ENZON, INC.

                  NON-QUALIFIED STOCK OPTION PLAN, AS AMENDED*/


A.   Purpose and Scope

          The purpose of this Plan is to encourage  stock ownership by employees
     and directors of, and independent  consultants to, Enzon,  Inc., a Delaware
     corporation, and its subsidiaries (herein called the "Company"), to provide
     an incentive to such persons to develop, expand and improve the profits and
     prosperity  of the  Company,  and to assist the Company in  attracting  key
     personnel and  consultants  through the grant of Options to purchase shares
     of the Company's Common Stock.

B.   Definitions

     Unless otherwise required by the context:

     1. "Board" shall mean the Board of Directors of the Company.

     2. "Committee" shall mean the Compensation Committee, which is appointed by
the Board, and which shall be composed of at least two Non-Employee Directors.

- --------
*/ The Plan was amended by vote of the Board of Directors on each of January 10,
1990,  February 6, 1990,  April 25,  1990,  February  23,  1991,  May 30,  1991,
November 21,  1991,  approved by vote of the  Stockholders  on January 22, 1992,
amended  by vote of the  Board of  Directors  on  December  28,  1992  with such
amendment  ratified by vote of the Stockholders on February 8, 1993,  amended by
vote of the Board of  Directors  on  September  13,  1993  with  such  amendment
ratified by vote of the  Stockholders on December 7, 1993,  amended by the Board
of  Directors  on July 17,  1995 with  such  amendment  ratified  by vote of the
Stockholders on December 5, 1995.


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     3. "Company" shall mean Enzon, Inc. and its subsidiaries.

     4. "Code" shall mean the Internal Revenue Code of 1986, as amended.

     5.  "Independent  Director" shall mean a director who is not an employee of
the Company.

     6.  "Non-Employee  Director" shall have the meaning  ascribed in Rule 16b-3
("Rule  16b-3")  promulgated  under  the  Securities  Exchange  Act of 1934,  as
amended.

     7. "Option" shall mean a right to purchase Stock,  granted  pursuant to the
Plan.

     8. "Option  Price" shall mean the purchase price for Stock under an Option,
as determined in Section F below.

     9.  "Participant"  shall mean an employee of the Company, a director of the
Company, a consultant to the Company, or any person to whom an Option is granted
under the Plan.

     10. "Plan" shall mean this Enzon, Inc.  Non-Qualified Stock Option Plan, as
amended.

     11. "Stock" shall mean the Common Stock of the Company, par value $.01.

C.   Stock to be Optioned

     Subject to the  provisions of Section L of the Plan,  the maximum number of
shares of Stock that may be optioned or sold under the Plan is 6,200,000 shares.
Such

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shares may be treasury,  or authorized but unissued  shares of, the Stock of the
Company.

D.   Administration

           The Plan shall be  administered  by the  Committee or the Board.  Two
members  of the  Committee  shall  constitute  a quorum for the  transaction  of
business.  Except as provided in Section Q hereof,  the  Committee  or the Board
shall  make all  decisions  with  respect  to the  operation  of the  Plan,  the
participation  in the Plan by employees or directors of, or  consultants  to the
Company,   and  with   respect  to  the  extent  of  that   participation.   The
interpretation and construction of any provision of the Plan by the Board or the
Committee  shall be final.  No member  of the  Board or the  Committee  shall be
liable for any action or determination made by him in good faith.

E.   Eligibility

     The Board or the Committee may grant Options to any employee  (including an
employee who is a director or an officer),  or any person who is not an employee
who is a director or an officer, or any person who is not an employee and serves
as a director of the Company,  or any consultant to the Company.  Options may be
awarded by the Board or the  Committee  at any time and from time to time to new
Participants,  or to then current Participants, or to a greater or lesser number
of Participants, and may include or exclude previous Participants, as the Board,
or the

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Committee  shall  determine.  Options granted at different times need not
contain similar provisions.

F.   Option Price

     The  purchase  price  for Stock  under  each  Option  shall be at least 100
percent of the fair market value of the Stock at the time the Option is granted,
but in no event less than the par value of the Stock.  The fair market  value of
the Company's Stock shall be determined as follows:

     a. If the  Common  Stock  continues  to be traded  on the  over-the-counter
     market as a  National  Market  System  Security  or is traded on a national
     securities  exchange,  the  fair  market  value of the  Stock  shall be the
     closing  sale price on such day that the Option is granted as  reported  by
     the National  Association of Securities Dealers Automated  Quotation System
     ("NASDAQ")  or the  national  securities  exchange  on which  the  Stock is
     trading, as the case may be; or

     b. If the  Common  Stock  ceases to be traded as a National  Market  System
     Security but  continues to be traded on the  over-the-counter  market,  the
     fair  market  value of the Stock shall be the closing bid price on such day
     that the Option is granted as reported by NASDAQ; or

     c. If the Common Stock ceases to be traded on the  over-the-counter  market
     and is not traded on a national  securities  exchange,  the current  market
     value shall be determined by a reputable  investment  banking firm

                                       4



     retained by the Board.

G.   Terms and Conditions of Options

     Except as provided  in Section Q hereof,  Options  granted  pursuant to the
Plan shall be authorized by the Board or the Committee and shall be evidenced by
agreements  ("Option  Agreements")  in such form as the Board or the  Committee,
shall  from time to time  approve.  Such  Agreements  shall  comply  with and be
subject to the following terms and conditions:

     1.  Employment  Agreement  -  The  Board  or  the  Committee  may,  in  its
discretion, include in any Option granted under the Plan to a Participant who is
an  employee  of the Company a  condition  that the  Participant  shall agree to
remain in the employ of, and/or to render  services to, the Company for a period
of time  (specified  in the Option  Agreement)  following the date the Option is
granted.  No  such  agreement  shall  impose  upon  the  Company,  however,  any
obligation to employ the Participant for any period of time, except as otherwise
agreed to by the Company.

     2. Time and Method of Payment - The Option  Price  shall be paid in full in
cash,  by  certified  check or  official  bank  check,  at the time an Option is
exercised  under the Plan. If the Board or the Committee in its sole  discretion
so authorizes, payment may be made by exchange of shares of the Company's Common
Stock  previously  owned by the  optionee,  having the same fair market value as
determined  in the manner set forth in Section F. Without  payment by one of the

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methods  described above, an exercise of any Option granted under the Plan shall
be invalid and of no effect.  Promptly  after the  exercise of an Option and the
payment of the full  Option  Price,  the  Participant  shall be  entitled to the
issuance of a stock  certificate  evidencing  his or her  ownership of the Stock
issuable  under such Option.  A  Participant  shall have none of the rights of a
stockholder  until the Option is duly exercised,  and no adjustment will be made
for  dividends  or other  rights for which the record  date is prior to the date
such Option is duly exercised.

     3. Number of Shares - Each Option shall state the total number of shares of
Stock to which it pertains.

     4.  Option  Period  and  Limitations  on  Exercise  of Options - Except for
Options  granted  pursuant  to Section Q hereof,  the Board or  Committee  shall
determine the period of time during which an Option may be exercised,  provided,
however,  that no Option may be exercised after the expiration of ten years from
the date it is granted. Except for Options granted pursuant to Section Q hereof,
the Board or the Committee  may, in its  discretion,  provide that an Option may
not be exercised in whole or in part for any period or periods of time specified
in the Option Agreement; provided, however, that no Option granted subsequent to
November 21, 1991 may be  exercisable  for a minimum of six months from the date
of grant.  Options  granted  pursuant to Section Q hereof will be exercisable in
accordance with Section R hereof. Except as provided in the Option Agreement and
in this Section G(4), an Option may be exercised in whole or in part at any time
during its term. No Option may be exercised for a fractional share of Stock.

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H.   Termination of Employment

     Except as provided in Section I below,  if an employee who is a Participant
ceases to be  employed  by the  Company,  his or her  Options  unless  otherwise
exercised,  shall  terminate  as of the close of business on the one hundred and
ninetieth (190th) day following the termination of the Participant's  employment
with the Company;  provided,  however, that such Participant may exercise his or
her Options  during such one hundred and ninety (190) day period  following such
termination of employment  only to the extent that he or she would  otherwise be
entitled  to  exercise  such  Options  during such  period;  provided,  further,
however,  that in no event  shall any Option be  exercisable  more than ten (10)
years from the date it was granted.  Notwithstanding the foregoing, the Board or
the  Committee  may cancel an Option during the one hundred and ninety (190) day
period referred to in this section,  if the Participant engages in employment or
activities contrary,  in the opinion of the Board or the Committee,  to the best
interests of the Company.  The Board or the  Committee  shall  determine in each
case whether a termination of employment  shall be considered a retirement  with
the consent of the Company,  and,  subject to applicable law, whether a leave of
absence shall constitute a termination of employment.  Any such determination of
the  Board or the  Committee  shall  be  final  and  conclusive.  The  foregoing
provisions  may be modified or waived by the Board or the  Committee and do not,
in any case,  apply to any  Participant  who is not an employee of the  Company.
Except  for  Options  granted

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pursuant to Section Q hereof, the Board or the Committee will determine what, if
any,  provisions  for earlier  termination of the Option will be included in the
Option Agreement  issued to any person who is not an employee.  The Board or the
Committee  will  determine  who shall be deemed to be an employee of the Company
for the purposes of this Section H and Section I below at the time the Option is
granted.

I.   Rights in Event of Death

     If an employee who is a Participant dies while employed by the Company,  or
within three months  after having  retired with the consent of the Company,  and
without   having  fully   exercised  his  or  her  Options,   the  executors  or
administrators,  or legatees or heirs, of his or her estate shall have the right
to  exercise  such  Options to the extent  that such  deceased  Participant  was
entitled  to  exercise  the  Options on the date of his or her death;  provided,
however,  that in no event shall the Options be exercisable  more than ten years
from the date they were  granted.  The foregoing  provisions  may be modified or
waived  by the Board or the  Committee  and do not,  in any  case,  apply to any
Participant  who is not an employee of the Company.  Except for Options  granted
pursuant to Section Q hereof, the Board or the Committee will

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determine what, if any,  provisions  concerning  exercise of the Option upon the
death of the  holder  will be  included  in the Option  Agreement  issued to any
person who is not an employee.

J.   No Obligations to Exercise Option

     The granting of an Option shall impose no obligation  upon the  Participant
to exercise such Option.

K.   Nonassignability

     Options  shall  not be  transferable  other  than by will or by the laws of
descent and distribution, and during a Participant's lifetime an Option shall be
exercisable only by such Participant.

L.   Effect of Chance in Stock Subject to the Plan

     The  aggregate  number of shares of Stock  available  for Options under the
Plan,  the shares subject to any Option,  and the price per share,  shall all be
proportionately  adjusted  for any  increase or decrease in the number of issued
shares of Stock  subsequent to the effective date of the Plan resulting from (1)
a subdivision or  consolidation of shares or any other capital  adjustment,  (2)
the payment of a stock  dividend on the  Company's  Common  Stock,  or (3) other
increase or decrease in such shares effected without receipt of consideration by
the Company. If the Company shall be the surviving  corporation in any merger or
consolidation,  any

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Option shall pertain,  apply,  and relate to the securities to which a holder of
the number of shares of Stock  subject to the  Option  would have been  entitled
after the  merger or  consolidation.  Upon  dissolution  or  liquidation  of the
Company,  or upon a merger  or  consolidation  in which the  Company  is not the
surviving  corporation,  all Options outstanding under the Plan shall terminate;
provided,  however,  that each Participant (and each other person entitled under
Section I to exercise an Option) shall have the right, immediately prior to such
dissolution or liquidation,  or such merger or  consolidation,  to exercise such
Participant's  Options  in  whole  or in part,  notwithstanding  any  provisions
contained in the Plan or the Option Agreement to the contrary.

M.   Amendment and Termination

     Subject  to the  last  paragraph  of  this  Section  M,  the  Board  or the
Committee, by resolution, may terminate,  amend, or revise the Plan with respect
to any shares as to which Options have not been  granted.  Neither the Board nor
the  Committee  may,  without the  consent of the holder of an Option,  alter or
impair  any  Option  previously  granted  under the Plan,  except as  authorized
herein.  Unless sooner terminated,  the Plan shall remain in effect for a period
of twenty  years  from the date of the  Plan's  initial  adoption  by the Board.
Termination of the Plan shall not affect any Option previously granted.

     No such amendment will require  stockholder  approval,  unless  stockholder
approval is  required by either the rules of Nasdaq or any other stock  exchange
upon

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which the Company's securities shall be listed or any applicable law.

N.   Agreement and Representation of Participants

     As a condition to the exercise of any portion of an Option, the Company may
require the person  exercising  such Option to represent and warrant at the time
of such  exercise  that  any  shares  of  Stock  acquired  at  exercise  are not
registered  under  the  Securities  Act of 1933  (the  "Act"),  are  "restricted
securities"  as that  term is  defined  in Rule 144  under the Act and are being
acquired  only for  investment  and  without any  present  intention  to sell or
distribute  such shares,  if, in the opinion of counsel for the Company,  such a
representation   is  required  under  the  Act  or  any  other  applicable  law,
regulation, or rule of any governmental agency.

O.   Reservation of Shares of Stock

     The Company,  during the term of this Plan,  will at all times  reserve and
keep  available,  and will  seek or  obtain  from  any  regulatory  body  having
jurisdiction any requisite  authority necessary to issue and to sell, the number
of shares of Stock that shall be sufficient to satisfy the  requirements of this
Plan.  The  inability of the Company to obtain from any  regulatory  body having
jurisdiction  the authority  deemed necessary by counsel for the Company for the
lawful issuance and sale of its Stock hereunder shall relieve the Company of any
liability  in  respect  of the  failure  to issue or sell  Stock as to which the
requisite authority has not been obtained.



                                       11


P.   Effective Date of Plan

     The Plan shall be effective  as of the date it is initially  adopted by the
Board,  provided  that  Section Q shall not become  effective  until it has been
ratified by the stockholders.

Q.   Grant of Options to Independent Directors

     (a) On each of  January  2,  1994,  January  2,  1997,  January 2, 2000 and
January 2, 2003, each Independent Director shall automatically receive an Option
to purchase 60,000 shares of Stock (the "Regular  Independent  Director Grant").
Notwithstanding  the foregoing,  should the date on which a Regular  Independent
Director  Grant is scheduled to be awarded  pursuant to the  preceding  sentence
fall on a Saturday,  Sunday or holiday,  the Regular Independent  Director Grant
shall be awarded on the first business day immediately  following such scheduled
date.

     (b) On the date of each  Independent  Director's  initial  election  to the
Board,  pursuant  to a vote of the  Company's  stockholders  or the Board,  such
newly-elected  Independent Director shall automatically receive (i) an Option to
purchase a pro rata share of the shares of Stock  underlying  an Option  granted
pursuant to a Regular  Independent  Director Grant,  which shall be equal to the
product of 1,666  multiplied  by the  number of whole  months  remaining  in the
relevant  three year period until the next Regular  Independent  Director  Grant
(the "Pro Rata  Independent  Director  Grant");  and (ii) an Option to  purchase
10,000  shares of Common  Stock  (the  "Initial  Independent  Director  Election
Grant").



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R.   Exercise Period of Options Granted to Independent Directors

     Subject  to the last  paragraph  of this  Section  R, each  Option  granted
pursuant to the Plan shall vest and become exercisable as follows:

     (1) Those Options granted pursuant to a Regular Independent  Director Grant
shall vest and become  exercisable as to 20,000 shares on the first  anniversary
of the date of grant; as to 20,000 shares on the second  anniversary of the date
of grant; and as to the remaining 20,000 shares on the third  anniversary of the
date of grant.

     (2) Those Options granted pursuant to a Pro Rata Independent Director Grant
shall  vest and  become  exercisable  as to that  number of shares  equal to the
product of 1,666 multiplied by the number of whole months remaining in the first
calendar  year in which the  Independent  Director is elected  initially  to the
Board on the January 1st following such Independent  Director's initial election
to the Board; and as to any remaining shares in accordance with the schedule for
Options granted pursuant to a Regular Independent  Director Grant as provided in
Section R(1) hereof.

     (3) Those  Options  granted  pursuant  to an Initial  Independent  Director
Election  Grant  shall  become  exercisable  as to  5,000  shares  on the  first
anniversary  of  the  date  of  grant;  and as to  5,000  shares  on the  second
anniversary of the date of grant.

     Notwithstanding  the  foregoing,  an  Option  shall  not  vest  and  become


                                       13



exercisable  as to the  relevant  shares  unless such  Independent  Director has
served  continuously  on the Board during the year  preceding  the date on which
such Options are scheduled to vest and become exercisable, or from the date such
Independent  Director  joined the board should such  Independent  Director  have
joined the board  during such  preceding  year;  provided,  however,  that if an
Independent Director does not fulfill such continuous service requirement due to
such  Independent  Director's  death or disability  all Options  granted to such
Independent  Director  pursuant to Section Q hereof shall  nonetheless  vest and
become exercisable as provided in this Section R. For purposes of this Section R
"disability"  shall  mean a  physical  or mental  condition  which  prevents  an
Independent  Director from  performing his duties as an Independent  Director of
the  Company  for a  continuous  six month  period or for a total of six  months
during  any 18  month  period.  Any  Option  which  does  not  vest  and  become
exercisable  in  accordance  with this  Section R shall  terminate  and be of no
further force or effect.


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