EXHIBIT 5.1

                        [DORSEY & WHITNEY LLP LETTERHEAD]

                                February 11, 1998

Enzon, Inc.
20 Kingsbridge Road
Piscataway, New Jersey 08854

     Re:  Registration Statement on Form S-3

Ladies and Gentlemen:

     You have requested our opinion with respect to the  registration  by Enzon,
Inc. (the  "Registrant")  pursuant to a Registration  Statement on Form S-3 (the
"Registration  Statement")  under the  Securities  Act of 1933,  as amended (the
"Act"), of an aggregate of 150,000 shares of the Registrant's Common Stock, $.01
par value  per  share  (the  "Common  Stock"),  issuable  upon the  exercise  of
outstanding warrants (the "Warrants").

     In so acting, we have examined originals or copies,  certified or otherwise
identified  to  our  satisfaction,   of  such  documents,   corporate   records,
certificates of public  officials and other  instruments and have conducted such
other investigations of fact and law as we have deemed relevant and necessary to
form a  basis  for  the  opinions  hereinafter  expressed.  In  conducting  such
examination,  we have assumed (i) that all signatures are genuine, (ii) that all
documents and instruments  submitted to us as copies conform with the originals,
and (iii) the due execution  and delivery of all  documents  where due execution
and delivery are a prerequisite to the  effectiveness  thereof.  As to any facts
material to this opinion,  we have relied upon statements and representations of
officers and other  representatives of the Registrant and certificates or public
officials and have not independently verified such facts.

     Based upon the foregoing,  it is our opinion that the Common Stock issuable
upon the proper exercise of the Warrants will be validly issued,  fully paid and
non-assessable when issued in accordance with the terms of such Warrants.

     We express no  opinion  as to the laws of any  jurisdiction  other than the
State of New York and the United  States of  America.  Insofar as the  foregoing
opinion relates to matters that would be controlled by the  substantive  laws of
any  jurisdiction  other than the  United  States of America or the State of New
York, we have assumed that the substantive laws of such jurisdiction  conform in
all respects to the internal laws of the State of New York.


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     We hereby  consent  to the  filing of this  opinion  as an  exhibit  to the
Registration  Statement,  and to the  reference  to our firm  under the  heading
"Legal  Matters"  in  the  Prospectus  constituting  part  of  the  Registration
Statement relating to the registration of 150,000 shares of Common Stock.

                                        Very truly yours,

                                        DORSEY & WHITNEY LLP

                                        By:  /s/KEVIN T. COLLINS
                                             -----------------------------
                                             Kevin T. Collins
                                             A Partner


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