their
shareholdings. The foregoing provisions of this paragraph shall not, however, be
deemed to require the  distribution  of assets among the holders of the Series E
Preferred  and the holders of the Common Stock in the event of a  consolidation,
merger,  lease,  or sale,  which does not in fact result in the  liquidation  or
winding up of the enterprise.

     6. Conversion of Series E Preferred for Common Stock. The holders of Series
E Preferred,  subject to the conditions  set forth below,  upon surrender of the
certificates  therefor,  shall have the right to convert  the Series E Preferred
into fully paid and non-assessable shares of Common Stock determined by dividing
(x) the sum of (i) $1,000 and (ii)  accrued  but unpaid  dividends  by (y) $2.00
(the "Exchange Rate");

     Shares of Series E Preferred  shall be exchanged only upon such  conditions
and at such times as follows:

          (A) As promptly as practicable after the conversion,  and in any event
     within 15 calendar days thereafter,  the Company, at its expense (including
     the payment by it of any applicable  issue taxes) will issue and deliver to
     the holder of record, or as such holder (upon payment by such holder of any
     applicable  transfer taxes) may direct,  a certificate or certificates  for
     the  number  of  shares  of Common  Stock  issuable  upon such  conversion,
     including fractional shares.


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          (B) In the event that  sufficient  authorized  and unissued  shares of
     Common  Stock  are not  available  in order to  convert  specific  Series E
     Preferred  into shares of Common Stock,  such  conversion  shall take place
     upon  obtaining  shareholder  approval  of an  amendment  to the  Company's
     Certificate of Incorporation authorizing additional Common Stock.

          (C) If, prior to the  exercise of the  conversion,  the Company  shall
     issue any shares of its Common Stock as a stock  dividend or subdivide  the
     number  of  outstanding  shares of Common  Stock  into a greater  number of
     shares,  then,  in either case,  the Exchange  Rate per share of the Common
     Stock shall be proportionately reduced, and, conversely,  in the event that
     the Company shall contract the number of outstanding shares of Common Stock
     by combining  such shares into a smaller  number of shares,  then,  in such
     case,   the  Exchange   Rate  per  share  of  the  Common  Stock  shall  be
     proportionately  increased and the number of shares of Common Stock at that
     time into which a share of Series E  Preferred  may be  converted  shall be
     proportionately  decreased.  If the Company  shall at any time prior to the
     exercise of the exchange  declare a dividend  payable in cash on its Common
     Stock and at substantially  the same time offer its holders of Common Stock
     a right to purchase  Common Stock from the proceeds of such dividend or for
     an amount  substantially  equal to such dividend,  then, in such cases, all
     Common  Stock so issued  shall be  deemed  to have  been  issued as a stock
     dividend.  Any dividend paid or distributed  upon the Common Stock in stock
     of any other class of  securities  convertible  into shares of Common Stock
     shall be  treated  as a dividend  paid in Common  Stock to the extent  that
     shares of Common Stock are issuable upon the exchange thereof.  Issuance of
     shares of a  subsidiary  of the  Company  as a  dividend  to the  Company's
     shareholders shall have no effect on the Exchange Rate.

     7.  Redemption.  The Company shall have the right,  exercisable on not less
than 5 days written  notice to the holders of record of Series E  Preferred,  to
redeem any or all of the Series E Preferred  Shares, at any time 12 months after
the effective date of a registration  statement registering the shares of Common
Stock  underlying  the Series E Preferred  under the  Securities Act of 1933, as
amended  (the  "Registration  Statement"),  at a price  per  share  of  Series E
Preferred equal to the sum of (i) $1,250 and (ii) accrued and unpaid dividends.

     8. Mandatory  Conversion.  So long as the  Registration  Statement shall be
effective, on the date which is 730 days after the date of delivery and issuance
of the Certificate  representing  the Series E Preferred  Shares to the holders,
all of the shares of Series E Preferred then outstanding shall be converted into
shares of Common Stock in accordance with the provisions of Section 5.


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     9.  Future  Offerings.  During the period  that the Series E  Preferred  is
outstanding,  the Company  shall not proceed with any  Regulation S offerings or
similarly structured Regulation D offerings which have a conversion price with a
floating discount to the market price of the Common Stock.


     IN WITNESS WHEREOF, we, the undersigned,  have executed and subscribed this
certificate on March 4, 1997.

                                            /s/ William A. Carter
                                            -----------------------------------
                                            William A. Carter, President


ATTEST:

/s/ Josephine Dolhancryk
- ----------------------------------------
Josephine Dolhancryk, Asst. Secretary


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