1 AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON OCTOBER 19, 1998 Registration No. 333-61261 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 --------------- POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-2 --------------- REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 --------------- SHAMAN PHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) --------------- DELAWARE 94-3095806 (STATE OR OTHER JURISDICTION OF (I.R.S. EMPLOYER INCORPORATION OR ORGANIZATION) IDENTIFICATION NUMBER) 213 EAST GRAND AVENUE SOUTH SAN FRANCISCO, CALIFORNIA 94080 (650) 952-7070 (Address, including zip code, and telephone number, including area code, of the Registrant's principal executive offices) LISA A. CONTE PRESIDENT AND CHIEF EXECUTIVE OFFICER SHAMAN PHARMACEUTICALS, INC. 213 EAST GRAND AVENUE SOUTH SAN FRANCISCO, CALIFORNIA 94080 (650) 952-7070 (Name, address, including zip code, and telephone number, including area code, of agent for service of process) Copies to: J. STEPHEN DOLEZALEK, ESQ. A. JOHN MURPHY, ESQ. BROBECK, PHLEGER & HARRISON LLP SHEPPARD, MULLIN, RICHTER & HAMPTON LLP TWO EMBARCADERO PLACE, 2200 GENG ROAD SEVENTEENTH FLOOR, FOUR EMBARCADERO CENTER PALO ALTO, CALIFORNIA 94303 SAN FRANCISCO, CALIFORNIA 94111-4106 (650) 424-0160 (415) 434-9100 2 SHAMAN PHARMACEUTICALS, INC. This Registration Statement, as amended to the date of its effectiveness (August 14, 1998), registered a minimum of 140,000 shares to a maximum of 200,000 shares of the Series C Convertible Preferred Stock (the "Shares") of Shaman Pharmaceuticals, Inc. (the "Registrant"). The Registrant sold an aggregate of 140,880 of the Shares to the Investors. The offering has now been terminated. Accordingly, the Registrant hereby deregisters 59,120 of the Shares originally covered by the Registration Statement. 2 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant has duly caused this Post-Effective Amendment No. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California on this 16th day of October, 1998. SHAMAN PHARMACEUTICALS, INC. By /s/ Lisa A. Conte ------------------------------------- Lisa A. Conte President and Chief Executive Officer Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 1 to the Registration Statement has been signed below by the persons whose signatures appear below, which persons have signed such Registration Statement in the capacities and on the dates indicated: NAME TITLE DATE ---- ----- ---- /s/ Lisa A. Conte Director, President, and Chief Executive Officer October 16, 1998 - ------------------------------------- (Principal Executive Officer) Lisa A. Conte * Chief Financial Officer (Chief Financial and October 16, 1998 - ------------------------------------- Accounting Officer) Stephanie C. Diaz * Chairman of the Board October 16, 1998 - ------------------------------------- G. Kirk Raab * - ------------------------------------- Director October 16, 1998 Adrian D.P. Bellamy - ------------------------------------- Director October , 1998 Jeffrey Berg * Director October 16, 1998 - ------------------------------------- Herbert H. McDade, Jr. * Director October 16, 1998 - ------------------------------------- M. David Titus *By: /s/ Lisa A. Conte --------------------------------- Lisa A. Conte, (Attorney-in-Fact) 3