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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                    FORM 8-A



                FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                     PURSUANT TO SECTION 12(b) OR (g) OF THE
                         SECURITIES EXCHANGE ACT OF 1934



                         LARGE SCALE BIOLOGY CORPORATION
             (Exact name of registrant as specified in its charter)



               Delaware                                   77-0154648
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(State of incorporation or organization)               (I.R.S. Employer
                                                      Identification no.)


3333 Vaca Valley Parkway, Suite 1000
       Vacaville, California                                 95688
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(Address of principal executive offices)                  (Zip code)


If this Form relates to the                If this Form relates to the
registration of a class of securities      registration of a class of securities
pursuant to Section 12(b) of the           pursuant to Section 12(g) of the
Exchange Act and is effective              Exchange Act and is effective
pursuant to General Instruction            pursuant to General Instruction
A.(c), please check the following          A.(d), please check the following
box.  [  ]                                 box.  [x]



                     Securities to be registered pursuant to
                         Section 12(b) of the Act: None.



        Securities to be registered pursuant to Section 12(g) of the Act:



                         Preferred Stock Purchase Rights
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                                (Title of Class)

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ITEM 1:        DESCRIPTION OF REGISTRANT'S SECURITIES TO BE REGISTERED.

               On April 27, 2001, the Board of Directors of Large Scale Biology
Corporation (the "COMPANY") declared a dividend of one preferred share purchase
right (a "RIGHT") for each outstanding share of common stock, par value $0.001
per share (the "COMMON SHARES"), of the Company. The dividend is payable to
stockholders of record on May 4, 2001 (the "RECORD DATE"). In addition, one
Right shall be issued with each Common Share that becomes outstanding (i)
between the Record Date and the earliest of the Distribution Date, the
Redemption Date and the Final Expiration Date (as such terms are defined in the
Agreement) or (ii) following the Distribution Date and prior to the Redemption
Date or Final Expiration Date, pursuant to the exercise of stock options or
under any employee plan or arrangement or upon the exercise, conversion or
exchange of other securities of the Company, which options or securities were
outstanding prior to the Distribution Date. Each Right entitles the registered
holder to purchase from the Company one one-hundredth of a share of Series A
Junior Participating Preferred Stock, par value $0.001 per share (the "PREFERRED
SHARES"), of the Company, at a price of $45.00 per one one-hundredth of a
Preferred Share (the "PURCHASE PRICE"), subject to adjustment. The description
and terms of the Rights are set forth in a Rights Agreement (the "RIGHTS
AGREEMENT") between the Company and Equiserve Trust Company, as Rights Agent
(the "RIGHTS AGENT").

               Until the earlier to occur of (i) 10 days following a public
announcement or disclosure that a person or group of affiliated or associated
persons (an "ACQUIRING PERSON"), has acquired beneficial ownership of 15% or
more of the outstanding Common Shares or (ii) 10 business days (or such later
date as may be determined by action of the Board of Directors), following the
announcement of an intention to make a tender offer or exchange offer the
consummation of which would result in a person or group becoming an Acquiring
Person (the earlier of such dates being called the "DISTRIBUTION DATE"), the
Rights will be evidenced, with respect to any of the Common Share certificates
outstanding as of the Record Date, by such Common Share certificates with a copy
of a Summary of Rights attached thereto. No person shall become an Acquiring
Person if the Board of Directors of the Company determines in good faith that a
Person who would otherwise be an Acquiring Person has become such inadvertently,
and such Person as promptly as practicable takes such actions as may be
necessary so that such Person would no longer be considered an Acquiring Person.
In addition, Technology Directors II, LLC and its affiliates and associates will
not be deemed an Acquiring Person by virtue of their stockholdings in the
Company as of the date of adoption of the Rights Agreement.

               The Rights Agreement provides that, until the Distribution Date,
the Rights will be transferred with and only with the Common Shares. Until the
Distribution Date (or earlier redemption or expiration of the Rights), new
Common Share certificates issued after the Record Date, upon transfer or new
issuance of Common Shares, will contain a notation incorporating the Rights
Agreement by reference. Until the Distribution Date (or earlier redemption or
expiration of the Rights), the surrender for transfer of any certificates for
Common Shares outstanding as of the Record Date, even without such notation or a
copy of the Summary of Rights being attached thereto, will also constitute the
transfer of the Rights associated with the Common Shares represented by such
certificate. As soon as practicable following the Distribution Date, separate
certificates evidencing the Rights ("Right Certificates") will be mailed to
holders of record of the

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Common Shares as of the Close of Business on the Distribution Date and such
separate Right Certificates alone will evidence the Rights.

               The Rights are not exercisable until the Distribution Date. The
Rights will expire on April 27, 2011 (the "Final Expiration Date"), unless the
Final Expiration Date is extended or unless the Rights are earlier redeemed or
exchanged by the Company, in each case, as described below.

               The Purchase Price payable, and the number of Preferred Shares or
other securities or property issuable, upon exercise of the Rights are subject
to adjustment from time to time to prevent dilution (i) in the event of a stock
dividend on, or a subdivision, combination or reclassification of, the Preferred
Shares, (ii) upon the grant to holders of the Preferred Shares of certain rights
or warrants to subscribe for or purchase Preferred Shares at a price, or
securities convertible into Preferred Shares with a conversion price, less than
the then current market price of the Preferred Shares or (iii) upon the
distribution to holders of the Preferred Shares of evidences of indebtedness or
assets (excluding regular periodic cash dividends paid out of earnings or
retained earnings or dividends payable in Preferred Shares) or of subscription
rights or warrants (other than those referred to above).

               The number of outstanding Rights and the number of one
one-hundredth of a Preferred Share issuable upon exercise of each Right are also
subject to adjustment in the event of a stock dividend on the Common Shares
payable in Common Shares or subdivisions, consolidations or combinations of the
Common Shares occurring, in any such case, prior to the Distribution Date.

               Preferred Shares purchasable upon exercise of the Rights will not
be redeemable. Each Preferred Share will be entitled to receive, when, as and if
declared by the Board of Directors, a quarterly dividend payment of 100 times
the dividend declared per Common Share. In the event of liquidation, each
Preferred Share will be entitled to a $1.00 preference, and thereafter the
holders of the Preferred Shares will be entitled to an aggregate payment of 100
times the aggregate payment made per Common Share. Each Preferred Share will
have 100 votes, voting together with the Common Shares. Finally, in the event of
any merger, consolidation or other transaction in which Common Shares are
exchanged, each Preferred Share will be entitled to receive 100 times the amount
received per Common Share. These rights are protected by customary antidilution
provisions.

               Because of the nature of the Preferred Shares' dividend,
liquidation and voting rights, the value of the one one-hundredth interest in a
Preferred Share purchasable upon exercise of each Right should approximate the
value of one Common Share.

               In the event that any person becomes an Acquiring Person, unless
the event causing the Designated Percentage threshold to be crossed and the
Person to thereby become an Acquiring Person is a merger or acquisition
described in the next paragraph, each holder of a Right, other than Rights
beneficially owned by the Acquiring Person (which will thereafter be void), will
thereafter have the right to receive upon exercise that number of Common Shares
having a market value of two times the exercise price of the Right on the terms
and conditions set forth in the Rights Agreement. If the Company does not have
authorized but unissued Common Shares sufficient to satisfy such obligation to
issue Common Shares, the Company is



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obligated to deliver upon payment of the exercise price of a Right an amount of
cash or other securities equivalent in value to the Common Shares issuable upon
exercise of a Right.

               In the event that any person or group becomes an Acquiring Person
and the Company merges into or engages in certain other business combination
transactions with an Acquiring Person or 50% or more of its consolidated assets
or earning power are sold to an Acquiring Person, each holder of a Right, other
than Rights beneficially owned by an Acquiring Person, will thereafter have the
right to receive, upon the exercise thereof at the then current exercise price
of the Right, that number of shares of common stock of the acquiring company
which at the time of such transaction will have a market value of two times the
exercise price of the Right.

               At any time after any person becomes an Acquiring Person and
prior to the acquisition by such person or group of a majority of the
outstanding Common Shares, the Board of Directors of the Company may exchange
the Rights (other than Rights owned by such person or group which have become
void), in whole or in part, at an exchange ratio of one Common Share, or one
one-hundredth of a Preferred Share (or of a share of a class or series of the
Company's preferred stock having equivalent rights, preferences and privileges),
per Right (subject to adjustment).

               With certain exceptions, no adjustment in the Purchase Price will
be required until cumulative adjustments require an adjustment of at least 1% in
such Purchase Price. No fractional Preferred Shares will be issued (other than
fractions which are integral multiples of one one-hundredth of a Preferred
Share, which may, at the election of the Company, be evidenced by depository
receipts) and in lieu thereof, an adjustment in cash will be made based on the
market price of the Preferred Shares on the last trading day prior to the date
of exercise.

               At any time prior to such time as a person or group becomes an
Acquiring Person, the Board of Directors of the Company may redeem the Rights in
whole, but not in part, at a price of $0.001 per Right (the "Redemption Price").
The redemption of the Rights may be made effective at such time, on such basis
and with such conditions as the Board of Directors in its sole discretion may
establish. After the period for redemption of the Rights has expired, the Board
may not amend the Rights Agreement to extend the period for redemption of the
Rights. Immediately upon any redemption of the Rights, the right to exercise the
Rights will terminate and the only right of the holders of Rights will be to
receive the Redemption Price.

               The terms of the Rights may be amended by a resolution of the
Board of Directors without the consent of the holders of the Rights, except that
from and after such time as a person or group becomes an Acquiring Person, no
such amendment may adversely affect the interests of the holders of the Rights
(other than an Acquiring Person).

               Until a Right is exercised, the holder thereof, as such, will
have no rights as a stockholder of the Company, including, without limitation,
the right to vote or to receive dividends.

               As of May 4, 2001 there were approximately 24.5 million of the
Company's Common Shares outstanding. Each Common Share outstanding at the close
of



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business on May 4, 2001 will receive one Right. As long as the Rights are
attached to the Common Shares, one additional Right shall be deemed to be
delivered for each Common Share issued or transferred by the Company in the
future, including but not limited to Common Shares issuable upon exercise of
options granted by the Company. 500,000 Preferred Shares are initially reserved
for issuance upon exercise of the Rights, such number to be subject to
adjustment from time to time in accordance with the Rights Agreement.

               The Rights Agreement, which specifies the terms of the Rights and
which includes as exhibits thereto the form of Certificate of Designations of
Series A Junior Participating Preferred Stock, the Form of Right Certificate and
the form of Summary of Rights to Purchase Preferred Shares, is filed as Exhibit
4.1 hereto. A copy of the Certificate of Designations of Series A Junior
Participating Preferred Stock as filed with the Delaware Secretary of State,
which specifies the terms of the Preferred Shares, is filed as Exhibit 3.2
hereto. The aforementioned exhibits hereto are incorporated herein by reference,
and the foregoing description of the Rights and Preferred Shares is qualified in
its entirety by reference to such exhibits.

ITEM 2:        EXHIBITS.


                   
               3.1    Amended and Restated Certificate of Incorporation of
                      Registrant. (Incorporated by reference to Exhibit 3.1 to
                      Registrant's registration statement on Form S-1,
                      Registration No. 333-34198, declared effective by the
                      Securities and Exchange Commission on August 9, 2000.)

               3.2    Certificate of Designations specifying the terms of the
                      Series A Junior Participating Preferred Stock of
                      Registrant, as filed with the Secretary of State of the
                      State of Delaware on May 4, 2001.

               4.1    Rights Agreement dated April 27, 2001 between Registrant
                      and Equiserve Trust Company, as Rights Agent, which
                      includes as Exhibit A the form of Certificate of
                      Designations of Series A Junior Participating Preferred
                      Stock, as Exhibit B the Form of Rights Certificate and as
                      Exhibit C the Summary of Rights to Purchase Preferred
                      Shares. The Rights Certificates will not be distributed
                      until after the Distribution Date (as such term is defined
                      in the Rights Agreement).




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                                    SIGNATURE

               Pursuant to the requirements of Section 12 of the Securities
Exchange Act of 1934, the Registrant has duly caused this registration statement
to be signed on its behalf by the undersigned, thereto duly authorized.


Dated: May 4, 2001                      LARGE SCALE BIOLOGY CORPORATION



                                        By  /s/ Robert L. Erwin
                                            ------------------------------------
                                            Robert L. Erwin
                                            Chief Executive Officer



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                                  EXHIBIT INDEX




Exhibit
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3.2            Certificate of Designations specifying the terms of the Series A
               Junior Participating Preferred Stock of Registrant, as filed with
               the Secretary of State of the State of Delaware on May 4, 2001.

4.1            Rights Agreement dated April 27, 2001 between Registrant and
               Equiserve Trust Company, as Rights Agent, which includes as
               Exhibit A the form of Certificate of Designations of Series A
               Junior Participating Preferred Stock, as Exhibit B the Form of
               Rights Certificate and as Exhibit C the Summary of Rights to
               Purchase Preferred Shares. The Rights Certificates will not be
               distributed until after the Distribution Date (as such term is
               defined in the Rights Agreement).