1 As filed with the Securities and Exchange Commission on August 4, 1997 Registration No. 333-______ ================================================================================ SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 MICROCIDE PHARMACEUTICALS, INC. (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER) DELAWARE 94-3186021 ------------------------ ------------------------------------ (STATE OF INCORPORATION) (I.R.S. EMPLOYER IDENTIFICATION NO.) 850 MAUDE AVENUE MOUNTAIN VIEW, CALIFORNIA 94043 (ADDRESS, INCLUDING ZIP CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES) 1993 AMENDED INCENTIVE STOCK PLAN (FULL TITLE OF THE PLAN) JAMES E. RURKA PRESIDENT, CHIEF EXECUTIVE OFFICER AND DIRECTOR MICROCIDE PHARMACEUTICALS, INC. 850 MAUDE AVENUE MOUNTAIN VIEW, CALIFORNIA 94043 (415) 478-1550 (NAME, ADDRESS, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE) Copies to: VAHE H. SARRAFIAN WILSON SONSINI GOODRICH & ROSATI PROFESSIONAL CORPORATION 650 PAGE MILL ROAD PALO ALTO, CA 94304-1050 (415) 493-9300 CALCULATION OF REGISTRATION FEE PROPOSED TITLE OF EACH CLASS AMOUNT OFFERING AGGREGATE AMOUNT OF OF SECURITIES TO TO BE PRICE OFFERING REGISTRATION BE REGISTERED REGISTERED(1) PER SHARE(2) PRICE FEE - --------------------------------------------------------------------------------------------------------------------- Common Stock $0.001 par value...................... 500,000 $11.125 $5,562,500 $1,686 ===================================================================================================================== (1) The shares covered by this Registration Statement represent 500,000 shares of Common Stock which have become available for issuance under the Registrant's 1993 Amended Incentive Stock Plan as a result of an amendment approved by the stockholders at the Registrant's Annual Meeting held on May 13, 1997 increasing the number of shares authorized for issuance thereunder from 1,380,000 to 1,880,000. (2) Estimated in accordance with Rule 457(c) solely for the purpose of calculating the registration fee based upon the average of the high and low prices of the Common Stock as reported on the Nasdaq National Market System on July 29, 1997. 2 STATEMENT UNDER GENERAL INSTRUCTION E REGISTRATION OF ADDITIONAL SECURITIES Unless as noted herein, the contents of the Registrant's Form S-8 Registration Statement (File No. 333-11759) is incorporated by reference into this Registration Statement. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT ITEM 8. EXHIBITS. Exhibit Number Document ------ -------- 5.1 Opinion of Wilson Sonsini Goodrich & Rosati, a Professional Corporation. 23.1 Consent of Ernst & Young LLP, Independent Auditors 23.2 Consent of Counsel (contained in Exhibit 5.1). 24.1 Power of Attorney (see page II-3). 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant, Microcide Pharmaceuticals, Inc., certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Mountain View, State of California, on this 28th day of July 1997. MICROCIDE PHARMACEUTICALS, INC. By: /s/James E. Rurka --------------------------------- James E. Rurka President, Chief Executive Officer II-2 4 POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each such person whose signature appears below constitutes and appoints, jointly and severally, James E. Rurka and Matthew Hogan his attorneys-in-fact, each with the power of substitution, for him in any and all capacities, to sign any amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof. PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THIS REGISTRATION STATEMENT HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE CAPACITIES AND ON THE DATES INDICATED. SIGNATURE TITLE DATE /s/James E. Rurka President, Chief Executive July 28, 1997 - ------------------------------ Officer, and Director James E. Rurka (Principal Executive Officer) /s/Matthew J. Hogan Chief Financial Officer July 28, 1997 - ------------------------------ Matthew J. Hogan /s/Keith A. Bostian, Ph.D. Chief Operating Officer July 28, 1997 - ------------------------------ Keith A. Bostian, Ph.D. /s/Joseph S. Lacob Chairman of the Board July 28, 1997 - ------------------------------ of Directors Joseph S. Lacob /s/Hugh Y. Rienhoff, M.D. Director July 28, 1997 - ------------------------------ Hugh Y. Rienhoff, M.D. /s/David Schnell, M.D. Director July 28, 1997 - ------------------------------ David Schnell, M.D. /s/L. James Strand, M.D. Director July 28, 1997 - ------------------------------ L. James Strand, M.D. /s/John P. Walker Director July 28, 1997 - ------------------------------ John P. Walker II-3 5 INDEX TO EXHIBITS EXHIBIT NUMBER EXHIBIT ------ ------- 5.1 Opinion of Wilson Sonsini Goodrich & Rosati, a Professional Corporation . . . . . . . 23.1 Consent of Ernst & Young LLP, Independent Auditors . . . . . . . . . . . . . . . . . . 23.2 Consent of Counsel (included in Exhibit 5.1) . . . . . . . . . . . . . . . . . . . . . 24.1 Power of Attorney (see page II-3). . . . . . . . . . . . . . . . . . . . . . . . . . . II-4