1 AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 4, 1995 REGISTRATION NO. 33-58185 - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ------------------------------------ AMENDMENT NO. 2 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ------------------------------------ COLLAGEN CORPORATION (exact name of registrant as specified in its charter) DELAWARE 2500 FABER PLACE 94-2300486 (State or other jurisdiction of PALO ALTO, CALIFORNIA 94303 (I.R.S. Employer Identification No.) incorporation (415) 856-0200 or organization) (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices) ------------------------------------ HOWARD D. PALEFSKY CHAIRMAN OF THE BOARD OF DIRECTORS AND CHIEF EXECUTIVE OFFICER COLLAGEN CORPORATION 2500 FABER PLACE PALO ALTO, CALIFORNIA 94303 (415) 856-0200 (Name, address, including zip code, and telephone number, including area code, of agent for service) ------------------------------------ TARGET THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) DELAWARE 47201 LAKEVIEW BOULEVARD 95-3962471 (State or other jurisdiction of FREMONT, CALIFORNIA 94538 (I.R.S. Employer Identification No.) incorporation (510) 440-7700 or organization) (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices) ------------------------------------ GARY R. BANG PRESIDENT AND CHIEF EXECUTIVE OFFICER TARGET THERAPEUTICS, INC. 47201 LAKEVIEW BOULEVARD FREMONT, CALIFORNIA 94538 (510) 440-7700 (Name, address, including zip code, and telephone number, including area code, of agent for service) COPIES TO: Michael W. Hall Alan C. Mendelson James L. Brock Paul B. Cleveland David A. Garcia COOLEY GODWARD CASTRO David C. Lee HUDDLESON & TATUM VENTURE LAW GROUP, P.C. Five Palo Alto Square 2800 Sand Hill Road Palo Alto, CA 94306 Menlo Park, CA 94025 (415) 843-5000 (415) 854-4488 ------------------------------------ APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after the effective date of this Registration Statement. If the only securities being registered on this form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: / / If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: /X/ The securities to be offered on a delayed or continuous basis pursuant to Rule 415 include only the shares of Common Stock, $0.0025 par value per share, of Target Therapeutics, Inc. ------------------------------------ CALCULATION OF REGISTRATION FEE - -------------------------------------------------------------------------------- PROPOSED MAXIMUM PROPOSED MAXIMUM TITLE OF EACH CLASS AMOUNT TO BE OFFERING PRICE AGGREGATE AMOUNT OF OF SECURITIES TO BE REGISTERED REGISTERED PER UNIT OFFERING PRICE REGISTRATION FEE - ---------------------------------------------------------------------------------------------------------------------------------- % Exchangeable Subordinated Notes of Collagen Corporation Due 2002......... $45,000,000(1) 100% $45,000,000 (2) - ---------------------------------------------------------------------------------------------------------------------------------- Common Stock, $0.0025 par value per share, of Target Therapeutics, Inc.(3)............................... -- -- -- --(4) - ---------------------------------------------------------------------------------------------------------------------------------- (1) Includes $5,000,000 principal amount of Notes that the Underwriters have the option to purchase from Collagen Corporation to cover over-allotments, if any, and shares of Common Stock of Target Therapeutics, Inc. (the "Target Common Stock") deliverable in exchange for such Notes. (2) Previously paid. (3) Such indeterminable number of shares of Target Common Stock as may be required to be delivered by Collagen Corporation upon exchange of the Notes being registered hereunder. (4) Pursuant to Rule 457(i) and Rule 416, no additional registration fee is required with respect to the indeterminable number of shares of Target Common Stock deliverable upon exchange of the Notes. ------------------------------------ THE REGISTRANTS HEREBY AMEND THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANTS SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF THE SECURITIES ACT OF 1933, AS AMENDED, OR UNTIL THIS REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), MAY DETERMINE. - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- 2 PART II INFORMATION NOT REQUIRED IN PROSPECTUS ITEM 16. EXHIBITS (a) Exhibits EXHIBIT NUMBER DESCRIPTION ------ -------------------------------------------------------------------------------- 1.1+ Form of Underwriting Agreement. 4.1 Form of Indenture by and between Collagen and The First National Bank of Boston, as Trustee (including Form of Note as Exhibit A). 4.2 Form of Exchange Agreement by and between Collagen and The First National Bank of Boston, as Exchange Agent. 5.1 Opinion of Venture Law Group. 12.1+ Computation of Ratio of Earnings to Fixed Charges of Collagen. 23.1 Consent of Ernst & Young LLP (see Page II-7). 23.2+ Consent of Venture Law Group. 23.3+ Consent of Morrison & Foerster. 24.1+ Powers of Attorney of certain directors and officers of Collagen. 24.2+ Powers of Attorney of certain directors and officers of Target. 25.1+ Form T-1 Statement of Eligibility and Qualification under the Trust Indenture Act of 1939 of the Trustee. - --------------- + Previously filed. ITEM 17. UNDERTAKINGS Target hereby undertakes (1) to file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement and to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement, (2) that, for the purposes of determining any liability under the Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof and (3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. The undersigned Registrants hereby undertake that, for purposes of determining any liability under the Securities Act, each filing of the Registrants' Annual Reports pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (as amended, the "Exchange Act") that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrants pursuant to the foregoing provisions described in Item 15 above, or otherwise, the Registrants have been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrants of expenses incurred or paid by a director, officer or controlling person of the Registrants in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrants will, unless in the opinion of its counsel the matter has II-1 3 been settled by controlling precedent, submit to a court of appropriate jurisdiction the question of whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue. The undersigned Registrants hereby undertake (1) that for purposes of determining any liability under the Act, the information omitted from the form of prospectus filed as part of a registrant statement in reliance upon Rule 430A and contained in a form of prospectus filed by the Registrants pursuant to Rule 424(b)(1) or (4) or 497(h) under the Act shall be deemed to be part of this registration statement as of the time it was declared effective and (2) that for the purpose of determining any liability under the Act, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at the time shall be deemed to be the initial bona fide offering thereof. II-2 4 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, Collagen Corporation certifies that it has duly caused this Amendment No. 2 to Registration Statement on Form S-3 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Palo Alto, State of California, on the 3rd day of April, 1995. COLLAGEN CORPORATION By /s/ HOWARD D. PALEFSKY ------------------------------------ (Howard D. Palefsky, Chairman of the Board of Directors and Chief Executive Officer) Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 2 to Registration Statement on Form S-3 has been signed below by the following persons in the capacities indicated on the 3rd day of April, 1995. SIGNATURE TITLE DATE - ------------------------------------- --------------------------------- --------------- /s/ HOWARD D. PALEFSKY Chairman of the Board and Chief April 3, 1995 - ------------------------------------- Executive Officer (Principal (Howard D. Palefsky) Executive Officer) /s/ GARY S. PETERSMEYER* President, Chief Operating April 3, 1995 - ------------------------------------- Officer and Director (Gary S. Petersmeyer) /s/ DAVID FOSTER Vice President, Finance and MIS, April 3, 1995 - ------------------------------------- and Chief Financial Officer (David Foster) (Principal Financial and Accounting Officer) /s/ REID W. DENNIS* Chairman Emeritus of the Board April 3, 1995 - ------------------------------------- (Reid W. Dennis) /s/ ANNE L. BAKAR* Director April 3, 1995 - ------------------------------------- (Anne L. Bakar) /s/ JOHN R. DANIELS* Director April 3, 1995 - ------------------------------------- (John R. Daniels) /s/ WILLIAM G. DAVIS* Director April 3, 1995 - ------------------------------------- (William G. Davis) II-3 5 SIGNATURE TITLE DATE - ------------------------------------- --------------------------------- --------------- /s/ CRAIG W. JOHNSON* Director April 3, 1995 - ------------------------------------- (Craig W. Johnson) /s/ TERRY R. KNAPP, M.D.* Director April 3, 1995 - ------------------------------------- (Terry R. Knapp, M.D.) /s/ MICHAEL F. MEE* Director April 3, 1995 - ------------------------------------- (Michael F. Mee) /s/ RODNEY PERKINS, M.D.* Director April 3, 1995 - ------------------------------------- (Rodney Perkins, M.D.) /s/CORNELIUS W. PETTINGA, PH.D.* Director April 3, 1995 - ------------------------------------- (Cornelius W. Pettinga, Ph.D.) /s/ ROGER H. SALQUIST* Director April 3, 1995 - ------------------------------------- (Roger H. Salquist) *By: /s/ HOWARD D. PALEFSKY (Howard D. Palefsky, Attorney-in-Fact) II-4 6 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, Target Therapeutics, Inc. has duly caused this Amendment No. 2 to Registration Statement on Form S-3 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Fremont, State of California, on the 3rd day of April, 1995. TARGET THERAPEUTICS, INC. By /s/ GARY R. BANG ------------------------------------ (Gary R. Bang, President and Chief Executive Officer) Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 2 to Registration Statement on Form S-3 has been signed below by the following persons in the capacities indicated on the 3rd day of April, 1995. SIGNATURE TITLE DATE - ------------------------------------- --------------------------------- --------------- /s/ GARY R. BANG President and Chief Executive April 3, 1995 - ------------------------------------- Officer (Principal Executive (Gary R. Bang) Officer) /s/ A. LARRY TANNENBAUM Vice President, Finance and April 3, 1995 - ------------------------------------- Administration (Principal (A. Larry Tannenbaum) Financial and Accounting Officer), Chief Financial Officer and Assistant Secretary /s/ CHARLES M. STROTHER* Director April 3, 1995 - ------------------------------------- (Charles M. Strother) /s/ WILLIAM G. DAVIS* Director April 3, 1995 - ------------------------------------- (William G. Davis) /s/ KATHLEEN MURRAY* Director April 3, 1995 - ------------------------------------- (Kathleen Murray) /s/ HOWARD D. PALEFSKY* Director April 3, 1995 - ------------------------------------- (Howard D. Palefsky) /s/ RICHARD D. RANDALL* Director April 3, 1995 - ------------------------------------- (Richard D. Randall) II-5 7 SIGNATURE TITLE DATE - ------------------------------------- --------------------------------- --------------- /s/ JOHN C. VILLFORTH* Director April 3, 1995 - ------------------------------------- (John C. Villforth) *By /s/ GARY R. BANG (Gary R. Bang, Attorney-in-Fact) II-6 8 EXHIBIT 23.1 CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS We consent to the reference to our firm under the captions "Experts," "Selected Consolidated Financial Data of Collagen" and "Selected Consolidated Financial Data of Target" and to the use of our report dated August 3, 1994, with respect to the consolidated financial statements of Collagen Corporation, and our report dated April 27, 1994, with respect to the consolidated financial statements of Target Therapeutics, Inc., included in Amendment No. 2 to the joint Registration Statement (Form S-3) of Collagen Corporation and Target Therapeutics, Inc. We also consent to the incorporation by reference therein of our report with respect to the financial statement schedules of Collagen Corporation for the years ended June 30, 1994, 1993 and 1992 included in the Annual Report (Form 10-K) for 1994 of Collagen Corporation and of our report with respect to the financial statement schedules of Target Therapeutics, Inc. for the years ended March 31, 1994, 1993 and 1992 included in the Annual Report (Form 10-K) for 1994 of Target Therapeutics, Inc., both filed with the Securities and Exchange Commission. ERNST & YOUNG LLP Palo Alto, California April 3, 1995 II-7 9 COLLAGEN CORPORATION AND TARGET THERAPEUTICS, INC. EXHIBIT INDEX EXHIBIT PAGE NUMBER DESCRIPTION NUMBER - ------ ------------------------------------------------------------------------- ------ 1.1+ Form of Underwriting Agreement........................................... 4.1 Form of Indenture by and between Collagen and The First National Bank of Boston, as Trustee (including Form of Note as Exhibit A)................. 4.2 Form of Exchange Agreement by and between Collagen and The First National Bank of Boston, as Exchange Agent........................................ 5.1 Opinion of Venture Law Group............................................. 12.1+ Computation of Ratio of Earnings to Fixed Charges of Collagen............ 23.1 Consent of Ernst & Young LLP (see Page II-7)............................. 23.2+ Consent of Venture Law Group............................................. 23.3+ Consent of Morrison & Foerster........................................... 24.1+ Powers of Attorney of certain directors and officers of Collagen......... 24.2+ Powers of Attorney of certain directors and officers of Target........... 25.1+ Form T-1 Statement of Eligibility and Qualification under the Trust Indenture Act of 1939 of the Trustee..................................... - --------------- + Previously filed.