Exhibit 99.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Caliper Technologies Corp. (the
"Company") on Form 10-Q for the period ending March 31, 2003 as filed with the
Securities and Exchange Commission on the date hereof (the "Report"), I, Michael
R. Knapp, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C.
Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of
the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material
respects, the financial condition and result of operations of the Company.

May 15, 2003

                                         /s/  MICHAEL R. KNAPP
                                         ---------------------------------------
                                         Michael R. Knapp
                                         Chief Executive Officer

A signed original of this written statement required by Section 906 has been
provided to Caliper Technologies Corp. and will be retained by Caliper
Technologies Corp. and furnished to the Securities and Exchange Commission or
its staff upon request.




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