EXHIBIT 5.1

July 10, 2003

Caliper Technologies Corp.
605 Fairchild Drive
Mountain View, Ca 94043-2234


Ladies and Gentlemen:

You have requested our opinion with respect to certain matters in connection
with the filing by Caliper Technologies Corp. (the "Registrant") of a
Registration Statement on Form S-8 (the "Registration Statement") with the
Securities and Exchange Commission covering the offering of up to 900,000 shares
of the Registrant's Common Stock, $0.001 par value, (the "Shares") pursuant to
its Acquisition Equity Incentive Plan (the "Plan").

In connection with this opinion, we have examined the Registration Statement and
related Prospectus, your Amended and Restated Certificate of Incorporation and
Bylaws, as amended, and such other documents, records, certificates, memoranda
and other instruments as we deem necessary as a basis for this opinion. We have
assumed the genuineness and authenticity of all documents submitted to us as
originals, the conformity to originals of all documents submitted to us as
copies thereof, and the due execution and delivery of all documents where due
execution and delivery are a prerequisite to the effectiveness thereof.

On the basis of the foregoing, and in reliance thereon, we are of the opinion
that the Shares, when sold and issued in accordance with the Plan, the
Registration Statement and related Prospectus, will be validly issued, fully
paid, and nonassessable (except as to shares issued pursuant to certain deferred
payment arrangements, which will be fully paid and nonassessable when such
deferred payments are made in full).

We consent to the filing of this opinion as an exhibit to the Registration
Statement.

Very truly yours,

Cooley Godward llp

/s/ Brett D. White

Brett D. White