1 As filed with the Securities and Exchange Commission on July 22, 1997 Registration No. 333-_______ ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT Under The Securities Act of 1933 NEUROCRINE BIOSCIENCES, INC. (Exact name of Registrant as specified in its charter) DELAWARE 33-0525145 - ----------------------- ----------------------------------- (State of incorporation) (I.R.S. Employer Identification No.) 3050 Science Park Road San Diego, California 92121 (Address, including zip code, of Registrant's principal executive offices) AMENDED 1992 INCENTIVE STOCK PLAN (Full title of the plan) GARY A. LYONS President, Chief Executive Officer and Director 3050 Science Park Road San Diego, California 92121 (619) 658-7600 (Name, address, and telephone number, including area code, of agent for service) Copies to: VAHE H. SARRAFIAN WILSON SONSINI GOODRICH & ROSATI PROFESSIONAL CORPORATION 650 PAGE MILL ROAD PALO ALTO, CA 94306 (415) 493-9300 CALCULATION OF REGISTRATION FEE =================================================================================================================== PROPOSED PROPOSED MAXIMUM MAXIMUM TITLE OF EACH CLASS AMOUNT OFFERING AGGREGATE AMOUNT OF OF SECURITIES TO TO BE PRICE OFFERING REGISTRATION BE REGISTERED REGISTERED(1) PER SHARE(2) PRICE FEE - ------------------------------------------------------------------------------------------------------------------- Common Stock $0.001 par value . . . . . . . 800,000 shares $8.8125 $7,050,000 $2,137 =================================================================================================================== (1) The shares covered by this Registration Statement represent the shares of Common Stock which have become available for issuance under the Registrant's Amended 1992 Incentive Stock Plan as a result of an amendment approved by the stockholders at the Registrant's Annual Meeting held on May 27, 1997 increasing the number of shares authorized for issuance thereunder from 3,300,000 to 4,100,000. (2) Estimated in accordance with Rule 457(c) solely for the purpose of calculating the registration fee based upon the average of the high and low prices of the Common Stock as reported on the Nasdaq National Market System on July 18, 1996. ================================================================================ 2 STATEMENT UNDER GENERAL INSTRUCTION E REGISTRATION OF ADDITIONAL SECURITIES Unless as noted herein, the contents of the Registrant's Form S-8 Registration Statement (File No. 333-14589) is incorporated by reference into this Registration Statement. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT ITEM 8. EXHIBITS. Exhibit Number Document ------- -------- 5.1 Opinion of Wilson Sonsini Goodrich & Rosati, a Professional Corporation. 23.1 Consent of Ernst & Young LLP, Independent Auditors 23.2 Consent of Counsel (contained in Exhibit 5.1). 24.1 Power of Attorney (see page II-3). 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant, Neurocrine Biosciences, Inc., certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on this 22nd day of July, 1997. NEUROCRINE BIOSCIENCES, INC. By: /s/ Gary A. Lyons -------------------------------------- Gary A. Lyons President and Chief Executive Officer II-2 4 POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each such person whose signature appears below constitutes and appoints, jointly and severally, Gary A. Lyons and Paul W. Hawran his attorneys-in-fact, each with the power of substitution, for him in any and all capacities, to sign any amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof. PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THIS REGISTRATION STATEMENT HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE CAPACITIES AND ON THE DATES INDICATED. SIGNATURE TITLE DATE - ------------------------------------- ------------------------------------- ---------------- /s/ Gary A. Lyons President, Chief Executive July 22, 1997 - ------------------------------------ Officer and Director Gary A. Lyons (Principal Executive Officer) /s/ Paul W. Hawran Chief Financial Officer July 22, 1997 - ------------------------------------ (Principal Financing Paul W. Hawran and Accounting Officer) /s/ Errol B. DeSouza Executive Vice President, Research & July 22, 1997 - ------------------------------------ Development and Director Errol B. DeSouza /s/ Harry F. Hixson, Jr., Ph.D. Chairman of the Board July 22, 1997 - ------------------------------------ of Directors Harry F. Hixson, Jr., Ph.D. /s/ Wylie W. Vale, Ph.D. Director July 22, 1997 - ------------------------------------ Wylie W. Vale, Ph.D. /s/ Howard C. Birndorf Director July 22, 1997 - ------------------------------------ Howard C. Birndorf /s/ David E. Robinson Director July 22, 1997 - ------------------------------------ David E. Robinson /s/ Joseph A. Mollica Director July 22, 1997 - ------------------------------------ Joseph A. Mollica II-3 5 INDEX TO EXHIBITS Exhibit Number Exhibit ------- ------- 5.1 Opinion of Wilson Sonsini Goodrich & Rosati, a Professional Corporation . . . . 23.1 Consent of Ernst & Young LLP, Independent Auditors . . . . . . . . . . . . . . 23.2 Consent of Counsel (included in Exhibit 5.1) . . . . . . . . . . . . . . . . . 24.1 Power of Attorney (see page II-3) . . . . . . . . . . . . . . . . . . . . . . . II-4