1 Exhibit 5.1 ATTORNEYS AT LAW San Francisco, CA 415 693-2000 Five Palo Alto Square Menlo Park, CA 3000 El Camino Real 650 843-5000 Palo Alto, CA 94306-2155 San Diego, CA Main 650 843-5000 619 550-6000 Fax 650 857-0663 Boulder, CO 303 546-4000 Denver, CO 303 606-4800 www.cooley.com JAMES C. KITCH 650 843-5027 kitchjc@cooley.com July 28, 1998 Coulter Pharmaceutical, Inc. 550 California Avenue, Suite 200 Palo Alto, California 94306-1440 Ladies and Gentlemen: You have requested our opinion with respect to certain matters in connection with the filing by Coulter Pharmaceutical, Inc. (the "Company") of a Registration Statement on Form S-3 on July 10, 1998, as amended (the "Registration Statement"), with the Securities and Exchange Commission covering the offering of up to Two Million Three Hundred Thousand (2,300,000) shares of the Company's Common Stock, $.001 par value (the "Shares"). In connection with this opinion, we have (i) examined the Registration Statement and related Prospectus, your Amended and Restated Certificate of Incorporation and Bylaws, as amended, and such other documents, records, certificates, memoranda and other instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below, (ii) assumed that the Amended and Restated Certificate of Incorporation, as set forth in Exhibit 3.1 of the Registration Statement, shall have been duly approved and filed with the office of the Delaware Secretary of State, and (iii) that the shares of Common Stock will be sold by the Underwriters at a price established by the Pricing Committee of the Board of Directors of the Company. We have assumed the genuineness and authenticity of all documents submitted to us as originals, the conformity to originals of all documents submitted to us as copies thereof, and the due execution and delivery of all documents where due execution and delivery are a prerequisite to the effectiveness thereof. On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when sold and issued in accordance with the Registration Statement and related Prospectus, will be validly issued, fully paid, and nonassessable. We consent to the filing of this opinion as an exhibit to the Registration Statement. Very truly yours, COOLEY GODWARD LLP /s/ James C. Kitch - ------------------ James C. Kitch