NEWS RELEASE

                                                           For Immediate Release
                                                           ---------------------

Press Contact
Connie Webster
21 Park Ave.
Hudson, NH 03051
Phone:  (603) 882-5200 ext. 204
Fax:  (603) 880-3843
E-mail:  cwebster@howtek.com


     Howtek Announces Execution of Agreement to Merge with Computer Assisted
         Detection Provider Intelligent Systems Software, Inc. ("ISSI")

Hudson, NH, February 19, 2002 - Howtek, Inc. (NASDAQ:HOWT)  announced today that
it has executed a definitive  agreement with Intelligent Systems Software,  Inc.
("ISSI"),  a privately  held company based in Boca Raton,  Florida,  pursuant to
which  ISSI  would  merge  with  and into a  subsidiary  of  Howtek.  A total of
8,400,000 shares of Howtek common stock will be issued in the merger in exchange
for all of the issued and  outstanding  capital  stock of ISSI. In January 2002,
ISSI received an approval from the U.S.  Food and Drug  Administration  (FDA) to
market and sell ISSI's new MammoReader(TM) Computer Aided Detection (CAD) system
in the United States.  ISSI's  MammoReader(TM)  system promises to help in early
detection of breast  cancer by assisting  the  radiologist  in detecting  subtle
signs of cancer.  This FDA approval for both screening and diagnostic use allows
ISSI to immediately  begin commercial  distribution of its product to hospitals,
clinics, doctor's offices, and mammography centers nationwide. A high-resolution
MultiRAD medical film digitizer manufactured by Howtek for ISSI is included as a
component of the MammoReader(TM) system.

Subsequent to completion of the contemplated merger,  Howtek's existing film and
photo digitizer operations,  including  engineering,  manufacturing  management,
marketing  and  support,  will be conducted  through a wholly  owned  subsidiary
corporation,  based at the Company's  current  headquarters  in Hudson,  NH. The
Company's   objective   is  to  continue  to  grow  this   business,   providing
industry-leading  digitizers to ISSI and to other  respected  customers.  ISSI's
operations will continue in Boca Raton and Clearwater,  Florida.  W. Kip Speyer,
ISSI's Chairman, President and Chief Executive Officer will be joining Howtek as
its  Chairman  and Chief  Executive  Officer.  W.  Scott Parr will  continue  as
Howtek's President.


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Maha Sallam and Kevin Woods, ISSI's principal  technologists and founders,  will
be joining Howtek upon completion of the merger. They and Robert Howard, founder
of Howtek,  expressed shared excitement "Our visions of technology and improving
health  care are  complementary,"  they  agreed,  "and more  powerful  for being
united."

The  completion  of the merger is subject to the  registration  of the shares of
Howtek common stock to be issued in the merger under the Securities Act of 1933,
as amended, and other customary conditions,  including approval of the merger by
stockholders  of both Howtek and ISSI.  It is  expected  that the merger will be
consummated by June 30, 2002.

About Howtek, Inc.

Howtek  designs,  engineers,  and  manufactures  digital  image  scanners,  film
digitizers and related software for applications in the medical imaging, women's
health and photographic markets.

About Intelligent Systems Software, Inc.

ISSI is engaged in the development of products for medical image  analysis.  Its
initial product,  the  MammoReader(TM)  was recently approved by the U.S. Food &
Drug Administration for both screening and diagnostic use.

Additional Information

In  connection  with  the  merger,  Howtek  will be  filing  a  prospectus/proxy
statement with the Securities  and Exchange  Commission.  Investors and security
holders of Howtek and ISSI are  invited to read the  prospectus/proxy  statement
regarding  the business  combination  transaction  referenced  in the  foregoing
information,   when   it   becomes   available.   Howtek   expects   to  mail  a
prospectus/proxy statement about the transaction to its stockholders.  Investors
and security  holders may obtain a free copy of the  prospectus/proxy  statement
(when  available)  and other  documents  filed by Howtek free of charge from the
Securities  and  Exchange  Commission's  website  at   http://www.sec.gov.   The
prospectus/proxy  statement  and such other  documents may also be obtained from
Howtek  free of charge by  directing  such  requests to the  respective  address
listed above.


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Howtek and its officers and  directors may be deemed to be  participants  in the
solicitation of proxies from stockholders of Howtek with respect to the approval
of the transactions  contemplated by the agreement.  Information  regarding such
officers and directors will be set forth in the proxy statement/prospectus.

Certain statements  contained in this News Release  constitute  "forward-looking
statements" within the meaning of the Private  Securities  Litigation Reform Act
of 1995. Such  forward-looking  statements involve a number of known and unknown
risks,  uncertainties  and other  factors  which may cause the  actual  results,
performance or achievements  of the Company to be materially  different from any
future  results,  performance  or  achievements  expressed  or  implied  by such
forward-looking  statements.  Such factors include,  but are not limited to, the
risks of uncertainty of stockholder and other approvals  necessary to consummate
the proposed merger,  patent protection,  the impact of supply and manufacturing
constraints or difficulties,  product market acceptance,  possible technological
obsolescence,  increased competition,  litigation, the effects of the decline of
the economy in markets  served by the Company,  and other risks  detailed in the
Company's other filings with the Securities and Exchange  Commission.  The words
"believe",   "demonstrate",   "intend",  "expect",   "estimate",   "anticipate",
"likely", and similar expressions identify forward-looking  statements.  Readers
are cautioned not to place undue reliance on those  forward-looking  statements,
which speak only as of the date the statement was made. .

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