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                            PROTEIN DESIGN LABS, INC.
Exhibit 11.1    STATEMENT OF COMPUTATION OF EARNINGS PER SHARE
                     (In thousands except per share amounts)





                                                                 Three Months Ended September 30,  Nine Months Ended September 30,
                                                                         1996            1995            1996            1995
                                                                      ------------------------        ------------------------
                                                                                                                
Computation of common and common equivalent shares outstanding:
  Weighted average common shares outstanding                            15,632          15,380          15,578          15,325
  Weighted average shares outstanding assuming
     conversion of preferred stock                                           -               -               -               -
                                                                      --------        --------        --------        --------
                                                                        15,632          15,380          15,578          15,325
                                                                      --------        --------        --------        --------
Stock related to SAB No. 55, 64. and 83                                      -               -               -               -
                                                                      --------        --------        --------        --------
Total weighted average common and common equivalent
   shares outstanding                                                   15,632          15,380          15,578          15,325
                                                                      ========        ========        ========        ========
Net loss                                                              $ (4,305)       $ (2,676)       $ (9,982)       $ (6,593)
                                                                      ========        ========        ========        ========
Loss per share                                                        $  (0.28)       $  (0.17)       $  (0.64)       $  (0.43)
                                                                      ========        ========        ========        ========