Exhibit 23.3




                       CONSENT OF INDEPENDENT ACCOUNTANTS



We hereby consent to the incorporation by reference in this Amendment No. 1 to
the Registration Statement on Form S-3 (No. 333-103257) of Nuvelo, Inc. of our
report dated June 2, 2003, relating to the financial statements of Variagenics,
Inc., which report appears in the Current Report on Form 8-K/A of Nuvelo, Inc.
dated July 3, 2003 and which Form 8-K/A is incorporated by reference in this
amendment to the Form S-3 of Nuvelo, Inc. We also consent to the reference to us
under the heading "Experts" in such Amendment No. 1 to the Registration
Statement.



/s/ PricewaterhouseCoopers LLP

- ------------------------------
Boston, Massachusetts

July 3, 2003