SECOND EXTENSION AGREEMENT

     This Second Extension Agreement (hereinafter, the "Agreement") is made this
11th day of March, 1999 by and among:

          FLEET BANK-N.H.,  a banking and trust company organized under the laws
          of New Hampshire ("Fleet");

          MELLON BANK, N.A., a national banking association ("Mellon"); and

          IGI,  INC., a Delaware  corporation  ("IGI"),  IGEN,  INC., a Delaware
          corporation  ("IGEN");  IMMUNOGENETICS,  INC., a Delaware  corporation
          ("Immunogenetics");  and BLOOD  CELLS,  INC.,  a Delaware  corporation
          ("BCI").

Fleet  and  Mellon  are  hereinafter  sometimes  individually  referred  to as a
"Lender"  and  collectively  referred  to  as  the  "Lenders",  and  IGI,  IGEN,
Immunogenetics,  BCI, and each of their subsidiaries as set forth on Exhibit "A"
annexed  hereto  and  specifically   incorporated  by  reference   herein,   are
hereinafter sometimes  individually referred to as a "Borrower" and collectively
referred to as the "Borrowers".

                                   BACKGROUND

     Reference  is made to certain  Loan  Arrangements  (hereinafter,  the "Loan
Arrangements")  entered  into by and  between  the  Lenders  and  the  Borrowers
evidenced by, among other  things,  the following  documents,  instruments,  and
agreements  (hereinafter,   singly  and  collectively,  as  amended,  the  "Loan
Documents"):

     (a) Fourth  Amended and Restated  Line of Credit Note dated  September  30,
1997 in the original  principal  amount of  $6,600,000.00  made by the Borrowers
payable to Fleet (the "Fleet Line of Credit Note");

     (b) Fourth  Amended and Restated  Line of Credit Note dated  September  30,
1997 in the original  principal  amount of  $5,400,000.00  made by the Borrowers
payable to Mellon (the "Mellon Line of Credit Note");

     (c) Third Amended and Restated  Revolving  Credit Note dated March 27, 1997
in the original  principal amount of $6,171,428.40 made by the Borrowers payable
to Fleet (the "Fleet Term Note");

     (d) Third Amended and Restated  Revolving  Credit Note dated March 27, 1997
in the original  principal amount of $4,114,285.60 made by the Borrowers payable
to Mellon (the "Mellon Term Note");





     (e) Second Amended and Restated Loan  Agreement  dated December 13, 1995 by
and among the Lenders and the Borrowers, as amended by a certain First Amendment
to Second  Amended and Restated Loan  Agreement  dated March 27, 1996, a certain
Second  Amendment to Second Amended and Restated Loan Agreement dated as of June
26,  1996,  a certain  Third  Amendment  to Second  Amended  and  Restated  Loan
Agreement  dated August 13, 1996, a certain  Fourth  Amendment to Second Amended
and Restated  Loan  Agreement  dated as of November  13,  1996, a certain  Fifth
Amendment to Second Amended and Restated Loan Agreement  dated March 27, 1997, a
certain Sixth Amendment to Second Amended and Restated Loan Agreement dated June
30,  1997, a certain  Seventh  Amendment  to Second  Amended and  Restated  Loan
Agreement dated July 31, 1997, and a certain Eighth  Amendment to Second Amended
and Restated  Loan  Agreement  dated as of September 30, 1997  (hereinafter,  as
amended and in effect, the "Loan Agreement");

     (f) A certain Security  Agreement  granted by, among others,  IGI, IGEN and
Immunogenetics, in favor of Fleet dated December 20, 1990;

     (g) A certain Security Agreement - Intellectual  Property granted by, among
others, IGI, IGEN and Immunogenetics in favor of Fleet dated December 20, 1990;

     (h) A certain Security  Documents  Modification  Agreement entered into by,
among others, the Borrowers and the Lenders dated as of December 13, 1995;

     (i) A certain  Joinder,  Assumption  and  Security  Documents  Modification
Agreement dated as of May 12, 1992 entered into by, among others, the Borrowers,
and Fleet;

     (j) A certain  Mortgage granted by  Immunogenetics  in favor of Fleet dated
December 20, 1990 encumbering  certain property located in the borough of Buena,
Atlantic County, New Jersey;

     (k) A certain  Mortgage granted by  Immunogenetics  in favor of Fleet dated
May 12,  1992  encumbering  certain  property  located in the  township of Buena
Vista, Atlantic County, New Jersey;

     (l) A certain  Mortgage granted by  Immunogenetics  in favor of Fleet dated
December 20, 1990 encumbering  certain property located in the city of Vineland,
Cumberland County, New Jersey;

     (m) A certain Collateral Assignment of Lessee's Interest in Leases executed
by, among others, Immunogenetics in favor of Fleet dated December 20, 1990;

     (n) A certain Stock Pledge  Agreement  executed by, among  others,  IGI and
IGEN in favor of Fleet dated December 20, 1990;


                                       2



     (o) A certain Conditional Assignment of Contracts granted by, among others,
IGI, IGEN and Immunogenetics in favor of Fleet dated December 20, 1990;

     (p) A certain  Extension  Agreement  dated April 29,  1998 (the  "Extension
Agreement") by and among the Lenders and the Borrowers; and

     (q) A certain Forbearance Agreement dated August 19, 1998 (the "Forbearance
Agreement") by and among the Lenders and the Borrowers.

     The Borrowers  acknowledge and agree that the Lenders' agreement to forbear
as set forth in the  Forbearance  Agreement has  terminated,  and have requested
that the Lenders (i) extend the time for  repayment of their entire  outstanding
indebtedness  under the Loan Documents  until March 31, 2000, (ii) waive certain
existing defaults,  and (iii) otherwise modify the existing Loan Documents.  The
Lenders have agreed,  but only upon the terms and  conditions  set forth herein.
Further,  to the extent that the terms and conditions of the Extension Agreement
are inconsistent with the terms and conditions of this Agreement,  the terms and
conditions  of this  Agreement  shall  supersede  the  conflicting  terms of the
Extension Agreement.

     Accordingly,   for  good  and  valuable  consideration,   the  receipt  and
sufficiency of which are hereby  acknowledged,  it is hereby agreed by and among
the Lenders and the Borrowers as follows:

                         ACKNOWLEDGMENT OF INDEBTEDNESS

     1. (a) The Borrowers hereby acknowledge and agree that they are jointly and
severally liable to the Lenders for the following  amounts which are outstanding
under the Loan Documents as of February 22, 1999:

                    Fleet Line of Credit Note:

                    Principal                           $6,600,000.00
                    Pay Rate(1) Interest                    39,462.50
                    Accrual(2)                          $   79,200.00
                                                        -------------
                             Subtotal                   $6,718,662.50

- ----------
     (1)  As defined in Paragraph 2, below.

     (2)  As defined in Paragraph 2, below.


                                       3



                    Mellon Line of Credit Note:

                    Principal                  $5,400,000.00
                    Pay Rate Interest              32,287.50
                    Accrual                    $   64,800.00
                                               -------------
                             Subtotal          $5,497,087.50

                    Fleet Term Note:

                    Principal                  $3,994,285.20
                    Pay Rate Interest              23,882.50
                    Accrual                    $   47,931.43
                                               =============
                             Subtotal          $4,066,099.13

                    Mellon Term Note:

                    Principal                  $2,662,856.80
                    Pay Rate Interest              15,921.67
                    Accrual                    $   31,954.28
                                               =============
                             Subtotal          $2,710,732.75


                                 TOTAL............................$18,992,581.88


     (b) The Borrowers further  acknowledge and agree that they are each jointly
and  severally  liable to the Lenders for all interest  accruing  under the Loan
Documents from and after February 22, 1999 (or January 31, 1999 as appropriate),
and for all late  fees,  costs,  expenses,  and costs of  collection  (including
attorneys' fees)  heretofore or hereafter  incurred by the Lenders in connection
herewith.  (Hereinafter,  all amounts due as set forth in this Paragraph 1 shall
be referred to collectively as the "Obligations").

                                REPAYMENT OF DEBT

     2. (a) Fleet Line of Credit Note and Mellon Line of Credit Note.

          (i) From and after the execution of this Agreement,  on the 1st day of
          each month,  the Borrowers shall pay to the Lenders a monthly interest
          payment equal to the accrued interest on the principal  balance of the
          Fleet  Line of  Credit  Note  and the  Mellon  Line  of  Credit  Note,
          calculated  at a floating rate equal to the aggregate of Fleet's Prime
          Rate (as such Prime Rate may be  announced by Fleet from time to time)
          plus 2.50% per annum (the "Pay Rate").

               Additional  interest,  the  "Accrual",  has  accrued,  and  shall
          continue  to  accrue,  on the  principal  balance of the Fleet Line of
          Credit Note and the Mellon Line of Credit Note at a fixed rate of 3.0%
          per annum (the "Accrual Rate"). The



                                        4



          Accrual shall be due and payable by the Borrowers  upon the earlier of
          (x)  satisfaction of the Obligations,  in their entirety,  or, (y) the
          Termination Date.

               (ii) Any  amounts  paid to cure the  financial  covenant  default
          pursuant to Paragraph 12(a)(iii) of the Extension Agreement,  shall be
          applied on a pro rata basis in reduction of the  principal  balance of
          the Fleet Line of Credit Note and the Mellon Line of Credit Note.

               (iii) At no time  shall the  combined  principal  balance  of the
          Fleet Line of Credit  Note and the Mellon  Line of Credit  Note exceed
          $12,000,000.00.

               (iv) Upon  receipt  by the  Lenders of each of the  payments  set
          forth in Paragraph  2(b)(ii) below, as and when due, the interest rate
          charged on the principal balances of the Fleet Line of Credit Note and
          the Mellon Line of Credit Note shall be reduced by (x) 25 basis points
          for the Pay Rate, and (y) 25 basis points for the Accrual Rate.

          (b)  Fleet Term Note and Mellon Term Note.

               (i) From and after the  execution of this  Agreement,  on the 1st
          day of each month,  the  Borrowers  shall pay to the Lenders a monthly
          interest  payment  equal  to the  accrued  interest  on the  principal
          balance of the Fleet Term Note and the Mellon Term Note, calculated at
          the Pay Rate.

               Additional  interest,  the  "Accrual",  has  accrued,  and  shall
          continue to accrue,  on the  principal  balance of the Fleet Term Note
          and the Mellon Term Note at the Accrual Rate. The Accrual shall be due
          and payable by the Borrowers upon the earlier of (x)  satisfaction  of
          the Obligations, in their entirety, or, (y) the Termination Date.

               (ii) The Borrowers shall pay to the Lenders the following amounts
          on or before the following  dates in collected  funds to be applied by
          the  Lenders  on a pro rata  basis  in  reduction  of the  outstanding
          indebtedness  under the Fleet  Term Note and the  Mellon  Term Note as
          permanent reductions to the outstanding indebtedness thereunder:

                            Date:                      Amount
                            -----                      ------
                            August 31, 1999            $4,000,000.00
                            November 30, 1999          $2,000,000.00

          Upon  receipt  by the  Lenders of each of these  payments  as and when
          required above,  then (x) the interest rate charged upon the remaining
          principal  balances  of the Fleet Term Note and the  Mellon  Term Note
          shall be reduced by (A) 25 basis


                                       5



          points for the Pay Rate, and (B) 25 basis points for the Accrual Rate,
          and (y) the Lenders  shall  waive the portion of the Accrual  equal to
          the  interest  charges  attributable  to the  amount of the  principal
          payment from August 1, 1998 through the date paid.  (Ex.  Upon receipt
          of the  $4,000,000.00  payment  the  Lenders  shall  waive the  unpaid
          interest on the $4,000,000.00 earned at 3% from August 1, 1998 through
          the date of the payment).

               (iii) Any  amounts  paid or  prepaid on account of the Fleet Term
          Note or the Mellon Term Note,  whether  pursuant to this  Agreement or
          otherwise, shall not be available for reborrowing.

     (c) The entire balance of the Obligations,  including,  without limitation,
all principal,  interest (accrued and hereafter  accruing),  costs and expenses,
and  other  charges  due in  connection  therewith  shall be paid in full by the
Borrowers on or before 5:00 P.M.  eastern  standard  time on March 31, 2000,  it
being expressly acknowledged and agreed that TIME IS OF THE ESSENCE.

            VOLUNTARY PRINCIPAL PAYMENTS; WAIVER OF ACCRUED INTEREST

     3. (a)  Provided  that  there is no then  existing  Event of Default as set
forth  in  Paragraph  19,  below,   if  the  Borrowers   shall  make   voluntary
extraordinary  principal  reductions  in  excess  of the  payments  set forth in
Paragraph 2(b), above, as a consequence of fixed asset dispositions permitted by
the Lenders in writing, or otherwise,  then: (i) such payments shall be applied,
on a pro rata basis, first to Fleet Term Note and the Mellon Term Note, and then
to the  Fleet  Line of  Credit  Note and the  Mellon  Line of  Credit  Note,  as
permanent  reductions which may not be reborrowed;  (ii) for each  $1,000,000.00
paid in  principal  reduction,  the interest  rate  charged  upon the  remaining
Obligations  shall be reduced by (x) 50 basis  points for the Pay Rate,  and (y)
100 basis  points for the Accrual Rate  (however,  in no event shall Pay Rate be
reduced by more than 150 basis points,  in the aggregate,  nor shall the Accrual
Rate  be  reduced  by  more  than  300  basis  points,  in the  aggregate,  as a
consequence of such mandatory and/or voluntary  extraordinary principal payments
as set forth in Paragraphs 2(b) and 3, and (iii),  provided such payment is made
on or before  December  31,  1999,  the  Lenders  shall waive the portion of the
Accrual  equal  to  the  interest  charges  attributable  to the  amount  of the
principal payment from August 1, 1998 through the date paid.

     (b) All  payments  of  principal  made prior to the  payment in full of the
principal payments set forth in Paragraph 2(b)(ii) shall be applied first to the
payments required by Paragraph 2(b)(ii), before being applied to the Obligations
pursuant to this Paragraph.

                                COMMITMENT LETTER

     4. On or before June 30, 1999,  the  Borrowers  shall  deliver a commitment
letter, or other evidence, reasonably acceptable to the Lenders, demonstrating a
commitment, subject only


                                        6



to  documentation  and no further  contingencies  of any kind,  from a financial
institution,  shareholder  group,  investor(s),  or other  entity  to  provide a
capital  infusion  (x) in an amount  sufficient  to  satisfy  the  $4,000,000.00
principal  payment required by Paragraph  2(b)(ii) above, and (y) to close on or
before August 31, 1999.  The identity of the entity or individual  providing the
capital,  as  well  as all of  terms  and  conditions  of the  proposed  capital
infusion,  must be reasonably acceptable to the Lenders. To the extent that such
funds are in the form of equity that may be converted to debt,  or  subordinated
debt, the Borrowers shall obtain whatever additional documents, instruments, and
agreements,  including,  without limitation, any subordination agreements,  that
the Lenders may require in connection therewith.

                 EQUITY OR PERMITTED DEBT ISSUANCE; TAX REFUNDS

     5. (a) In the event the  Borrowers  shall raise funds from the  issuance of
either debt permitted by the Lenders and/or equity instruments,  such funds will
be  applied  (i)  first,  on a pro rata basis in  reduction  of the  outstanding
indebtedness  under  the Fleet  Term Note and the  Mellon  Term  Note;  and (ii)
second,  on a  pro  rata  basis  as  permanent  reductions  to  the  outstanding
indebtedness  under the Fleet Line of Credit  Note and the Mellon Line of Credit
Note and shall  permanently  reduce  the  available  credit  thereunder  by that
amount.

     (b) In the event the  Borrowers  receive  actual  funds from any tax refund
(local, state,  federal, or otherwise),  the Borrowers shall immediately deliver
the same to the Lenders,  in the identical  form received and with all necessary
endorsements thereon, which funds will be applied (i) first, on a pro rata basis
in reduction of the outstanding  indebtedness  under the Fleet Term Note and the
Mellon Term Note; and (ii) second,  on a pro rata basis as permanent  reductions
to the  outstanding  indebtedness  under the Fleet  Line of Credit  Note and the
Mellon Line of Credit Note and shall  permanently  reduce the  available  credit
thereunder by that amount.

                 CASH MANAGEMENT; DEPOSITORY ACCOUNTS; PAYMENTS

     6. (a) The Borrowers shall continue to maintain their corporate  depository
bank  accounts  with Fleet as  required  by the Loan  Agreement.  The  Borrowers
further  acknowledge and agree that no overdrafts in any of their demand deposit
accounts shall be permitted.

     (b) Until further notice from the Lenders, all payments required under this
Agreement  shall be made as and when due to Fleet's  address  set forth below in
Paragraph 22. All receivables collected by the Borrowers shall be deposited into
the  Borrowers'  account  with Fleet,  Account No.  099-0059-160  (the  "General
Account").  Any and all funds  deposited  in the  Borrowers'  existing  lock box
account at Fleet shall be transferred  to the General  Account on a daily basis.
Until the  occurrence  of an Event of Default as defined in  Paragraph 19 below,
all funds in the General Account shall be available to the Borrowers, subject to
Fleet's usual and customary rules and procedures regarding uncollected funds, to
pay their regular and ordinary business expenses.


                                       7



     (c) Any payments due under this Agreement,  or costs and expenses  incurred
by the Lenders which are  reimbursable  under this Agreement,  may be debited by
Fleet from the General Account without any further  instruction or authorization
of the Borrowers.

                               WAIVER OF DEFAULTS

     7. The Lenders  hereby waive the  following  specific  defaults  which have
occurred under the terms and conditions of the Extension  Agreement prior to the
execution of this Agreement:

     (a) Section 2(b)(ii) -$500,000.00 and $200,000.00 principal payments due on
     July 15, 1998 and August 15, 1998 not paid;

     (b)  Section  12(a)  -  Minimum  Eligible  Accounts  and  Minimum  Eligible
     Inventory levels not met;

     (c) Sections  12(b)-Minimum Fixed Charge Coverage Ratio of 1.00 to 1.00 not
     met;

     (d) Section 12(c) -Minimum Net Worth not met;

     (e)  Section  13(d)  -Submission  of  final,  original,  audited  financial
     statements for fiscal year ended December 31, 1997, together with certified
     public accountant's unqualified opinion and management letter not delivered
     by May 15, 1998 and  without  material  adverse  change from the 1997 draft
     financial statement previously delivered to the Lenders;

     (f) Section 13(e) - Rolling thirteen week Cash Flow Forecast not met;

     (g) Section 13(f) -Business Plan/Refinancing not met; and

     (h) Section 15  -Additional  Documents  (failure to obtain  foreign  credit
     insurance  on behalf of Lenders or failure  to  coordinate  arrangement  to
     factor receivables by May 31, 1998.

     Additionally,  the Lenders  hereby waive any defaults  which have  occurred
under Section 6.10 of the Loan Agreement.

     The  above-listed  defaults  constitute  all of the  defaults  known to the
Borrowers  or the Lenders.  However,  nothing  contained in this  Paragraph 7 is
intended to be, nor shall it be  construed  as, a waiver of any default or Event
of Default occurring or continuing after the execution of this Agreement,  or of
any  other  default  or Event of  Default,  other  than  the  specific  defaults
referenced above.


                                        8



                                INVESTMENT BANKER

     8. The  Borrowers  have  retained,  and shall  continue to retain,  Berwind
Financial Group,  L.P., or some other  nationally-recognized  investment  banker
acceptable  to the  Lenders  in their  reasonable  discretion  (the  "Investment
Banker"),  for the purpose of  formulating  alternative  business  strategies on
behalf of the  Borrowers  and to  coordinate  the  orderly  satisfaction  of the
Obligations.  The  Investment  Banker  shall  furnish the Lenders  with  monthly
written progress reports and periodic verbal reports  commencing on February 23,
1999 and  continuing  on the last  Tuesday of each month during the term of this
Agreement.

                                    WARRANTS

     9. Grant. In addition to the Warrants (the "Existing  Warrants") granted to
the Lenders under the Extension Agreement (which Existing Warrants are no longer
conditional and may be exercised by the Lenders at any time at a strike price of
$3.50), upon the execution of this Agreement,  IGI, Inc. shall, in consideration
for the  extension and other  accommodations  provided by the Lenders under this
Agreement,  grant to the Lenders,  and their respective  successors and assigns,
stand-alone  warrants  (collectively,  the "New  Warrants"),  the terms of which
shall be in conformance  with the provisions of this Paragraph 9 and which shall
be in a form  acceptable,  in all respects,  to the Lenders in their  reasonable
discretion, exercisable for shares of IGI, Inc. common stock, as follows:

     As to  Fleet:  Two  Warrants,  one  for  150,000  shares  (the  "New  Fleet
Unconditional  Warrant") and one for 150,000 shares (the "New Fleet  Conditional
Warrant")

     As to  Mellon:  Two  Warrants,  one for  120,000  shares  (the "New  Mellon
Unconditional  Warrant," and, together with the Fleet Unconditional Warrant, the
"New  Unconditional  Warrants")  and one for  120,000  shares  (the "New  Mellon
Conditional Warrant," and, together with the Fleet Conditional Warrant, the "New
Conditional Warrants").

     Exercise Price.  The exercise price for the New Warrants shall be $2.00 per
common share (subject to customary adjustments).  In addition to other customary
warrant  provisions,  the New Warrants  shall each contain  "cashless"  exercise
provisions and anti-dilution provisions.

     Exercise Period.

               (a) New Unconditional  Warrants.  The New Unconditional  Warrants
          will be  exercisable  at any time during the period  commencing  sixty
          (60) days after issuance and ending on October 1, 2004.

               (b) Conditional  Warrants.  The New Conditional  Warrants will be
          exercisable  during the period  commencing  September  30,  1999,  and
          ending on  October  1,  2004,  unless,  by 5:00 PM,  Boston  time,  on
          September 30, 1999, either (a) all Obligations of the Borrowers to the
          Lenders  shall  have  been  paid  in  full,  in  which  case  the  New
          Conditional


                                        9



          Warrants  shall  expire,  or  (b)  the  Borrowers  have  delivered  an
          acceptable  commitment  letter,  subject only to documentation  and no
          further  contingencies  of  any  kind,  from a  financial  institution
          acceptable  to the  Lenders,  contemplating  a full  refinance  of the
          existing  obligations which  contemplates a closing within thirty (30)
          days, in which case the New Conditional  Warrants  exercise start date
          shall be extended  to October  30,  1999;  provided,  however,  if all
          Obligations  of the Borrowers to the Lenders have been paid in full on
          or before such extended start date, the New Conditional Warrants shall
          expire upon such payment.

               (c)  Acceleration  of Exercise Start Dates.  Notwithstanding  the
          foregoing,  the New  Unconditional  Warrants  and the New  Conditional
          Warrants shall become  immediately  exercisable upon the occurrence of
          an Event of Default,  or the exercise by IGI,  Inc. of the call option
          for the issuable shares under such Warrant  described below (to afford
          the Lenders the opportunity to exercise the subject Warrant before the
          call option closing).

     Call  Option.  IGI,  Inc.  shall  have a call  option on the New  Warrants,
subject to the following terms:

               (a) The option may only be exercised as to all, and not less than
          all, of the shares  issuable  at such time under the subject  Warrant,
          and shall not cover issued shares (or shares pending issuance).

               (b) The option may be  exercised  as to a subject  Warrant at any
          time up to the time that the Lender  exercises  its  rights  under the
          subject Warrant.

               (c) The repurchase price (subject to customary  adjustments based
          upon  the  operation  of  the  anti-dilution  provisions  of  the  New
          Warrants) will be (i) $500,000 for the 150,000  shares  issuable under
          the New Fleet  Unconditional  Warrant;  (ii)  $500,000 for the 150,000
          shares  issuable  under  the  New  Fleet  Conditional  Warrant;  (iii)
          $400,000  for  the  120,000  shares  issuable  under  the  New  Mellon
          Unconditional  Warrant;  and  (iv)  $400,000  for the  120,000  shares
          issuable under the New Mellon Conditional  Warrant.  In the event that
          the  number of shares  issuable  under a Warrant at the time of a call
          exercise  is  less  than  the  number  of  shares  initially  issuable
          thereunder due to an exercise thereunder or a transfer, the repurchase
          price will be proportionately adjusted.


                                       10



     Registration  Rights. The Lenders acknowledge that the shares issuable upon
the exercise of the New Warrants  (when  issued,  the "Warrant  Shares") will be
"restricted  securities" within the meaning of Rule 144 of the Securities Act of
1933, as amended (the "Securities Act"). IGI, Inc. will use its best efforts to,
as soon as practicable  following the exercise of any of the New Warrants but in
no event  less  that 180 days  from the  actual  exercise  date,  (a) to file an
appropriate  registration  statement  under the Securities Act for the resale of
the Warrant Shares by the Lenders, and (b) to cause such registration  statement
(which shall specifically permit sales either thereunder or under Rule 144 if it
becomes available at any time during the period such  registration  statement is
effective)  to  become  effective,  and  to  keep  such  registration  statement
effective  until the earlier of (i) the resale of all of the  Warrant  Shares by
the Lenders;  or (ii) the later of (as may be applicable)  (A) 120 days from the
initial effective date of such registration statement; (B) the date which is one
year from the date the New Warrants are issued to the Lenders;  and (C) the date
as of which the resale of all of the Warrant Shares has been  permissible  under
Rule  144  for a  continuous  120  day  period  without  regard  to  the  volume
limitations  set  forth  in Rule  144(e)  and  assuming  only  for  purposes  of
determining  permissibility under this clause (C) (regardless of whether the New
Warrants  are  exercised  in a cashless  exercise)  that all New  Warrants  were
exercised in full in cashless exercises as of the respective dates when such New
Warrants were first exercisable.  IGI, Inc. will also use its best efforts to at
all times while the New  Warrants  or Warrant  Shares are held by the Lenders to
comply with the current public information conditions of Rule 144(c).

     IGI,  Inc. has informed the Lenders that IGI, Inc. is ineligible to utilize
a Form S-3  registration  statement  until a date on or about  October  1, 1999.
Accordingly,  notwithstanding  the terms of the preceding  paragraph,  IGI, Inc.
shall have no obligation to file a registration  statement  until the earlier of
(x) October 1, 1999,  or (y) such earlier date at which IGI, Inc. is eligible to
file a registration statement on Form S-3.

     The Lenders will also be granted  "piggy-back"  registration  rights for as
long as they own Warrant Shares.

     IGI, Inc.  agrees to list the Warrant Shares on the  NASDAQ/American  Stock
Exchange within six months of any exercise under a New Warrant or New Warrants.

     Return of Warrants.  If the Borrowers pay all of the Obligations in full on
or before  June 30,  1999,  the  Lenders  shall  return the  following  Existing
Warrants to the Borrowers:

               (a) One  Warrant  for  150,000  shares  defined in the  Extension
          Agreement  as the "Fleet  Conditional  Warrant",  which  shares have a
          strike price of $3.50; and

               (b) One  Warrant  for  120,000  shares  defined in the  Extension
          Agreement  as the "Mellon  Conditional  Warrant",  which shares have a
          strike price of $3.50.


                                       11



     Waiver of Anti-Dilution Provisions of Existing Warrants. In connection with
the  issuance of the New  Warrants,  the Lenders  hereby  irrevocably  waive all
rights to adjustment  to the exercise  price of the Existing  Warrants,  and any
correlative  adjustment  to the  number of  Warrant  Shares  (as  defined in the
Existing Warrants) issuable upon exercise of the Existing Warrants, as set forth
in Section 3 of the  Existing  Warrants,  as a result of the issuance of the New
Warrants or the issuance of Warrant Shares upon exercise of such New Warrants.

                                  EXTENSION FEE

     10.  In  consideration  of  the  Lenders'  agreement  to  enter  into  this
Agreement,  the Borrowers shall pay to Fleet, as agent on behalf of the Lenders,
an  extension  fee  (the  "Extension  Fee")  in the sum of  $350,000.00  by bank
cashiers' check,  certified check, federal funds wire transfer,  or direct debit
from the General Account or the Collection Account as follows:

          (a) $50,000.00 on or before the execution of this Agreement;

          (b) $60,000.00 on or before May 31, 1999;

          (c) $70,000.00 on or before August 31, 1999;

          (d) $80,000.00 on or before November 30, 1999; and

          (e) $90,000.00 on or before February 24, 2000.

Each portion of the  Extension  Fee shall be fully earned as of the date of this
Agreement and shall be distributed upon receipt by Fleet to the Lenders on a pro
rata basis as a fee and not applied to the Obligations.

     Notwithstanding  the foregoing,  if the Lenders  receive payment in full of
all of the  Obligations,  then the  Lenders'  shall  waive  any  portion  of the
extension fee which becomes  payable after the date the Lenders  receive payment
in full.

                                   AGENT'S FEE

     11. In consideration of Fleet's  agreement to enter into this Agreement and
to  continue  to  administer  the Loan  Arrangements  as agent on  behalf of the
Lenders,  the  Borrowers  shall pay to Fleet a monthly  $5,000.00  agent's  fee,
commencing upon the execution of this Agreement and continuing on the 1st day of
each month  thereafter.  The agent's fee for each month shall be fully earned as
of the 1st day of that month,  and shall be retained by Fleet as a fee and shall
not be applied in reduction of the Obligations.


                                       12



                               FINANCIAL COVENANTS

     12. In addition to all other  covenants  contained  in the Loan  Documents,
during the term of this Agreement,  the Borrowers shall at all times comply with
the following covenants:

     (a) Minimum Eligible  Accounts  Receivable and Minimum Eligible  Inventory:
The Borrowers shall maintain,  at month end, combined "Minimum Eligible Accounts
Receivable" and "Minimum Eligible Inventory" of $9,750,000.00.

               (i) "Minimum  Eligible  Accounts  Receivable"  shall include both
          "Eligible Domestic Accounts Receivable" and "Eligible Foreign Accounts
          Receivable".   "Eligible  Domestic  Accounts  Receivable"  shall  mean
          invoices for  domestic  shipments  and services  less than ninety (90)
          days old and otherwise reasonably acceptable to the Lenders. "Eligible
          Foreign  Accounts  Receivable"  shall mean invoices for  international
          shipments  and  services  not more than  sixty  (60) days past due and
          otherwise reasonably acceptable to the Lenders.

               (ii)   "Eligible   Inventory"   shall  mean  the  lesser  of  (x)
          $6,000,000.00  or (y) gross inventory  calculated on a FIFO basis less
          (a)work-in-process, (b) cartons, labels, and obsolescence reserves and
          (c) any other  reserves  reasonably  deemed  necessary by the Lenders.
          Until further notice from Fleet on behalf of the Lenders,  the portion
          of  work-in-process  inventory  consisting of completed products which
          has passed all quality  assurance tests, and only awaits packaging and
          labeling, may be included in the calculation of "Eligible Inventory".

               (iii) The Borrowers may, within  forty-eight (48) hours of actual
          knowledge of any violation under this covenant, cure such violation by
          either, or combination, of the following methods:

                    (1) Paying to the Lenders an amount sufficient to reduce the
               aggregate balance of the Fleet Line of Credit Note and the Mellon
               Line of Credit Note by an amount equal to (x) $9,750,000.00 minus
               (y)  the  sum of  Eligible  Domestic  Accounts  Receivable,  plus
               Eligible Foreign Accounts  Receivable,  plus Eligible  Inventory,
               plus (z)  amounts  previously  paid by the  Borrowers  under this
               subsection only in the event there shall exist a further decrease
               from the collateral  level most recently  reported.  Said amounts
               may  be  reborrowed   provided  that  the  Borrowers   remain  in
               compliance with the terms and conditions of this  Agreement,  and
               the combined  Minimum  Eligible  Accounts  Receivable and Minimum
               Eligible Inventory totals at least $9,750,000.00; or

                    (2)  Providing  the Lenders  with (x) a covenant  compliance
               certificate  in  the  form  of  Exhibit  C,   demonstrating   the
               Borrowers'


                                       13



               compliance with each of the covenants  contained in Paragraph 12,
               and (y) documentary evidence,  including, without limitation, all
               invoices  for  new  shipments  and  services,  demonstrating  the
               increase  in the  Borrowers'  Eligible  Accounts  Receivable  and
               Eligible Inventory to the required collateral level.

     (b)  Minimum Net Worth:  The  Borrowers  shall  maintain,  at all times,  a
minimum "Net Worth" (as defined in accordance with generally accepted accounting
principles)  of no less than  $4,200,000.00.  In addition,  the Borrowers  shall
maintain a Minimum Net Worth of no less than the following  amounts on the dates
set forth below:

                     Dates                         Amount
                     -----                         ------

                    3/31/99                    $5,405,000.00
                    6/30/99                    $5,019,000.00
                    9/30/99                    $4,769,000.00
                    12/31/99                   $4,718,000.00
                    3/31/00                    $4,451,000.00

     (c)  Maximum  Capital  Expenditures:  For the period  from  January 1, 1999
through  December 31, 1999,  the Borrower shall not incur  consolidated  Capital
Expenditures  (as  defined in  accordance  with  generally  accepted  accounting
principles) in excess of the aggregate  amount  $2,000,000.00,  and no more than
the following amounts for each of the following periods:

                            Dates                   Amount
                            -----                   ------

                    1/1/99 through 3/31/99       $500,000.00
                    4/1/99 through 6/30/99       $500,000.00
                    7/1/99 through 9/30/99       $500,000.00
                    10/1/99 through 12/31/99     $500,000.00

In addition,  for the period  commencing  January 1, 2000 through and  including
March 31, 2000, the Borrowers shall not incur consolidated  Capital Expenditures
in excess of  $250,000.00.  The  Borrowers  may obtain lease  facilities  and/or
purchase money financing to fund the above referenced Capital Expenditures.

     (d) Cash Flow: The Borrowers  shall, as of the end of each period set forth
below,  maintain  consolidated  cumulative EBITDA (as defined in accordance with
generally accepted accounting principles) of no less than the following amounts:

                           Dates:                  Amounts:
                           ------                  --------

                    1/1/99 through 3/31/99       $253,000.00
                    1/1/99 through 6/30/99       $877,000.00


                                       14



                    1/1/99 through 9/30/99     $1,586,000.00
                    1/1/99 through 12/31/99    $2,550,000.00
                    1/1/00 through 3/31/00     $  633,000.00

     (e)  Dividends:  The  Borrowers  shall  not pay  dividends,  or make  other
distributions  of any kind,  nature,  or manner to any party  without  the prior
written consent of Fleet on behalf of the Lenders.

     (f)  Additional  Indebtedness/Liens:  The  Borrowers  shall  not  incur any
additional indebtedness from and after the date of this Agreement other than (i)
in connection with the ordinary  course of their business,  or (ii) as set forth
in Paragraph  12(c) above,  nor shall the Borrowers  grant or permit any lien or
other  encumbrance  to exist or be placed  upon any of their  assets,  except as
approved by the Lenders in writing.

     (g) Year 2000  Compliance.  The Borrowers will be "Year 2000  Compliant" by
September 30, 1999. As used herein"Year 2000 Compliant"  means,  with respect to
the Borrowers and/or their suppliers, vendors, and customers, that all software,
embedded microchips, and other processing capabilities utilized by, and material
to the business  operations  or financial  condition of, such entity are able to
interpret and manipulate data on and involving all calendar dates correctly, and
without causing any abnormal ending scenario,  including, without limitation, in
relation to dates on or after January 1, 2000. Such compliance will be evidenced
by a publicly  issued  statement by the Borrowers to the Securities and Exchange
Commission ("SEC"), with a copy delivered to each of the Lenders.

                               FINANCIAL REPORTING

     13. In addition to all other reporting  requirements  contained in the Loan
Documents, the Borrowers shall also furnish to the Lenders the following:

     (a)  Accounts  Receivable  Agings  and  Borrowing  Base  Certificate:   The
Borrowers shall submit to each of the Lenders on Wednesday of each week both (i)
Domestic and Foreign  Accounts  Receivable  Agings and (ii) a certificate in the
form of Exhibit B annexed  hereto and  specifically  incorporated  by  reference
herein and setting forth the Borrowers'  compliance with Paragraph 12(a), above,
each of which (i) and (ii) shall be dated as of the last day of the  immediately
preceding  week.  In connection  with the  provision of the Accounts  Receivable
Agings contemplated  herein, the Borrowers shall include a detailed  calculation
of (x) the total value of the otherwise  eligible domestic  accounts  receivable
wherein fifty (50%) percent or more of an individual  customer  accounts account
balances  are in excess of ninety  (90) days from the  invoice  date and (y) the
total value of otherwise  eligible  foreign  accounts  receivable  wherein fifty
(50%) percent or more of an individual  customer  account balances are more than
sixty (60) days past due.


                                       15



     (b) Inventory Report:  The Borrowers shall submit to each of the Lenders by
the 15th of each month, a detailed  inventory report dated as of the last day of
the immediately preceding month; and

     (c) Monthly Financial Statements: The Borrowers shall submit to each of the
Lenders,  within  forty-five  (45)  days of the  close of a  calendar  month,  a
consolidated  and  consolidating  statement  of  profit  or loss,  cash flow and
balance  sheet for the  immediately  preceding  month and  year-to-date  period.
Simultaneously with the furnishing of such financial information,  the Borrowers
shall submit to each of the  Lenders,  a  reconciliation  analysis of the actual
monthly and year-to-date  results compared to the projected results set forth in
the "IGI,  Inc.  Operating Plan Year 1999" dated January 5, 1999, and amended by
an IGI, Inc. Bank Covenant  Budget dated March 5, 1999 (the  "Operating  Plan"),
together with a detailed explanation of any and all material variances.

     (d) Financial Statements: The Borrowers shall deliver final original copies
of  audited   financial   statements,   together  with  their  certified  public
accountant's  unqualified  opinion  and  management  letter for the fiscal  year
ending December 31, 1998 to each of the Lenders on or before March 31, 1999. The
final,  original  audited  financial  statements  shall be in form and substance
without  material  adverse   deviation  from  the  draft  financial   statements
previously delivered to the Lenders.  Further, the unqualified opinion shall not
(i) disclaim the  auditor's  obligation  to address the so called "Yk2" or "Year
2000 Risk"  issue as it  relates to the  Borrower's  liabilities  or  contingent
liabilities, and (ii) be qualified as to the Borrower's possible failure to take
all appropriate steps to successfully address the so called "Yk2" issue.

     (e) Cash Flow Reports:  The Borrowers  shall submit to each of the Lenders,
by the fifteenth (15) day of each month,  a  consolidated  summary of the actual
cash flow results of the  Borrowers for the preceding  month.  In addition,  the
Borrowers  shall  submit,  with the Monthly  Financial  Statements  set forth in
sub-paragraph  (c) above,  detailed  consolidated  cash flow  statements for the
Borrowers  comparing  the  actual  cash flow for the  preceding  month  with the
projected  results  set forth in  Operating  Plan.  In addition to the cash flow
statements,  the Borrowers  shall submit a narrative  description  detailing the
variances between the actual results with the projected results set forth in the
Operating Plan.

     (f) Certifications: All such financial reporting shall be certified (to the
best knowledge and belief of the certifying officer) both as to the accuracy and
compliance  with  required  covenants by IGI's Chief  Executive  Officer,  Chief
Operating Officer, Chief Financial Officer, or Treasurer. Any such certification
shall be deemed to have been made on behalf of each of the Borrowers.

                              ADDITIONAL DOCUMENTS

     14. Upon the execution of this Agreement,  and at any time thereafter,  the
Borrowers  shall  also  execute  and  deliver  to the  Lenders  such  additional
documentation as the Lenders in


                                       16



their  discretion  may  reasonably  require in order to grant and/or perfect the
Lenders'  security interest in all assets of the Borrowers,  including,  without
limitation,  all (i)  motor  vehicles,  (ii)  intellectual  property  including,
without limitation, all patents and/or trademarks, and (iii) license agreements.
The Borrowers  represent that all locations  where  inventory is located and all
patents or other  intellectual  property in which the Borrowers have an interest
are listed, respectively,  on Exhibit "D" and Exhibit "E" each as annexed hereto
and specifically incorporated by reference herein.

                             COMPLIANCE CERTIFICATE

     15. Upon or before the execution of this  Agreement,  and within forty five
(45) days of each  month end during the term of this  Agreement,  the  Borrowers
shall deliver to each of the Lenders, a covenant  compliance  certificate in the
form of  Exhibit C  setting  forth the  Borrowers'  compliance  with each of the
financial covenants referenced in Paragraph 12, above.

          APPRAISALS; FIELD EXAMINATIONS; LENDERS' FINANCIAL CONSULTANT

     16. (a) The  Borrowers  agree to  cooperate  with the Lenders to enable the
Lenders to obtain  updated  appraisals of all real estate and personal  property
owned by the  Borrowers and to conduct  independent  field  examinations  of the
Borrowers'  books  and  records  which   cooperation   shall  include,   without
limitation,  providing the Lenders  and/or their  appraisers,  examiners  and/or
other  representatives,  reasonable  access  to such  property  and  shall  make
available such financial and/or other information regarding the property,  books
and records, and other assets of the Borrowers as may be reasonably requested by
the Lenders in their  discretion.  The Borrowers shall reimburse the Lenders for
all  reasonable  out of pocket costs and expenses of  independent  third parties
incurred  by  the  Lenders  in  connection   with  such   appraisals  and  field
examinations.

     (b) The Borrowers agree that the Lenders may continue to retain a financial
consultant  to act on behalf of the  Lenders for the  purpose of  assessing  the
status of the business  operations of the Borrowers and analyzing the Borrowers'
current  and  future  plans and  business  operations,  and their  effect on the
ability of the  Borrowers to satisfy the  Obligations.  The  Borrowers  agree to
cooperate with any such financial  consultant and agree to reimburse the Lenders
for all reasonable fees and expenses  incurred by the Lenders in connection with
the retention of such financial consultant.

                                WAIVER OF CLAIMS

     17. The Borrowers  hereby  acknowledge and agree that they have no offsets,
defenses, claims, or counterclaims against the Lenders or the Lenders' officers,
directors,  employees,  attorneys,  representatives,  predecessors,  affiliates,
successors, and assigns with respect to the Obligations,  or otherwise, and that
if the Borrowers now have, or ever did have, any offsets,  defenses,  claims, or
counterclaims against the Lenders or the Lenders' officers, directors,


                                       17



employees, attorneys, representatives, predecessors, affiliates, successors, and
assigns,  whether known or unknown,  at law or in equity,  from the beginning of
the world through this date and through the time of execution of this Agreement,
all of them are hereby expressly  WAIVED,  and the Borrowers each hereby RELEASE
the  Lenders  and  the  Lenders'  officers,  directors,   employees,  attorneys,
representatives,  predecessors,  affiliates,  successors,  and assigns  from any
liability therefor, to the extent allowed by applicable laws.

               RATIFICATION OF LOAN DOCUMENTS; FURTHER ASSURANCES

     18. (a) The Borrowers hereby ratify, confirm, and reaffirm all and singular
the  terms  and  conditions  of the Loan  Documents,  and  specifically  ratify,
confirm,  and reaffirm their  authority to execute same.  The Borrowers  further
acknowledge and agree that,  except as specifically  modified in this Agreement,
all terms and conditions of those documents,  instruments,  and agreements shall
remain in full force and effect.

     (b) The Borrowers  shall,  from and after the execution of this  Agreement,
execute and deliver to the Lenders whatever additional  documents,  instruments,
and  agreements  that the  Lenders  may  reasonably  require in order to vest or
perfect the Loan Documents and the collateral  granted  therein more securely in
the Lenders and to  otherwise  give effect to the terms and  conditions  of this
Agreement,  including,  without limitation, a complete amendment and restatement
of the Loan Documents  within thirty (30) days of any request by the Lenders for
any such additional documentation.

                                EVENTS OF DEFAULT

     19.  The  occurrence  of any  one or  more of the  following  events  shall
constitute an event of default  (hereinafter,  an "Event of Default") under this
Agreement:

          (a) The  failure of the  Borrowers  to pay or deposit  any amounts due
     hereunder or under any of the Loan Documents as and when due;

          (b) The  failure  of the  Borrowers  to comply  with any other term or
     condition of this  Agreement  (which  default,  other than a default  under
     Paragraph  12(a), may be cured within three (3) days in connection with any
     non-monetary default capable of being cured);

          (c) The filing of a petition  for relief by or against any one or more
     of the Borrowers under the United States Bankruptcy Code;

          (d) The existence or issuance of any directive or action by either the
     United States  Department of Agriculture or Office of the Inspector General
     of the  United  States,  or any  other  governing  body,  which  materially
     adversely  impact the  Borrowers'  ability to  manufacture,  sell,  or ship
     products,  or otherwise have a Material  Adverse Effect  (defined below) on
     the Borrowers' financial condition or with the passage of time could have a
     material adverse impact


                                       18



     on  the  Borrowers'  financial  condition,  assets,  operating  status,  or
     projected  financial  condition.   For  the  purposes  of  this  Agreement,
     "Material  Adverse Effect" shall be defined as any material  adverse effect
     on  the  Borrowers'  financial  condition,   assets,  operating  status  or
     projected  financial  condition or any fact or circumstance that, singly or
     in the aggregate with any fact or circumstance, has a reasonable likelihood
     of resulting in or leading to the  inability of the Borrowers to perform in
     any material  respect their  obligations  under this Agreement or under any
     Loan  Document or the  inability of Agent and/or  Lenders to enforce in any
     material  respect  the  rights  purported  to be granted to them under this
     Agreement  or any Loan  Document or which have a reasonable  likelihood  of
     having a  material  adverse  effect  on the  ability  of the  Borrowers  to
     effectuate  (including  hindering  or  unduly  delaying)  the  transactions
     contemplated  by  this  Agreement  and  the  loan  Documents  on the  terms
     contemplated hereby and thereby.

     (e) The  occurrence of any further event of default  under,  and as defined
in, any of the Loan Documents.

                               RIGHTS UPON DEFAULT

     20. Upon the occurrence of any Event of Default:

          (a) All Obligations shall become  immediately due and payable in full,
     without  demand,  notice,  or  protest,  all of which are hereby  expressly
     WAIVED.

          (b) The Lenders may  immediately  commence  enforcing their rights and
     remedies pursuant to the Loan Documents and otherwise.

          (c) Interest shall accrue on the outstanding  principal balance of the
     Obligations  at the  default  rate  of  interest  set  forth  in  the  Loan
     Documents.

          (d) Any waiver of the Accrual under Paragraphs  2(b)(ii) or 3(a) shall
     be void,  and the full  amount of the  Accrual  shall be due and payable in
     full.

          (e) The  agreement  of the Lenders  contained in Paragraph 9 to return
     certain of the Existing Warrants shall be void, and of no further force and
     effect.

     Notwithstanding  the  occurrence of any Event of Default,  if the Borrowers
pay all  Obligations  in full,  then the Borrowers  shall retain the benefits of
prepayment set forth in Paragraphs 2(b)(ii),  3(a), 9, and 10, provided that the
ability of the Borrowers to obtain such  benefits has not  terminated or expired
under the terms and conditions of those Paragraphs.

                       REIMBURSEMENT OF COSTS AND EXPENSES

     21. Upon the execution of this  Agreement,  the Borrowers  shall pay to the
Lenders an amount equal to any and all reasonable  attorneys'  fees and expenses
incurred in connection with


                                       19



this matter through the date of this  Agreement.  In addition,  upon Demand,  or
upon the occurrence of any Event of Default,  as defined in Paragraph 19, above,
the Borrowers shall  reimburse the Lenders for any and all reasonable  costs and
expenses, including, without limitation, all reasonable costs, expenses and fees
of all  accountants,  appraisers,  auditors  and  other  representatives  of the
Lenders, and costs of collection  (including attorneys' fees) hereafter incurred
by the Lenders in connection with the clarification,  modification,  protection,
preservation, and enforcement by the Lenders of their rights and remedies.

                                     NOTICES

     22. Any notices  required to be sent to the Lenders and the Borrowers shall
be forwarded via recognized overnight courier, addressed as follows:

               If to the Lenders:    Fleet National Bank
                                     40 Westminster Street
                                     Mail Code: RI OP TO5A
                                     Providence, Rhode Island 02901
                                     Attn: Mr. Daniel D. Butler, Vice President
                                     Telephone: (401) 459-4678
                                     Fax: (401) 459-4963

               With a copy to:       Steven T. Greene, Esquire
                                     Riemer & Braunstein
                                     Three Center Plaza
                                     Boston, Massachusetts 02108
                                     Telephone: (617) 523-9000
                                     Fax: (617) 723-6831

                                     Mellon Bank
                                     Mellon Bank Center
                                     1735 Market Street, P.O. Box 7899
                                     Philadelphia, PA   19101-7899
                                     Telephone: 215-553-2043
                                     Fax: 215-553-4560
                                     Attn: Walter J. Letts
                                     Vice President

               With a copy to:       Peter Leibundgut, Esquire
                                     Blank, Rome and Comisky
                                     Woodland Falls Corporate Park
                                     210 Lake Drive East
                                     Cherry Hill, New Jersey   08002
                                     Telephone:  609-779-3644
                                     Fax:  609-779-7647


                                       20





               If to the Borrowers:  IGI, Inc.
                                     IGEN, Inc.
                                     Immunogenetics, Inc.
                                     Blood Cells, Inc.
                                     Wheat Road and Lincoln Avenue
                                     Buena, New Jersey 08310
                                     Attn: John F. Wall, CFO
                                     Telephone: (609) 697-1441
                                     Fax: (609) 697-1001

               With a copy to:       Paul Brountas, Esquire
                                     Hale and Dorr, LLP
                                     60 State Street
                                     Boston, Massachusetts 02109
                                     Telephone: (617) 526-6000
                                     Fax: (617)526-5000


                                     WAIVERS

     23.  Non-Interference.  From  and  after  the  occurrence  of any  Event of
Default,  the Borrowers  agree not to interfere with the exercise by the Lenders
of any of their rights and remedies. The Borrowers further agree that they shall
not seek to distrain or otherwise  hinder,  delay, or impair the Lenders' lawful
efforts to realize upon the Collateral, or otherwise to enforce their rights and
remedies  pursuant to the Loan  Documents.  This provision shall be specifically
enforceable by the Lenders.

     24.  Automatic  Stay.  The  Borrowers  agree  that  upon the  filing of any
Petition  for Relief by or against  any one or more of the  Borrowers  under the
United States  Bankruptcy  Code,  the Lenders shall be entitled to file a motion
for immediate and complete relief from the automatic stay, and the Lenders shall
be permitted to proceed to protect and enforce  their rights and remedies  under
applicable law.

     25. Jury Trial. The Borrowers  hereby make the following waiver  knowingly,
voluntarily,  and  intentionally,  and understand that the Lenders,  in entering
into this  Agreement or making any financial  accommodations  to the  Borrowers,
whether now or in the future,  are relying on such waiver: TO THE EXTENT ALLOWED
BY APPLICABLE LAW, THE BORROWERS HEREBY  IRREVOCABLY WAIVE ANY PRESENT OR FUTURE
RIGHT TO A JURY IN ANY TRIAL OF ANY CASE OR  CONTROVERSY  IN WHICH  THE  LENDERS
BECOME A PARTY  (WHETHER SUCH CASE OR CONTROVERSY IS INITIATED BY OR AGAINST THE
LENDERS OR IN WHICH THE LENDERS ARE JOINED AS A PARTY  LITIGANT),  WHICH CASE OR
CONTROVERSY ARISES OUT


                                       21



OF, OR IS IN RESPECT OF, ANY  RELATIONSHIP  BETWEEN THE BORROWERS,  OR ANY OTHER
PERSON, AND THE LENDERS.

                                ENTIRE AGREEMENT

     26. This  Agreement  shall be binding upon the Borrowers and the Borrowers'
officers, directors,  employees,  representatives,  successors, and assigns, and
shall  inure to the  benefit of the  Lenders  and the  Lenders'  successors  and
assigns.  This Agreement and the Loan Documents and all documents,  instruments,
and agreements executed in connection  herewith or therewith  incorporate all of
the discussions and negotiations  between the Borrowers and the Lenders,  either
expressed or implied,  concerning the matters  included herein and in such other
documents,  instruments and  agreements,  any statute,  custom,  or usage to the
contrary  notwithstanding.  No such  discussions  or  negotiations  shall limit,
modify, or otherwise affect the provisions  hereof. No modification,  amendment,
or waiver of any  provision  of this  Agreement,  or any  provision of any other
document,  instrument,  or agreement between the Borrowers and the Lenders shall
be  effective  unless  executed in writing by the party to be charged  with such
modification,  amendment, or waiver, and if such party be the Lenders, then by a
duly authorized officer thereof.

                            CONSTRUCTION OF AGREEMENT

     27. (a) This Agreement and all other documents, instruments, and agreements
incidental  hereto and all  rights and  obligations  hereunder  and  thereunder,
including matters of construction,  validity, and performance, shall be governed
by and  construed in  accordance  with the law of the State of New Hampshire and
are intended to take effect as sealed instruments.  The Borrowers hereby consent
to the jurisdiction of the Courts of the State of New Hampshire for all purposes
with  respect  to this  Agreement  and the  Obligations.  The  captions  of this
Agreement are for convenience purposes only, and shall not be used in construing
the intent of the Lenders and the Borrowers under this  Agreement.  In the event
of any  inconsistency  between the  provisions  of this  Agreement and any other
document,  instruments, or agreement entered into by and between the Lenders and
the  Borrowers,  including  the  Extension  Agreement,  the  provisions  of this
Agreement shall govern and control.

     (b) The Borrowers  further  acknowledge  and agree that the Lenders and the
Borrowers  have prepared  this  Agreement and all  documents,  instruments,  and
agreements incidental hereto and with the aid and assistance of their respective
counsel.  Accordingly,  when  interpreting  this  Agreement  and all such  other
documents,  instruments,  and  agreements,  each of them shall be deemed to have
been drafted by the Lenders and the Borrowers and shall not be construed against
either the Lenders or the Borrowers.


                                       22



                         ILLEGALITY OR UNENFORCEABILITY

     28. Any  determination  that any provision or application of this Agreement
is invalid,  illegal, or unenforceable in any respect, or in any instance, shall
not effect the validity,  legality,  or  enforceability of any such provision in
any other instance,  or the validity,  legality,  or enforceability of any other
provision of this Agreement.

                             COMPREHENSIVE AGREEMENT

     29. The Borrowers  warrant and represent to the Lenders that the Borrowers:
(i) have read and understand all of the terms and conditions of this  Agreement,
(ii) intend to be bound by the terms and conditions of this Agreement, (iii) are
executing  this  Agreement  freely  and  voluntarily,   without  duress,   after
consultation with independent counsel of their own selection.

     IN WITNESS  WHEREOF,  this  Agreement  has been  executed  this ____ day of
March, 1999.


FLEET BANK-N.H.                                   IGI, INC.

By: /s/ Fred H. Manning                           By: /s/ Edward B. Hager
   -------------------------                          -------------------------
Title: Senior Vice President                      Title:


MELLON BANK                                       IGEN, INC.

By: /s/ Walter Letts                              By: /s/ George P. Warren, Jr.
   -------------------------                          -------------------------
Title: Vice President                             Title: Assistant Secretary

                                                  IMMUNOGENETICS, INC.

                                                  By: /s/ Edward B. Hager
                                                      --------------------------
                                                  Title: Chairman and Chief
                                                          Executive Officer


                                                  BLOOD CELLS, INC.

                                                  By: /s/ Edward B. Hager
                                                      --------------------------
                                                  Title: Chairman and Chief
                                                          Executive Officer


                                       23



                              STATE OF RHODE ISLAND

County of Providence, ss                                          March 11, 1999


     Then  personally  appeared  the above named Fred H.  Manning,  the Sr. Vice
President of Fleet Bank- N.H. and  acknowledged the foregoing to be the free act
and deed of Fleet Bank- N.H., before me,

                                               /s/ Jane A. Martin
                                               ---------------------------------
                                               Notary Public Jane A. Martin
                                               My Commission Expires: 2/12/02

                              STATE OF PENNSYLVANIA

______________, ss                                                 March 9, 1999

     Then personally  appeared the above named Walter Letts,  the Vice President
of Mellon Bank, N.A. and  acknowledged the foregoing to be the free act and deed
of Mellon Bank, N.A., before me,

                                               /s/ Yolanda D. Arnold
                                               ---------------------------------
                                               Notary Public Yolanda D. Arnold
                                               My Commission Expires: 3/13/00


                               STATE OF NEW JERSEY

_____________, ss                                                 March 10, 1999

     Then personally  appeared the above named Edward B. Hager,  the Chairman of
IGI,  Inc. and  acknowledged  the  foregoing to be the free act and deed of IGI,
Inc., before me,

                                               /s/ Theresa R. Dematte
                                               ---------------------------------
                                               Notary Public Theresa R. Dematte
                                               My Commission Expires: 5/24/00


                                       24



                                STATE OF DELAWARE

County of Newcastle, ss                                           March 10, 1999

     Then personally  appeared the above named George P. Warren, Jr. , the Asst.
Secretary of IGEN,  Inc. and  acknowledged  the foregoing to be the free act and
deed of IGEN, Inc., before me,

                                               /s/ Cynthia L. Conner
                                               ---------------------------------
                                               Notary Public Cynthia L. Conner
                                               My Commission Expires: 7/6/99



                               STATE OF NEW JERSEY

_____________, ss                                                 March 10, 1999

     Then personally  appeared the above named Edward B. Hager,  the Chariman of
Immunogenetics,  Inc. and acknowledged the foregoing to be the free act and deed
of Immunogenetics, Inc., before me,

                                               /s/ Theresa R. Dematte
                                               ---------------------------------
                                               Notary Public Theresa R. Dematte
                                               My Commission Expires: 5/24/00


                               STATE OF NEW JERSEY

_____________, ss                                                 March 10, 1999

     Then personally  appeared the above named Edward B. Hager,  the Chairman of
Blood Cells,  Inc. and acknowledged the foregoing to be the free act and deed of
Blood Cells, Inc., before me,

                                               /s/ Theresa R. Dematte
                                               ---------------------------------
                                               Notary Public Theresa R. Dematte
                                               My Commission Expires: 5/24/00


                                       25