EXHIBIT 23.1 CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS We consent to the incorporation by reference in the Registration Statements (Form S-8 No. 333-86155, 333-86159, 333-45288, 333-63036, 333-91996 and 333-106698 pertaining to the LJL BioSystems, Inc. 1994 Equity Incentive Plan, LJL BioSystems, Inc. 1997 Stock Plan, LJL BioSystems, Inc. 1998 Directors' Stock Option Plan, 1995 Stock Option Plan, 1995 Non-Employee Directors' Stock Option Plan, 1995 Employee Stock Purchase Plan and 2001 Stock Option Plan) of Molecular Devices Corporation of our report dated January 30, 2004, with respect to the consolidated financial statements and schedule of Molecular Devices Corporation included in the Annual Report (Form 10-K) for the year ended December 31, 2003. /s/ Ernst & Young LLP Palo Alto, California March 5, 2004