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                                                                  Exhibit 10.82

                       FIRST AMENDMENT TO LEASE SCHEDULE


          MASTER PROPERTY LEASE AGREEMENT NO. 943 DATED MARCH 29, 1994
                      SCHEDULE NO. 3 DATED MARCH 29, 1994



     The Initial Term of the Lease for the Units covered by the Schedule No. 3
to the Master Property Lease Agreement No. 943, is hereby extended beyond the
original expiration date of August 31, 1997 of the Lease Schedule such that the
lease term will continue through NOVEMBER 30, 1999. 

     The rent per month during the extended term, beginning December 1, 1997 and
continuing through November 30, 1999, shall be $3,472.30, plus applicable 
taxes. 

     The rental payments during the extended lease term shall be made monthly in
advance on the first day of each month, beginning on December 1, 1997. 

     Section 6 of the Lease Schedule shall be replaced with the following new
Section 6: 

     Provided that the Lease has not been terminated and that no Event of
Default or event which, with notice or lapse of time or both, would become an
Event of Default shall have occurred and be continuing, and provided that all
rents and other payments due under the Lease shall have been paid, title to the
Units covered by the schedule for Special Equipment under the Lease shall pass
to Lessee at the end of the extended lease term. 

     Except as specifically amended hereby, Schedule No. 3 shall be and remain
in full force and effect. 

     This Amendment has been entered into, and is made a part of the above
referenced Schedule, as of October 29, 1997. 

ARRIS PHARMACEUTICAL                    HAMBRECHT & QUIST
CORPORATION                             GUARANTY FINANCE, LLC

By: /s/ Frederick Ruegsegger            By: /s/ Donald M. Campbell
    ---------------------------             --------------------------
Name: Frederick Ruegsegger              Name: Donald M. Campbell
      -------------------------               ------------------------ 
Title: VP & CFO                         Title: Chief Executive Officer
       ------------------------                -----------------------



  First Amendment to Schedule No. 3 to Master Property Lease Agreement No. 943