MASTER LOAN AND SECURITY AGREEMENT


     THIS  AGREEMENT  dated as of June 18, 1997,  is made by GalaGen  Inc.  (the
"Borrower"),  a Delaware  corporation having its principal place of business and
chief executive  office at 4001 Lexington Avenue North,  Arden Hills,  Minnesota
55126,  in  favor  of  Transamerica  Business  Credit  Corporation,  a  Delaware
corporation  (the  "Lender"),  having its principal  office at Riverway II, West
Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018.

     WHEREAS,  the Borrower has requested  that the Lender make Loans to it from
time to time; and

     WHEREAS,  the  Lender  has  agreed  to make  such  Loans on the  terms  and
conditions of this Agreement.

     NOW,  THEREFORE,  in consideration of the premises and to induce the Lender
to extend credit, the Borrower hereby agrees with the Lender as follows:

     SECTION 1. DEFINITIONS.

     As used herein, the following terms shall have the following meanings,  and
shall be equally  applicable  to both the singular and plural forms of the terms
defined:

Agreement shall mean this Master Loan and Security  Agreement  together with all
schedules and exhibits hereto, as amended,  supplemented,  or otherwise modified
from time to time.

Applicable  Law  shall  mean the laws of the  State of  Illinois  (or any  other
jurisdiction whose laws are mandatorily applicable  notwithstanding the parties'
choice of Illinois law) or the laws of the United  States of America,  whichever
laws  allow the  greater  interest,  as such laws now exist or may be changed or
amended or come into effect in the future.

Business Day shall mean any day other than a Saturday, Sunday, or public holiday
or the equivalent for banks in New York City.

Code shall have the meaning specified in Section 8(d).

Collateral shall have the meaning specified in Section 2.

Effective Date shall mean the date on which all of the  conditions  specified in
Section 3.3 shall have been satisfied.

Equipment shall have the meaning specified in Section 2.

Event of Default shall mean any event specified in Section 7.

Exempt  Property  shall mean the  property  covered by those  certain  financing
statements  on file with the  Minnesota  Secretary  of State  with  file  number
1905942,  listing Cargill Leasing  Corporation  ("Cargill") as secured party and
9700264, also listing Cargill as secured party.

Financial Statements shall have the meaning specified in Section 6.1.

GAAP shall mean generally accepted accounting principles in the United States of
America, as in effect from time to time.

Loans shall mean the loans and  financial  accommodations  made by the Lender to
the Borrower in accordance with the terms of this Agreement and the Notes.





Loan Documents  shall mean,  collectively,  this Agreement,  the Notes,  and all
other documents,  agreements,  certificates,  instruments, and opinions executed
and delivered in connection herewith and therewith, as the same may be modified,
extended, restated, or supplemented from time to time.

Material  Adverse  Change  shall mean,  with  respect to any Person,  a material
adverse  change in the  business,  operations,  results of  operations,  assets,
liabilities,  or condition  (financial  or  otherwise) of such Person taken as a
whole.

Material  Adverse  Effect  shall mean,  with  respect to any Person,  a material
adverse effect on the business,  prospects,  operations,  results of operations,
assets,  liabilities, or condition (financial or otherwise) of such Person taken
as a whole.

Note  shall  mean  each  Promissory  Note made by the  Borrower  in favor of the
Lender, as amended,  supplemented,  or otherwise  modified from time to time, in
each case substantially in the form of Exhibit A.

Obligations  shall mean all  indebtedness,  obligations,  and liabilities of the
Borrower  under the Notes  and under  this  Agreement,  whether  on  account  of
principal,   interest,   indemnities,   fees  (including,   without  limitation,
attorneys' fees,  remarketing fees,  origination fees,  collection fees, and all
other professionals' fees), costs, expenses, taxes, or otherwise.

Permitted  Liens shall mean such of the  following  as to which no  enforcement,
collection,   execution,   levy,  or  foreclosure  proceeding  shall  have  been
commenced: (a) liens for taxes,  assessments,  and other governmental charges or
levies or the claims or demands of landlords, carriers, warehousemen, mechanics,
laborers, materialmen, and other like Persons arising by operation of law in the
ordinary course of business for sums which are not yet due and payable, or liens
which are being  contested in good faith by appropriate  proceedings  diligently
conducted  and with respect to which  adequate  reserves are  maintained  to the
extent  required  by GAAP;  (b)  deposits  or pledges  to secure the  payment of
workmen's  compensation,   unemployment  insurance,  or  other  social  security
benefits  or  obligations,  public or  statutory  obligations,  surety or appeal
bonds, bid or performance  bonds, or other obligations of a like nature incurred
in the ordinary course of business; (c) licenses, restrictions, or covenants for
or on the use of the Equipment which do not materially  impair either the use of
the  Equipment in the  operation of the business of the Borrower or the value of
the Equipment;  (d) attachment or judgment liens that do not constitute an Event
of Default;  (e) any  security  interest,  lien or  encumbrance  in favor of the
Lender;  (f) any purchase money security  interest,  security interest for lease
payment obligations or other lien or encumbrance incurred in connection with the
acquisition  of equipment for use in the business of Borrower;  (g) any security
interest,  lien or encumbrance  on the Exempt  Property;  (h) liens,  charges or
encumbrances permitted under the Side Agreement; and (i) other liens, charges or
encumbrances  incidental  to the  conduct  of  the  Borrower's  business  or the
ownership of its property which are not incurred in connection with borrowing of
money or obtaining advances or credit.

Person  shall  mean any  individual,  sole  proprietorship,  partnership,  joint
venture,   trust,   unincorporated   organization,   association,   corporation,
institution,  entity, party, or government  (including any division,  agency, or
department thereof), and the successors, heirs, and assigns of each.

Schedule shall mean each Schedule in the form of Schedule A hereto  delivered by
the Borrower to the Lender from time to time.

Side  Agreement  shall mean the letter  agreement  dated June 18,  1997  between
Borrower and Lender.

Solvent means, with respect to any Person,  that as of the date as to which such
Person's solvency is measured:

     (a) the fair saleable  value of its assets is in excess of the total amount
of its  liabilities  (including  contingent  liabilities as valued in accordance
with GAAP) as they become absolute and matured;

     (b) it has sufficient capital to conduct its business; and

     (c) it is able generally to meet its debts as they mature.

Taxes shall have the meaning specified in Section 5.5.



                                       2



     SECTION 2. CREATION OF SECURITY INTEREST;  COLLATERAL.  The Borrower hereby
assigns and grants to the Lender a continuing  general,  first priority lien on,
and security interest in, all the Borrower's  right,  title, and interest in and
to the collateral  described in the next sentence (the  "Collateral")  to secure
the payment and performance of all the Obligations.  The Collateral  consists of
all of  Borrower's  fixed  assets  other  than the Exempt  Property,  including,
without limitation, all equipment, goods, tenant improvements, fixtures, and the
specific  items of equipment set forth on all the Schedules  delivered from time
to time under the terms of this Agreement (the  "Equipment"),  together with all
present and future additions,  parts, accessories,  attachments,  substitutions,
repairs,  improvements,  and  replacements  thereof or thereto,  and any and all
proceeds thereof, including,  without limitation,  proceeds of insurance and all
manuals, blueprints,  know-how, warranties, and records in connection therewith,
all rights against suppliers, warrantors,  manufacturers,  sellers, or others in
connection  therewith,  and  together  with  all  substitutes  for  any  of  the
foregoing.

     SECTION 3. THE CREDIT FACILITY.

     SECTION  3.1.  Borrowings.  Each Loan  shall be in an amount  not less than
$50,000,  and in no event shall the sum of the  aggregate  Loans made exceed the
amount of the Lender's written commitment to the Borrower in effect from time to
time.  Notwithstanding  anything  herein to the  contrary,  the Lender  shall be
obligated to make the initial Loan and each other Loan only after the Lender, in
its sole  discretion,  determines  that the applicable  conditions for borrowing
contained in Sections 3.3 and 3.4 are satisfied.  The timing and financial scope
of Lender's  obligation  to make Loans  hereunder  are limited as set forth in a
commitment  letter  executed by Lender and Borrower,  dated as of April 18, 1997
and attached hereto as Exhibit B (the "Commitment Letter").

     SECTION 3.2.  Application  of Proceeds.  The Borrower shall not directly or
indirectly use any proceeds of the Loans, or cause,  assist,  suffer,  or permit
the use of any  proceeds  of the  Loans,  for any  purpose  other  than  for the
purchase,   acquisition,   installation,   or  upgrading  of  Equipment  or  the
reimbursement of the Borrower for its purchase,  acquisition,  installation,  or
upgrading of Equipment.

     SECTION 3.3. Conditions to Initial Loan.

     (a) The obligation of the Lender to make the initial Loan is subject to the
Lender's receipt of the following, each dated the date of the initial Loan or as
of an earlier date acceptable to the Lender, in form and substance  satisfactory
to the Lender and its counsel:

          (i)  completed  requests for  information  (Form  UCC-11)  listing all
     effective Uniform Commercial Code financing  statements naming the Borrower
     as debtor  and all tax lien,  judgment,  and  litigation  searches  for the
     Borrower as the Lender shall deem necessary or desirable;

          (ii) Uniform  Commercial Code financing  statements  (Form UCC-1) duly
     executed  by the  Borrower  (naming  the  Lender as  secured  party and the
     Borrower as debtor and in form  acceptable for filing in all  jurisdictions
     that the Lender  deems  necessary  or  desirable  to perfect  the  security
     interests  granted  to it  hereunder)  and,  if  applicable  and  except as
     permitted by the Side Agreement,  termination  statements or other releases
     duly  filed  in all  jurisdictions  that  the  Lender  deems  necessary  or
     desirable  to perfect and protect the  priority of the  security  interests
     granted to it hereunder in the Equipment related to such initial Loan;

          (iii) a Note duly  executed by the Borrower  evidencing  the amount of
     such Loan;

          (iv)  certificates  of insurance  required  under  Section 5.4 of this
     Agreement  together  with loss  payee  endorsements  for all such  policies
     naming the Lender as lender loss payee and as an additional insured;

          (v) a copy  of  the  resolutions  of the  Board  of  Directors  of the
     Borrower (or a unanimous consent of directors in lieu thereof)  authorizing
     the execution,  delivery, and performance of this Agreement, the other Loan
     Documents, and the transactions  contemplated hereby and thereby,  attached
     to which is a certificate of the Secretary or an Assistant Secretary of


                                       3



     the  Borrower  certifying  (A) that the  copy of the  resolutions  is true,
     complete,  and  accurate,  that such  resolutions  have not been amended or
     modified  since the date of such  certification  and are in full  force and
     effect and (B) the incumbency,  names,  and true signatures of the officers
     of the  Borrower  authorized  to sign the Loan  Documents  to which it is a
     party; and

          (vi)  such  other  agreements  and  instruments  as the  Lender  deems
     necessary  in its sole  and  absolute  discretion  in  connection  with the
     transactions contemplated hereby.

     (b) There shall be no pending or, to the  knowledge of the  Borrower  after
due inquiry,  threatened  litigation,  proceeding,  inquiry, or other action (i)
seeking an injunction or other restraining order,  damages, or other relief with
respect to the  transactions  contemplated  by this  Agreement or the other Loan
Documents  or  thereby  or (ii) which  affects  or could  affect  the  business,
prospects,   operations,   assets,   liabilities,  or  condition  (financial  or
otherwise)  of the  Borrower,  except,  in the case of clause  (ii),  where such
litigation, proceeding, inquiry, or other action could not be expected to have a
Material Adverse Effect in the judgment of the Lender.

     (c) The Borrower shall have paid all fees and expenses  required to be paid
by it to the Lender as of such date.

     (d) The  security  interests in the  Equipment  related to the initial Loan
granted  in favor of the  Lender  under  this  Agreement  shall  have  been duly
perfected and shall constitute first priority liens.

     SECTION 3.4.  Conditions  Precedent  to Each Loan.  The  obligation  of the
Lender  to make  each  Loan is  subject  to the  satisfaction  of the  following
conditions precedent:

     (a)  the  Lender  shall  have  received  the  documents,   agreements,  and
instruments set forth in Section  3.3(a)(i) through (v) applicable to such Loan,
each in form and substance  satisfactory  to the Lender and its counsel and each
dated the date of such Loan or as of an earlier date acceptable to the Lender;

     (b) the Lender shall have received a Schedule of the  Equipment  related to
such Loan, in form and substance satisfactory to the Lender and its counsel, and
the security  interests in such Equipment  related to such Loan granted in favor
of the Lender  under this  Agreement  shall have been duly  perfected  and shall
constitute first priority liens;

     (c) all representations and warranties  contained in this Agreement and the
other  Loan  Documents  shall be true and  correct on and as of the date of such
Loan as if then made, other than  representations  and warranties that expressly
relate  solely to an earlier  date,  in which case they shall have been true and
correct as of such earlier date;

     (d) no Event of  Default  or event  which  with the giving of notice or the
passage  of time,  or both,  would  constitute  an Event of  Default  shall have
occurred and be continuing or would result from the making of the requested Loan
as of the date of such request; and

     (e) the Borrower shall be deemed to have hereby reaffirmed and ratified all
security  interests,  liens, and other  encumbrances  heretofore  granted by the
Borrower to the Lender.

     SECTION 4. THE BORROWER'S REPRESENTATIONS AND WARRANTIES.

     SECTION 4.1. Good Standing;  Qualified to do Business.  The Borrower (a) is
duly  organized,  validly  existing,  and in good standing under the laws of the
State of its organization, (b) has the power and authority to own its properties
and assets and to transact the businesses in which it is presently,  or proposes
to be,  engaged,  and (c) is duly qualified and authorized to do business and is
in good standing in every  jurisdiction  in which the failure to be so qualified
could have a Material  Adverse  Effect on (i) the Borrower,  (ii) the Borrower's
ability to perform its obligations under the Loan Documents, or (iii) the rights
of the Lender hereunder.

     SECTION 4.2. Due Execution,  etc. The execution,  delivery, and performance
by the Borrower of each of the Loan  Documents to which it is a party are within
the powers of the Borrower, do not


                                       4



contravene the organizational documents, if any, of the Borrower, and do not (a)
violate  any  law or  regulation,  or any  order  or  decree  of  any  court  or
governmental  authority,  (b)  conflict  with  or  result  in a  breach  of,  or
constitute a default under, any material indenture,  mortgage,  or deed of trust
or any material lease, agreement, or other instrument binding on the Borrower or
any of its properties, or (c) require the consent, authorization by, or approval
of or notice to or filing or  registration  with any  governmental  authority or
other Person.  This  Agreement is, and each of the other Loan Documents to which
the Borrower is or will be a party, when delivered hereunder or thereunder, will
be, the legal, valid, and binding obligation of the Borrower enforceable against
the  Borrower in  accordance  with its terms,  except as  enforceability  may be
limited by bankruptcy,  insolvency,  or similar laws affecting creditors' rights
generally and by general principles of equity.

     SECTION  4.3.  Solvency;  No Liens.  The  Borrower  is Solvent  and will be
Solvent upon the completion of all transactions  contemplated to occur hereunder
(including,  without limitation, the Loan to be made on the Effective Date); the
security  interests  granted herein constitute and shall at all times constitute
the first and only liens on the Collateral  other than Permitted  Liens; and the
Borrower is, or will be at the time additional Collateral is acquired by it, the
absolute  owner of the  Collateral  with full  right to pledge,  sell,  consign,
transfer,  and create a security interest therein, free and clear of any and all
claims or liens in favor of any other Person other than Permitted Liens.

     SECTION 4.4. No Judgments, Litigation. No judgments are outstanding against
the  Borrower  nor is  there  now  pending  or,  to the  best of the  Borrower's
knowledge after diligent inquiry, threatened any litigation, contested claim, or
governmental  proceeding by or against the Borrower except judgments and pending
or threatened litigation,  contested claims, and governmental  proceedings which
would not, in the aggregate, have a Material Adverse Effect on the Borrower.

     SECTION  4.5.  No  Defaults.  The  Borrower  is not in  default  or has not
received a notice of default under any material  contract,  lease, or commitment
to which it is a party or by which it is bound. The Borrower knows of no dispute
regarding any contract, lease, or commitment which could have a Material Adverse
Effect on the Borrower.

     SECTION 4.6.  Collateral  Locations.  On the date hereof,  each item of the
Collateral  is  located at the place of  business  specified  in the  applicable
Schedule.

     SECTION 4.7. No Events of Default.  No Event of Default has occurred and is
continuing  nor has any event occurred  which,  with the giving of notice or the
passage of time, or both, would constitute an Event of Default.

     SECTION 4.8. No Limitation on Lender's Rights.  Except as permitted herein,
none of the Collateral is subject to contractual  obligations  that may restrict
or inhibit the Lender's rights or abilities to sell or dispose of the Collateral
or any part thereof after the occurrence of an Event of Default.

     SECTION  4.9.Perfection and Priority of Security  Interest.  This Agreement
creates a valid and,  upon  completion  of all  required  filings  of  financing
statements,  perfected  first  priority and exclusive  security  interest in the
Collateral, securing the payment of all the Obligations.

     SECTION 4.10.  Model and Serial  Numbers.  The Schedules set forth the true
and  correct  model  number and  serial  number of each item of  Equipment  that
constitutes Collateral.

     SECTION 4.11. Accuracy and Completeness of Information.  All data, reports,
and information heretofore,  contemporaneously,  or hereafter furnished by or on
behalf  of the  Borrower  in  writing  to the  Lender or for  purposes  of or in
connection  with this Agreement or any other Loan Document,  or any  transaction
contemplated hereby or thereby, are or will be true and accurate in all material
respects on the date as of which such data,  reports,  and information are dated
or certified and not incomplete by omitting to state any material fact necessary
to make such data,  reports,  and information not misleading at such time. There
are no facts now known to the Borrower  which  individually  or in the aggregate
would  reasonably be expected to have a Material  Adverse  Effect and which have
not been specified herein, in the Financial  Statements,  or in any certificate,
opinion, or other written statement (including  Borrower's reports on Forms 10-K
and 10-Q) previously furnished by the Borrower to


                                       5



the Lender.

     SECTION 4.12.  Price of Equipment.  The cost of each item of Equipment does
not exceed the fair and usual price for such type of equipment purchased in like
quantity and reflects all  discounts,  rebates and  allowances for the Equipment
(including,  without  limitation,  discounts for  advertising,  prompt  payment,
testing, or other services) given to the Borrower by the manufacturer, supplier,
or any other person.

     SECTION 5. COVENANTS OF THE BORROWER.

     SECTION 5.1.  Existence,  etc. The Borrower shall: (a) retain its existence
and its current yearly  accounting  cycle, (b) maintain in full force and effect
all licenses, bonds, franchises,  leases,  trademarks,  patents,  contracts, and
other rights  necessary or desirable to the  profitable  conduct of its business
unless the failure to do so could not  reasonably be expected to have a Material
Adverse  Effect on the Borrower,  (c) continue in, and limit its  operations to,
the same general lines of business as those presently  conducted or contemplated
by it, and (d) comply with all applicable  laws and  regulations of any federal,
state, or local governmental authority, except for such laws and regulations the
violations of which would not, in the aggregate,  have a Material Adverse Effect
on the Borrower.

     SECTION 5.2.  Notice to the Lender.  As soon as possible,  and in any event
within five days after the Borrower  learns of the following,  the Borrower will
give written notice to the Lender of (a) any proceeding instituted or threatened
to be instituted  by or against the Borrower in any federal,  state,  local,  or
foreign court or before any commission or other regulatory body (federal, state,
local, or foreign)  involving a sum, together with the sum involved in all other
similar  proceedings,  in excess of $50,000 in the  aggregate,  (b) any contract
that is terminated or amended and which has had or could  reasonably be expected
to have a Material  Adverse  Effect on the Borrower,  (c) the  occurrence of any
Material Adverse Change with respect to the Borrower,  and (d) the occurrence of
any Event of Default or event or condition  which,  with notice or lapse of time
or both, would constitute an Event of Default,  together with a statement of the
action which the Borrower has taken or proposes to take with respect thereto.

     SECTION 5.3.  Maintenance of Books and Records.  The Borrower will maintain
books and records  pertaining to the Collateral in such detail,  form, and scope
as the Lender shall require in its commercially reasonable judgment.  Subject to
the consent of Borrower's landlord,  Land O'Lakes,  Inc. (which consent Borrower
shall use its best efforts to obtain),  the  Borrower  agrees that the Lender or
its agents may enter upon the  Borrower's  premises at any time and from time to
time during  normal  business  hours,  and at any time upon the  occurrence  and
continuance of an Event of Default, for the purpose of inspecting the Collateral
and any and all records pertaining thereto.

     SECTION  5.4.  Insurance.  The  Borrower  will  maintain  insurance  on the
Collateral under such policies of insurance,  with such insurance companies,  in
such amounts,  and covering such risks as are at all times  satisfactory  to the
Lender.  All such policies on Equipment shall be made payable to the Lender,  in
case of loss,  under a standard  non-contributory  "lender" or  "secured  party"
clause and are to contain  such other  provisions  as the Lender may  reasonably
require to protect the Lender's  interests in the Collateral and to any payments
to be made under such  policies.  Certificates  of insurance  policies are to be
delivered to the Lender,  premium prepaid,  with the loss payable endorsement in
the  Lender's  favor,  and shall  provide for not less than  thirty  days' prior
written notice to the Lender, of any alteration or cancellation of coverage.  If
the Borrower  fails to maintain such  insurance,  the Lender may arrange for (at
the Borrower's  expense and without any responsibility on the Lender's part for)
obtaining  the  insurance.  Unless the  Lender  shall  otherwise  agree with the
Borrower in writing,  the Lender  shall have the sole right,  in the name of the
Lender or the Borrower,  to file claims under any insurance policies, to receive
and give  acquittance  for any payments that may be payable  thereunder,  and to
execute any endorsements,  receipts, releases,  assignments,  reassignments,  or
other documents that may be necessary to effect the collection,  compromise,  or
settlement of any claims under any such insurance policies.

     SECTION  5.5.   Taxes.   The  Borrower  will  pay,  when  due,  all  taxes,
assessments,  claims,  and other charges  ("Taxes")  lawfully levied or assessed
against  the  Borrower  or the  Collateral  other  than  taxes  that  are  being
diligently  contested in good faith by the Borrower by  appropriate  proceedings
promptly instituted and for which an adequate reserve is being maintained by the
Borrower in  accordance  with GAAP.  If any Taxes  remain  unpaid after the date
fixed for the payment thereof,  or if any lien shall be claimed therefor,  then,


                                       6



without notice to the Borrower, but on the Borrower's behalf, the Lender may pay
such Taxes, and the amount thereof shall be included in the Obligations.

     SECTION  5.6.  Borrower  to  Defend  Collateral  Against  Claims;  Fees  on
Collateral.  The  Borrower  will  defend the  Collateral  against all claims and
demands of all Persons at any time  claiming the same or any  interest  therein.
The Borrower will not permit any notice creating or otherwise  relating to liens
on the  Collateral  or any portion  thereof to exist or be on file in any public
office  other than  Permitted  Liens.  The Borrower  shall  promptly  pay,  when
payable, all transportation,  storage, and warehousing charges and license fees,
registration  fees,  assessments,  charges,  permit fees, and taxes  (municipal,
state,  and federal)  which may now or hereafter be imposed upon the  ownership,
leasing, renting,  possession,  sale, or use of the Collateral, other than taxes
on or measured by the Lender's income and fees, assessments,  charges, and taxes
which are being  contested in good faith by appropriate  proceedings  diligently
conducted  and with respect to which  adequate  reserves are  maintained  to the
extent required by GAAP.

     SECTION 5.7. No Change of Location,  Structure,  or Identity.  The Borrower
will not (a) change the location of its chief executive  office or establish any
place of business  other than those  specified  herein or (b) move or permit the
movement of any item of Collateral from the location specified in the applicable
Schedule,  except that the  Borrower may change its chief  executive  office and
keep  Collateral at other  locations  within the United States provided that the
Borrower has delivered to the Lender (i) prior written  notice  thereof and (ii)
duly executed financing  statements and other agreements and instruments (all in
form and substance  satisfactory to the Lender)  necessary or, in the opinion of
the Lender,  desirable  to perfect  and  maintain in favor of the Lender a first
priority  security interest in the Collateral.  Notwithstanding  anything to the
contrary  in the  immediately  preceding  sentence,  the  Borrower  may keep any
Collateral  consisting of motor vehicles or rolling stock at any location in the
United  States  provided  that  the  Lender's  security  interest  in  any  such
Collateral is  conspicuously  marked on the certificate of title thereof and the
Borrower has complied with the provisions of Section 5.9.

     SECTION 5.8. Use of Collateral;  Licenses;  Repair. The Collateral shall be
operated by competent,  qualified  personnel in connection  with the  Borrower's
business purposes,  for the purpose for which the Collateral was designed and in
accordance  with  applicable  operating   instructions,   laws,  and  government
regulations,  and the Borrower shall use every reasonable  precaution to prevent
loss or damage to the  Collateral  from fire and other  hazards.  The Collateral
shall not be used or operated for personal,  family, or household purposes.  The
Borrower   shall   procure  and   maintain  in  effect  all  orders,   licenses,
certificates,  permits,  approvals,  and consents required by federal, state, or
local laws or by any governmental  body, agency, or authority in connection with
the delivery,  installation,  use, and operation of the Collateral. The Borrower
shall  keep  all  of  the  Equipment  in a  satisfactory  state  of  repair  and
satisfactory operating condition in accordance with industry standards, and will
make all repairs and  replacements  when and where necessary and practical.  The
Borrower will not waste or destroy the  Equipment or any part thereof,  and will
not be negligent in the care or use thereof.

     SECTION 5.9. Further  Assurances.  The Borrower will, promptly upon request
by the  Lender,  execute  and  deliver  or use its best  efforts  to obtain  any
document required by the Lender (including, without limitation,  warehouseman or
processor disclaimers, mortgagee waivers, landlord disclaimers, or subordination
agreements  with  respect  to the  Obligations  and the  Collateral),  give  any
notices,  execute  and  file  any  financing  statements,  mortgages,  or  other
documents  (all in form and  substance  satisfactory  to the  Lender),  mark any
chattel paper,  deliver any chattel paper or instruments to the Lender, and take
any other actions that are necessary or, in the opinion of the Lender, desirable
to perfect or continue  the  perfection  and the first  priority of the Lender's
security  interest  in the  Collateral,  to protect the  Collateral  against the
rights,  claims, or interests of any Persons,  or to effect the purposes of this
Agreement.  A carbon,  photographic,  or other reproduction of this Agreement or
any  financing  statement  covering the  Collateral or any part thereof shall be
sufficient  as a  financing  statement  where  permitted  by law.  To the extent
required  under this  Agreement,  the  Borrower  will pay all costs  incurred in
connection with any of the foregoing.

     SECTION 5.10. No Disposition  of  Collateral.  The Borrower will not in any
way  hypothecate  or create or  permit  to exist  any lien,  security  interest,
charge, or encumbrance on or other interest in any of the Collateral, except for
the lien and security  interest  granted  hereby and  Permitted  Liens which are
junior to the lien and security  interest of the Lender,  and the Borrower  will
not sell, transfer, assign, pledge,  collaterally assign, exchange, or otherwise
dispose of any of the Collateral  except in the ordinary course of business.  In
the event the


                                       7



Collateral, or any part thereof, is sold, transferred,  assigned,  exchanged, or
otherwise disposed of in violation of these provisions, the security interest of
the Lender shall  continue in such  Collateral  or part thereof  notwithstanding
such  sale,  transfer,  assignment,  exchange,  or  other  disposition,  and the
Borrower will hold the proceeds thereof in a separate account for the benefit of
the Lender.  Following  such a sale, the Borrower will transfer such proceeds to
the Lender in kind.

     SECTION 5.11. No Limitation on Lender's Rights. The Borrower will not enter
into any  contractual  obligations  which may  restrict or inhibit the  Lender's
rights or ability to sell or  otherwise  dispose of the  Collateral  or any part
thereof.

     SECTION  5.12.  Protection  of  Collateral.  Upon  notice  to the  Borrower
(provided  that if an Event of Default has occurred and is continuing the Lender
need not give any  notice),  the Lender shall have the right at any time to make
any payments and do any other acts the Lender may deem  necessary to protect its
security interests in the Collateral,  including, without limitation, the rights
to satisfy,  purchase,  contest, or compromise any encumbrance,  charge, or lien
which,  in the  reasonable  judgment  of the  Lender,  appears to be prior to or
superior to the security interests granted hereunder,  and appear in, and defend
any action or proceeding  purporting to affect its security interests in, or the
value of, any of the  Collateral.  The Borrower  hereby  agrees to reimburse the
Lender  for all  payments  made  and  expenses  incurred  under  this  Agreement
including  fees,  expenses,   and  disbursements  of  attorneys  and  paralegals
(including  the  allocated  costs of  in-house  counsel)  acting for the Lender,
including  any of the  foregoing  payments  under,  or acts taken to protect its
security  interests  in, any of the  Collateral,  which amounts shall be secured
under this  Agreement,  and agrees it shall be bound by any payment  made or act
taken by the Lender  hereunder  absent the Lender's gross  negligence or willful
misconduct.  The Lender shall have no  obligation  to make any of the  foregoing
payments or perform any of the foregoing acts.

     SECTION 5.13.  Delivery of Items. The Borrower will (a) promptly (but in no
event later than one  Business  Day) after its receipt  thereof,  deliver to the
Lender  any  documents  or  certificates  of title  issued  with  respect to any
property included in the Collateral, and any promissory notes, letters of credit
or instruments  related to or otherwise in connection with any property included
in the  Collateral,  which in any such  case  come  into the  possession  of the
Borrower,  or shall cause the issuer thereof to deliver any of the same directly
to the  Lender,  in each case with any  necessary  endorsements  in favor of the
Lender and (b) deliver to the Lender as soon as available  copies of any and all
press releases and other similar communications issued by the Borrower.

     SECTION 5.14.  Solvency.  The Borrower  shall be and remain  Solvent at all
times.

     SECTION  5.15.  Fundamental  Changes.  The Borrower  shall not (a) amend or
modify its name, unless the Borrower delivers to the Lender thirty days prior to
any such proposed amendment or modification  written notice of such amendment or
modification and within ten days before such amendment or modification  delivers
executed  Uniform  Commercial  Code financing  statements (in form and substance
satisfactory  to the Lender) or (b) merge or  consolidate  with any other entity
without the Lender's  prior  written  consent which shall not be withheld if (i)
the  Borrower is the  survivor of such  merger or  consolidation  and remains in
compliance  with all the terms and conditions of the Loan Documents or any other
survivor of such merger or consolidation assumes all the Obligations, including,
without  limitation,  all of the  Borrower's  payment  obligations,  pursuant to
assignment documentation  acceptable to the Lender in its sole discretion,  (ii)
in the reasonable  judgment of the Lender,  the ability of such surviving entity
to perform  its  obligations  hereunder  is no worse  than that of the  Borrower
immediately before such merger or consolidation, and (iii) such surviving entity
delivers Uniform Commercial Code financing statements (Form UCC-1) duly executed
by the  surviving  entity  (naming the Lender as secured party and the surviving
entity as debtor and in form acceptable for filing in all jurisdictions that the
Lender deems necessary or advisable to perfect the security interests granted to
it hereunder) and, if applicable, termination statements, or other releases duly
filed in all  jurisdictions  that the Lender  deems  necessary  or  advisable to
perfect and  protect  the  priority  of the  security  interests  granted by the
Borrower hereunder).

     SECTION 5.16.  Additional  Requirements.  The Borrower  shall take all such
further  actions and execute all such further  documents and  instruments as the
Lender may  reasonably  request to carry out the intent and  purpose of the Loan
Documents.

     SECTION 6. FINANCIAL STATEMENTS. Until the payment and satisfaction in full
of all  Obligations,  the  Borrower  shall  deliver to the Lender the  following
financial information:


                                       8



     SECTION 6.1. Annual  Financial  Statements.  As soon as available,  but not
later than 120 days after the end of each  fiscal year of the  Borrower  and its
consolidated subsidiaries, the consolidated balance sheet, income statement, and
statements  of cash  flows and  shareholders  equity  for the  Borrower  and its
consolidated  subsidiaries (the "Financial  Statements") for such year, reported
on by independent certified public accountants and

     SECTION 6.2. Quarterly Financial Statements.  As soon as available, but not
later than 60 days after the end of each of the first three  fiscal  quarters in
any fiscal year of the Borrower and its consolidated subsidiaries, the Financial
Statements for such fiscal quarter,  together with a certification duly executed
by a responsible  officer of the Borrower that such  Financial  Statements  have
been  prepared in  accordance  with GAAP and are fairly  stated in all  material
respects (subject to normal year-end audit adjustments).

     SECTION 7. EVENTS OF DEFAULT. The occurrence of any of the following events
shall constitute an Event of Default hereunder:

     (a) the Borrower  shall fail to pay within five days of when due any amount
required to be paid by the  Borrower  under or in  connection  with any Note and
this Agreement;

     (b) any  representation  or warranty  made or deemed  made by the  Borrower
under or in connection  with any Loan Document or any Financial  Statement shall
prove to have been false or incorrect in any material respect when made;

     (c) the  Borrower  shall fail to  perform or observe  (i) any of the terms,
covenants or  agreements  contained in Sections 5.4,  5.7,  5.10,  5.14, or 5.15
hereof or (ii) any other term,  covenant,  or  agreement  contained  in any Loan
Document  (other than the other  Events of Default  specified in this Section 7)
and such failure remains unremedied for the earlier of fifteen days from (A) the
date on which the Lender has given the Borrower  written  notice of such failure
and (B) the  date on  which  the  Borrower  knew or  should  have  known of such
failure;

     (d) any  provision  of any Loan  Document to which the  Borrower is a party
shall for any  reason  cease to be valid and  binding  on the  Borrower,  or the
Borrower shall so state;

     (e)  dissolution,  liquidation,  winding up, or cessation of the Borrower's
business,  failure of the  Borrower  generally  to pay its debts as they mature,
admission in writing by the Borrower of its inability generally to pay its debts
as they mature, or calling of a meeting of the Borrower's creditors for purposes
of compromising any of the Borrower's debts;

     (f)  the  commencement  by or  against  the  Borrower  of  any  bankruptcy,
insolvency,  arrangement,  reorganization,  receivership, or similar proceedings
under  any  federal  or  state  law and,  in the  case of any  such  involuntary
proceeding,  such proceeding remains undismissed or unstayed for forty-five days
following  the  commencement  thereof,  or any action by the  Borrower  is taken
authorizing any such proceedings;

     (g) an  assignment  for the benefit of creditors  is made by the  Borrower,
whether  voluntary or  involuntary,  the  appointment  of a trustee,  custodian,
receiver,  or similar official for the Borrower or for any substantial  property
of the Borrower, or any action by the Borrower authorizing any such proceeding;

     (h) the Borrower  shall default in (i) the payment of principal or interest
on any indebtedness in excess of $50,000 (other than the Obligations) beyond the
period of grace,  if any,  provided in the  instrument or agreement  under which
such  indebtedness  was created;  or (ii) the  observance or  performance of any
other  material  agreement or  condition  relating to any such  indebtedness  or
contained in any instrument or agreement  relating  thereto,  or any other event
shall occur or condition  exist,  the effect of which  default or other event or
condition is to cause,  or to permit the holder or holders of such  indebtedness
to cause, with the giving of notice if required, such indebtedness to become due
prior to its stated maturity;

     (i) the Borrower suffers or sustains a Material Adverse Change;


                                       9



     (j) any tax lien,  other than a Permitted  Lien, is filed of record against
the Borrower and is not bonded or discharged within five Business Days;

     (k) any judgment  which has had or could  reasonably  be expected to have a
Material  Adverse  Effect on the Borrower and such judgment shall not be stayed,
vacated, bonded, or discharged within sixty days;

     (l) any material covenant,  agreement, or obligation,  as determined in the
sole  discretion  of the  Lender,  made  by the  Borrower  and  contained  in or
evidenced by any of the Loan Documents shall cease to be  enforceable,  or shall
be determined to be  unenforceable,  in accordance with its terms;  the Borrower
shall deny or disaffirm the  Obligations  under any of the Loan Documents or any
liens  granted  in  connection  therewith;  or any liens  granted  on any of the
Collateral in favor of the Lender shall be determined to be void,  voidable,  or
invalid, or shall not be given the priority contemplated by this Agreement; or

     (m) there is a change,  which change  results from a single  transaction or
series of related transactions, but not from the sale of newly issued securities
to investors,  in more than 50% of the ownership of any equity  interests of the
Borrower on the date hereof.

     SECTION 8.  REMEDIES.  If any Event of Default  shall have  occurred and be
continuing:

     (a) The Lender may, without  prejudice to any of its other rights under any
Loan Document or Applicable  Law,  declare all Obligations to be immediately due
and payable  (except  with  respect to any Event of Default set forth in Section
7(f)  hereof,  in  which  case  all  Obligations  shall   automatically   become
immediately  due and  payable  without  necessity  of any  declaration)  without
presentment,  representation,  demand of payment,  or protest,  which are hereby
expressly waived.

     (b) The Lender may take  possession of the Collateral and, for that purpose
may enter,  with the aid and  assistance of any person or persons,  any premises
where the  Collateral  or any part  hereof is, or may be placed,  and remove the
same,  except that Lender shall have no rights to take  possession of Collateral
consisting of  improvements to the premises where the Exempt Property is, or may
be, placed or to take possession of parts,  accessories or attachments to Exempt
Property.

     (c) The  obligation  of the  Lender,  if any, to make  additional  Loans or
financial   accommodations  of  any  kind  to  the  Borrower  shall  immediately
terminate.

     (d) The Lender may  exercise in respect of the  Collateral,  in addition to
other  rights and  remedies  provided  for herein (or in any Loan  Document)  or
otherwise  available to it, all the rights and remedies of a secured party under
the  applicable  Uniform  Commercial  Code (the "Code")  whether or not the Code
applies to the affected Collateral and also may (i) require the Borrower to, and
the Borrower  hereby  agrees that it will at its expense and upon request of the
Lender  forthwith,  assemble  all or part of the  Collateral  as directed by the
Lender and make it  available to the Lender at a place to be  designated  by the
Lender that is  reasonably  convenient  to both parties and (ii) without  notice
except as specified  below,  sell the  Collateral  or any part thereof in one or
more  parcels  at public or  private  sale,  at any of the  Lender's  offices or
elsewhere,  for cash,  on credit,  or for future  delivery,  and upon such other
terms as the Lender may deem commercially reasonable.  The Borrower agrees that,
to the extent notice of sale shall be required by law, at least ten days' notice
to the Borrower of the time and place of any public sale or the time after which
any private sale is to be made shall  constitute  reasonable  notification.  The
Lender  shall not be  obligated  to make any sale of  Collateral  regardless  of
notice of sale having  been given.  The Lender may adjourn any public or private
sale from time to time by announcement at the time and place fixed therefor, and
such sale may, without further notice, be made at the time and place to which it
was so adjourned.

     (e) All cash  proceeds  received  by the  Lender in respect of any sale of,
collection  from, or other  realization  upon all or any part of the  Collateral
may, in the discretion of the Lender,  be held by the Lender as collateral  for,
or then or at any time  thereafter  applied  in  whole or in part by the  Lender
against,  all or any part of the  Obligations  in such order as the Lender shall
elect.  Any  surplus  of such  cash  or cash  proceeds  held by the  Lender  and
remaining after the full and final payment of all the Obligations  shall be paid
over to the Borrower or to such other Person to which the Lender may be required
under applicable law, or directed by a court of competent jurisdiction,  to make
payment of such surplus.


                                       10



     SECTION 9. MISCELLANEOUS PROVISIONS.

     SECTION 9.1.  Notices.  Except as otherwise  provided herein,  all notices,
approvals, consents, correspondence, or other communications required or desired
to be given  hereunder  shall be given in  writing  and  shall be  delivered  by
overnight  courier,  hand  delivery,  or certified or registered  mail,  postage
prepaid, if to the Lender, then to Transamerica  Technology Finance Division, 76
Batterson Park Road, Farmington,  Connecticut 06032,  Attention:  Assistant Vice
President, Lease Administration,  with a copy to the Lender at Riverway II, West
Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018, Attention: Legal
Department,  and if to the Borrower,  then to GalaGen  Inc.,  at 4001  Lexington
Avenue North,  Arden Hills,  Minnesota  55126, or such other address as shall be
designated  by the  Borrower  or the  Lender  to the other  party in  accordance
herewith. All such notices and correspondence shall be effective when received.

     SECTION 9.2.  Headings.  The headings in this Agreement are for purposes of
reference only and shall not affect the meaning or construction of any provision
of this Agreement.

     SECTION 9.3.  Assignments.  The Borrower shall not have the right to assign
any Note or this Agreement or any interest  therein unless the Lender shall have
given the Borrower prior written consent and the Borrower and its assignee shall
have delivered  assignment  documentation in form and substance  satisfactory to
the Lender in its sole discretion. The Lender may assign its rights and delegate
its obligations under any Note or this Agreement.

     SECTION 9.4. Amendments,  Waivers, and Consents. Any amendment or waiver of
any provision of this Agreement and any consent to any departure by the Borrower
from any provision of this Agreement shall be effective only by a writing signed
by the Lender and shall bind and benefit the  Borrower  and the Lender and their
respective successors and assigns,  subject, in the case of the Borrower, to the
first sentence of Section 9.3.

     SECTION 9.5.  Interpretation  of Agreement.  Time is of the essence in each
provision of this  Agreement of which time is an element.  All terms not defined
herein or in a Note shall have the  meaning  set forth in the  applicable  Code,
except where the context otherwise  requires.  To the extent a term or provision
of this Agreement conflicts with any Note, or any term or provision thereof, and
is not dealt with herein with more  specificity,  this  Agreement  shall control
with respect to the subject  matter of such term or provision.  Acceptance of or
acquiescence in a course of performance  rendered under this Agreement shall not
be  relevant  in  determining  the  meaning of this  Agreement  even  though the
accepting or  acquiescing  party had knowledge of the nature of the  performance
and opportunity for objection.

     SECTION 9.6.  Continuing  Security Interest.  This Agreement shall create a
continuing  security  interest  in the  Collateral  and shall (i) remain in full
force and effect until the indefeasible payment in full of the Obligations, (ii)
be binding  upon the Borrower  and its  successors  and assigns and (iii) inure,
together with the rights and remedies of the Lender hereunder, to the benefit of
the Lender and its successors, transferees, and assigns.

     SECTION 9.7. Reinstatement.  To the extent permitted by law, this Agreement
and the  rights and powers  granted to the Lender  hereunder  and under the Loan
Documents  shall  continue to be effective or be  reinstated  if at any time any
amount received by the Lender in respect of the Obligations is rescinded or must
otherwise be restored or returned by the Lender upon the insolvency, bankruptcy,
dissolution,  liquidation,  or  reorganization  of  the  Borrower  or  upon  the
appointment  of any  receiver,  intervenor,  conservator,  trustee,  or  similar
official for the Borrower or any substantial  part of its assets,  or otherwise,
all as though such payments had not been made.

     SECTION 9.8. Survival of Provisions.  All representations,  warranties, and
covenants  of the Borrower  contained  herein shall  survive the  execution  and
delivery of this  Agreement,  and shall  terminate  only upon the full and final
payment and performance by the Borrower of the Obligations secured hereby.


                                       11



     SECTION 9.9.  Indemnification.  The Borrower  agrees to indemnify  and hold
harmless the Lender and its directors,  officers, agents, employees, and counsel
from and against any and all costs,  expenses,  claims, or liability incurred by
the Lender or such  Person  hereunder  and under any other Loan  Document  or in
connection herewith or therewith, unless such claim or liability shall be due to
willful misconduct or gross negligence on the part of the Lender or such Person.

     SECTION 9.10.  Counterparts;  Telecopied Signatures.  This Agreement may be
executed in counterparts,  each of which when so executed and delivered shall be
an  original,  but  both of which  shall  together  constitute  one and the same
instrument.  This Agreement and each of the other Loan Documents and any notices
given in  connection  herewith or  therewith  may be executed  and  delivered by
telecopier or other facsimile transmission all with the same force and effect as
if the same was a fully executed and delivered original manual counterpart.

     SECTION 9.11.  Severability.  In case any provision in or obligation  under
this Agreement or any Note or any other Loan Document shall be invalid, illegal,
or unenforceable in any jurisdiction, the validity, legality, and enforceability
of the remaining  provisions or obligations,  or of such provision or obligation
in any other jurisdiction, shall not in any way be affected or impaired thereby.

     SECTION 9.12. Delays; Partial Exercise of Remedies. No delay or omission of
the Lender to exercise any right or remedy  hereunder,  whether  before or after
the  happening  of any Event of  Default,  shall  impair any such right or shall
operate  as a waiver  thereof or as a waiver of any such  Event of  Default.  No
single or partial  exercise by the Lender of any right or remedy shall  preclude
any other or further exercise thereof, or preclude any other right or remedy.

     SECTION 9.13. Entire Agreement. The Borrower and the Lender agree that this
Agreement,  the Schedule hereto,  and the Commitment Letter are the complete and
exclusive  statement  and  agreement  between  the parties  with  respect to the
subject matter hereof,  superseding all proposals and prior agreements,  oral or
written,  and all other  communications  between the parties with respect to the
subject matter hereof. Should there exist any inconsistency between the terms of
the Commitment  Letter and this  Agreement,  the terms of this  Agreement  shall
prevail.

     SECTION 9.14. Setoff. In addition to and not in limitation of all rights of
offset  that the Lender may have under  Applicable  Law,  and whether or not the
Lender has made any demand or the Obligations of the Borrower have matured,  the
Lender  shall  have the right to  appropriate  and apply to the  payment  of the
Obligations  of  the  Borrower  all  deposits  and  other  obligations  then  or
thereafter  owing by the  Lender  to or for the  credit  or the  account  of the
Borrower.

     SECTION 9.15. WAIVER OF JURY TRIAL. THE BORROWER AND THE LENDER IRREVOCABLY
WAIVE  ALL RIGHT TO TRIAL BY JURY IN ANY  ACTION,  PROCEEDING,  OR  COUNTERCLAIM
ARISING OUT OF OR RELATING TO THIS  AGREEMENT,  ANY OTHER LOAN DOCUMENT,  OR THE
TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY.

     SECTION 9.16. GOVERNING LAW. THE VALIDITY,  INTERPRETATION, AND ENFORCEMENT
OF THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS
OF THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO THE CONFLICT OF LAW PRINCIPLES
THEREOF.

     SECTION  9.17.  Venue;  Service of Process.  ANY LEGAL ACTION OR PROCEEDING
WITH RESPECT TO THIS  AGREEMENT OR ANY OTHER LOAN DOCUMENT MAY BE BROUGHT IN THE
COURTS OF THE STATE OF ILLINOIS SITUATED IN COOK COUNTY, OR OF THE UNITED STATES
OF AMERICA FOR THE NORTHERN DISTRICT OF ILLINOIS, AND, BY EXECUTION AND DELIVERY
OF THIS AGREEMENT,  THE BORROWER HEREBY ACCEPTS FOR ITSELF AND IN RESPECT OF ITS
PROPERTY,  GENERALLY  AND  UNCONDITIONALLY,  THE  JURISDICTION  OF THE AFORESAID
COURTS.  THE BORROWER  HEREBY  IRREVOCABLY  WAIVES,  IN CONNECTION WITH ANY SUCH
ACTION


                                       12



OR PROCEEDING,  ANY OBJECTION,  INCLUDING,  WITHOUT LIMITATION, ANY OBJECTION TO
THE LAYING OF VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, THAT IT MAY
NOW OR HEREAFTER  HAVE TO THE BRINGING OF ANY SUCH ACTION OR  PROCEEDING IN SUCH
RESPECTIVE  JURISDICTIONS.  THE BORROWER  IRREVOCABLY CONSENTS TO THE SERVICE OF
PROCESS OF ANY OF THE AFOREMENTIONED  COURTS IN ANY SUCH ACTION OR PROCEEDING BY
THE MAILING OF COPIES THEREOF BY REGISTERED OR CERTIFIED MAIL,  POSTAGE PREPAID,
TO THE BORROWER AT THE ADDRESS FOR IT  SPECIFIED IN SECTION 9.1 HEREOF.  NOTHING
HEREIN SHALL AFFECT THE RIGHT OF THE LENDER TO SERVE PROCESS IN ANY OTHER MANNER
PERMITTED BY LAW OR TO COMMENCE LEGAL  PROCEEDINGS OR OTHERWISE  PROCEED AGAINST
THE  BORROWER  IN ANY  OTHER  JURISDICTION,  SUBJECT  IN  EACH  INSTANCE  TO THE
PROVISIONS HEREOF WITH RESPECT TO RIGHTS AND REMEDIES.

     IN WITNESS WHEREOF,  the undersigned  Borrower has caused this Agreement to
be duly executed and delivered by its proper and duly  authorized  officer as of
the date first set forth above.

                                             GALAGEN INC.


                                             By:
                                                -----------------------------
                                                  Name:
                                                  Title:

Accepted as of the
____ day of June, 1997

TRANSAMERICA BUSINESS CREDIT CORPORATION


By:
   -------------------------------------
   Name:
   Title:

                                       13





                                                                       EXHIBIT A

                                 PROMISSORY NOTE


                                                               Date: ___________


     FOR  VALUE  RECEIVED,  the  undersigned  promises  to pay to the  order  of
Transamerica  Business  Credit  Corporation  or its assigns (the "Payee") at its
office  located at Riverway  II,  West Office  Tower,  9399 West  Higgins  Road,
Rosemont,  Illinois  60018,  or at such  other  place as the Payee or the holder
hereof may designate in writing,  the principal amount of  __________________and
00/100 Dollars  ($_______.__)  received by the  undersigned,  plus interest,  in
lawful money of the United States and in immediately  available funds. This Note
shall be payable  commencing  with a first  installment  of  _____________00/100
Dollars ($_______.__) payable on _____ __, 19__ and thereafter in 46 consecutive
equal monthly installments of ___________ 00/100 Dollars ($_____.__)  commencing
_____ __, 19__ and a final balloon  payment on ____ __, 20__ of  _______________
($______.__)  together  with any amounts due and owing the Lender.  No amount of
principal paid or prepaid hereunder may be reborrowed.

     This Note is one of the Notes  referred to in the Master Loan and  Security
Agreement  dated  as of May 1,  1997  (as  amended,  supplemented  or  otherwise
modified from time to time, the  "Agreement"),  between the  undersigned and the
Payee and is subject  and  entitled  to all  provisions  and  benefits  thereof.
Capitalized  terms used but not defined herein shall have the meanings set forth
in the Agreement.

     If any  installment of this Note is not paid within five days after its due
date, the undersigned agrees to pay on demand, in addition to the amount of such
installment,  an amount equal to 5% of such installment,  but only to the extent
permitted by Applicable Law.

     The  undersigned  shall  have the right to prepay  this Note at any time on
thirty  days'  prior  written  notice  to the  Payee.  On the  date of any  such
prepayment,  the undersigned  shall pay, an amount equal to the present value of
the remaining payments  (principal and interest) due hereunder (i) if paid prior
to June 1, 1999  discounted  at 6% simple  interest  per annum,  or (ii) if paid
after June 1, 1999 discounted at 10% simple interest per annum together with all
interest,  fees and  other  amounts  payable  on the  amount  so  prepaid  or in
connection  therewith to the date of such prepayment.  Any prepayments  shall be
applied to the installments hereof in the inverse order of maturity.

     Upon the maturity of this Note or the  acceleration of the maturity of this
Note in accordance with the terms of the Agreement,  the entire unpaid principal
amount on this Note, together with all interest,  fees and other amounts payable
hereon or in connection  herewith,  shall be immediately due and payable without
further  notice  or  demand,  with  interest  on all such  amounts  at a rate of
eighteen   percent  (18%)  per  annum,   from  the  date  of  such  maturity  or
acceleration, as the case may be, until all such amounts have been paid.

     If any payment on this Note becomes  payable on a day other than a Business
Day, the maturity thereof shall be extended to the next succeeding Business Day.

     The undersigned hereby waives diligence,  demand, presentment,  protest and
notice of any kind,  and assents to extensions of the time of payment,  release,
surrender or  substitution  of security,  or  forbearance  or other  indulgence,
without  notice.  The  undersigned  agrees to pay all  amounts  under  this Note
without offset, deduction,  claim,  counterclaim,  defense or recoupment, all of
which are hereby waived.


                                       14



     The Payee,  the  undersigned  and any other  parties to the Loan  Documents
intend to contract in strict  compliance with applicable  usury law from time to
time in effect.  In  furtherance  thereof such Persons  stipulate and agree that
none of the terms and provisions  contained in the Loan Documents  shall ever be
construed to create a contract to pay, for the use,  forbearance or detention of
money,  interest in excess of the maximum  amount of  interest  permitted  to be
charged by Applicable Law from time to time in effect.  Neither the  undersigned
nor any present or future  guarantors,  endorsers,  or other  Persons  hereafter
becoming liable for payment of any Obligation  shall ever be liable for unearned
interest  thereon or shall ever be required to pay interest thereon in excess of
the maximum amount that may be lawfully  charged under  Applicable Law from time
to time in effect,  and the provisions of this paragraph  shall control over all
other  provisions  of the Loan  Documents  which may be in  conflict or apparent
conflict  herewith.  The Payee  expressly  disavows  any  intention to charge or
collect excessive unearned interest or finance charges in the event the maturity
of any  Obligation  is  accelerated.  If (a) the maturity of any  Obligation  is
accelerated  for any reason,  (b) any  Obligation is prepaid and as a result any
amounts held to constitute  interest are determined to be in excess of the legal
maximum,  or (c) the Payee or any other holder of any or all of the  Obligations
shall  otherwise  collect  amounts which are  determined to constitute  interest
which would otherwise  increase the interest on any or all of the Obligations to
an amount in excess of that  permitted to be charged by  Applicable  Law then in
effect,  then all sums determined to constitute interest in excess of such legal
limit shall, without penalty, be promptly applied to reduce the then outstanding
principal of the related Obligations or, at the Payee's or such holder's option,
promptly  returned to the undersigned  upon such  determination.  In determining
whether or not the interest  paid or payable,  under any specific  circumstance,
exceeds the maximum amount  permitted  under  Applicable  Law, the Payee and the
undersigned  (and  any  other  payors  thereof)  shall  to the  greatest  extent
permitted under Applicable Law, (i) characterize any non-principal payment as an
expense,  fee or  premium  rather  than  as  interest,  (ii)  exclude  voluntary
prepayments and the effects thereof, and (iii) amortize,  prorate, allocate, and
spread the total amount of interest through the entire contemplated term of this
Note in accordance with the amount  outstanding from time to time thereunder and
the maximum legal rate of interest from time to time in effect under  Applicable
Law in order to lawfully  charge the maximum amount of interest  permitted under
Applicable Law.

     This Note may not be changed, modified or terminated orally, but only by an
agreement  in  writing  signed by the  undersigned  and the Payee or any  holder
hereof.

     The undersigned shall, upon demand, pay to the Payee all costs and expenses
incurred by the Payee (including the fees and disbursements of counsel and other
professionals)  in connection  with the  preparation,  execution and delivery of
this  Note  and  all  other  Loan   Documents,   and  in  connection   with  the
administration, modification and amendment of the Loan Documents, and pay to the
Payee all costs and expenses  (including the fees and  disbursements  of counsel
and other  professionals)  paid or  incurred  by the Payee in (A)  enforcing  or
defending  its rights  under or in respect of this Note or any of the other Loan
Documents, (B) collecting any of the liabilities by the undersigned to the Payee
or otherwise  administering  the Loan  Documents,  (C)  foreclosing or otherwise
collecting upon any collateral and (D) obtaining any legal,  accounting or other
advice in connection with any of the foregoing.

     This  Note  shall  be  binding  upon  the  successors  and  assigns  of the
undersigned and inure to the benefit of the Payee and its successors,  endorsees
and  assigns.  If any term or  provision  of this  Note  shall be held  invalid,
illegal or unenforceable,  the validity of all other terms and provisions hereof
shall in no way be affected thereby.


                                       15





     EACH OF THE  UNDERSIGNED  AND, BY ITS ACCEPTANCE  HEREOF,  THE PAYEE HEREBY
KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES (TO THE FULLEST EXTENT PERMITTED
BY  APPLICABLE  LAW) ANY  RIGHT  IT MAY  HAVE TO A TRIAL BY JURY OF ANY  DISPUTE
ARISING UNDER OR RELATING TO THIS NOTE AND AGREES THAT ANY SUCH DISPUTE SHALL BE
TRIED BEFORE A JUDGE SITTING WITHOUT A JURY.

     THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF
THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO PRINCIPLES OF CONFLICTS OF LAW.




                                        GALAGEN INC.

                                        By:
                                           ---------------------------------
                                             Name:
                                             Title:





                                       16






                                    EXHIBIT B



April 18, 1997



Mr. Gregg A. Waldon
Chief Financial Officer
GalaGen, Inc.
4001 Lexington Avenue North
Arden Hills, Minnesota 55128

Dear Gregg:

Transamerica Business Credit  Corporation-Technology  Finance Division ("Lender)
is pleased to offer financing for the Equipment described below to GalaGen, Inc.
("Borrower").  This Commitment supersedes all prior  correspondence,  proposals,
and  oral or other  communications  relating  to  lending  arrangements  between
Borrower and Lender.

The outline of this offer is as follows:

Borrower:                        GalaGen, Inc.

Lender:                          Transamerica   Business   Credit   Corporation-
                                 Technology  Finance Division ("TFD") and/or its
                                 affiliates, successors or assigns.

Guarantors:                      None

Equipment:                       Laboratory  Equipment,  Pilot  Plant,  Computer
                                 Equipment and Tenant Improvements.

Loans:                           Lender shall make one loan or a series of loans
                                 for new equipment (each a "Loan").

Security:                        Lender  shall  be  granted  a  perfected  first
                                 priority  interest  in all fixed  assets of the
                                 Borrower  now owned or  hereafter  acquired and
                                 all  cash  and  non-cash  proceeds   (including
                                 insurance  proceeds)  of all  of the  foregoing
                                 (the "Collateral").

Amount of Loan:                  Not to exceed $2,000,000  (Tenant  Improvements
                                 not to exceed $1,111,700).

Equipment Location:              4001  Lexington  Avenue  North,   Arden  Hills,
                                 Minnesota 55128.

Anticipated Delivery:            Through June 30, 1998.

Termination of Commitment:       This  commitment  will  terminate  if the first
                                 delivery  of  Equipment   and  funding  is  not
                                 completed on or before May 15, 1997.

Loan Term
Commencement:                    Upon  making  each Loan,  which will occur upon
                                 delivery   of  the   Equipment   or  upon  each
                                 completion  of deliveries of items of Equipment
                                 with  aggregate  cost of not less than $50,000,
                                 and shall be no later than June 30, 1998.


                                       17


Term:                            From  each  Loan  Term  Commencement  until  48
                                 months  from the first  day of the  month  next
                                 following  or  coincident  with  that Loan Term
                                 Commencement.

Repayment Terms:                 Monthly  Payments  equal to 2.5782% of the Loan
                                 shall be payable monthly in advance.  The first
                                 and last month's  payment shall be payable upon
                                 each Loan.

                                 As of the date of each Loan Term  Commencement,
                                 the  Monthly  Payments  shall be fixed  for the
                                 term. A schedule of the actual Monthly Payments
                                 shall be provided by the Lender  following each
                                 Loan Term Commencement.

                                 The Lender shall increase the Monthly  Payments
                                 as of the date of each Loan  Term  Commencement
                                 commensurate   to  the  change  in  the  weekly
                                 average of the interest rates of four-year U.S.
                                 Treasury   Securities   from  the  week  ending
                                 February  28,  1997 to the week  preceding  the
                                 date  of  each  Loan  Term   Commencement,   as
                                 published in the Wall Street Journal.

Balloon Payment:                 At the end of each 48 month Loan,  the Borrower
                                 shall be  obligated  to make one final  balloon
                                 payment   equal  to   12.5%  of  the   original
                                 principal  amount of such Loan,  plus any other
                                 amounts due and owing to Lender.

Interim Payments:                In the event that the Loan Term Commencement is
                                 not on the  first  day  of the  month,  Interim
                                 Payments  shall  accrue  from  each  Loan  Term
                                 Commencement until the next following first day
                                 of a month and shall be  payable  at the end of
                                 that   Month.   Interim   Payments   shall   be
                                 calculated  at  the  daily  equivalent  of  the
                                 currently adjusted Monthly Payment.

Documentation:                   The documentation  relating to this transaction
                                 shall implement the transaction contemplated by
                                 this commitment  letter to the  satisfaction of
                                 Lender   and   its   counsel,   shall   contain
                                 conditions     precedent,      representations,
                                 warranties  and covenants by Borrower and shall
                                 provide  for events of defaults  and  remedies,
                                 all as required by Lender for  transactions  of
                                 this type. The documentation shall include, but
                                 not be  limited  to,  the terms and  conditions
                                 described in this commitment letter.

Insurance:                       Prior  to  any  delivery  of   Equipment,   the
                                 Borrower   shall  furnish  a   certificate   of
                                 insurance  acceptable  to the Lender in amount,
                                 type and term, covering the Equipment including
                                 primary,  all risk,  physical damage,  property
                                 damage and bodily injury with  appropriate loss
                                 payee and additional  insured  endorsements  in
                                 favor of Lender.

Representation and               There shall be no actual or threatened conflict
Additional Covenants:            with, or violation of, any regulatory  statute,
                                 standard or rule relating to the Borrower,  its
                                 present or future operations, or the Equipment.

                                 All information  supplied by the Borrower shall
                                 be  correct  and shall  not omit any  statement
                                 necessary to make the information  supplied not
                                 to be  misleading.  There  shall be no material
                                 breach of the  representation and warranties of
                                 the Borrower in the Loan.  The  representations
                                 shall include that the  Equipment  cost of each
                                 item of Equipment  does not exceed the fair and
                                 usual   price  for  such   type  of   equipment
                                 purchased  in like  quantity  and  reflects all
                                 discounts,   rebates  and  allowances  for  the
                                 Equipment    given   to    Borrower    by   the
                                 manufacturer,  supplier  or  any  other  person
                                 including,  without  limitation,  discounts for
                                 advertising,  prompt payment,  testing or other
                                 services.

Warrant Coverage:                In consideration of the Lender's  commitment to
                                 enter into this loan transaction, in accordance
                                 with the terms  herein,  Lender will be granted
                                 warrants to purchase
                                 

                                       18



                                 shares  of the  Borrower's  common  stock in an
                                 amount  determined  as follows:  The  aggregate
                                 exercise   price  of  the  warrants   shall  be
                                 $100,000 (5% of the aggregate  loan  commitment
                                 of  $2,000,000),  and the  exercise  price  per
                                 share  will  be  the   closing   price  of  the
                                 Borrower's stock on the date of this commitment
                                 by Lender.  The  warrants  will be  exercisable
                                 from the date of issuance,  and have a term of,
                                 5  years.   The  warrants   will  have  a  "net
                                 exercise" option. Lender may retain or transfer
                                 the warrants or the shares issuable thereunder,
                                 in whole or the part, whether or not the Lender
                                 sells the Loan or any participation therein.

Conditions Precedent to          1.    No   material   adverse   change  in  the
Lending:                               financial   condition,    operations   or
                                       prospects  of  the   Borrower   prior  to
                                       funding.
                                 2.    Completion of the documentation and final
                                       terms   of   the    proposed    financing
                                       satisfactory   to  Lender  and   Lender's
                                       counsel.
                                 3.    Results of all due  diligence,  including
                                       lien,  judgment  and tax search and other
                                       matters   Lender  may  request  shall  be
                                       satisfactory   to  Lender  and   Lender's
                                       counsel.
                                 4.    Receipt by Lender of duly  executed  loan
                                       documentation   in  form  and   substance
                                       satisfactory to Lender and its counsel.
                                 5.    Lender   shall   receive   a  valid   and
                                       perfected   first   priority   lien   and
                                       security  interest in the  Collateral  of
                                       Borrower and Lender  shall have  received
                                       satisfactory  evidence  that there are no
                                       liens  on  any   Collateral   except   as
                                       expressly permitted herein.
                                 6.    Evidence   of   repayments   of  existing
                                       indebtedness of any Lender's  Collateral,
                                       and  UCC  and  other  lien  releases,  as
                                       Lender deems appropriate.
                                  7.   A Uniform Commercial Code Fixture Filing.
                                  8.   Satisfactory     review    of    Lender's
                                       Scientific   Advisory   Board   prior  to
                                       funding.

Fees and Expenses:               The  Borrower  shall  be  responsible  for  the
                                 Lender's  reasonable  expenses (including legal
                                 expenses) in connection with the transaction.

Law:                             This letter and the proposed  Loan are intended
                                 to be governed by and  construed in  accordance
                                 with   Illinois  law  without   regard  to  its
                                 conflict of law provisions.

Indemnity:                       Borrower   agrees  to  indemnify  and  to  hold
                                 harmless Lender and its officers, directors and
                                 employees   against   all   claims,    damages,
                                 liabilities  and expenses which may be incurred
                                 by or  asserted  against  any  such  person  in
                                 connection  with or arising  out of this letter
                                 and the transactions contemplated hereby, other
                                 than  for  claims,  damages,   liability,   and
                                 expense  resulting  from  such  person's  gross
                                 negligence or willful misconduct.

Confidentiality:                 This  letter  is  delivered  to  you  with  the
                                 understanding that neither it nor its substance
                                 shall be disclosed publicly or privately to any
                                 third   person   except  those  who  are  in  a
                                 confidential  relationship to you (such as your
                                 legal  counsel and  accountants),  or where the
                                 same is  required  by law and then  only on the
                                 basis that it not be further  disclosed,  which
                                 conditions the Borrower and its agents agree to
                                 be  bound  by upon  acceptance  of this  letter
                                 without   limiting   the   generality   of  the
                                 foregoing,  name of such  persons  shall use or
                                 refer to  Lender or to any  affiliated  name in
                                 any disclosures  made in connection with any of
                                 the transactions without Lender's prior written
                                 consent.

Conditions of Acceptance:        This  Commitment  Letter  is  intended  to be a
                                 summary of the most  important  elements of the
                                 agreement to enter into a financing transaction
                                 with  Borrower,   and  it  is  subject  to  all
                                 requirements  and conditions  contained in loan
                                 documentation proposed by Lender or its counsel
                                 in  the   course  of  closing   the   financing
                                 described  herein.  Not  every  provision  that
                                 imposes  duties,   obligations,   burdens,   or

                                       19

                                 limitations  on Borrower is  contained  herein,
                                 but  shall  be  contained  in  the  final  loan
                                 documentation  satisfactory  to Lender  and its
                                 counsel.

                                 EACH  OF THE  PARTIES  HERETO  IRREVOCABLY  AND
                                 UNCONDITIONALLY  WAIVES  ALL  RIGHT TO TRIAL BY
                                 JURY  IN  ANY  SUIT,   ACTION,   PROCEEDING  OR
                                 COUNTERCLAIM  ARISING OUT OF OR RELATED TO THIS
                                 LETTER  OR THE  TRANSACTION  DESCRIBED  IN THIS
                                 LETTER.

Commitment Fee:                  A non-refundable  Commitment Fee equal to 1% of
                                 the  Loan  shall  be  payable  to  Lender  upon
                                 acceptance  of  this  Commitment.  The  $14,200
                                 Application  Fee  previously  paid by  Borrower
                                 shall be applied to the  Commitment Fee leaving
                                 an   outstanding   balance   of   $5,800.   The
                                 Commitment  Fee shall be first  applied  to the
                                 costs and expenses of the Lender in  connection
                                 with the  transaction,  and any remainder shall
                                 be applied to the second month's  payment under
                                 the Loan.

Commitment Expiration:           This Commitment shall expire on April 25, 1997,
                                 unless prior thereto either extended in writing
                                 by the Lender or accepted as provided  below by
                                 the Borrower.

Should  you have any  questions,  please  call me.  If you wish to  accept  this
Commitment,  please so indicate by signing and returning the enclosed  duplicate
copy of this letter to me by April 25, 1997.

                                        Yours truly,

                                        TRANSAMERICA BUSINESS CREDIT
                                        CORPORATION-TECHNOLOGY FINANCE
                                        DIVISION

                                        By
                                           -----------------------------------
                                        Gerald A. Michaud
                                        Senior Vice President
                                        Marketing

Accepted this _____day of _______________, 1997


GalaGen, Inc.


By
  ---------------------------------
Name:
Title:

                                       20



THESE  SECURITIES HAVE NOT BEEN REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS
AMENDED,  OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD OR OFFERED FOR SALE
IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER
SAID ACT AND ANY APPLICABLE  STATE  SECURITIES  LAWS OR THE  AVAILABILITY  OF AN
EXEMPTION FROM  REGISTRATION  UNDER SAID ACT AND ANY APPLICABLE STATE SECURITIES
LAWS.



                           STOCK SUBSCRIPTION WARRANT

                           To Purchase Common Stock of

                          GalaGen, Inc. (the "Company")

                     DATE OF INITIAL ISSUANCE: July 1, 1997

     THIS  CERTIFIES  THAT for  value  received,  TRANSAMERICA  BUSINESS  CREDIT
CORPORATION  or its  registered  assigns  (hereinafter  called the  "Holder") is
entitled  to  purchase  from the  Company,  at any time  during the Term of this
Warrant,  Forty Thousand (40,000) shares of common stock, $.01 par value, of the
Company (the "Common Stock"),  at the Warrant Price,  payable in lawful money of
the United States of America to be paid upon the exercise  hereof.  The exercise
of this Warrant shall be subject to the provisions, limitations and restrictions
herein contained, and may be exercised in whole or in part.

SECTION 1. Definitions.

     For all  purposes  of this  Warrant,  the  following  terms  shall have the
meanings indicated:

     Common  Stock - shall mean and  include  the  Company's  authorized  Common
Stock, $.01 par value, as constituted at the date hereof.

     Exchange Act - shall mean the  Securities  Exchange Act of 1934, as amended
from time to time.

     Securities Act - the Securities Act of 1933, as amended.

     Term of this  Warrant  - shall  mean the  period  beginning  on the date of
initial issuance hereof and ending on June 30, 2002.

         Warrant  Price - $2.50 per share,  subject to  adjustment in accordance
with Section 5 hereof.

     Warrant  Shares - shares of Common Stock  purchased or  purchasable  by the
Holder of this Warrant upon the exercise hereof.

SECTION 2. Exercise of Warrant.

     2.1.  Procedure for Exercise of Warrant.  To exercise this Warrant in whole
or in part (but not as to any  fractional  share of Common  Stock),  the  Holder
shall  deliver to the Company at its office  referred to in Section 12 hereof at
any time and from time to time during the Term of this  Warrant:  (i) the Notice
of Exercise in the form attached hereto,  (ii) cash,  certified or official bank
check  payable  to the  order  of the  Company,  wire  transfer  of funds to the
Company's account,  or evidence of any indebtedness


                                       21




of the Company to the Holder (or any combination of any of the foregoing) in the
amount of the  Warrant  Price for each  share  being  purchased,  and (iii) this
Warrant.  Notwithstanding any provisions herein to the contrary,  if the Current
Market Price (as defined in Section 5) is greater than the Warrant Price (at the
date of calculation,  as set forth below), in lieu of exercising this Warrant as
hereinabove  permitted,  the Holder may elect to receive  shares of Common Stock
equal to the value (as determined below) of this Warrant (or the portion thereof
being  canceled)  by  surrender  of this  Warrant at the  office of the  Company
referred to in Section 12 hereof, together with the Notice of Exercise, in which
event the  Company  shall  issue to the Holder  that  number of shares of Common
Stock computed using the following formula:

                               CS = WCS x (CMP-WP)
                               ------------------
                                       CMP

Where

          CS   equals the  number of shares of Common  Stock to be issued to the
               Holder

          WCS  equals the number of shares of Common Stock purchasable under the
               Warrant or, if only a portion of the Warrant is being  exercised,
               the portion of the Warrant  being  exercised (at the date of such
               calculation)

          CMP  equals the Current Market Price (at the date of such calculation)

          WP   equals  the  Warrant  Price  (as  adjusted  to the  date  of such
               calculation)

In the event of any  exercise  of the  rights  represented  by this  Warrant,  a
certificate  or  certificates  for the  shares  of  Common  Stock so  purchased,
registered  in the  name of the  Holder  or such  other  name or names as may be
designated  by the Holder,  shall be  delivered  to the Holder  hereof  within a
reasonable time, not exceeding  fifteen (15) days, after the rights  represented
by this  Warrant  shall have been so  exercised;  and,  unless this  Warrant has
expired,  a new Warrant  representing  the number of shares  (except a remaining
fractional  share),  if any,  with respect to which this Warrant  shall not then
have been exercised  shall also be issued to the Holder hereof within such time.
The person in whose name any  certificate  for shares of Common  Stock is issued
upon  exercise of this  Warrant  shall for all purposes be deemed to have become
the  holder  of  record of such  shares  on the date on which  the  Warrant  was
surrendered and payment of the Warrant Price and any applicable  taxes was made,
irrespective  of the date of delivery of such  certificate,  except that, if the
date of such  surrender and payment is a date when the stock  transfer  books of
the Company are closed, such person shall be deemed to have become the holder of
such shares at the close of business  on the next  succeeding  date on which the
stock transfer books are open.

     2.2. Transfer Restriction Legend. Each certificate for Warrant Shares shall
bear  the  following  legend  (and any  additional  legend  required  by (i) any
applicable  state  securities  laws and (ii) any securities  exchange upon which
such Warrant  Shares may, at the time of such  exercise,  be listed) on the face
thereof  unless at the time of exercise such Warrant  Shares shall be registered
under the Securities Act:

          "The shares  represented by this  certificate have not been registered
          under the Securities  Act of 1933, as amended,  and may not be sold or
          transferred  in the  absence  of  such  registration  or an  exemption
          therefrom under said Act."

Any  certificate  issued  at any  time  in  exchange  or  substitution  for  any
certificate bearing such legend (except a new certificate issued upon completion
of a  public  distribution  under a  registration  statement  of


                                       22





the securities  represented  thereby) shall also bear such legend unless, in the
opinion of counsel for the holder  thereof  (which  counsel  shall be reasonably
satisfactory to counsel for the Company) the securities  represented thereby are
not, at such time, required by law to bear such legend.

SECTION 3. Covenants as to Common Stock.  The Company  covenants and agrees that
all shares of Common  Stock that may be issued  upon the  exercise of the rights
represented by this Warrant will, upon issuance,  be validly issued,  fully paid
and  nonassessable,  and free from all taxes,  liens and charges with respect to
the issue  thereof.  The Company  further  covenants and agrees that it will pay
when due and payable any and all federal and state taxes which may be payable in
respect  of the  issue of this  Warrant  or any  Common  Stock  or  certificates
therefor  issuable upon the exercise of this  Warrant,  but not capital gains or
other taxes on or measured by the  increase or decrease of net income or loss of
the Holder.  The Company  further  covenants and agrees that the Company will at
all  times  have  authorized  and  reserved,  free  from  preemptive  rights,  a
sufficient  number of shares of Common  Stock to provide for the exercise of the
rights  represented by this Warrant.  The Company  further  covenants and agrees
that if any  shares of  capital  stock to be  reserved  for the  purpose  of the
issuance of shares upon the exercise of this Warrant require  registration  with
or approval of any governmental  authority under any federal or state law before
such shares may be validly issued or delivered  upon exercise,  then the Company
will in good faith and as  expeditiously  as  possible  endeavor  to secure such
registration  or approval,  as the case may be except that the Company shall not
be  required  to  make  any  filings  because  a  holder  of this  warrant  is a
non-accredited  investor.  If and so long as the Common Stock  issuable upon the
exercise of this  Warrant is listed on any  national  securities  exchange,  the
Company will, if permitted by the rules of such  exchange,  list and keep listed
on such exchange,  upon official  notice of issuance,  all shares of such Common
Stock issuable upon exercise of this Warrant.

SECTION 4.  Adjustment of Number of Shares.  Upon each adjustment of the Warrant
Price as  provided  in Section 5, the Holder  shall  thereafter  be  entitled to
purchase,  at the Warrant Price  resulting from such  adjustment,  the number of
shares  (calculated to the nearest tenth of a share) obtained by multiplying the
Warrant Price in effect  immediately  prior to such  adjustment by the number of
shares  purchasable  pursuant  hereto  immediately  prior to such adjustment and
dividing  the  product   thereof  by  the  Warrant  Price  resulting  from  such
adjustment.

SECTION 5.  Adjustment of Warrant  Price.  The Warrant Price shall be subject to
adjustment from time to time as follows:

     (i) If, at any time during the Term of this  Warrant,  the number of shares
of Common Stock  outstanding is increased by a stock dividend  payable in shares
of Common Stock or by a subdivision or split-up of shares of Common Stock, then,
following the record date fixed for the determination of holders of Common Stock
entitled to receive such stock  dividend,  subdivision or split-up,  the Warrant
Price shall be  appropriately  decreased  so that the number of shares of Common
Stock issuable upon the exercise hereof shall be increased in proportion to such
increase in outstanding shares.

     (ii) If, at any time during the Term of this Warrant,  the number of shares
of Common Stock  outstanding  is decreased by a combination  of the  outstanding
shares of Common Stock,  then,  following the record date for such  combination,
the Warrant Price shall  appropriately  increase so that the number of shares of
Common Stock issuable upon the exercise  hereof shall be decreased in proportion
to such decrease in outstanding shares.

     (iii) In case,  at any time  during the Term of this  Warrant,  the Company
shall declare a cash dividend upon its Common Stock payable  otherwise  than out
of earnings or earned surplus or shall distribute to holders of its Common Stock
shares of its capital stock (other than Common Stock), stock or other securities
of other  persons,  evidences  of  indebtedness  issued by the  Company or other
persons,


                                       23





assets  (excluding  cash  dividends  and  distributions)  or  options  or rights
(excluding options to purchase and rights to subscribe for Common Stock or other
securities of the Company  convertible  into or exchangeable  for Common Stock),
then,  in each such case,  immediately  following  the record date fixed for the
determination  of the holders of Common Stock  entitled to receive such dividend
or distribution,  the Warrant Price in effect  thereafter shall be determined by
multiplying the Warrant Price in effect immediately prior to such record date by
a fraction of which the numerator  shall be an amount equal to the difference of
(x) the  Current  Market  Price of one share of Common  Stock minus (y) the fair
market value (as  determined  by the Board of  Directors  of the Company,  whose
determination  shall be  conclusive)  of the  stock,  securities,  evidences  of
indebtedness,  assets,  options or rights so distributed in respect of one share
of Common  Stock,  and of which the  denominator  shall be such  Current  Market
Price.

     (iv) All  calculations  under this  Section 5 shall be made to the  nearest
cent or to the nearest one-tenth (1/10) of a share, as the case may be.

     (v) For the  purpose of any  computation  pursuant  to this  Section 5, the
Current Market Price at any date of one share of Common Stock shall be deemed to
be the average of the daily closing prices for the 15 consecutive  business days
ending no more than 5 business  days before the day in question (as adjusted for
any stock  dividend,  split,  combination or  reclassification  that took effect
during such 15 business day period). The closing price for each day shall be the
last reported  sales price  regular way or, in case no such reported  sales took
place on such day, the average of the last reported bid and asked prices regular
way, in either case on the principal national  securities  exchange on which the
Common  Stock is listed or  admitted  to trading or as reported by Nasdaq (or if
the Common  Stock is not at the time listed or admitted  for trading on any such
exchange or if prices of the Common  Stock are not  reported by Nasdaq then such
price shall be equal to the average of the last reported bid and asked prices on
such day as  reported  by The  National  Quotation  Bureau  Incorporated  or any
similar  reputable  quotation and reporting  service,  if such  quotation is not
reported by The National Quotation Bureau Incorporated); provided, however, that
if the Common Stock is not traded in such manner that the quotations referred to
in this clause (v) are available for the period required hereunder,  the Current
Market Price shall be  determined in good faith by the Board of Directors of the
Company or, if such  determination  cannot be made,  by a nationally  recognized
independent  investment  banking firm  selected by the Board of Directors of the
Company  (or if such  selection  cannot  be  made,  by a  nationally  recognized
independent  investment  banking  firm  selected  by  the  American  Arbitration
Association in accordance with its rules).

     (vi) Whenever the Warrant Price shall be adjusted as provided in Section 5,
the  Company  shall  prepare  a  statement  showing  the  facts  requiring  such
adjustment and the Warrant Price that shall be in effect after such  adjustment.
The Company shall cause a copy of such statement to be sent by mail, first class
postage  prepaid,  to each  Holder of this  Warrant at its,  his or her  address
appearing on the Company's records. Where appropriate, such copy may be given in
advance and may be included  as part of the notice  required to be mailed  under
the provisions of subsection (viii) of this Section 5.

     (vii)  Adjustments made pursuant to clauses (i), (ii) and (iii) above shall
be made  on the  date  such  dividend,  subdivision,  split-up,  combination  or
distribution,  as the case may be, is made,  and shall  become  effective at the
opening of business on the business day next  following  the record date for the
determination of stockholders entitled to such dividend, subdivision,  split-up,
combination or distribution.

     (viii) In the event the  Company  shall  propose  to take any action of the
types  described in clauses (i),  (ii),  or (iii) of this Section 5, the Company
shall  forward,  at the same time and in the same manner,  to the Holder of this
Warrant  such  notice,  if any,  which the Company  shall give to the holders of
capital stock of the Company.



                                       24





     (ix) In any case in which the  provisions  of this Section 5 shall  require
that an adjustment shall become effective immediately after a record date for an
event,  the Company may defer until the  occurrence of such event issuing to the
Holder of all or any part of this Warrant  which is exercised  after such record
date and before the  occurrence of such event the  additional  shares of capital
stock issuable upon such exercise by reason of the  adjustment  required by such
event over and above the shares of capital  stock  issuable  upon such  exercise
before giving effect to such adjustment exercise;  provided,  however,  that the
Company shall deliver to such Holder a due bill or other appropriate  instrument
evidencing  such  Holder's  right to receive  such  additional  shares  upon the
occurrence of the event requiring such adjustment.


                                       25






SECTION 6. Ownership.

     6.1.  Ownership of This Warrant.  The Company may deem and treat the person
in whose  name this  Warrant  is  registered  as the  holder  and  owner  hereof
(notwithstanding  any  notations of  ownership or writing  hereon made by anyone
other than the Company) for all purposes and shall not be affected by any notice
to the contrary until  presentation of this Warrant for registration of transfer
as provided in this Section 6.

     6.2.  Transfer and  Replacement.  This Warrant and all rights hereunder are
transferable  in whole or in part upon the books of the  Company  by the  Holder
hereof in person or by duly authorized attorney,  and a new Warrant or Warrants,
of the same tenor as this Warrant but  registered in the name of the  transferee
or  transferees  (and in the  name  of the  Holder,  if a  partial  transfer  is
effected)  shall be made and  delivered  by the Company  upon  surrender of this
Warrant duly  endorsed,  at the office of the Company  referred to in Section 12
hereof. Upon receipt by the Company of evidence reasonably satisfactory to it of
the loss,  theft or  destruction,  and, in such case,  of  indemnity or security
reasonably  satisfactory to it, and upon surrender of this Warrant if mutilated,
the Company  will make and deliver a new Warrant of like tenor,  in lieu of this
Warrant;  provided that if the Holder hereof is an instrumentality of a state or
local  government  or  an  institutional   holder  or  a  nominee  for  such  an
instrumentality or institutional holder an irrevocable agreement of indemnity by
such Holder  shall be  sufficient  for all  purposes  of this  Section 6, and no
evidence of loss or theft or destruction shall be necessary.  This Warrant shall
be promptly canceled by the Company upon the surrender hereof in connection with
any  transfer or  replacement.  Holder will not  transfer  this  Warrant and the
rights hereunder except in compliance with federal and state securities laws.

SECTION  7.  Mergers,  Consolidation,   Sales.  In  the  case  of  any  proposed
consolidation or merger of the Company with another entity, or the proposed sale
of all or  substantially  all of its assets to another person or entity,  or any
proposed reorganization or reclassification of the capital stock of the Company,
then, as a condition of such  consolidation,  merger,  sale,  reorganization  or
reclassification, lawful and adequate provision shall be made whereby the Holder
of this Warrant  shall  thereafter  have the right to receive upon the basis and
upon the terms and  conditions  specified  herein,  in lieu of the shares of the
Common Stock of the Company immediately theretofore purchasable hereunder,  such
shares of stock,  securities or assets as may (by virtue of such  consolidation,
merger,  sale,  reorganization  or  reclassification)  be issued or payable with
respect  to or in  exchange  for the  number  of  shares  of such  Common  Stock
purchasable  hereunder  immediately  before such  consolidation,  merger,  sale,
reorganization or reclassification. In any such case appropriate provision shall
be made with  respect to the rights and  interests of the Holder of this Warrant
to the end that the provisions  hereof shall  thereafter be applicable as nearly
as may be, in relation to any shares of stock,  securities or assets  thereafter
deliverable upon the exercise of this Warrant.

SECTION 8. Notice of Dissolution or Liquidation.  In case of any distribution of
the  assets  of  the  Company  in  dissolution  or  liquidation   (except  under
circumstances  when the foregoing  Section 7 shall be  applicable),  the Company
shall give notice thereof to the Holder hereof and shall make no distribution to
shareholders  until the  expiration of thirty (30) days from the date of mailing
of the  aforesaid  notice and, in any case,  the Holder hereof may exercise this
Warrant within thirty (30) days from the date of the giving of such notice,  and
all rights herein granted not so exercised  within such thirty-day  period shall
thereafter become null and void.

SECTION 9. Notice of Extraordinary  Dividends.  If the Board of Directors of the
Company  shall  declare any dividend or other  distribution  on its Common Stock
except out of earned surplus or by way of a stock dividend  payable in shares of
its Common Stock, the Company shall mail notice thereof to the Holder hereof not
less than  thirty  (30) days  prior to the  record  date  fixed for  determining
shareholders


                                       26






entitled to participate in such dividend or other  distribution,  and the Holder
hereof shall not participate in such dividend or other distribution  unless this
Warrant is exercised prior to such record date. The provisions of this Section 9
shall not apply to distributions made in connection with transactions covered by
Section 7.

SECTION 10.  Fractional  Shares.  Fractional shares shall not be issued upon the
exercise of this Warrant but in any case where the Holder would,  except for the
provisions  of this Section 10, be entitled  under the terms hereof to receive a
fractional share upon the complete exercise of this Warrant,  the Company shall,
upon the  exercise of this  Warrant for the largest  number of whole shares then
called  for,  pay a sum in  cash  equal  to the  excess  of the  value  of  such
fractional share  (determined in such reasonable  manner as may be prescribed in
good faith by the Board of Directors of the Company)  over the Warrant Price for
such fractional share.

SECTION 11.  Special  Arrangements  of the Company.  The Company  covenants  and
agrees that during the Term of this Warrant,  unless  otherwise  approved by the
Holder of this Warrant:

     11.1. Will Reserve Shares.  The Company will reserve and set apart and have
available for issuance at all times, free from preemptive or other  preferential
rights, the number of shares of authorized but unissued Common Stock deliverable
upon the exercise of this Warrant.

     11.2.  Will  Not  Amend  Certificate.   The  Company  will  not  amend  its
Certificate  of  Incorporation  to eliminate as an  authorized  class of capital
stock that class denominated as "Common Stock" on the date hereof.

     11.3.  Will  Bind  Successors.  This  Warrant  shall  be  binding  upon any
corporation  or other  person or entity  succeeding  to the  Company  by merger,
consolidation  or  acquisition  of all  or  substantially  all of the  Company's
assets.

SECTION 12.  Notices.  Any notice or other document  required or permitted to be
given or delivered to the Holder shall be delivered  at, or sent by certified or
registered mail to, the Holder at Transamerica  Technology Finance Division,  76
Batterson Park Road, Farmington,  Connecticut 06032,  Attention:  Assistant Vice
President, Lease Administration,  with a copy to the Lender at Riverway II, West
Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018, Attention: Legal
Department or to such other address as shall have been  furnished to the Company
in writing by the Holder.  Any notice or other document required or permitted to
be given or delivered to the Company shall be delivered at, or sent by certified
or registered mail to, the Company at 4001 Lexington Avenue North,  Arden Hills,
Minnesota 55128 or to such other address as shall have been furnished in writing
to the Holder by the Company.  Any notice so addressed  and mailed by registered
or  certified  mail shall be deemed to be given  when so  mailed.  Any notice so
addressed  and  otherwise  delivered  shall be deemed to be given when  actually
received by the addressee.

SECTION 13. No Rights as  Stockholder;  Limitation  of  Liability.  This Warrant
shall not  entitle  the  Holder to any of the  rights  of a  shareholder  of the
Company. No provision hereof, in the absence of affirmative action by the Holder
to purchase shares of Common Stock, and no mere enumeration herein of the rights
or privileges of the Holder,  shall give rise to any liability of the Holder for
the Warrant  Price  hereunder or as a shareholder  of the Company,  whether such
liability is asserted by the Company or by creditors of the Company.

SECTION 14. Law Governing. THE VALIDITY, INTERPRETATION, AND ENFORCEMENT OF THIS
WARRANT SHALL BE GOVERNED BY AND  CONSTRUED IN  ACCORDANCE  WITH THE


                                       27






LAWS OF THE STATE OF  DELAWARE  WITHOUT  GIVING  EFFECT TO THE  CONFLICT  OF LAW
PRINCIPLES THEREOF.

SECTION 15. Miscellaneous.

     (a)  This  Warrant  and  any  provision  hereof  may  be  changed,  waived,
discharged  or terminated  only by an instrument in writing  signed by the party
(or any predecessor in interest  thereof) against which  enforcement of the same
is sought.  The headings in this Warrant are for purposes of reference  only and
shall not affect the meaning or construction of any of the provisions hereof

     (b) All  capitalized  terms used herein and not  otherwise  defined  herein
shall have the meanings ascribed to them in the Financing Agreement.


     IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its
duly authorized officer this _______ day of June, 1997.



                                        GALAGEN, INC.

                                        By:
                                           --------------------------------


                                        Title:
                                              -----------------------------




                                       28






                           FORM OF NOTICE OF EXERCISE

                [To be signed only upon exercise of the Warrant]

                     TO BE EXECUTED BY THE REGISTERED HOLDER
                         TO EXERCISE THE WITHIN WARRANT


     The undersigned  hereby exercises the right to purchase _________ shares of
Common Stock which the  undersigned  is entitled to purchase by the terms of the
within Warrant according to the conditions thereof, and herewith

[check one]
                    |_|  makes payment of $__________ therefor; or

                    |_|  directs  the  Company to issue  ______  shares,  and to
                         withhold  ____ shares in lieu of payment of the Warrant
                         Price, as described in Section 2.1 of the Warrant.

All shares to be issued  pursuant  hereto shall be issued in the name of and the
initial  address of such person to be entered on the books of the Company  shall
be:



     The shares are to be issued in certificates of the following denominations:




                                             ----------------------------------
                                             [Type Name of Holder]


                                             By:
                                                -------------------------------

                                             Title:
                                                   ----------------------------


Dated:
      -------------------------------


                                       29





                               FORM OF ASSIGNMENT
                                    (ENTIRE)

               [To be signed only upon transfer of entire Warrant]

                     TO BE EXECUTED BY THE REGISTERED HOLDER
                         TO TRANSFER THE WITHIN WARRANT

     FOR VALUE RECEIVED  ___________________________  hereby sells,  assigns and
transfers  unto  _______________________________  all rights of the  undersigned
under and  pursuant  to the within  Warrant,  and the  undersigned  does  hereby
irrevocably constitute and appoint  _______________________________  Attorney to
transfer  the said  Warrant  on the books of the  Company,  with  full  power of
substitution.




                                             ----------------------------------
                                             [Type Name of Holder]


                                             By:
                                                -------------------------------

                                             Title:
                                                   ----------------------------


Dated:
      -------------------------------


NOTICE

     The signature to the foregoing  Assignment  must  correspond to the name as
written  upon the  face of the  within  Warrant  in  every  particular,  without
alteration or enlargement or any change whatsoever.


                                       30





                               FORM OF ASSIGNMENT
                                    (PARTIAL)

              [To be signed only upon partial transfer of Warrant]

                     TO BE EXECUTED BY THE REGISTERED HOLDER
                         TO TRANSFER THE WITHIN WARRANT

     FOR VALUE  RECEIVED  _________________________  hereby  sells,  assigns and
transfers unto _______________________________ (i) the rights of the undersigned
to purchase ___ shares of Common Stock under and pursuant to the within Warrant,
and (ii) on a non-exclusive basis, all other rights of the undersigned under and
pursuant to the within Warrant,  it being understood that the undersigned  shall
retain,  severally (and not jointly) with the  transferee(s)  named herein,  all
rights  assigned  on such  non-exclusive  basis.  The  undersigned  does  hereby
irrevocably  constitute  and  appoint  __________________________   Attorney  to
transfer  the said  Warrant  on the books of the  Company,  with  full  power of
substitution.




                                             ----------------------------------
                                             [Type Name of Holder]


                                             By:
                                                -------------------------------

                                             Title:
                                                   ----------------------------



Dated:
      ----------------------------------


NOTICE

     The signature to the foregoing  Assignment  must  correspond to the name as
written  upon the  face of the  within  Warrant  in  every  particular,  without
alteration or enlargement or any change whatsoever.


                                       31