1 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 April 30, 2001 (Date of earliest event reported) HYSEQ, INC. (Exact name of Registrant as specified in its charter) Nevada 000-22873 36-3855489 (State of (Commission File No.) (IRS Employer Incorporation) Identification No.) 670 Almanor Avenue Sunnyvale, California 94085 (Address of principal executive offices, including zip code) 408-524-8100 (Registrant's telephone number, including area code) 2 Item 5. Other Events. On April 30, 2001, Hyseq, Inc. ("we" or "our") leased an additional 138,698 square feet of space at 985 Almanor Avenue in Sunnyvale, California, adjacent to our current operating facilities. The lease on this new space requires base lease payment of approximately $451,000 per month and extends through May 31, 2011. Lease payments over the ten-year term of the lease total approximately $54.1 million. Pursuant to the terms of the lease, we are required to provide a letter of credit in the amount of $4.0 million as additional security for the lease, which requirement expires after 5 years if we are not in default under the lease. Item 7. Financial Statements and Exhibits. (c) Exhibit 10.18 Lease between The Irvine Company and Hyseq, Inc. dated as of April 30, 2001 SIGNATURE Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. HYSEQ, INC. /s/ Ted W. Love ----------------------------------------- Name: Ted W. Love Title: President and Chief Executive Officer Date: May 21, 2001 3 EXHIBIT INDEX Exhibit No. Description of Exhibit - ----------- ---------------------- 10.18 Lease between The Irvine Company and Hyseq, Inc. dated as of April 30, 2001