Cypros Pharmaceutical Corporation Form 10-K Items 14(a) (1) and (2) Contents Report of Ernst & Young LLP, Independent Auditors F-2 Financial Statements (Item 14(a) (1)): Balance Sheets F-3 Statements of Operations F-4 Statements of ShareholdersO Equity F-5 Statements of Cash Flows F-6 Notes to Financial Statements F-7 Financial Statement Schedules (Item 14(a) (2)): All financial statement schedules are omitted because the information described therein is not applicable, not required or is furnished in the financial statements or notes thereto. Report of Independent Auditors The Board of Directors and Shareholders Cypros Pharmaceutical Corporation We have audited the accompanying balance sheets of Cypros Pharmaceutical Corporation as of July 31, 1996 and 1995, and the related statements of operations, shareholders' equity, and cash flows for each of the three years in the period ended July 31, 1996. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Cypros Pharmaceutical Corporation at July 31, 1996 and 1995, and the results of its operations and its cash flows for each of the three years in the period ended July 31, 1996 in conformity with generally accepted accounting principles. [ERNST & YOUNG LLP] (Signature) [San Diego, California] [August 26, 1996, except for Note 4, as to which the date is August 26, 1997.] Cypros Pharmaceutical Corporation Balance Sheets July 31, 1996 1995 Assets Current assets: Cash and cash equivalents $8,306,752 $5,026,745 Short-term investments, held to maturity (Notes 1 and 2) 7,690,297 8,415,250 Accounts receivable 149,626 - Inventory 63,386 - Prepaid expenses and other current assets 61,409 25,910 Total current assets 16,271,470 13,467,905 Property, equipment and leasehold improvements, net (Note 2) 608,206 411,651 Purchased technology, net of accumulated amortization of $438,238 at July 31, 1996 (Note 1) 2,629,427 [Deferred financing costs (Note 1) 520,011 -] Licenses and patents, net of accumulated amortization of $87,277 and $61,418 at July 31, 1996 and 1995, repectively (Note 4) 111,231 99,591 Deposits and other assets 126,180 195,692 [Total assets $ 20,266,525 $14,174,839] Liabilities and shareholders' equity Current liabilities: Accounts payable $ 119,092 138,537 Accrued compensation 155,748 83,594 Other accrued liabilities 231,864 189,713 Purchased asset obligation (Note 1) 200,000 - Current portion of long-term debt (Note 3) 99,282 99,282 Current portion of capital lease obligation (Note 4) 81,035 22,517 Total current liabilities 887,021 533,643 Long-term debt (Note 3) 41,367 140,650 Capital lease obligations (Note 4) 187,265 54,149 Deferred rent (Note 4) 120,411 80,519 Commitments (Note 4) [Mandatorily convertible notes (Note 4) 6,395,574 -] Shareholders' equity: (Notes 4 and 5) Common stock, 30,000,000 shares authorized, 11,613,748 and 11,352,017 shares issued and outstandingas of July 31, 1996and 1995, respectively 23,421,428 20,944,995 Deferred compensation (304,309) (186,993) Accumulated deficit (10,482,232) (7,392,124) Total shareholders' equity 12,634,887 13,365,878 Total liabilities and shareholder's equity $ 20,266,525 $14,174,839 See accompanying notes. Cypros Pharmaceutical Corporation Statements of Operations Years ended July 31, 1996 1995 1994 Net sales $ 1,275,240 - - Cost of sales 405,142 - - Gross profit 870,098 - - Operating expenses: Sales and marketing 343,054 - General and administrative 2,254,000 1,583,420 1,015,666 Clinical testing and regulatory 1,389,128 1,537,964 1,022,134 Research and development 1,002,226 788,424 526,835 Total operating expenses 4,988,408 3,909,808 2,564,635 Loss from operations (4,118,310) (3,909,808) (2,564,635) Research grant income 270,510 250,000 - Interest income, net (Note 3) 757,692 547,107 189,372 Net loss $ (3,090,108) $(3,112,701) $ (2,375,263) Net loss per share $ (0.27) $ (0.32) $ (0.32) Shares used in computing net loss per share 11,518,169 9,859,857 7,357,960 See accompanying notes. Cypros Pharmaceutical Corporation Statements of Shareholders' Equity For each of the three years ended July 31, 1996, 1995 and 1994 * Common stock Shares Amount Balance at July 31, 1993 6,083,329 $6,748,419 Exercise of warrants 1,343,750 725,625 Exercise of Class A warrants (Program I) 760,306 2,355,123 Issuance of common stock for cash and services 35,650 83,641 Common stock repurchased (203,255) (53,205) Deferred compensation related to grant of stock options - 66,958 Amortization of deferred compensation - - Net loss - - Balance at July 31, 1994 8,019,780 9,926,561 Exercise of Class A warrants (program II) 2,605,180 8,205,215 Exercise of Unit Purchase Options and underlying Class A warrants 543,745 1,681,266 Exercise of stock options 183,312 528,924 Deferred compensation related to grant of stock options and warrants - 603,029 Amortization of deferred compensation - - Net loss - - Balance at July 31, 1995 11,352,017 20,944,995 Discount on mandatorily convertible notes - 1,582,935 Issuance of common stock, net of offering costs 162,500 940,956 Issuance of common stock in business acquisitions 169,231 1,032,309 Issuance of common stock for services 200,000 284,375 Common stock repurchased (280,000)(1,540,000) Exercise of stock options 10,000 35,163 Deferred compensation related to grant of stock options - 140,695 Amortization of deferred compensation - - Net loss - - Balance at July 31, 1996 11,613,748 $23,421,428 Total Deferred Accumulate Shareholder's Compensation Deficit Equity [C] [C] [C] $(266,273) $1,904,16 $4,577,986 - - 725,625 - - 2,355,123 - - 83,641 51,624 - (1,581) (66,958) - - 110,667 - 110,667 - (2,375,263) (2,375,263) (170,940) (4,279,423) 5,476,198 - - 8,205,215 - - 1,681,266 - - 528,924 (110,842) - 492,187 94,789 - 94,789 - (3,112,701) (3,112,701) (186,993) (7,392,124) 13,365,878 - - 1,582,935 - - 940,956 - - 1,032,309 (284,375) - - - - (1,540,000) - - 35,163 (140,695) - - 307,754 - 307,754 - (3,090,108) (3,090,108) $(304,309) $(10,482,232) $12,634,887 See accompanying notes. Cypros Pharmaceutical Corporation Statements of Cash Flows 1996 1995 1994 Operating activities Net loss $(3,090,108) $(3,112,701) $(2,375,263) adjustments to reconcile net loss to net cash used in operating activities: Amortization of deferr 307,754 94,789 110,667 compensation Expense related to warrant issuances - 492,187 - Depreciation and amortization 173,610 112,713 81,002 Amortization of purchased technology 438,238 - - Deferred rent expen se 39,892 10,889 69,630 Write off of patent - 14,000 - Issuance of common stock for property - - 12,000 and services Changes in operating assets and liabilities, net of effects from acquisitions: Accounts receivable (149,626) - - Inventory 18,829 - - Prepaid expenses and other current 18,536 (41,897) (8,832) assets Accounts payable (19,445) (138,572) 187,254 Other accrued liabilities 114,305 233,909 2,618 Net cash flows used in operating activities (2,148,015) (2,334,683) (1,920,924) Investing activities Payment for purchase of inventory in Business acquisition (82,215) - - Payment for purchase of acquired businesses (1,835,356) - - Short-term investments 724,953 (3,957,538) (828,137) Purchase of property, equipment and leasehold improvements (100,770) (193,689) (134,174) Increase in licenses and patents (37,499) (10,863) (45,455) Decrease in deposits and other assets 6,197 16,673 22,729 Net cash flows used in investing activities (1,324,690) (4,145,417) (985,037) Financing activities Issuance of common stock, net 976,119 10,415,405 3,150,808 Issuance of mandatorily convertible notes 7,458,498 Repurchase and retirement of common stock (1,540,000) Proceeds from long-term debt - - 267,759 Repayments of long-term debt (99,283) (99,282) (119,129) Repayments of capital leases (42,622) (17,439) - Net cash flows provided by financing activities 6,752,712 10,298,684 3,299,438 Increase in cash and cash equivalents 3,280,007 3,818,584 393,477 Cash and cash equivalents at beginning of year 5,026,745 1,208,161 814,684 Cash and cash equivalents at end of year $8,306,752 $5,026,745 $1,208,161 Supplemental disclosures of cash flow information: Cash paid for interest 47,953 39,170 28,450 Noncash investing and financing activities: Equipment financed under capital leases 234,256 89,549 6,427 Purchased asset obligation $200,000 - - Common stock issued for business Acquisitions $1,032,309 - - See accompanying notes. Cypros Pharmaceutical Corporation Notes to Financial Statements July 31, 1996 1. Organization and Summary of Significant Accounting Policies Organization and Business Activity Cypros Pharmaceutical Corporation (the "Company") was incorporated in San Diego, California on November 2, 1990. The Company develops and markets acute-care, hospital-based products. The Company is currently marketing Glofil and Inulin, two injectable renal diagnostic products. The Company's pre- clinical and clinical development programs focus on cytoprotective drugs designed to reduce ischemia (low blood flow) induced tissue damage in acute-care settings. The Company's two clinical programs are currently in six Phase II trials, which include four for CPC-111 (acute complications of angioplasty, coronary artery bypass grafting surgery, congestive heart failure and sickle cell anemia crises), and two for CPC-211 (stroke and head injury). Through July 31, 1995, the Company was considered to be in the development stage. On August 9, 1995, the Company acquired two businesses, including (i) the New Drug Application for Glofil and finished goods inventory of Glofil on hand at the time of closing from Iso-Tex Diagnostics, Inc., a Texas corporation, (the "Glofil Acquisition") and (ii) the New Drug Application for Inulin and the raw material and finished goods inventory of Inulin on hand at the time of closing from Iso-Tex Diagnostics "B", Inc. ("ITDB"), a Texas corporation (the "Inulin Acquisition"). The Glofil Acquisition was accomplished in an arms' length negotiation through a purchase of assets and the Inulin Acquisition was accomplished through a merger of ITDB with and into the Company (the "Merger"). The total purchase price was $3,149,880, of which $1,582,215 in cash and 169,231 newly issued shares of restricted common stock of the Company (the "Restricted Shares") were paid at closing. The Company used its working capital to make the cash payments for the acquisitions at closing. Both acquisitions were accounted for using the purchase method and, accordingly, the financial statements include the operations of the businesses from the date of acquisition. As part of the Glofil Acquisition, the Company made an additional cash payment of $200,000 on January 15, 1996 and a final cash payment of $200,000 on August 9, 1996. As part of the Inulin Acquisition, the Company has agreed to register the Restricted Shares, upon the request of the sole stockholder of ITDB, at any time after one year from the date of closing and if the registration statement has not become effective within 90 days of the date of the holder's request, the Company is obligated to repurchase the Restricted Shares at their market value based upon the closing bid price of the Company's common stock on such date. [If the holder requests the Company to Register the Restricted Shares, then the Company intends to and has the ability to register them within 90 days of such request.] As a result of the acquisitions of Glofil and Inulin, the Company commended product sales and is therefore an operating company. 1. Organization and Summary of Significant Accounting Policies (continued) Organization and Business Activity (continued) The following unaudited pro forma data reflects the combined results of operations of the Company and the two businesses as if the acquisitions had occurred on August 1, 1994: July 31, 1996 1995 Net revenue $ 1,275,240 $1,031,486 Net loss (3,090,108) (2,993,386) Net loss per share (0.27) (0.30) In January 1996, the Company entered into an agreement with Syncor International ("Syncor") to distribute Glofil in unit doses through Syncor's nationwide pharmacies. Under the agreement, the Company ships whole vials of Glofil on consignment to selected pharmacies which then repackage them into unit doses and ship them to customers upon request. Syncor is also responsible for billing, collections and disposal of expired unused vials. Cash, Cash Equivalents and Short-term Investments The Company considers highly liquid investments with remaining maturities of three months or less when acquired, primarily money market funds, to be cash equivalents. Short-term investments consist of certificates of deposit, U.S. government securities and investment grade corporate obligations. The Company has established guidelines relative to diversification and maturities that maintain safety and liquidity. The Company has not experienced any losses on its cash equivalents or short- term investments. Management believes the credit risk associated with these investments is limited due to the nature of the investments. Management determines the appropriate classification of debt securities at the time of purchase and reevaluates such designations as of each balance sheet date. Debt securities are classifed as held-to-maturity when the Company has the positive intent and the ability to hold the securities to maturity. Heldto-maturity securities are carried at cost, adjusted for amortization of premiums and accretion of discounts. Interest, dividends and amortization on the securities classified as held to-maturity are included in interest income. Concentration of Credit Risk The Company extends credit to its customers, primarily hospitals and large pharmaceutical companies conducting clinical research, in connection with its product sales. The Company has not experienced significant credit losses on its customer accounts. Two customers individually accounted for 39% and 15% of current year sales. 1. Organization and Summary of Significant Accounting Policies (continued) Inventory Inventory is stated at the lower of cost (first-in, first-out method) or market and is comprised of raw materials of $3,437 and finished goods of $59,949. Depreciation and Amortization Property and equipment are stated at cost and depreciated over the estimated useful lives of the assets (generally 5 years) using the straight-line method. Leasehold improvements are amortized over the lesser of the estimated useful lives (7 years) or the remaining term of the lease, whichever is less. Purchased Technology Purchased technology associated with the acquisitions of Glofil and Inulin is stated at cost and amortized on a straight-line basis over the period estimated to be benefited (7 years). Effective August 1, 1996, the Company will adopt Statement of Financial Accounting Standards No. 121 ("FAS 121"), Accounting for the Impairment of Long-Lived Assets and for Long-Lived Assets to be Disposed Of. The Company does not believe the adoption of FAS 121 will have a material effect on the its financial position or results of operations. [Deferred Financing Costs The Company has capitalized banking, legal and accounting fees associated with the issuance of $8 million in principal amount of mandatorily convertible notes in 1996. These costs are amortized to expense over the term of the notes, which is three years, using the straight-line method commencing at the closing of the transactions.] License and Patent Costs The Company capitalizes certain costs related to license rights and patent applications. Accumulated costs are amortized over the estimated economic lives of the license rights and patents (generally 6 years) using the straight- line method commencing at the time the license rights are granted or the patents are issued. Revenue Recognition Revenues from product sales of whole vials of Glofil and Inulin are recognized upon shipment. Revenues from Glofil sales under the Syncor agreement are recognized upon receipt by the Company of monthly sales reports from Syncor on unit dose sales by its pharmacies. The Company is not obligated to accept returns of products sold that have reached their expiration date. Net Loss Per Share Net loss per share is computed using the weighted average number of common shares outstanding during the periods. 1. Organization and Summary of Significant Accounting Policies (continued) Reclassifications Certain previously reported amounts have been reclassified to conform with the 1996 presentation. Use of Estimates The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and disclosures made in the accompanying notes to the financial statements. Actual results could differ from those estimates. Accounting and Disclosure of Stock Based Compensation Effective August 1, 1996, the Company will adopt Statement of Financial Accounting Standards No. 123 ("FAS 123"), Accounting and Disclosure of Stock-Based Compensation. As allowed under FAS 123, the Company will elect to continue to account for stock option grants in accordance with Accounting Principles Board Opinion No. 25 ("APB 25"), Accounting for Stock Issued to Employees and related interpretations. Accordingly, when the Company grants stock options with an exercise price equal to the fair market value of the shares on the date of grant, no compensation expense is recorded. The Company does not believe the adoption of FAS 123 will have a material effect on its financial position or results of operations. 2. Financial Statement Details Short-Term Investments All short-term investments of the Company are classified as held to-maturity. The following is a summary of held-to-maturity investments at amortized cost as of July 31: 1996 1995 Corporate Debt Securities $ 6,902,848 $ 5,210,665 U.S. Government Obligations 749,780 2,778,223 Certificates of Deposit 37,669 426,362 $ 7,690,297 $ 8,415,250 As of July 31, 1996, the difference between cost and estimated fair value of the held-to-maturity investments was not significant. Of the above-referenced 1996 investments, $6,715,067 will mature at various dates through July 31, 1997 and $975,230 will mature at various dates after July 31, 1997 through July 31, 1998. 2. Financial Statement Details (continued) Property, Equipment and Leasehold Improvements Property, equipment and leasehold improvements consist of the following as of July 31: 1996 1995 Laboratory equipment $ 570,865 $337,622 Office equipment, furniture and fixtures 224,932 124,553 Leasehold improvements 89,517 88,113 885,314 550,288 Less accumulated depreciation and (277,108) (138,637) amortization $ 608,206 $ 411,651 Depreciation expense was $138,471, $83,313 and $44,252 for the years ended July 31, 1996, 1995 and 1994, respectively. Other Accrued Liabilities At July 31, 1996 and 1995, other accrued liabilities consist primarily of clinical costs related to the Phase II clinical trials of CPC-111. 3. Long-Term Debt As of July 31, 1996, the Company had an installment note payable to a financial institution of $140,649, of which $99,282 was classified as current. The outstanding balance was collateralized by $242,000 of the Company's short-term investments as of July 31, 1996. The installment note bears interest at the prime rate plus 1.6% (or 9.85% at July 31, 1996) and is being repaid in monthly installments through December 1997. Interest expense incurred on the installment note was $19,897, $29,947 and $25,971 for the years ended July 31, 1996, 1995 and 1994, respectively. 4. Commitments Leases The Company leases its office and research facilities under operating lease agreements and certain equipment under capital lease agreements. A security deposit of $85,714 under one of the facilities lease agreements is included in deposits and other assets. 4. Commitments (continued) Leases (continued) Minimum future obligations under both operating and capital leases as of July 31, 1996 are as follows: Operating Capital Leases Leases 1997 $ 355,780 $111,236 1998 378,040 106,832 1999 397,550 70,134 2000 421,561 35,231 2001 310,573 - Thereafter 102,749 - - $1,966,253 $323,433 Less amounts representing interest 55,133 Present value of net minimum lease payments 268,300 Current portion of obligations under capital leases 81,035 Long-term obligations under capital leases 187,265 Rent expense totaled $193,880, $107,952 and $80,127 for the years ended July 31, 1996, 1995 and 1994, respectively. Equipment acquired under capital leases totaled $277,669 and $82,614 (net of accumulated amortization of $52,564 and $13,362) as of July 31, 1996 and 1995, respectively. [Mandatorily Convertible Notes During the year ended July 31, 1996, the Company issued $8 million in principal amount of non-interest bearing, mandatorily convertible notes to institutional investors in private placements under the provisions of the Securities and Exchange Commission ("SEC") Regulation D. The notes are convertible at the option of the investors into shares of the Company's Common Stock at various dates from January 31, 1997 through July 31, 1999 at a discount to the market price of the stock immediately preceding conversion, ranging from 15% to 25%, with the actual discount depending on the length of time each investor has held the note being converted. The notes must be converted at various dates through July 31, 1999. The Company is required to register with the SEC the shares of Common Stock issuable upon conversion of the notes on or prior to the expiration of the allowable conversion periods. The notes were originally classified as a component of shareholders' equity for several reasons, including the fact that they are non-interest-bearing and convertible only into Common Stock of the Company, absent unusual circumstances. However, on August 26, 1997, in conjunction with an SEC review of a registration statement filed by the Company and in consideration of certain positions formally adopted by the SEC in March 1997, the Company reclassified the notes to long-term debt. The notes are recorded net of the $1,582,935 discount available upon conversion (assuming full conversion at the earliest possible date(s), and the discount represents an effective interest rate of 33%. The discount has been added to Common Stock and will be amortized to expense in fiscal 1997.] [License Agreements The Company has licenses to various patents for CPC-111 and CPC 211, its two clinical development programs, for the remaining term of the patents. The license agreements require payments of cash, warrants or the issuance of stock options to the licensors upon the accomplishment of various development milestones and the payment of royalties to the licensors upon the commercial sale of products incorporating the licensed compound. Under the agreement for CPC-211, the Company issued a warrant to the licensor in fiscal 1995 exercisable into 43,750 shares of the Company's Common Stock at an exercise price of $1.60 per share, as a result of the completion of the Phase I trials of that compound. The only remaining significant development milestone under these agreements is the requirement that the Company pay the licensor of CPC-111 $250,000 upon the filing of a New Drug Application with the Food and Drug Administration (the "FDA") for the approval to market that compound. In the event milestone or royalty payments to the licensor of CPC-111 are not made by the Company within specified time periods, that licensor may elect to terminate the license agreement and all rights thereunder. Such a termination could have a significant adverse impact upon the Company.] 5. Shareholders' Equity Preferred Stock The Company has authorized 1,000,000 shares of convertible preferred stock. As of July 31, 1996, no such shares were issued or outstanding. 5. Shareholders' Equity (continued) Common Stock During the year ended July 31, 1996, the Company purchased and retired 280,000 shares of its outstanding Common Stock at $5.50 per share in a privately negotiated transaction. * Warrants In connection with the Company's initial public offering in 1992 (the "Offering"), the Company issued 2,875,000 Redeemable Class A and Class B Warrants. During fiscal years 1994 and 1995, the Company initiated special programs designed to encourage holders of Redeemable Class A Warrants to exercise their warrants immediately (the "Special Class A Warrant Programs"). Under the Special Class A Warrant Programs, the Company received net proceeds of $10,497,005 from the exercise of 2,847,037 Redeemable Class A Warrants and the concurrent issuance of 3,345,236 shares of Common Stock and 1,423,512 Redeemable Class B Warrants. Subsequent to the end of the Special Class A Warrant Programs, the Company issued a notice of mandatory redemption to the remaining holders of Class A Warrants. The holders of 20,250 Class A Warrants exercised their warrants upon their original terms, resulting in $63,787 proceeds to the Company and the issuance of 20,250 shares of Common Stock. The Company repurchased all of the unexercised Class A Warrants outstanding at the end of the 30-day mandatory redemption period for $0.02 per warrant. As of July 31, 1996, there were no Redeemable Class A Warrants outstanding. During the course of the Special Class A Warrant Programs, all of the 250,000 Unit Purchase Options issued to the underwriter of the Offering were exercised at $3.02 per option, and the 250,000 Redeemable Class A Warrants within such units were immediately exercised resulting in aggregate net proceeds of $1,681,266 and the concurrent issuance of 543,745 shares of Common Stock and 375,000 Redeemable Class B Warrants. 5. Shareholders' Equity (continued) Warrants (continued) The Company issued an additional warrant in 1995 exercisable into 312,500 shares of the Company's Common Stock at a purchase price of $5 per share to a firm as consideration for financial advisory services. In January 1996, the Company cancelled the warrant and issued 200,000 shares of Common Stock at $3.39 in lieu of the cancelled warrant. As of July 31, 1996, 4,673,512 Redeemable Class B Warrants were outstanding. Warrant holders are entitled to purchase one share of Common Stock at $5.50 per share for each warrant until November 3, 1997. The Company is entitled to redeem the warrants on not less than than 30 days written notice at $0.02 per warrant when the average closing bid price of the Common Stock exceeds $9.60 per share over a period of 20 consecutive trading days, ending within 15 days of the date of notice of redemption. Stock Option Plans As of July 31, 1996, 2,274,038 shares of Common Stock were reserved for issuance under the 1992 Stock Option Plan (the "1992 Plan"). The 1992 Plan provides for the grant of incentive and nonstatutory stock options with various vesting periods, generally four years, to employees, directors and consultants. The exercise price of incentive stock options must equal at least the fair market value on the date of grant, and the exercise price of nonstatutory stock options may be no less than 85% of the fair market value on the date of grant. The maximum term of options granted under the Plan is ten years. In June 1993, the Company adopted the 1993 Non- Employee Directors' Stock Option Plan (the "1993 Plan"), under which 250,000 shares of Common Stock were reserved for issuance. The 1993 Plan provides for the granting of 25,000 options to purchase Common Stock upon appointment as a non- employee director and an additional 3,000 options each January thereafter, beginning January 1, 1994. Options vest over four years. The exercise price of the options is 85% of the fair market value on the date of grant. 5. Shareholders' Equity (continued) Stock Option Plans (continued) The following table summarizes stock option activity under the 1992 and 1993 Plans: Options Exercise Price Outstanding per Share Balance at July 31, 661,750 $1.44 - $4.05 1993 Granted 358,125 $3.06 - $4.70 Exercised (32,650) $1.44 - $2.90 Canceled (40,600) $1.58 - $2.90 Balance at July 31, 946,625 $1.44 - $4.70 1994 Granted 292,500 $4.25 - $6.40 Exercised (183,312) $1.44 - $4.60 Canceled (37,813) $3.87 - $4.60 Balance at July 31, 1,018,000 $1.44 - $6.40 1995 Granted 360,000 $3.08 - $8.50 Exercised (10,000) $3.44 - $4.60 Canceled (12,188) $5.40 Balance at July 31, 1,355,812 $1.44 - $8.50 1996 At July 31, 1996, options to purchase 789,011 shares of Common Stock were exercisable and there were 1,168,226 shares available for grant under the Plans. Deferred Compensation The Company has recorded deferred compensation for the difference between the price of certain stock sold and options granted and the fair value of the Company's Common Stock. Deferred compensation is amortized to expense during the vesting period of the related stock or options. 6. Income Taxes The Company accounts for income taxes using the liability method under Financial Accounting Standards Board Statement No. 109, Accounting for Income Taxes. Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. 6. Income Taxes (continued) Significant components of the Company's deferred tax assets and liabilities as of July 31, 1996 and 1995 are as follows: 1996 1995 Deferred tax assets: Net operating loss carryforwards $3,358,000 $ 2,366,000 Capitalized research and development costs 404,000 264,000 Research and development tax credit carryforwards 378,000 355,000 Other 231,000 168,000 Total deferred tax assets 4,371,000 3,153,000 Deferred tax liabilities: Other (19,000) (16,000) 4,352,000 3,137,000 Valuation allowance (4,352,000) (3,137,000) Net deferred tax assets $ - $ - As of July 31, 1996, the Company has federal and California tax net operating loss carryforwards of approximately $9,305,000 and $1,676,000, respectively. The federal and California tax loss carryforwards will begin expiring in 2007 and 1997, respectively, unless previously utilized. The Company also has federal and California research and development tax credit carryforwards of $288,000 and $138,000, respectively, which will begin expiring in 2007 unless previously utilized. The above carryforwards were determined as if the Company were filing a tax return at July 31, 1996; however, for tax return purposes the Company uses a calendar year end. Use of the Company's net operating loss and credit carryforwards will be limited because of the Offering which resulted in a cumulative change in ownership of more than 50%. However, the Company does not believe such change will have a material impact upon the Company's ability to utilize these carryforwards. The valuation allowance increased $1,215,000 from July 31, 1995 to July 31, 1996 due principally to the increase in deferred tax assets resulting from the increase in tax net operating loss carryforwards. Realization of deferred tax assets is dependent on future earnings, the timing and amount of which will be dependent on scientific success, results of clinical trials and regulatory approval of the Company's products currently under development. Accordingly, the full valuation reserve has been established to