Exhibit 16



                 [LETTERHEAD OF SCILLIA DOWLING & NATARELLI LLC]




Securities and Exchange Commission
450 5th Street, N.W.
Washington, D.C. 20549


Gentlemen:

We have read and agree with the comments in Item 4 of Form 8-K of
Pro-Pharmaceuticals, Inc. dated February 25, 2002.


/s/ Scillia Dowling & Natarelli LLC

Hartford, Connecticut
February 25, 2002